Inflammatory mediators in acute pancreatitis

Journal of Pathology

Volumn 190, Issue 2, 2000, Pages 117-125

  Bhatia, Madhav ^a   Brady, Mark ^a   Shokuhi, Sheila ^a   Christmas, Stephen ^a   Neoptolemos, John P ^b   Slavin, John ^a  

^a ROYAL LIVERPOOL UNIVERSITY HOSPITAL   (United Kingdom)

^b NONE

Author keywords

Adult respiratory distress syndrome; Chemokines; Cytokines; Leukocytes

Indexed keywords

COMPLEMENT COMPONENT C5A; CYTOKINE; INTERCELLULAR ADHESION MOLECULE 1; INTERLEUKIN 10; INTERLEUKIN 1BETA; INTERLEUKIN 6; INTERLEUKIN 8; SUBSTANCE P; THROMBOCYTE ACTIVATING FACTOR; TUMOR NECROSIS FACTOR ALPHA;

ACUTE PANCREATITIS; ADULT RESPIRATORY DISTRESS SYNDROME; CYTOKINE PRODUCTION; HUMAN; HUMAN TISSUE; INFLAMMATION; LEUKOCYTE; MULTIPLE ORGAN FAILURE; PATHOPHYSIOLOGY; PRIORITY JOURNAL; REVIEW; SYSTEMIC INFLAMMATORY RESPONSE SYNDROME;

ACUTE DISEASE; CHEMOKINES; CYTOKINES; HUMANS; INFLAMMATION MEDIATORS; PANCREATITIS;

EID: 0033952637     PISSN: 00223417     EISSN: None     Source Type: Journal    
DOI: 10.1002/(SICI)1096-9896(200002)190:2<117::AID-PATH494>3.0.CO;2-K     Document Type: Review

References (97)

