메뉴 건너뛰기




Volumn 10, Issue 1, 2004, Pages 68-74

RNA Interference: A New Mechanism by which FMRP Acts in the Normal Brain? What Can Drosophila Teach Us?

Author keywords

Drosophila; FMR1; miRNA; RNAi; Translational repression

Indexed keywords

ARGONAUTE 2 PROTEIN; DICER; FRAGILE X MENTAL RETARDATION PROTEIN; MICRORNA; PROTEIN; RIBOSOME PROTEIN; RNA; RNA BINDING PROTEIN; RNA INDUCED SILENCING COMPLEX; SMALL INTERFERING RNA; UNCLASSIFIED DRUG;

EID: 1642326115     PISSN: 10804013     EISSN: None     Source Type: Journal    
DOI: 10.1002/mrdd.20011     Document Type: Review
Times cited : (28)

References (82)
  • 1
    • 0028246435 scopus 로고
    • Fmr1 knockout mice: A model to study Fragile X mental retardation
    • The Dutch-Belgian Fragile X Consortium. 1994. Fmr1 knockout mice: a model to study Fragile X mental retardation. Cell 78:23-33.
    • (1994) Cell , vol.78 , pp. 23-33
  • 2
    • 0036468432 scopus 로고    scopus 로고
    • Chaperone suppression of alpha-synuclein toxicity in a Drosophila model for Parkinson's disease
    • Auluck PK, Chan HY, Trojanowski JQ, et al. 2002. Chaperone suppression of alpha-synuclein toxicity in a Drosophila model for Parkinson's disease. Science 295:865-868.
    • (2002) Science , vol.295 , pp. 865-868
    • Auluck, P.K.1    Chan, H.Y.2    Trojanowski, J.Q.3
  • 3
    • 0035905766 scopus 로고    scopus 로고
    • Role for a bidentate ribonuclease in the initiation step of RNA interference
    • Bernstein E, Caudy AA, Hammond SM, et al. 2001. Role for a bidentate ribonuclease in the initiation step of RNA interference. Nature 409:363-366.
    • (2001) Nature , vol.409 , pp. 363-366
    • Bernstein, E.1    Caudy, A.A.2    Hammond, S.M.3
  • 4
    • 0036802605 scopus 로고    scopus 로고
    • Establishing and sculpting the synapse in Drosophila and C. elegans
    • Broadie KS, Richmond JE. 2002. Establishing and sculpting the synapse in Drosophila and C. elegans. Curr Opin Neurobiol 12:491-498.
    • (2002) Curr Opin Neurobiol , vol.12 , pp. 491-498
    • Broadie, K.S.1    Richmond, J.E.2
  • 5
    • 18044379515 scopus 로고    scopus 로고
    • Microarray identification of FMRP-associated brain mRNAs and altered mRNA translational profiles in Fragile X syndrome
    • Brown V, Jin P, Ceman S, et al. 2001. Microarray identification of FMRP-associated brain mRNAs and altered mRNA translational profiles in Fragile X syndrome. Cell 107:477-487.
    • (2001) Cell , vol.107 , pp. 477-487
    • Brown, V.1    Jin, P.2    Ceman, S.3
  • 6
    • 0342804533 scopus 로고    scopus 로고
    • Gene silencing in worms and fungi
    • Catalanotto C, Azzalin G, Macino G, et al. 2000. Gene silencing in worms and fungi. Nature 404:245.
    • (2000) Nature , vol.404 , pp. 245
    • Catalanotto, C.1    Azzalin, G.2    Macino, G.3
  • 7
    • 0036792769 scopus 로고    scopus 로고
    • Fragile X-related protein and VIG associate with the RNA interference machinery
    • Caudy AA, Myers M, Hannon GJ, et al. 2002. Fragile X-related protein and VIG associate with the RNA interference machinery. Genes Dev 16:2491-2496.
    • (2002) Genes Dev , vol.16 , pp. 2491-2496
    • Caudy, A.A.1    Myers, M.2    Hannon, G.J.3
  • 8
    • 0036897569 scopus 로고    scopus 로고
    • Asymmetric segregation of Numb: A mechanism for neural specification from Drosophila to mammals
    • Cayouette M, Raff M. 2002. Asymmetric segregation of Numb: A mechanism for neural specification from Drosophila to mammals. Nat Neurosci 5:1265-1269.
    • (2002) Nat Neurosci , vol.5 , pp. 1265-1269
    • Cayouette, M.1    Raff, M.2
  • 9
    • 0033669621 scopus 로고    scopus 로고
    • Post-transcriptional gene silencing across kingdoms
    • Cogoni C, Macino G. 2000. Post-transcriptional gene silencing across kingdoms. Curr Opin Genet Dev 10:638-643.
