The signal to move: D. discoideum Go orienteering

Science

Volumn 300, Issue 5625, 2003, Pages 1525-1527

  Kimmel, Alan R ^a   Parent, Carole A ^b  

^a NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES   (United States)

^b NATIONAL CANCER INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CELLS; PROTEINS;

CYTOSKELETAL ORGANIZATIONS;

BIOCOMMUNICATIONS;

CHEMOATTRACTANT; CYCLIC AMP; CYCLIC AMP RECEPTOR; F ACTIN; GUANINE NUCLEOTIDE BINDING PROTEIN; MYOSIN II;

MICROBIOLOGY;

CELL ACTIVATION; CELL MIGRATION; CELL SURFACE; CHEMOTAXIS; CYTOSKELETON; DICTYOSTELIUM DISCOIDEUM; EUKARYOTIC CELL; MOLECULAR INTERACTION; NONHUMAN; PHOSPHORYLATION; PRIORITY JOURNAL; REVIEW; SIGNAL TRANSDUCTION;

1-PHOSPHATIDYLINOSITOL 3-KINASE; ACTINS; ANIMALS; CELL POLARITY; CHEMOTAXIS; CYCLIC AMP; CYCLIC GMP; DICTYOSTELIUM; GUANYLATE CYCLASE; HETEROTRIMERIC GTP-BINDING PROTEINS; MYOSIN TYPE II; PHOSPHORIC MONOESTER HYDROLASES; PHOSPHORYLATION; PROTOZOAN PROTEINS; PSEUDOPODIA; PTEN PHOSPHOHYDROLASE; RECEPTORS, CYCLIC AMP; SIGNAL TRANSDUCTION; TUMOR SUPPRESSOR PROTEINS;

DICTYOSTELIUM DISCOIDEUM; EUKARYOTA; FUNGI; PROTOZOA;

EID: 0037567299     PISSN: 00368075     EISSN: None     Source Type: Journal    
DOI: 10.1126/science.1085439     Document Type: Review

References (25)

1. S. H. Zigmond, J. Cell Biol. 75, 606 (1977).
2. L. Kreppel, A. R. Kimmel, Nucleic Acid Res. 30, 84 (2002).
3. L. Aubry, R. A. Firtel, Annu. Rev. Cell Dev. Biol. 15, 469 (1999).
4. C. A. Parent, P. N. Devreotes, Science 284, 765 (1999).
5. A. R. Kimmel, C. A. Parent, Dictyostellium discoideum cAMP receptor, cAMP chemotaxis pathway, Science's STKE (Connections Map as seen June 2003), http:// stke.sciencemag.org/cgi/cm/stkecm;CMP_7918.
6. A. R. Kimmel, C. A. Parent, Dictyostelium discoideum cAMP receptor, G protein independent pathway, Science's STKE (Connections Map as seen June 2003), http://stke.sciencemag.org/cgi/cm/stkecm; CMP_11471.
7. A. L. Drayer, J. Van der Kaay, G. W. Mayr, P. J. Van Haastert, EMBO J. 13, 1601 (1994).
8. D. Traynor, J. L. Milne, R. H. Insall, R. R. Kay, EMBO J. 19, 4846 (2000).
9. P. W. Kriebel, V. A. Barr, C. A. Parent, Cell 112, 549 (2003).
10. D. J. Wessels et al., Mol. Biol. Cell 11, 2803 (2000).
11. H. Zhang et al., Eukaryot. Cell 2, 62 (2003).
12. S. Funamoto, R. Meikli, S. Lee, L. Parry, R. A. Firtel, Cell 109, 611 (2002).
13. M. Iijima, P. Devreotes, Cell 109, 599 (2002).
14. Y. H. Han et al., J. Biol. Chem. 277, 49877 (2002).
15. J. E. Bear, J. F. Rawls, C. L. Saxe III, J. Cell. Biol. 142, 1325 (1998).
16. A. Wilkins, R. H. Insall, Trends Genet. 17, 41 (2001).
17. C. Y. Chung, G. Potikyan, R. A. Firtel, Mol. Cell 7, 937 (2001).
18. L. Bosgraaf et al., EMBO J. 21, 4560 (2002).
19. M. A. de la Roche, J. L. Smith, V. Betapudi, T. T. Egelhoff, G. P. Cote, J. Muscle Res. Cell Motil., in press.
20. M. Iijima, Y. E. Huang, P. Devreotes, Dev. Cell 3, 469 (2002).
21. A. Levchenko, P. A. Iglesias, Biophys, J. 82, 50 (2002).
22. M. Postma, P. J. Van Haastert, Biophys. J. 81, 1314 (2001).
23. A. Narang, K. K. Subramanian, D. A. Lauffenburger, Ann. Biomed. Eng. 29, 677 (2001).
24. W. J. Rappel, P. J. Thomas, H. Levine, W. F. Loomis, Biophys. J. 83, 1361 (2002).
25. We are extremely grateful to the members of the Kimmel and Parent laboratories. Special thanks to S. Shu and E. Korn for generating the image in Fig. 1. The pathways described rely on the contributions of the many groups studying chemotaxis, and we are indebted to everyone who has generously provided us access to their unpublished data. An integrated genetic and literature database about D. discoideum can be found at http://dictybase. org.