X-chromosome inactivation and the search for chromosome-wide silencers

Current Opinion in Genetics and Development

Volumn 12, Issue 2, 2002, Pages 219-224

  Cohen, Dena E ^a   Lee, Jeannie T ^a  

^a MASSACHUSETTS GENERAL HOSPITAL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CORE PROTEIN; DNA; GENE PRODUCT; GREEN FLUORESCENT PROTEIN; HISTONE; HISTONE H2A; PEPTIDE NUCLEIC ACID; RNA;

CHROMATIN; CHROMOSOME; GENE EXPRESSION; GENE SILENCING; HUMAN; MUTATION; NONHUMAN; NUCLEOSOME; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN DOMAIN; PROTEIN LOCALIZATION; REVIEW; SILENCER GENE; X CHROMOSOME INACTIVATION;

EID: 0036532224     PISSN: 0959437X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0959-437X(02)00289-7     Document Type: Review

References (48)

1. Gene action in the X-chromosome of the mouse (Mus Musculus L.)
2. A morphological distinction between neurones of the male and female, and the behaviour of the nucleolar satellite during accelerated nucleoprotein synthesis
3. In vivo footprint and methylation analysis by PCR-aided genomic sequencing: Comparison of active and inactive X chromosomal DNA at the CpG island and promoter of human PGK-1
4. Reduced levels of histone H3 acetylation on the inactive X chromosome in human females
5. The inactive X chromosome in female mammmals is distinguished by a lack of histone H4 acetylation, a cytogenetic marker for gene expression
6. Asynchronous duplication of human chromosomes and the origin of sex chromatin
7. Localization of the X inactivation centre on the human X chromosome in Xq13
8. The human XIST gene: Analysis of a 17kb inactive X-specific RNA that contains conserved repeats and is highly localized within the nucleus
9. The product of the mouse xist gene is a 15kb inactive X-specific transcript containing no conserved ORF and located in the nucleus
10. Forty years of decoding the silence in X-chromosome inactivation
11. Imprinted X inactivation in eutherians: A model of gametic execution and zygotic relaxation
12. X inactivation: Tsix and Xist as yin and yang
13. X-chromosome inactivation: Counting, choice and initiation
14. Making sense (and antisense) of the X inactivation center
15. XIST RNA paints the inactive X chromosome at interphase: Evidence for a novel RNA involved in nuclear/chromosome structure
16. Tsix, a gene antisense to Xist at the X-inactivation center
17. CTCF, a candidate trans-acting factor for X-inactivation choice
18. A shift from reversible to irreversible X inactivation is triggered during ES cell differentiation
19. Conditional deletion of Xist disrupts histone macroH2A localization but not maintenance of X inactivation
20. The human X-inactivation centre is not required for maintenance of X-chromosome inactivation
21. PNA interference mapping demonstrates functional domains in the noncoding RNA Xist
22. Chromosomal silencing and chromosomal localization are mediated by different domains of Xist RNA
23. Evolutionary conservation of possible functional domains of the human and murine Xist genes
24. Identification and characterization of the human XIST gene promoter: Implications for models of X chromosome inactivation
25. Developmentally regulated Xist promoter switch mediates initiation of X inactivation
26. Murine Xist RNA isoforms are different at their 3′ ends: A role for differential polyadenylation
27. MacroH2A, a core histone containing a large nonhistone region
28. Evolutionary conservation of histone macroH2A subtypes and domains
29. Histone macroH2A1 is concentrated in the inactive X chromosome of female mammals
30. MACROH2A2, a new member of the MARCOH2A core histone family
31. Histone H2A variants and the inactive X chromosome: Identification of a second macroH2A variant
32. A novel chromatin protein, distantly related to histone H2A, is largely excluded from the inactive X chromosome
33. Histone macroH2A1 is concentrated in the inactive X chromosome of female preimplantation mouse embryos
34. Histone macroH2A1.2 relocates to the inactive X chromosome after initiation and propagation of X-inactivation
35. Dynamic relocalization of histone MacroH2A1 from centrosomes to inactive X chromosomes during X inactivation
36. Centrosomal association of histone macroH2A1.2 in embryonic stem cells and somatic cells
37. Expression of Xist RNA is sufficient to initiate macrochromatin body formation
38. XIST RNA associates with specific regions of the inactive X chromatin
39. Higher concentrations of histone macroH2A in the Barr body are correlated with higher nucleosome density
40. Promoter-specific hypoacetylation of X-inactivated genes
41. Differentially methylated forms of histone H3 show unique association patterns with inactive human X chromosomes
42. Histone H3 lysine 9 methylation is an epigenetic imprint of facultative heterochromatin
43. Regulation of chromatin structure by site-specific histone H3 methyltransferases
44. Methylation of histone H3 at Lys-9 is an early mark on the X chromosome during X-inactivation
45. Murine Polycomb- and trithorax- group genes regulate homeotic pathways and beyond
46. Imprinted X inactivation maintained by a mouse Polycomb group gene
47. Transcriptional repression mediated by the human polycomb-group protein EED involves histone deacetylation
48. Identification of an autoimmune serum containing antibodies against the Barr body