    • (2000) Curr Opin Genet Dev , vol.10 , pp. 638-643
    • Cogoni, C.1    Macino, G.2
  • 10
    • 0035900649 scopus 로고    scopus 로고
    • Fragile X mental retardation protein targets G quartet mRNAs important for neuronal function
    • Darnell JC, Jensen KB, Jin P, et al. 2001. Fragile X mental retardation protein targets G quartet mRNAs important for neuronal function. Cell 107:489-499.
    • (2001) Cell , vol.107 , pp. 489-499
    • Darnell, J.C.1    Jensen, K.B.2    Jin, P.3
  • 11
    • 0033133863 scopus 로고    scopus 로고
    • Unwinding RNA in Saccharomyces cerevisiae: DEAD-box proteins and related families
    • de la Cruz J, Kressler D, Linder P. 1999. Unwinding RNA in Saccharomyces cerevisiae: DEAD-box proteins and related families. Trends Biochem Sci 24:192-198.
    • (1999) Trends Biochem Sci , vol.24 , pp. 192-198
    • De La Cruz, J.1    Kressler, D.2    Linder, P.3
  • 12
    • 0037071905 scopus 로고    scopus 로고
    • Drosophila lacking dfmr1 activity show defects in circadian output and fail to maintain courtship interest
    • Dockendorff TC, Su HS, McBride SM, et al. 2002. Drosophila lacking dfmr1 activity show defects in circadian output and fail to maintain courtship interest. Neuron 34:973-984.
    • (2002) Neuron , vol.34 , pp. 973-984
    • Dockendorff, T.C.1    Su, H.S.2    McBride, S.M.3
  • 13
    • 0037425583 scopus 로고    scopus 로고
    • Short-interfering-RNA-mediated gene silencing in mammalian cells requires Dicer and eIF2C translation initiation factors
    • Doi N, Zenno S, Ueda R, et al. 2003. Short-interfering-RNA-mediated gene silencing in mammalian cells requires Dicer and eIF2C translation initiation factors. Curr Biol 13:41-46.
    • (2003) Curr Biol , vol.13 , pp. 41-46
    • Doi, N.1    Zenno, S.2    Ueda, R.3
  • 14
    • 0031923221 scopus 로고    scopus 로고
    • Gene discovery in Drosophila: New insights for learning and memory
    • Dubnau J, Tully T. 1998. Gene discovery in Drosophila: New insights for learning and memory. Annu Rev Neurosci 21:407-444.
    • (1998) Annu Rev Neurosci , vol.21 , pp. 407-444
    • Dubnau, J.1    Tully, T.2
  • 15
    • 0033593306 scopus 로고    scopus 로고
    • Molecular bases for circadian clocks
    • Dunlap JC. 1999. Molecular bases for circadian clocks. Cell 96:271-290.
    • (1999) Cell , vol.96 , pp. 271-290
    • Dunlap, J.C.1
  • 16
    • 0035863097 scopus 로고    scopus 로고
    • RNA interference is mediated by 21- and 22-nucleotide RNAS
    • Elbashir SM, Lendeckel W, Tuschl T. 2001. RNA interference is mediated by 21- and 22-nucleotide RNAS. Genes Dev 15:188-200.
    • (2001) Genes Dev , vol.15 , pp. 188-200
    • Elbashir, S.M.1    Lendeckel, W.2    Tuschl, T.3
  • 17
    • 0032545933 scopus 로고    scopus 로고
    • Potent and specific genetic interference by double-stranded RNA in Caenorhabditis elegans
    • Fire A, Xu S, Montgomery MK, et al. 1998. Potent and specific genetic interference by double-stranded RNA in Caenorhabditis elegans. Nature 391:806-811.
    • (1998) Nature , vol.391 , pp. 806-811
    • Fire, A.1    Xu, S.2    Montgomery, M.K.3
  • 18
    • 0034176088 scopus 로고    scopus 로고
    • Modeling human neurodegenerative diseases in Drosophila: On a wing and a prayer
    • Fortini ME, Bonini NM. 2000. Modeling human neurodegenerative diseases in Drosophila: on a wing and a prayer. Trends Genet 16:161-167.
    • (2000) Trends Genet , vol.16 , pp. 161-167
    • Fortini, M.E.1    Bonini, N.M.2
  • 19
    • 0034639286 scopus 로고    scopus 로고
    • Melatonin profiles and sleep characteristics in boys with Fragile X syndrome: A preliminary study
    • Gould EL, Loesc, DZ, Martin MJ, et al. 2000. Melatonin profiles and sleep characteristics in boys with Fragile X syndrome: A preliminary study. Am J Med Genet 95:307-315.
