Structural basis for activation of α-boranophosphate nucleotide analogues targeting drug-resistant reverse transcriptase

EMBO Journal

Volumn 19, Issue 14, 2000, Pages 3520-3529

  Meyer, Philippe ^a   Schneider, Benoît ^b   Sarfati, Simon ^b   Deville Bonne, Dominique ^b   Guerreiro, Catherine ^b   Boretto, Joëlle ^c   Janin, Joël ^a   Véron, Michel ^b   Canard, Bruno ^c  

^a LABORATOIRE D ENZYMOLOGIE ET BIOCHIMIE STRUCTURALES   (France)

^b INSTITUT PASTEUR   (France)

^c Centre National de la Recherche Scientifique   (France)

Author keywords

CH...O bond; Crystallography; HIV; Nucleoside diphosphate kinase; Pyrophosphorolysis

Indexed keywords

BORANE DERIVATIVE; NUCLEOTIDE DERIVATIVE; PHOSPHATE; RNA DIRECTED DNA POLYMERASE; RNA DIRECTED DNA POLYMERASE INHIBITOR; STAVUDINE; ZIDOVUDINE;

ARTICLE; COVALENT BOND; DRUG RESISTANCE; DRUG TARGETING; ENZYME ACTIVATION; ENZYME PHOSPHORYLATION; ENZYME STRUCTURE; ENZYME SUBSTRATE COMPLEX; HUMAN IMMUNODEFICIENCY VIRUS 1; NONHUMAN; PRIORITY JOURNAL; PROTEIN TARGETING; X RAY ANALYSIS;

HUMAN IMMUNODEFICIENCY VIRUS; HUMAN IMMUNODEFICIENCY VIRUS 1; RNA VIRUSES;

EID: 0034679569     PISSN: 02614189     EISSN: None     Source Type: Journal    
DOI: 10.1093/emboj/19.14.3520     Document Type: Article

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