1. Sinclair MT, McCarthy A, McKay C, Sharples CE, Imrie CW. The increasing incidence and high mortality rate from acute pancreatitis in Scotland over the last ten years. Gastroenterology 1997; 112: A482.
2. Wilson PG, Manji M, Neoptolemos JP. Acute pancreatitis as a model of sepsis. J Antimicr Chemother 1998; 41: 51-63.
3. Winslet MC, Hall C, London NJM, Neoptolemus JP. Relationship of diagnostic serum amylase levels to aetiology and severity of acute pancreatitis. Gut 1992; 33: 982-986.
4. Neoptolemos JP, Raraty M, Finch M, Sutton R. Acute pancreatitis: the substantial human and financial costs. Gut 1998; 42: 886-891.
5. Gorelick FS, Otani T. Mechanisms of intracellular zymogen activation. Baillière's Clin Gastroenterol 1999; 13: 227-240.
6. Steer ML. Early events in acute pancreatitis. Baillière's Clin Gastroenterol 1999; 13: 213-216.
7. Saluja AK, Lee HS, Bhatia M, Frossard JL, Steer ML. Secretagogue-induced digestive enzyme activation and cell injury in rat pancreatic acini. Am J Physiol 1999; 276: G835-842.
8. Grady T, Mah'Moud M, Otani T, Rhee S, Lerch MM, Gorelick FS. Zymogen proteolysis within the pancreatic acinar cell is associated with cellular injury. Am J Physiol 1998; 275: G1010-G1017.
9. Whitcomb DC, Gorry MC, Preston RA, et al. Hereditary pancreatitis is caused by a mutation in the cationic trypsinogen gene. Nature Genet 1996; 14: 141-145.
10. Ward JB, Sutton R, Jenkins SA, Petersen OH. Progressive disruption of acinar cell calcium signalling is an early feature of cerulein-induced pancreatitis in mice. Gastroenterology 1996; 111: 481-491.
11. Raraty M, Petersen OH, Sutton R, Neoptolemos JP. Intracellular free ionized calcium in the pathogenesis of acute pancreatitis. Baillière's Clin Gastroenterol 1999; 13: 241-252.
12. Moore FA, Moore EE. Evolving concepts in the pathogenesis of post injury multiple organ failure. Surg Clin North Am 1995; 75: 257-277.
13. Ashbaugh DG, Bigelow DB, Petty JL, Levine BE. Acute respiratory distress in adults. Lancet 1967; 2: 219-223.
14. 2-generation and neutrophil accumulation in rat lungs after acute necrotizing pancreatitis. Surgery 1995; 118: 547-554.
15. Kivilaakso E, Valtonen W, Malkamaki M, et al. Endotoxaemia and acute pancreatitis: correlation between the severity of the disease and the anti-enterobacterial common antigen antibody titre. Gut 1984; 25: 1065-1070.
16. Norman JG, Fink GW, Franz MG. Acute pancreatitis induces intrapancreatic tumor necrosis factor gene expression. Arch Surg 1995; 130: 966-970.
17. Gukovskaya AS, Gukovsky I, Zaninovic V, et al. Pancreatic acinar cells produce, release, and respond to tumor necrosis factor-alpha. Role in regulating cell death and pancreatitis. J Clin Invest 1997; 100: 1853-1862.
18. Hughes CB, Henry J, Kotb M, Lobaschevsky A, Sabek O, Gaber AO. Up-regulation of TNF alpha mRNA in the rat spleen following induction of acute pancreatitis. J Surg Res 1995; 59: 687-693.
19. de Beaux AC, Goldie AS, Ross JA, Carter DC, Fearon KC. Serum concentrations of inflammatory mediators related to organ failure in patients with acute pancreatitis. Br J Surg 1996; 83: 349-353.
20. Scholmerich J. Interleukins in acute pancreatitis. Scand J Gastroenterol Suppl 1996; 219: 37-42.
21. Fink GW, Norman JG. Specific changes in the pancreatic expression of the interleukin-1 family of genes during experimental acute pancreatitis. Cytokine 1997; 9: 1023-1027.
22. Okusawa S, Gelfand JA, Ikejima T. Interleukin 1 induces a shock like state in rabbits. Synergism with tumour necrosis factor and the effect of cyclo-oxygenase inhibition. J Clin Invest 1988; 81: 1162-1172.
23. Fisher CJ, Dhainut JFA, Opal SM. Recombinant interleukin-1 receptor antagonist in the treatment of patients with sepsis syndrome. Results from a randomised, double blind, placebo controlled trial. J Am Med Assoc 1994; 271: 1836-1843.
24. Viguerie N, Bertrand V, Dufresne M. Interleukin-6 regulation of CCK/gastrin receptors and amylase secretion in a rat pancreatic acinar cell line. Eur Cyt Netw 1994; 5: 433-440.
25. Denham W, Yang J, Fink G, et al. Gene targeting demonstrates additive detrimental effects of interleukin-1 and tumor necrosis factor during pancreatitis. Gastroenterology 1997; 113: 1741-1746.