    • (2000) Am J Med Genet , vol.95 , pp. 307-315
    • Gould, E.L.1    Loesc, D.Z.2    Martin, M.J.3
  • 20
    • 0035912771 scopus 로고    scopus 로고
    • Synaptic regulation of protein synthesis and the Fragile X protein
    • Greenough WT, Klintsova AY, Irwin SA, et al. 2001. Synaptic regulation of protein synthesis and the Fragile X protein. Proc Natl Acad Sci USA 98:7101-7106.
    • (2001) Proc Natl Acad Sci USA , vol.98 , pp. 7101-7106
    • Greenough, W.T.1    Klintsova, A.Y.2    Irwin, S.A.3
  • 21
    • 17844364875 scopus 로고    scopus 로고
    • Genes and mechanisms related to RNA interference regulate expression of the small temporal RNAs that control C. elegans developmental timing
    • Grishok A, Pasquinelli AE, Conte D, et al. 2001. Genes and mechanisms related to RNA interference regulate expression of the small temporal RNAs that control C. elegans developmental timing. Cell 106:23-34.
    • (2001) Cell , vol.106 , pp. 23-34
    • Grishok, A.1    Pasquinelli, A.E.2    Conte, D.3
  • 22
    • 0029801668 scopus 로고    scopus 로고
    • A bulged lin-4/lin-14 RNA duplex is sufficient for Caenorhabditis elegans lin-14 temporal gradient formation
    • Ha I, Wightman B, Ruvkun G. 1996. A bulged lin-4/lin-14 RNA duplex is sufficient for Caenorhabditis elegans lin-14 temporal gradient formation. Genes Dev 10:3041-3050.
    • (1996) Genes Dev , vol.10 , pp. 3041-3050
    • Ha, I.1    Wightman, B.2    Ruvkun, G.3
  • 23
    • 0001966753 scopus 로고    scopus 로고
    • The physical and behavioral phenotype
    • Hagerman RJ and Hagerman PJ, editors. Baltimore, MD: John Hopkins University Press
    • Hagerman RJ. 2002. The physical and behavioral phenotype. In Hagerman RJ and Hagerman PJ, editors. Fragile X Syndrome, Diagnosis, Treatment, and Research. Baltimore, MD: John Hopkins University Press. p. 3-109.
    • (2002) Fragile X Syndrome, Diagnosis, Treatment, and Research , pp. 3-109
    • Hagerman, R.J.1
  • 24
    • 0037183856 scopus 로고    scopus 로고
    • Establishment and maintenance of a heterochromatin domain
    • Hall IM, Shankaranarayana GD, Noma K, et al. 2002. Establishment and maintenance of a heterochromatin domain. Science 297:2232-2237.
    • (2002) Science , vol.297 , pp. 2232-2237
    • Hall, I.M.1    Shankaranarayana, G.D.2    Noma, K.3
  • 25
    • 0028360968 scopus 로고
    • The mating of a fly
    • Hall JC. 1994. The mating of a fly. Science 264:1702-1714.
    • (1994) Science , vol.264 , pp. 1702-1714
    • Hall, J.C.1
  • 26
    • 0034673638 scopus 로고    scopus 로고
    • An RNA-directed nuclease mediates post-transcriptional gene silencing in Drosophila cells
    • Hammond SM, Bernstein E, Beach D, et al. 2000. An RNA-directed nuclease mediates post-transcriptional gene silencing in Drosophila cells. Nature 404:293-296.
    • (2000) Nature , vol.404 , pp. 293-296
    • Hammond, S.M.1    Bernstein, E.2    Beach, D.3
  • 27
    • 0035839109 scopus 로고    scopus 로고
    • Argonaute2, a link between genetic and biochemical analyses of RNAi
    • Hammond SM, Boettcher S, Caudy AA, et al. 2001. Argonaute2, a link between genetic and biochemical analyses of RNAi. Science 293:1146-1150.
    • (2001) Science , vol.293 , pp. 1146-1150
    • Hammond, S.M.1    Boettcher, S.2    Caudy, A.A.3
  • 28
    • 0037062951 scopus 로고    scopus 로고
    • RNA interference
    • Hannon GJ. 2002. RNA interference. Nature 418:244-251.
    • (2002) Nature , vol.418 , pp. 244-251
    • Hannon, G.J.1
  • 29
    • 0035800521 scopus 로고    scopus 로고
    • A cellular function for the RNA-interference enzyme Dicer in the maturation of the let-7 small temporal RNA
    • Hutvagner G, McLachlan J, Pasquinelli AE, et al. 2001. A cellular function for the RNA-interference enzyme Dicer in the maturation of the let-7 small temporal RNA. Science 293:834-838.
    • (2001) Science , vol.293 , pp. 834-838
    • Hutvagner, G.1    McLachlan, J.2    Pasquinelli, A.E.3
  • 30
  • 31
    • 0037144546 scopus 로고    scopus 로고
    • A microRNA in a multiple-turnover RNAi enzyme complex
    • Hutvagner G, Zamore PD. 2002b. A microRNA in a multiple-turnover RNAi enzyme complex. Science 297:2056-2060.
