Discovery of novel nonpeptide tricyclic inhibitors of ras farnesyl protein transferase

Bioorganic and Medicinal Chemistry

Volumn 5, Issue 1, 1997, Pages 101-113

  Njoroge, F George ^a   Doll, Ronald J ^a   Vibulbhan, Bancha ^a   Alvarez, Carmen S ^a   Bishop, W Robert ^a   Petrin, Joanne ^a   Kirschmeier, Paul ^a   Carruthers, Nicholas I ^a   Wong, Jesse K ^a   Albanese, Margaret M ^a   Piwinski, John J ^a   Catino, Joseph ^a   Girijavallabhan, V ^a   Ganguly, Ashit K ^a  

^a MERCK RESEARCH LABORATORIES   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

4 (8 CHLORO 5,6 DIHYDRO 3 METHYL 11H BENZO[5,6]CYCLOHEPTA[1,2 B]PYRIDIN 11 YLIDENE) 1 (4 PYRIDYLACETYL)PIPERIDINE; AMIDE; GERANYLTRANSFERASE; PROTEIN FARNESYLTRANSFERASE; RAS PROTEIN; TRANSFERASE; TRANSFERASE INHIBITOR; UNCLASSIFIED DRUG;

CELL STRAIN COS1; CONFERENCE PAPER; DRUG SYNTHESIS; ENZYME INHIBITION; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; ONCOGENE H RAS; PROTEIN PROCESSING; STEREOCHEMISTRY; STRUCTURE ACTIVITY RELATION;

ALKYL AND ARYL TRANSFERASES; ENZYME INHIBITORS; MAGNETIC RESONANCE SPECTROSCOPY; SPECTROMETRY, MASS, FAST ATOM BOMBARDMENT; STRUCTURE-ACTIVITY RELATIONSHIP; TRANSFERASES;

EID: 18544398961     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0968-0896(96)00206-4     Document Type: Conference Paper

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