Probing the mechanism of action and decomposition of amino acid phosphomonoester amidates of antiviral nucleoside prodrugs

Journal of Medicinal Chemistry

Volumn 40, Issue 21, 1997, Pages 3323-3331

  Mclntee, Edward J ^a  

^a UNIVERSITY OF MINNESOTA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

3' FLUOROTHYMIDINE; NUCLEOSIDE DERIVATIVE; PHOSPHORAMIDIC ACID DERIVATIVE; THYMIDINE DERIVATIVE; ZIDOVUDINE DERIVATIVE;

ANTIVIRAL ACTIVITY; ARTICLE; DECOMPOSITION; DRUG CYTOTOXICITY; DRUG SYNTHESIS; HUMAN; HUMAN CELL; HUMAN IMMUNODEFICIENCY VIRUS 1; MONONUCLEAR CELL; STRUCTURE ACTIVITY RELATION; VIRUS INHIBITION;

ANTI-HIV AGENTS; CELLS, CULTURED; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; DIDEOXYNUCLEOSIDES; HIV-1; HUMANS; LEUKOCYTES, MONONUCLEAR; MAGNETIC RESONANCE SPECTROSCOPY; PRODRUGS; THYMIDINE MONOPHOSPHATE; VIRUS REPLICATION; ZIDOVUDINE;

EID: 0030871081     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm960694f     Document Type: Article

References (45)

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45. Although the purity of 5 was verified by NMR, HPLC, and MS analyses, the hydroscopic nature prevented the obtaining of satisfactory (5% of theoretical) elemental analyses. The compound was, therefore, judged pure by observation of a single peak using two different RP-HPLC methods.