Uncharged AZT and D4T derivatives of phosphonoformic and phosphonoacetic acids as anti-HIV pronucleosides

Journal of Medicinal Chemistry

Volumn 47, Issue 14, 2004, Pages 3606-3614

  Shirokova, Elena A ^a   Jasko, Maxim V ^a   Khandazhinskaya, Anastasiya L ^a   Ivanov, Alexander V ^a   Yanvarev, Dmitry V ^a   Skoblov, Yury S ^a   Mitkevich, Vladimir A ^a   Bocharov, Eduard V ^b   Pronyaeva, Tatyana R ^c   Fedyuk, Nina V ^c   Kukhanova, Marina K ^a   Pokrovsky, Andrey G ^c  

^a ENGELHARDT INSTITUTE OF MOLECULAR BIOLOGY   (Russian Federation)

^b SHEMYAKIN OVCHINNIKOV INSTITUTE OF BIOORGANIC CHEMISTRY   (Russian Federation)

^c STATE RESEARCH CENTER OF VIROLOGY AND BIOTECHNOLOGY VECTOR   (Russian Federation)

Author keywords

[No Author keywords available]

Indexed keywords

ANTI HUMAN IMMUNODEFICIENCY VIRUS AGENT; FOSCARNET DERIVATIVE; NUCLEOSIDE DERIVATIVE; PHOSPHATE; PHOSPHONOACETIC ACID; PRODRUG; STAVUDINE; ZIDOVUDINE DERIVATIVE;

ANTIVIRAL ACTIVITY; ARTICLE; DRUG EFFICACY; DRUG SCREENING; DRUG SYNTHESIS; HUMAN; HUMAN CELL; HUMAN IMMUNODEFICIENCY VIRUS 1; LIPOPHILICITY; MOLECULAR STABILITY; NONHUMAN; SERUM;

ANTI-HIV AGENTS; CELL LINE; DRUG STABILITY; FOSCARNET; HIV-1; HUMANS; HYDROLYSIS; PHOSPHONOACETIC ACID; PRODRUGS; STAVUDINE; STEREOISOMERISM; STRUCTURE-ACTIVITY RELATIONSHIP; ZIDOVUDINE;

EID: 3042636470     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm0310176     Document Type: Article

References (23)

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