    • (2002) Science , vol.297 , pp. 2056-2060
    • Hutvagner, G.1    Zamore, P.D.2
  • 32
    • 0001299954 scopus 로고    scopus 로고
    • FMR1 and mutations in Fragile X syndrome: Molecular biology, biochemistry, and genetics
    • Wells RD and Warren ST, editors. San Diego: Academic Press
    • Imbert G, Feng Y, Nelson DL, et al. 1998. FMR1 and mutations in Fragile X syndrome: Molecular biology, biochemistry, and genetics. In Wells RD and Warren ST, editors. Genetic Instabilities and Hereditary Neurological Diseases. San Diego: Academic Press. p. 27-53.
    • (1998) Genetic Instabilities and Hereditary Neurological Diseases , pp. 27-53
    • Imbert, G.1    Feng, Y.2    Nelson, D.L.3
  • 33
    • 0034244140 scopus 로고    scopus 로고
    • Molecular mechanisms of Fragile X syndrome
    • Inoue SB, Siomi MC, Siomi, H. 2000. Molecular mechanisms of Fragile X syndrome. J Med Invest 47:101-107.
    • (2000) J Med Invest , vol.47 , pp. 101-107
    • Inoue, S.B.1    Siomi, M.C.2    Siomi, H.3
  • 34
    • 0037031153 scopus 로고    scopus 로고
    • A role for the Drosophila Fragile X-related gene in circadian output
    • Inoue SB, Shimoda M, Nishinokubi I, et al. 2002. A role for the Drosophila Fragile X-related gene in circadian output. Curr Biol 12:1331-1335.
    • (2002) Curr Biol , vol.12 , pp. 1331-1335
    • Inoue, S.B.1    Shimoda, M.2    Nishinokubi, I.3
  • 35
    • 0035863624 scopus 로고    scopus 로고
    • Abnormal dendritic spine characteristics in the temporal and visual cortices of patients with Fragile-X syndrome: A quantitative examination
    • Irwin SA, Patel B, Idupulapati M, et al. 2001. Abnormal dendritic spine characteristics in the temporal and visual cortices of patients with Fragile-X syndrome: A quantitative examination. Am J Med Genet 98:161-167.
    • (2001) Am J Med Genet , vol.98 , pp. 161-167
    • Irwin, S.A.1    Patel, B.2    Idupulapati, M.3
  • 36
    • 0036791671 scopus 로고    scopus 로고
    • A Drosophila Fragile X protein interacts with components of RNAi and ribosomal proteins
    • Ishizuka A, Siomi MC, Siomi H. 2002. A Drosophila Fragile X protein interacts with components of RNAi and ribosomal proteins. Genes Dev 16:2497-2508.
    • (2002) Genes Dev , vol.16 , pp. 2497-2508
    • Ishizuka, A.1    Siomi, M.C.2    Siomi, H.3
  • 37
    • 0034817335 scopus 로고    scopus 로고
    • Common developmental genetic mechanisms for patterning invertebrate and vertebrate brains
    • Kammermeier L, Reichert H. 2001. Common developmental genetic mechanisms for patterning invertebrate and vertebrate brains. Brain Res Bull 55:675-682.
    • (2001) Brain Res Bull , vol.55 , pp. 675-682
    • Kammermeier, L.1    Reichert, H.2
  • 38
    • 0030861891 scopus 로고    scopus 로고
    • Spatial and temporal expression of the period and timeless genes in the developing nervous system of Drosophila: Newly identified pacemaker candidates and novel features of clock gene product cycling
    • Kaneko M, Helfrich-Forster C, Hall JC. 1997. Spatial and temporal expression of the period and timeless genes in the developing nervous system of Drosophila: Newly identified pacemaker candidates and novel features of clock gene product cycling. J Neurosci 17:6745-6760.
    • (1997) J Neurosci , vol.17 , pp. 6745-6760
    • Kaneko, M.1    Helfrich-Forster, C.2    Hall, J.C.3
  • 39
    • 18544379477 scopus 로고    scopus 로고
    • A bivalent Huntingtin binding peptide suppresses polyglutamine aggregation and pathogenesis in Drosophila
    • Kazantsev A, Walker HA, Slepko N, et al. 2002. A bivalent Huntingtin binding peptide suppresses polyglutamine aggregation and pathogenesis in Drosophila. Nat Genet 30:367-376.
    • (2002) Nat Genet , vol.30 , pp. 367-376
    • Kazantsev, A.1    Walker, H.A.2    Slepko, N.3
  • 40
    • 0035887005 scopus 로고    scopus 로고
    • Dicer functions in RNA interference and in synthesis of small RNA involved in developmental timing in C. elegans
    • Ketting RF, Fischer SE, Bernstein E, et al. 2001. Dicer functions in RNA interference and in synthesis of small RNA involved in developmental timing in C. elegans. Genes Dev 15:2654-2659.