26. Norman J. The role of cytokines in the pathogenesis of acute pancreatitis. Am J Surg 1998; 175: 76-83.
27. Norman J, Franz M, Messina J, et al. Interleukin-1 receptor antagonist decreases severity of experimental acute pancreatitis. Surgery 1995; 117: 648-655.
28. Grewal HP, Mohey el Din A, Gaber L, Kotb M, Gaber AO. Amelioration of the physiologic and biochemical changes of acute pancreatitis using an anti-TNF-alpha polyclonal antibody. Am J Surg 1994; 167: 214-219.
29. Hughes CB, Grewal HP, Gaber LW, et al. Anti-TNF alpha therapy improves survival and ameliorates the pathophysiologic sequelae in acute pancreatitis in the rat. Am J Surg 1996; 171: 274-280.
30. Hughes CB, el-Din AB, Kotb M, Gaber LW, Gaber AO. Calcium channel blockade inhibits release of TNF alpha and improves survival in a rat model of acute pancreatitis. Pancreas 1996; 13: 22-28.
31. Norman J, Yang J, Fink G, et al. Severity and mortality of experimental pancreatitis are dependent on interleukin-1 converting enzyme (ICE). J Interf Cyt Res 1997; 17: 113-118.
32. Nijsten NWN, Hack CE, Helle M, ten Duis HJ, Klassen HJ, Aarden LA. Interleukin-6 and its relation to the humoral immune response and clinical response in burnt patients. Surgery 1991; 109: 761-767.
33. Borrelli E, Roux-Lombard P, Grau GE, Giardin E, Ricou B, Dayer J. Plasma concentrations of cytokines, their soluble receptors, and antioxidant vitamins can predict the development of multiple organ failure in patients at risk. Crit Care Med 1996; 24: 392-397.
34. Geiger T, Andus T, Klapproth J, Hirano T, Kishimoto T, Heinrich P. Induction of rat acute phase proteins by interleukin-6 in vivo. Eur J Immunol 1988; 18: 717-721.
35. Castell JV, Gomez-Lechon MJ, David M, et al. Interleukin-6 is the major regulator of acute phase protein synthesis in adult human hepatocytes. FEBS Lett 1989; 242: 237-239.
36. Leser HG, Gross C, Scheibenbogen C, et al. Elevation of serum interleukin-6 concentration precedes acute phase response and reflects severity in acute pancreatitis. Gastroenterology 1991; 101: 782-785.
37. Viedma JA, Perez-Mateo M, Dominguez JE, Carballo F. Role of interleukin-6 in acute pancreatitis. Comparison with C reactive protein and phospholipase A. Gut 1992; 33: 1264-1267.
38. Pezzilli R, Cappelletti O, Barakat B. Serum interleukin 6 in the prognosis of acute biliary pancreatitis. Ital J Gastroenterol Hepatol 1998; 30: 291-294.
39. Kasama T, Stricter RM, Lukacs NW, Burdick MD, Kunkel SL. Regulation of neutrophil-derived chemokine expression by IL-10. J Immunol 1994; 152: 3559-3569.
40. Fiorentino D, Zlotnik A, Mosmann T, Howard M, O'Garra A. IL-10 inhibits cytokine production by activated macrophages. J Immunol 1991; 147: 3815-3822.
41. Howard M, O'Garra A, Ishida H, Malefyt RD, Devries J. Biological properties of interleukin-10. J Clin Immunol 1992; 12: 239-247.
42. Howard M, Muchamuel T, Andrade S, Menon S. Interleukin-10 protects mice from lethal endotoxemia. J Exp Med 1993; 177: 1205-1208.
43. Smith SR, Terminelli C, Kenworthy-Bott L, Calzetta A, Donkin J. The cooperative effects of TNF-alpha and IFN-gamma are determining factors in the ability of IL-10 to protect mice from lethal endotoxemia. J Leuk Biol 1994; 55: 711-718.
44. van der Poll T, Smith SR, Swanson SW, Hack CE, Lowry SF, Moldawer LL. Effects of IL-10 on systemic inflammatory response during lethal primate endotoxemia. J Immunol 1997; 158: 1971-1975.
45. Seitz M, Dewald B, Towbin H, Gallati H, Baggiolini M. Interleukin-10 differentially regulates cytokine inhibitor and chemokine release from blood mononuclear cells and fibroblasts. Eur J Immunol 1995; 25: 1129-1132.
46. Pezzilli R, Billi P, Miniero R, Barakat B. Serum interleukin-10 in human acute pancreatitis. Dig Dis Sci 1997; 42: 1469-1472.
47. Kusske AM, Rongione AJ, Ashley SW, McFadden DW. Reber HA. Interleukin-10 prevents death in lethal necrotizing pancreatitis in mice. Surgery 1996; 120: 284-288.
48. Rongione AJ, Kusske AM, Kwan K, Ashley SW, Reber HA, McFadden DW. Interleukin-10 reduces the severity of acute pancreatitis in rats. Gastroenterology 1997; 112: 960-967.
