Amino acid phosphoramidate monoesters of 3′-azido-3′-deoxythymidine: Relationship between antiviral potency and intracellular metabolism

Journal of Medicinal Chemistry

Volumn 44, Issue 2, 2001, Pages 223-231

  Chang, S L ^a   Griesgraber, G W ^a   Southern, P J ^a   Wagner, C R ^a  

^a UNIVERSITY OF MINNESOTA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AMINO ACID DERIVATIVE; CARBAMIC ACID DERIVATIVE; ESTER DERIVATIVE; HYDROLASE; PHENYLALANINE; PHOSPHORAMIDIC ACID DERIVATIVE; THYMIDINE; TRYPTOPHAN; ZIDOVUDINE DERIVATIVE;

ANTIVIRAL ACTIVITY; ARTICLE; CELL FREE SYSTEM; CELL LEVEL; CELL STRAIN; CONCENTRATION RESPONSE; CONTROLLED STUDY; CYTOTOXICITY; DNA INTEGRATION; DRUG DEGRADATION; DRUG MECHANISM; DRUG METABOLISM; DRUG POTENCY; HUMAN; HUMAN CELL; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; MONONUCLEAR CELL; STEREOCHEMISTRY; VIRUS REPLICATION;

ANTI-HIV AGENTS; DRUG RESISTANCE, MICROBIAL; HIV-1; HUMANS; HYDROLASES; LEUKOCYTES, MONONUCLEAR; PHOSPHORYLATION; STRUCTURE-ACTIVITY RELATIONSHIP; TUMOR CELLS, CULTURED; VIRUS REPLICATION; ZIDOVUDINE;

EID: 0035905850     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm000260r     Document Type: Article

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