    • (2001) Genes Dev , vol.15 , pp. 2654-2659
    • Ketting, R.F.1    Fischer, S.E.2    Bernstein, E.3
  • 42
    • 0037372019 scopus 로고    scopus 로고
    • Of mice and the Fragile X syndrome
    • Kooy, RF. 2003. Of mice and the Fragile X syndrome. Trends Genet 19:148-154.
    • (2003) Trends Genet , vol.19 , pp. 148-154
    • Kooy, R.F.1
  • 43
    • 0035864826 scopus 로고    scopus 로고
    • Evidence that Fragile X mental retardation protein is a negative regulator of translation
    • Laggerbauer B, Ostareck D, Keidel EM, et al. 2000. Evidence that Fragile X mental retardation protein is a negative regulator of translation. Hum Mol Genet 10:329-338.
    • (2000) Hum Mol Genet , vol.10 , pp. 329-338
    • Laggerbauer, B.1    Ostareck, D.2    Keidel, E.M.3
  • 44
    • 0035955374 scopus 로고    scopus 로고
    • Identification of novel genes coding for small expressed RNAs
    • Lagos-Quintana M, Rauhut R, Lendeckel W, et al. 2001. Identification of novel genes coding for small expressed RNAs. Science 294:853-858.
    • (2001) Science , vol.294 , pp. 853-858
    • Lagos-Quintana, M.1    Rauhut, R.2    Lendeckel, W.3
  • 45
    • 0035955361 scopus 로고    scopus 로고
    • An abundant class of tiny RNAs with probable regulatory roles in Caenorhabditis elegans
    • Lau NC, Lim le-EP, Weinstein EG, et al. 2001. An abundant class of tiny RNAs with probable regulatory roles in Caenorhabditis elegans. Science 294:858-862.
    • (2001) Science , vol.294 , pp. 858-862
    • Lau, N.C.1    Lim, L.-E.P.2    Weinstein, E.G.3
  • 46
    • 0035955366 scopus 로고    scopus 로고
    • An extensive class of small RNAs in Caenorhabditis elegans
    • Lee RC, Ambros V. 2001. An extensive class of small RNAs in Caenorhabditis elegans. Science 294:862-864.
    • (2001) Science , vol.294 , pp. 862-864
    • Lee, R.C.1    Ambros, V.2
  • 47
    • 0027751663 scopus 로고
    • The C. elegans heterochronic gene lin-4 encodes small RNAs with antisense complementarity to lin-14
    • Lee RC, Feinbaum RL, Ambros V. 1993. The C. elegans heterochronic gene lin-4 encodes small RNAs with antisense complementarity to lin-14. Cell 75:843-854.
    • (1993) Cell , vol.75 , pp. 843-854
    • Lee, R.C.1    Feinbaum, R.L.2    Ambros, V.3
  • 48
    • 0035368955 scopus 로고    scopus 로고
    • The Fragile X mental retardation protein inhibits translation via interacting with mRNA
    • Li Z, Zhang Y, Ku L, et al. 2000. The Fragile X mental retardation protein inhibits translation via interacting with mRNA. Nucleic Acids Res 29:2276-2283.
    • (2000) Nucleic Acids Res , vol.29 , pp. 2276-2283
    • Li, Z.1    Zhang, Y.2    Ku, L.3
  • 49
    • 0030598904 scopus 로고    scopus 로고
    • The role of the genome project in determining gene function: Insights from model organisms
    • Miklos GL, Rubin GM. 1996. The role of the genome project in determining gene function: Insights from model organisms. Cell 86:521-529.
    • (1996) Cell , vol.86 , pp. 521-529
    • Miklos, G.L.1    Rubin, G.M.2
  • 50
    • 0037421721 scopus 로고    scopus 로고
    • RNA cargoes associating with FMRP reveal deficits in cellular functioning in Fmr1 null mice
    • Miyashiro KY, Beckel-Mitchener A, Purk TP, et al. 2003. RNA cargoes associating with FMRP reveal deficits in cellular functioning in Fmr1 null mice. Neuron 37:417-431.
    • (2003) Neuron , vol.37 , pp. 417-431
    • Miyashiro, K.Y.1    Beckel-Mitchener, A.2    Purk, T.P.3
  • 51
    • 0037071888 scopus 로고    scopus 로고
    • Drosophila Fragile X protein, DFXR, regulates neuronal morphology and function in the brain
    • Morales J, Hiesinger PR, Schroeder AJ, et al. 2002. Drosophila Fragile X protein, DFXR, regulates neuronal morphology and function in the brain. Neuron 34:961-972.