49. Van Laethem JL, Marchant A, Delvaux A, et al. Interleukin 10 prevents necrosis in murine experimental acute pancreatitis. Gastroenterology 1995; 108: 1917-1922.
50. Zhou W, Levine BA, Olson MS. Platelet activating factor: a mediator of pancreatic inflammation during cerulein stimulation. Am J Pathol 1993; 142: 1504-1512.
51. Konturek SJ, Dembinski A, Konturek PJ, Warzecha Z, Jaworek J, Gustaw P. Role of platelet activating factor in pathogenesis of acute pancreatitis in rats. Gut 1992; 33: 1268-1274.
52. Emmanuelli G. Experimental acute pancreatitis induced by platelet activating factor in rabbits. Am J Pathol 1989; 134: 315-326.
53. Emmanuelli G, Montrucchio G, Dughera L. et al. Role of platelet activating factor in acute pancreatitis induced by lipopolysaccharides in rabbits. Eur J Pharmacol 1994; 261: 265-272.
54. Formela LJ, Wood LM, Whittaker M, Kingsnorth AN. Amelioration of experimental acute pancreatitis with a potent platelet-activating factor antagonist. Br J Surg 1994; 81: 1783-1785.
55. Galloway SW, Kingsnorth AN. Lung injury in the microembolic model of acute pancreatitis and amelioration by lexipafant (BB-882), a platelet-activating factor antagonist. Pancreas 1996; 13: 140-146.
56. Sandoval D, Gukovskaya A, Reavey P, et al. The role of neutrophils and platelet activating factor in mediating experimental pancreatitis. Gastroenterology 1996; 111: 1081-1091.
57. Rivera JA, Werner J, Warshaw AL, Lewandrowski KB, Rattner DW, Fernandez-del Castillo C. Lexipafant fails to improve survival in severe necrotizing pancreatitis in rats. Int J Pancreatol 1998; 23: 101-106.
58. Hofbauer B, Bhatia M, Frossard JL, Lee HS, Bhagat L, Steer ML. Effect of recombinant platelet-activating factor acetylhydrolase on two models of experimental acute pancreatitis. Gastroenterology 1998; 115: 1238-1247.
59. Kingsnorth AN, Galloway SW, Formela LJ. Randomized double-blind phase II trial of lexipafant, a platelet factor antagonist, in human acute pancreatitis. Br J Surg 1995; 82: 1414-1420.
60. Kingsnorth AN. Early treatment with lexipafant, a platelet activating factor antagonist, reduces mortality in acute pancreatitis: a double blind, randomised, placebo controlled study. Gastroenterology 1997; 112: A453.
61. Adams DH, Nash GB. Disturbance of leucocyte circulation and adhesion to the endothelium as factors in circulatory pathway. Br J Anaesth 1996; 77: 17-31.
62. Bhatia M, Hofbauer B, Lee HS, Frossard JL, Steer ML. The effects of neutrophil depletion on a completely noninvasive model of acute pancreatitis-associated lung injury. Int J Pancreatol 1998; 24: 77-83.
63. Guo L, Yamaguchi Y, Ikei S, Sugita H, Ogawa M. Neutrophil elastase inhibitor (ONO-5046) prevents lung hemorrhage induced by lipopolysaccharide in rat model of cerulein pancreatitis. Dig Dis Sci 1995; 40: 2177-2183.
64. Inoue S, Nakao A, Kishimoto W, et al. LFA-1 (CD11a/CD18) and ICAM-1 (CD54) antibodies attenuate superoxide anion release from polymorphonuclear leukocytes in rats with experimental acute pancreatitis. Pancreas 1996; 12: 183-188.
65. Inoue S, Nakao A, Kishimoto W, et al. Anti-neutrophil antibody attenuates the severity of acute lung injury in rats with experimental acute pancreatitis. Arch Surg 1995; 130: 93-98.
66. Springer TA. Adhesion receptors of the immune system. Nature 1990; 346: 425-434.
67. Fabry Z, Hendrickson D, Keiner J, Love-Horman L, Takei F, Hart MN. Adhesion molecules on murine brain microvascular endothelial cells: expression and regulation of ICAM-1 and Lgp 55. J Neuroimmunol 1992; 36: 1-11.
68. Frossard JL, Saluja A, Bhagat L, et al. The role of intercellular adhesion molecule 1 and neutrophils in acute pancreatitis and pancreatitis-associated lung injury. Gastroenterology 1999; 116: 694-701.
69. Gerard C, Gerard NP. C5A anaphylatoxin and its seven transmembrane-segment receptor. Annu Rev Immunol 1994; 12: 775-808.
70. Czermak BJ, Bless NM, Schmal H, Friedl HP, Ward PA. Role of complement in in vitro and in vivo lung inflammatory reactions. J Leukoc Biol 1998; 64: 40-48.
71. Matis LA, Rollins SA. Complement-specific antibodies: designing novel anti-inflammatories. Nature Med 1995; 1: 839-842.
72. Hopken UE, Gerard NP, Gerard C. The C5a chemoattractant receptor mediates mucosal defence to infection. Nature 1996; 383: 86-89.
