Inhibitors of farnesyl protein transferase. 4-Amido, 4-carbamoyl, and 4- carboxamido derivatives of 1-(8-chloro-6,11-dihydro-5H-benzo[5,6]- cyclohepta[1,2-b]pyridin-11-yl)piperazine and 1-(3-bromo-8-chloro-6,11- dihydro-5H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-yl)piperazine

Journal of Medicinal Chemistry

Volumn 41, Issue 6, 1998, Pages 877-893

  Mallams, Alan K ^a   Rossman, Randall R ^a   Doll, Ronald J ^a   Girijavallabhan, Viyyoor M ^a   Ganguly, Ashit K ^a   Petrin, Joanne ^a   Wang, Lynn ^a   Patton, Robert ^a   Bishop, W Robert ^a   Carr, Donna M ^a   Kirschmeier, Paul ^a   Catino, Joseph J ^a   Bryant, Matthew S ^a   Chen, Kwang Jong ^a   Korfmacher, Walter A ^a   Nardo, Cymbelene ^a   Wang, Shiyong ^a   Nomeir, Amin A ^a   Lin, Chin Chung ^a   Li, Zujun ^a   Chen, Jianping ^a   Lee, Suining ^a   Dell, Janet ^a   Lipari, Philip ^a   Malkowski, Michael ^a   Yaremko, Bodan ^a   King, Ivan ^a   Liu, Ming ^a   more..

^a MERCK RESEARCH LABORATORIES   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

PROTEIN FARNESYLTRANSFERASE INHIBITOR; SCH 59228; SCH 60677; SCH 61129; UNCLASSIFIED DRUG;

ANCHORAGE INDEPENDENT GROWTH; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTINEOPLASTIC ACTIVITY; ARTICLE; CANCER; CELL STRAIN 3T3; CONTROLLED STUDY; DRUG BIOAVAILABILITY; DRUG METABOLISM; DRUG STRUCTURE; DRUG SYNTHESIS; KIDNEY CELL; MONKEY; MOUSE; NONHUMAN; NUDE MOUSE; ONCOGENE H RAS; ORAL DRUG ADMINISTRATION; STRUCTURE ACTIVITY RELATION;

3T3 CELLS; ADMINISTRATION, ORAL; ALKYL AND ARYL TRANSFERASES; ANIMALS; ANTINEOPLASTIC AGENTS; BIOLOGICAL AVAILABILITY; CELL LINE, TRANSFORMED; COS CELLS; CYCLIC N-OXIDES; DRUG SCREENING ASSAYS, ANTITUMOR; ENZYME INHIBITORS; GENES, RAS; MACACA FASCICULARIS; MICE; MICE, NUDE; NEOPLASM TRANSPLANTATION; PIPERAZINES; PIPERIDINES; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 15644380004     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm970462w     Document Type: Article

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