2-Substituted piperazines as constrained amino acids. Application to the synthesis of potent, non carboxylic acid inhibitors of farnesyltransferase [1]

Journal of Medicinal Chemistry

Volumn 39, Issue 7, 1996, Pages 1345-1348

  Williams, T M ^a   Ciccarone, T M ^a   MacTough, S C ^a   Bock, R L ^a   Conner, M W ^a   Davide, J P ^a   Hamilton, K ^a   Koblan, K S ^a   Kohl, N E ^a   Kral, A M ^a   Mosser, S D ^a   Omer, C A ^a   Pompliano, D L ^a   Rands, E ^a   Schaber, M D ^a   Shah, D ^a   Wilson, F R ^a   Gibbs, J B ^a   Graham, S L ^a  

^a NONE

Author keywords

[No Author keywords available]

Indexed keywords

1 (2 AMINO 3 MERCAPTOPROPYL) 2 ETHOXYMETHYL 4 (1 NAPHTHOYL)PIPERAZINE; ENZYME INHIBITOR; PIPERAZINE DERIVATIVE; PROTEIN FARNESYLTRANSFERASE; PROTEIN FARNESYLTRANSFERASE INHIBITOR; UNCLASSIFIED DRUG;

ANCHORAGE INDEPENDENT GROWTH; ANIMAL CELL; ARTICLE; CANCER CHEMOTHERAPY; CELL TRANSFORMATION; CYTOTOXICITY; DRUG POTENCY; DRUG SELECTIVITY; DRUG STRUCTURE; DRUG SYNTHESIS; ENZYME INHIBITION; GENE MUTATION; GROWTH INHIBITION; MOUSE; NONHUMAN; NUDE MOUSE; ONCOGENE RAS; TUMOR GROWTH;

ALKYL AND ARYL TRANSFERASES; ANIMALS; ANTINEOPLASTIC AGENTS; CELL DEATH; CELL DIVISION; CELL LINE, TRANSFORMED; ENZYME INHIBITORS; FARNESYLTRANSTRANSFERASE; MICE; MICE, NUDE; MOLECULAR CONFORMATION; MOLECULAR STRUCTURE; NEOPLASM TRANSPLANTATION; PIPERAZINES; POLYISOPRENYL PHOSPHATES; PROTEIN ISOPRENYLATION; PROTEIN PROCESSING, POST-TRANSLATIONAL; RAS PROTEINS; RATS; SARCOMA, EXPERIMENTAL; TRANSFERASES;

EID: 0029986149     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm9508090     Document Type: Article

References (0)