73. Bozic CR, Hopken UE, Gerard C, Gerard NP. Neurogenic amplification of immune complex inflammation. Science 1996; 273: 1722-1725.
74. Bhatia M, Saluja AK, Hofbauer B, et al. Deletion of C5a receptor increases the severity of acute pancreatitis and pancreatitis-associated lung injury. Pancreas 1997; 15: 428.
75. Bowden JJ, Garland AM, Baluk P, et al. Direct observation of substance P-induced internalization of neurokinin 1 (NK1) receptors at sites of inflammation. Proc Natl Acad Sci U S A 1994; 91: 8964-8968.
76. Thurston G, Baluk P, Hirata A, McDonald DM. Permeability-related changes revealed at endothelial cell borders in inflamed venules by lectin binding. Am J Physiol 1996; 271: H2547-H2562.
77. Bhatia M, Saluja A, Hofbauer B, et al. Role of substance P and the neurokinin 1 receptor in acute pancreatitis and pancreatitis-associated lung injury. Proc Natl Acad Sci U S A 1998; 95: 4760-4765.
78. Bhatia M, Saluja AK, Hofbauer B, et al. Neutral endopeptidase (NEP) plays an anti-inflammatory role in acute pancreatitis and pancreatitis-associated lung injury. Pancreas 1997; 15: 428.
79. Murphy PM. The molecular biology of leukocyte chemoattractant receptors. Annu Rev Immunol 1994; 12: 593-633.
80. Yan Z, Zhang J, Holt JC, Stewart GJ, Niewiarowski S, Poncz M. Structural requirements of platelet chemokines for neutrophil activation. Blood 1994; 84: 2329-2339.
81. Wu DQ, La Rosa GJ, Simon MI. G-protein-coupled signal-transduction pathways for interleukin-8. Science 1993; 261: 101-103.
82. Horuk R. Molecular properties of the chemokine receptor family. TIPS 1994; 15: 159-165.
83. Baggiolini M, Walz A, Kunkel SL. Neutrophil-activating peptide-1 interleukin-8, a novel cytokine that activates neutrophils. J Clin Invest 1989; 84: 1045-1049.
84. Jeannin P, Delneste Y, Gosset P, et al. Histamine induces interleukin-8 secretion by endothelial cells. Blood 1994; 84: 2229-2233.
85. Adams DH, Shaw S. Leukocyte-endothelial interactions and regulation of leukocyte migration. Lancet 1994; 343: 831-836.
86. Hack CE, Hart M, van Schijndel RJ, et al. Interleukin-8 in sepsis: relation to shock and inflammatory mediators. Infect Immun 1992; 60: 2835-2842.
87. Gross V, Andeesen R, Leser HG, et al. Interleukin-8 and neutrophil activation in acute pancreatitis. Eur J Clin Invest 1992; 22: 200-203.
88. Rau B, Steinbach G, Gansauge F, Mayer JM, Grunert A, Beger HG. The potential role of procalcitonin and interleukin 8 in the prediction of infected necrosis in acute pancreatitis. Gut 1997; 41: 832-840.
89. Grady T, Liang P, Ernst SA, Logsdon CD. Chemokine gene expression in rat pancreatic acinar cells is an early event associated with acute pancreatitis. Gastroenterology 1997; 113: 1966-1975.
90. Zisman DA, Kunkel SL, Stricter RM, et al. MCP-1 protects mice in lethal endotoxemia. J Clin Invest 1997; 99: 2832-2836.
91. Sekido N, Mukaido N, Harada A, Nakanishi I, Watanabe Y, Matsushima K. Prevention of lung reperfusion injury in rabbits by a monoclonal antibody against interleukin-8. Nature 1993; 365: 654-657.
92. Osman MO, Kristensen JU, Jacobsen NO, et al. A monoclonal anti-interleukin 8 antibody (WS-4) inhibits cytokine response and acute lung injury in experimental severe acute necrotising pancreatitis in rabbits. Gut 1998; 43; 232-239.
93. Gerard C, Frossard JL, Bhatia M, et al. Targeted disruption of the beta-chemokine receptor CCR1 protects against pancreatitis-associated lung injury. J Clin Invest 1997; 100; 2022-2027.
94. Zagorski J, Wahl SM. Inhibition of acute peritoneal inflammation in rats by a cytokine-induced neutrophil chemoattractant receptor antagonist. J Immunol 1997; 159: 1059-1062.
95. White JR, Young PR, Hertzberg RP, et al. Identification of a potent, selective non-peptide CXCR2 antagonist that inhibits interleukin-8-induced neutrophil migration. J Biol Chem 1998; 273: 10095-10098.
96. Kledal TN, Rosenkilde MM, Coulin F, et al. A broad-spectrum chemokine antagonist encoded by Kaposi's sarcoma-associated herpesvirus. Science 1997; 277: 1656-1659.
97. Dinarello CA, Gelfand JA, Wolff SM. Anticytokine strategies in the treatment of the systemic inflammatory response syndrome. J Am Med Assoc 1993; 269: 1829-1835.