Effects of monocrotaline, a pyrrolizidine alkaloid, on glutathione metabolism in the rat

Biochemical Pharmacology

Volumn 51, Issue 3, 1996, Pages 375-379

  Yan, Chong Chao ^a   Huxtable, Ryan J ^a  

^a UNIVERSITY OF ARIZONA COLLEGE OF MEDICINE   (United States)

Author keywords

GSH S transferases; pyrrolic metabolites; glutamyl transpeptidase; glutamylcysteine synthetase

Indexed keywords

DIPEPTIDASE; GAMMA GLUTAMYLTRANSFERASE; GLUTAMATE CYSTEINE LIGASE; GLUTATHIONE; GLUTATHIONE SYNTHASE; GLUTATHIONE TRANSFERASE; MONOCROTALINE; PYRROLIZIDINE ALKALOID;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BRAIN; CONTROLLED STUDY; CYTOSOL; DETOXIFICATION; ENZYME ACTIVITY; HEART; KIDNEY; LIVER METABOLISM; LUNG; MALE; MICROSOME; NONHUMAN; PRIORITY JOURNAL; RAT; XENOBIOTIC METABOLISM;

EID: 0030059519     PISSN: 00062952     EISSN: None     Source Type: Journal    
DOI: 10.1016/0006-2952(95)02189-2     Document Type: Article

References (27)

1. Huxtable RJ, Human health implications of pyrrolizidine alkaloids and herbs containing them. In: Toxicants of Plant Origin (Ed. Cheeke PR), Vol. 1, pp. 41-86. CRC Press, Boca Raton, FL, 1989.
2. Hooper PT, The pathology of Senecio jacobaea poisoning of mice. J Pathol 113: 227-230, 1974.
3. Rose AL, Gardner CA, McDonnell JD and Bull LB, Horses (Kimberley horse disease) in northern Australia: Cortalaria poisoning in horses. Part II. Aust Vet J 33: 49-62, 1957.
4. Todd L, Mullen M, Olley PM and Rabinovitch M, Pulmonary toxicity of monocrotaline differs at critical periods of lung development. Pediatr Res 19: 731-737, 1985.
5. Altiere RJ, Olson JW and Gillespie MN, Altered pulmonary vascular smooth muscle responsiveness in monocrotaline-induced pulmonary hypertension. J Pharmacol Exp Ther 236: 390-395, 1986.
6. Glowaz SL, Michnika M and Huxtable RJ, Detection of a reactive pyrrole in the hepatic metabolism of the pyrrolizidine alkaloid, monocrotaline. Toxicol Appl Pharmacol 115: 168-173, 1992.
7. Mattocks AR, Toxicity of pyrrolizidine alkaloids. Nature 217: 723-728, 1968.
8. Yan CC and Huxtable RJ, Quantitation of the hepatic release of metabolites of the pyrrolizidine alkaloid, monocrotaline. Toxicol Appl Pharmacol 127: 58-63, 1994.
9. Yan CC and Huxtable RJ, The relationship between the concentration of the pyrrolizidine alkaloid, monocrotaline, and the pattern of metabolites released from the isolated liver. Toxicol Appl Pharmacol 130: 1-8, 1995.
10. Yan CC and Huxtable RJ, The effect of the pyrrolizidine alkaloids, monocrotaline and trichodesmine, on tissue pyrrole binding and glutathione metabolism in the rat. Toxicon 33: 627-634, 1995.
11. Yan CC and Huxtable RJ, Relationship between glutathione concentration and metabolism of the pyrrolizidine alkaloid, monocrotaline, in the isolated, perfused liver. Toxicol Appl Pharmacol 130: 132-139, 1995.
12. Cheeke PR and Garman GR, Influence of dietary protein and sulfur amino acid levels on the toxicity of Senecio jacobea (tansy ragwort) to rats. Nutr Rep Int 9: 197-207, 1974.
13. Buckmaster GW, Cheeke PR and Shull LR, Pyrrolizidine alkaloid poisoning in rats: Protective effects of dietary cysteine. J Anim Sci 43: 464-473, 1976.
14. Miranda CL, Buhler DR, Ramsdell HS, Cheeke PR and Schmitz JA, Modifications of chronic hepatotoxicity of pyrrolizidine (Senecio) alkaloids by butylated hydroxyanisole and cysteine. Toxicol Lett 10: 177-182, 1982.
15. Adams R and Rogers EF, The structure of monocrotaline, the alkaloid in Crotalaria spectabilis and Crotalaria retusa. I. J Am Chem Soc 61: 2815-2819, 1939.
16. Yan CC and Huxtable RJ, Effect of the pyrrolizidine alkaloid, monocrotaline, on bile composition of the isolated, perfused rat liver. Life Sci 57: 617-626, 1995.
17. Yan CC and Huxtable RJ, Fluorometric determination of monobromobimane and orthophthaldehyde adducts of γ-glutamylcysteine and glutathione: Application of assay to γ-glutamylcysteine synthetase activity and glutathione concentration in the liver. J Chromatog (B: Biomedical Applications) 672: 217-224, 1995.
18. Meister A, Tate SS and Griffith OW, γ-Glutamyl transpeptidase. Methods Enzymol 77: 237-251, 1981.
19. Habit WH, Pabst MJ and Jakoby WB, Glutathione S-transferases: The first enzymatic step in mercapturic acid formation. J Biol Chem 249: 7130-7139, 1974.
20. Mattocks AR and White INH, Estimation of metabolites of pyrrolizidine alkaloids in animal tissues. Anal Biochem 38: 529-535, 1970.
21. Lowry OH, Rosebrough NJ, Farr AL and Randall RJ, Protein measurement with the Folin phenol reagent. J Biol Chem 193: 265-275, 1951.
22. Mattocks AR, Acute hepatotoxicity and pyrrolic metabolites in rats dosed with pyrrolizidine alkaloids. Chem Biol Interact 5: 227-242, 1972.
23. Bruner LH, Hilliker KS and Roth RA, Pulmonary hypertension and ECG changes from monocrotaline pyrrole in the rat. Am J Physiol 245: H300-H306, 1983.
24. Reindel JF, Ganey PE, Wagner JG, Slocombe RF and Roth RA, Development of morphologic, hemodynamic, and biochemical changes in lungs of rats given monocrotaline pyrrole. Toxicol Appl Pharmacol 106: 179-200, 1990.
25. Pan LC, Wilson DW, Lamé MW, Jones AD and Segall HJ, COR pulmonale is caused by monocrotaline and dehydromonocrotaline, but not by glutathione or cysteine conjugates of dihydropyrrolizine. Toxicol Appl Pharmacol 118: 87-97, 1993.
26. Nigra L and Huxtable RJ, Hepatic glutathione concentrations and the release of pyrrolic metabolites of the pyrrolizidine alkaloid, monocrotaline, from the isolated perfused liver. Toxicon 30: 1195-1202, 1992.
27. Huxtable RJ, Taurine and the oxidative metabolism of cysteine. In: Biochemistry of Sulfur (Ed. Huxtable RJ), pp. 121-198. Plenum Press, New York, 1986.