Differential mutation patterns in thymidine kinase and DNA polymerase genes of herpes simplex virus type 1 clones passaged in the presence of acyclovir or penciclovir

Antimicrobial Agents and Chemotherapy

Volumn 47, Issue 5, 2003, Pages 1707-1713

  Suzutani, Tatsuo ^a,b   Ishioka, Ken ^a   De Clercq, Erik ^d   Ishibashi, Kei ^a   Kaneko, Hisatoshi ^a   Kira, Toshihiko ^a   Hashimoto, Koh ichi ^a   Ogasawara, Masahiro ^b   Ohtani, Katsuki ^b   Wakamiya, Nobutaka ^b   Saijo, Masayuki ^c  

^a FUKUSHIMA MEDICAL UNIVERSITY   (Japan)

^b ASAHIKAWA MEDICAL COLLEGE   (Japan)

^c NATIONAL INSTITUTE OF INFECTIOUS DISEASES   (Japan)

^d REGA INSTITUTE FOR MEDICAL RESEARCH   (Belgium)

Author keywords

[No Author keywords available]

Indexed keywords

ACICLOVIR; DNA POLYMERASE; PENCICLOVIR; THYMIDINE KINASE;

ANTIBIOTIC RESISTANCE; ARTICLE; CLONE; CONTROLLED STUDY; DNA SEQUENCE; FRAMESHIFT MUTATION; GENE MUTATION; GENOTYPE; HERPES SIMPLEX VIRUS 1; HUMAN; HUMAN CELL; NONHUMAN; NUCLEIC ACID BASE SUBSTITUTION; NUCLEOTIDE SEQUENCE; PHENOTYPE; PRIORITY JOURNAL; STRUCTURAL GENE; VIRUS CULTURE; VIRUS ISOLATION; VIRUS MUTANT; VIRUS MUTATION; VIRUS REPLICATION; VIRUS RESISTANCE; VIRUS STRAIN;

ACYCLOVIR; ANTIVIRAL AGENTS; DNA, VIRAL; DNA-DIRECTED DNA POLYMERASE; DRUG RESISTANCE, VIRAL; GENOTYPE; HERPESVIRUS 1, HUMAN; HUMANS; MUTATION; PHENOTYPE; RESEARCH DESIGN; THYMIDINE KINASE; TUMOR CELLS, CULTURED;

EID: 10744231664     PISSN: 00664804     EISSN: None     Source Type: Journal    
DOI: 10.1128/AAC.47.5.1707-1713.2003     Document Type: Article

References (35)