    • (2002) Neuron , vol.34 , pp. 961-972
    • Morales, J.1    Hiesinger, P.R.2    Schroeder, A.J.3
  • 52
    • 0037087780 scopus 로고    scopus 로고
    • miRNPs: A novel class of ribonucleoproteins containing numerous microRNAs
    • Mourelatos Z, Dostie J, Paushkin S, et al. 2002. miRNPs: A novel class of ribonucleoproteins containing numerous microRNAs. Genes Dev 16:720-728.
    • (2002) Genes Dev , vol.16 , pp. 720-728
    • Mourelatos, Z.1    Dostie, J.2    Paushkin, S.3
  • 53
    • 0036514504 scopus 로고    scopus 로고
    • Modelling neurodegenerative diseases in Drosophila: A fruitful approach?
    • Muqit MM, Feany MB. 2002. Modelling neurodegenerative diseases in Drosophila: A fruitful approach? Nat Rev Neurosci 3:237-243.
    • (2002) Nat Rev Neurosci , vol.3 , pp. 237-243
    • Muqit, M.M.1    Feany, M.B.2
  • 55
    • 0036301947 scopus 로고    scopus 로고
    • A decade of molecular studies of Fragile X syndrome
    • O'Donnell WT, Warren ST. 2002. A decade of molecular studies of Fragile X syndrome. Annu Rev Neurosci 25:315-338.
    • (2002) Annu Rev Neurosci , vol.25 , pp. 315-338
    • O'Donnell, W.T.1    Warren, S.T.2
  • 56
    • 0033572284 scopus 로고    scopus 로고
    • The lin-4 regulatory RNA controls developmental timing in Caenorhabditis elegans by blocking LIN-14 protein synthesis after the initiation of translation
    • Olsen PH, Ambros V. 1999. The lin-4 regulatory RNA controls developmental timing in Caenorhabditis elegans by blocking LIN-14 protein synthesis after the initiation of translation. Dev Biol 216:671-680.
    • (1999) Dev Biol , vol.216 , pp. 671-680
    • Olsen, P.H.1    Ambros, V.2
  • 57
    • 0028163938 scopus 로고
    • Developmental evolution: Insights from studies of insect segmentation
    • Patel NH. 1994. Developmental evolution: Insights from studies of insect segmentation. Science 266:581-590.
    • (1994) Science , vol.266 , pp. 581-590
    • Patel, N.H.1
  • 58
    • 0016251748 scopus 로고
    • Dendritic spine "dysgenesis" and mental retardation
    • Purpura DP. 1974. Dendritic spine "dysgenesis" and mental retardation. Science 186:1126-1128.
    • (1974) Science , vol.186 , pp. 1126-1128
    • Purpura, D.P.1
  • 59
    • 0034708122 scopus 로고    scopus 로고
    • The 21-nucleotide let-7 RNA regulates developmental timing in Caenorhabditis elegans
    • Reinhart BJ, Slack FJ, Basson M, et al. 2000. The 21-nucleotide let-7 RNA regulates developmental timing in Caenorhabditis elegans. Nature 403:901-906.
    • (2000) Nature , vol.403 , pp. 901-906
    • Reinhart, B.J.1    Slack, F.J.2    Basson, M.3
  • 60
    • 0034708444 scopus 로고    scopus 로고
    • Comparative genomics of the eukaryotes
    • Rubin GM, Yandell MD, Wortman JR, et al. 2000. Comparative genomics of the eukaryotes. Science 287:2204-2215.
    • (2000) Science , vol.287 , pp. 2204-2215
    • Rubin, G.M.1    Yandell, M.D.2    Wortman, J.R.3
  • 61
    • 0035919690 scopus 로고    scopus 로고
    • Absence of junctional glutamate receptor clusters in Drosophila mutants lacking spontaneous transmitter release
    • Saitoe M, Schwarz TL, Umbach JA, et al. 2001. Absence of junctional glutamate receptor clusters in Drosophila mutants lacking spontaneous transmitter release. Science 293:514-517.
    • (2001) Science , vol.293 , pp. 514-517
    • Saitoe, M.1    Schwarz, T.L.2    Umbach, J.A.3
  • 62
    • 0035801393 scopus 로고    scopus 로고
    • The Fragile X mental retardation protein binds specifically to its mRNA via a purine quartet motif
    • Schaeffer C, Bardoni B, Mandel J-L, et al. 2001. The Fragile X mental retardation protein binds specifically to its mRNA via a purine quartet motif. EMBO J 20:4803-4013.
    • (2001) EMBO J , vol.20 , pp. 4803-4013
    • Schaeffer, C.1    Bardoni, B.2    Mandel, J.-L.3
  • 63
    • 0037085968 scopus 로고    scopus 로고
    • Two genetic circuits repress the Caenorhabditis elegans heterochronic gene lin-28 after translation initiation
    • Seggerson K, Tang L, Moss, EG. 2002. Two genetic circuits repress the Caenorhabditis elegans heterochronic gene lin-28 after translation initiation. Dev Biol 243:215-225.
