Synthesis of diuridine 3',5'-boranophosphate: H-phosphonate approach

Tetrahedron Letters

Volumn 40, Issue 25, 1999, Pages 4601-4604

  He, Kaizhang ^a   Sergueev, Dmitri S ^a   Sergueeva, Zinaida A ^a   Shaw, Barbara Ramsay ^a  

^a DUKE UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BORANE DERIVATIVE; DIURIDINE 3',5' BORANOPHOSPHATE; PHOSPHONIC ACID DERIVATIVE; UNCLASSIFIED DRUG;

ARTICLE; COMPLEX FORMATION; DIASTEREOISOMER; GENE EXPRESSION REGULATION; PHOSPHORUS NUCLEAR MAGNETIC RESONANCE; REACTION ANALYSIS; REVERSED PHASE LIQUID CHROMATOGRAPHY; SOLID PHASE EXTRACTION; STRUCTURE ANALYSIS; SYNTHESIS;

EID: 0033580996     PISSN: 00404039     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0040-4039(99)00742-X     Document Type: Article

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16. 1H NMR spectra were acquired at 400.0 MHz.
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18. 3): δ 8.12 (d, J=8.0 Hz, 1H, H6), 7.97 (d, 2H, Ar-H), 7.85 (d, 2H, Ar-H), 7.55 (t, 1H, Ar-H), 7.48 (t, 1H, Ar-H), 7.38 (t, 2H, Ar-H), 7.29 (t, 2H, Ar-H), 6.54 (d, J=8.0 Hz, 1H, H1′), 5.88 (d, J=4.0 Hz, 1H, H3′), 5.82 (, J=8.0 Hz, 1H, H5), 5.69 (m, 1H, H2′), 4.49 (unresolved m, 1H, H4′), 4.24, 4.19 (2m, 2H, H5′).
19. U15′), 0.76 (s, 9H, t-BuSi), -0.05 (s, 6H, MeSi).
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23. 3).
24. 3).