1. Balfour, H. H. 1983. Resistance of herpes simplex to acyclovir. Ann. Intern. Med. 98:404-406.
2. Coen, D. M. P., A. Schaffer, P. A. Furman, P. M. Keller, and M. H. St. Clair. 1982. Biochemical and genetic analysis of acyclovir-resistant mutants of herpes simplex virus type 1. Am. J. Med. 73(Suppl. 1A):351-360.
3. Collins, P. 1988. Viral sensitivity following the introduction of acyclovir. Am. J. Med. 85(Suppl. 2A):129-134.
4. Derse, D., Y.-C. Cheng, P. A. Furman, M. H. St. Clair, and G. B. Elion. 1981. Inhibition of purified human and herpes simplex virus-induced DNA polymerases by 9-(2-hydroxyethoxymethyl)guanine triphosphate. J. Biol. Chem. 256:11447-11451.
5. Detema, R., A. C. Ericson, H. J. Field, A. Larsson, and K. Stenber. 1987. Critical determinants of antiherpes efficacy of buciclovir and related acyclic guanosine analogs. Antivir. Res. 7:303-316.
6. Dowdle, W. R., A. J. Nahmias, R. W. Harwell, and F. P. Pauls. 1967. Association of antigenic type of herpesvirus hominis with site of viral recovery. J. Immunol. 99:974-980.
7. Earnshaw, D. L., T. H. Bacon, S. J. Darlison, K. Edmonds, R. M. Parkins, and R. A. Vere Hodge. 1992. Penciclovir: mode of antiviral action of penciclovir in MRC-5 cells infected with herpes simplex virus (HSV-1), HSV-2, and varicella-zoster virus. Antimicrob. Agents Chemother. 36:2747-2757.
8. Englund, J. A., M. E. Zimmerman, E. M. Swierkosz, J. L. Goodman, D. R. Scholl, and H. H. Balfour, Jr. 1990. Herpes simplex virus resistant to acyclovir. A study in a tertiary care center. Ann. Intern. Med. 112:416-422.
9. Furman, P. A., P. V. McGuirt, P. M. Keller, J. A. Fyfe, and G. B. Elion. 1980. Inhibition by acyclovir of cell growth and DNA synthesis of cells biochemically transformed with herpesvirus genetic information. Virology 102:420-430.
10. Gaudreau, A., E. Hill, H. H. Balfour, A. Erice, Jr., and G. Boivin. 1998. Phenotypic and genotypic characterization of acyclovir-resistant herpes simplex viruses from immunocompromised patients. J. Infect. Dis. 178:297-303.
11. Hasegawa, T., T. Kawana, T. Okuda, M. Horii, T. Tsukada, and K. Shiraki. 2001. Susceptibility to acyclovir of herpes simplex virus isolates obtained between 1977 and 1996 in Japan. J. Med. Virol. 63:57-63.
12. Hill, E. L., G. A. Hunter, and M. N. Ellis. 1991. In vitro and in vivo characterization of herpes simplex virus clinical isolates recovered from patients infected with human immunodeficiency virus. Antimicrob. Agents Chemother. 35:2322-2328.
13. Ilsley, D. D., S. H. Lee, W. H. Miller, and R. D. Kuchta. 1995. Acyclic guanosine analogs inhibit polymerase α, δ, and ε with very different potencies and have unique mechanisms of action. Biochemistry 34:2504-2510.
14. Jamieson, A. T., G. A. Gentry, and J. H. Subak-Sharp. 1974. Induction of both thymidine and deoxycytidine kinase activity by herpes viruses. J. Gen. Virol. 24:465-480.
15. Kit, S., M. Sheppard, II. Ichimura, S. Nusinoff-Lehrman, M. N. Ellis, J. A. Fyfe, and H. Otsuka. 1987. Nucleotide sequence changes in thymidine kinase gene of herpes simplex virus type 2 clones from an isolate of a patient treated with acyclovir. Antimicrob. Agents Chemother. 31:1483-1490.
16. Larsson, A., K. Stenberg, A. C. Ericson, U. Haglund, W. A. Yisak, N. G. Johansson, B. Oberg, and R. Detema. 1986. Mode of action, toxicity, pharmacokinetics, and efficacy of some new antiherpesvirus guanosine analogs related to buciclovir. Antimicrob. Agents Chemother. 30:598-605.
17. McGeoch, D. J. M., M. A. Dalrymple, A. J. Davison, A. Dolan, M. C. Frame, D. McNab, L. J. Perry, J. E. Scott, and P. Taylor. 1988. The complete DNA sequence of the long unique region in the genome of herpes simplex virus type 1. J. Gen. Virol. 69:1531-1574.
18. Nugier, F., J. N. Colin, M. Aymard, and M. Langlois. 1992. Occurrence and characterization of acyclovir-resistant herpes simplex virus isolates: report on a two-year sensitivity screening survey. J. Med. Virol. 36:1-12.