    • (2002) Dev Biol , vol.243 , pp. 215-225
    • Seggerson, K.1    Tang, L.2    Moss, E.G.3
  • 64
    • 0027327486 scopus 로고
    • The protein product of the Fragile X gene, FMR1, has characteristics of an RNA-binding protein
    • Siomi H, Siomi MC, Nussbaum RL, et al. 1993. The protein product of the Fragile X gene, FMR1, has characteristics of an RNA-binding protein. Cell 74:291-298.
    • (1993) Cell , vol.74 , pp. 291-298
    • Siomi, H.1    Siomi, M.C.2    Nussbaum, R.L.3
  • 65
    • 0029069223 scopus 로고
    • FXR1, an autosomal homolog of the Fragile X mental retardation gene
    • Siomi MC, Siomi H, Sauer WH, et al. 1995. FXR1, an autosomal homolog of the Fragile X mental retardation gene. EMBO J 14:2401-2408.
    • (1995) EMBO J , vol.14 , pp. 2401-2408
    • Siomi, M.C.1    Siomi, H.2    Sauer, W.H.3
  • 66
    • 0036892046 scopus 로고    scopus 로고
    • Casein kinase II phosphorylates the Fragile X mental retardation protein and modulates its biological properties
    • Siomi MC, Higashijima K, Ishizuka A, et al. 2002. Casein kinase II phosphorylates the Fragile X mental retardation protein and modulates its biological properties. Mol Cell Biol 22:8438-8447.
    • (2002) Mol Cell Biol , vol.22 , pp. 8438-8447
    • Siomi, M.C.1    Higashijima, K.2    Ishizuka, A.3
  • 67
    • 0033634943 scopus 로고    scopus 로고
    • The lin-41 RBCC gene acts in the C. elegans heterochronic pathway between the let-7 regulatory RNA and the LIN-29 transcription factor
    • Slack FJ, Basson M, Liu Z, et al. 2000. The lin-41 RBCC gene acts in the C. elegans heterochronic pathway between the let-7 regulatory RNA and the LIN-29 transcription factor. Mol Cell 5:659-669.
    • (2000) Mol Cell , vol.5 , pp. 659-669
    • Slack, F.J.1    Basson, M.2    Liu, Z.3
  • 68
    • 0035909330 scopus 로고    scopus 로고
    • Histone deacetylase inhibitors arrest polyglutamine-dependent neurodegeneration in Drosophila
    • Steffan JS, Bodai L, Pallos J, et al. 2001. Histone deacetylase inhibitors arrest polyglutamine-dependent neurodegeneration in Drosophila. Nature 413:739-743.
    • (2001) Nature , vol.413 , pp. 739-743
    • Steffan, J.S.1    Bodai, L.2    Pallos, J.3
  • 69
    • 0036082991 scopus 로고    scopus 로고
    • Genetic manipulation of single neurons in vivo reveals specific roles of flamingo in neuronal morphogenesis
    • Sweeney NT, Li W, Gao FB. 2002. Genetic manipulation of single neurons in vivo reveals specific roles of flamingo in neuronal morphogenesis. Dev Biol 247:76-88.
    • (2002) Dev Biol , vol.247 , pp. 76-88
    • Sweeney, N.T.1    Li, W.2    Gao, F.B.3
  • 70
    • 0032717319 scopus 로고    scopus 로고
    • The rde-1 gene, RNA interference, and transposon silencing in C. elegans
    • Tabara H, Sarkissian M, Kelly WG, et al. 1999. The rde-1 gene, RNA interference, and transposon silencing in C. elegans. Cell 99:123-132.
    • (1999) Cell , vol.99 , pp. 123-132
    • Tabara, H.1    Sarkissian, M.2    Kelly, W.G.3
  • 71
    • 0037188904 scopus 로고    scopus 로고
    • rde-4 encodes a double-stranded RNA binding protein that interacts in vivo with RDE-1, DCR-1 and a conserved DExH-box helicase to direct RNA interference in C. elegans
    • Tabara H, Yigit E, Siomi H, et al. 2002. rde-4 encodes a double-stranded RNA binding protein that interacts in vivo with RDE-1, DCR-1 and a conserved DExH-box helicase to direct RNA interference in C. elegans. Cell 109:861-871.
    • (2002) Cell , vol.109 , pp. 861-871
    • Tabara, H.1    Yigit, E.2    Siomi, H.3
  • 72
    • 0035933512 scopus 로고    scopus 로고
    • RNA silencing in plants: Defense and counterdefense
    • Vance V, Vaucheret H. 2001. RNA silencing in plants: defense and counterdefense. Science 292:2277-2280.