19. Parris, D. S., and J. E. Harrington. 1982. Herpes simplex virus variants restraint to high concentrations of acyclovir exist in clinical isolates. Antimicrob. Agents Chemother. 22:71-77.
20. Pelosi, E., G. B. Mulanba, and D. M. Coen. 1998. Penciclovir and pathogenesis phenotypes of drug-resistant herpes simplex virus mutants. Antivir. Res. 37:17-28.
21. Reardon, J. E. 1989. Herpes simplex virus type 1 and human DNA polymerase interactions with 2′-deoxyguanosine 5′-triphosphate analogues. J. Biol. Chem. 264:19039-19044.
22. Reid, R., E. C. Mar, E. S. Huang, and M. D. Topal. 1988. Insertion and extension of acyclic dideoxy and ara nucleotides by herpesviridae human α and β polymerases: a unique inhibition mechanism for 9-(1, 3-dihydroxy-2-propoxymethyl)guanine triphosphate. J. Biol. Chem. 263:3898-3904.
23. Rubsam, L. Z., B. L. Davidson, and D. S. Shewach. 1998. Superior cytotoxicity with ganciclovir compared with acyclovir and 1-β-D-arabinofuranosylthymine in herpes simplex virus-thymidine kinase-expressing cells: a novel paradigm for cell killing. Cancer Res. 58:3873-3882.
24. Saijo, M., T. Suzutani, E. De Clercq, M. Niikura, A. Maeda, S. Morikawa, and I. Kurane. 2002. Genotypic and phenotypic characterization of the thymidine kinase of ACV-resistant HSV-1 derived from an acyclovir-sensitive herpes simplex virus type 1 strain. Antivir. Res. 56:253-262.
25. Sarisky, R. T., M. R. Quail, P. E. Clark, T. T. Nguyen, W. S. Halsey, R. J. Wittrock, J. O'Leary Bartus, M. M. Van Horn, G. M. Sathe, S. Van Horn, M. D. Kelly, T. H. Bacon, and J. J. Leary. 2001. Characterization of herpes simplex viruses in culture for resistance to penciclovir or acyclovir. J. Virol. 75:1761-1769.
26. Sarisky, R. T., T. T. Nguyen, K. E. Duffy, R. J. Wittrock, and J. J. Leary. 2000. Difference in incidence of spontaneous mutations between herpes simplex virus types 1 and 2. Antimicrob. Agents Chemother. 44:1524-1529.
27. Sasadeusz, J. J., F. Tufaro, S. Safrin, K. Schubert, M. M. Hubinette, P. K. Cheung, and S. L. Sacks. 1997. Homopolymer mutational hot spots mediate herpes simplex virus resistance to acyclovir. J. Virol. 71:3872-3878.
28. Shin, Y. K., G. Y. Cai, A. Weinberg, J. J. Leary, and M. J. Levin. 2001. Frequency of acyclovir-resistant herpes simplex virus in clinical specimens and laboratory isolates. J. Clin. Microbiol. 39:913-917.
29. Suzutani, T., S. Koyano, M. Takada, I. Yoshida, and M. Azuma. 1995. Analysis of the relationship between cellular thymidine kinase activity and virulence of thymidine kinase-negative herpes simplex virus types 1 and 2. Microbiol. Immunol. 39:787-794.
30. Suzutani, T., and H. Machida. 1992. Analysis of toxic and mutagenic activities of antiherpesvirus nucleosides against HeLa cells and herpes simplex virus type 1. Mutat. Res. 267:125-131.
31. Suzutani, T., H. Machida, and T. Sakuma. 1988. Efficacies of antiherpesvirus nucleosides against two strains of herpes simplex virus type 1 in Vero and human embryo lung fibroblast cells. Antimicrob. Agents Chemother. 32:1046-1052.
32. Tomicic, M. T., E. Bey, P. Wutzler, R. Thust, and B. Kaina. 2002. Comparative analysis of DNA breakage, chromosomal aberrations and apoptosis induced by the anti-herpes purine nucleoside analogues aciclovir, ganciclovir and penciclovir. Mutat. Res. 505:1-11.
33. Tomicic, M. T., R. Thust, and B. Kaina. 2002. Ganciclovir-induced apoptosis in HSV-1 thymidine kinase expressing cells: critical role of DNA breaks, bcl-2 decline and caspase-9 activation. Oncogene 21:2141-2153.
34. Vere Hodge, R. A., and Y.-C. Cheng. 1993. The mode of action of penciclovir. Antivir. Chem. Chemother. 4(Suppl. 1):13-24.
35. Vere Hodge, R. A., and R. M. Perkins. 1989. Mode of action of 9-(4-hydroxy-3-hydroxymethylbut-1-yl)guanine (BRL 39123) against herpes simplex virus in MRC-5 cells. Antimicrob. Agents Chemother. 33:223-229.