    • (2001) Science , vol.292 , pp. 2277-2280
    • Vance, V.1    Vaucheret, H.2
  • 73
    • 0027236971 scopus 로고
    • Characterization and localization of the FMR-1 gene product associated with Fragile X syndrome
    • Verheij C, Bakker CE, de Graaff E, et al. 1993. Characterization and localization of the FMR-1 gene product associated with Fragile X syndrome. Nature 363:722-724.
    • (1993) Nature , vol.363 , pp. 722-724
    • Verheij, C.1    Bakker, C.E.2    De Graaff, E.3
  • 74
    • 0037072661 scopus 로고    scopus 로고
    • Regulation of heterochromatic silencing and histone H3 lysine-9 methylation by RNAi
    • Volpe TA, Kidner C, Hall IM, et al. 2002. Regulation of heterochromatic silencing and histone H3 lysine-9 methylation by RNAi. Science 297:1833-1837.
    • (2002) Science , vol.297 , pp. 1833-1837
    • Volpe, T.A.1    Kidner, C.2    Hall, I.M.3
  • 75
    • 0035576875 scopus 로고    scopus 로고
    • What can we teach Drosophila? What can they teach us?
    • Waddell S, Quinn WG. 2001. What can we teach Drosophila? What can they teach us? Trends Genet 17:719-726.
    • (2001) Trends Genet , vol.17 , pp. 719-726
    • Waddell, S.1    Quinn, W.G.2
  • 76
    • 0033761489 scopus 로고    scopus 로고
    • Characterization of dFMR1, a Drosophila melanogaster homolog of the Fragile X mental retardation protein
    • Wan L, Dockendorff TC, Jongens TA, et al. 2000. Characterization of dFMR1, a Drosophila melanogaster homolog of the Fragile X mental retardation protein. Mol Cell Biol 20:8536-8547.
    • (2000) Mol Cell Biol , vol.20 , pp. 8536-8547
    • Wan, L.1    Dockendorff, T.C.2    Jongens, T.A.3
  • 77
    • 0035859046 scopus 로고    scopus 로고
    • Gene silencing as an adaptive defense against viruses
    • Waterhouse PM, Wang MB, Lough T. 2001. Gene silencing as an adaptive defense against viruses. Nature 411:834-842.
    • (2001) Nature , vol.411 , pp. 834-842
    • Waterhouse, P.M.1    Wang, M.B.2    Lough, T.3
  • 78
    • 0027730383 scopus 로고
    • Posttranscriptional regulation of the heterochronic gene lin-14 by lin-4 mediates temporal pattern formation in C. elegans
    • Wightman B, Ha I, Ruvkun G. 1993. Posttranscriptional regulation of the heterochronic gene lin-14 by lin-4 mediates temporal pattern formation in C. elegans. Cell 75:855-862.
    • (1993) Cell , vol.75 , pp. 855-862
    • Wightman, B.1    Ha, I.2    Ruvkun, G.3
  • 79
    • 0031715040 scopus 로고    scopus 로고
    • The molecular control of circadian behavioral rhythms and their entrainment in Drosophila
    • Young MW. 1998. The molecular control of circadian behavioral rhythms and their entrainment in Drosophila. Annu Rev Biochem 67:135-152.
    • (1998) Annu Rev Biochem , vol.67 , pp. 135-152
    • Young, M.W.1
  • 80
    • 0034737298 scopus 로고    scopus 로고
    • RNAi: Double-stranded RNA directs the ATP-dependent cleavage of mRNA at 21 to 23 nucleotide intervals
    • Zamore PD, Tuschl T, Sharp PA, et al. 2000. RNAi: Double-stranded RNA directs the ATP-dependent cleavage of mRNA at 21 to 23 nucleotide intervals. Cell 101:25-33.
    • (2000) Cell , vol.101 , pp. 25-33
    • Zamore, P.D.1    Tuschl, T.2    Sharp, P.A.3
  • 81
    • 0028971722 scopus 로고
    • The Fragile X mental retardation syndrome protein interacts with novel homologs FXR1 and FXR2
    • Zhang Y, O'Connor JP, Siomi MC, et al. 1995. The Fragile X mental retardation syndrome protein interacts with novel homologs FXR1 and FXR2. EMBO J 14:5358-5366.
    • (1995) EMBO J , vol.14 , pp. 5358-5366
    • Zhang, Y.1    O'Connor, J.P.2    Siomi, M.C.3
  • 82
    • 0035977134 scopus 로고    scopus 로고
    • Drosophila Fragile X-related gene regulates the MAP1B homolog futsch to control synaptic structure and function
    • Zhang YQ, Bailey AM, Matthies HJ, et al. 2001. Drosophila Fragile X-related gene regulates the MAP1B homolog futsch to control synaptic structure and function. Cell 107:591-603.
    • (2001) Cell , vol.107 , pp. 591-603
    • Zhang, Y.Q.1    Bailey, A.M.2    Matthies, H.J.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.