Comparative analysis of functional assays for characterization of agonist ligands at G protein-coupled receptors

Journal of Biomolecular Screening

Volumn 8, Issue 5, 2003, Pages 500-510

  Niedernberg, Anke ^a   Tunaru, Sorin ^b   Blaukat, Andree ^b   Harris, Bruce ^c   Kostenis, Evi ^a,d  

^a SANOFI AVENTIS DEUTSCHLAND GMBH   (Germany)

^b UNIVERSITY OF HEIDELBERG   (Germany)

^c SANOFI   (France)

^d 7TM Pharma A S   (Denmark)

Author keywords

G protein; G protein coupled receptor; S1P5 receptor; Sphingosine 1 phosphate

Indexed keywords

ADENYLATE CYCLASE; AEQUORIN; CELL SURFACE PROTEIN; FLICE INHIBITORY PROTEIN; G PROTEIN COUPLED RECEPTOR; GUANINE NUCLEOTIDE BINDING PROTEIN; LIGAND; MITOGEN ACTIVATED PROTEIN KINASE; SPHINGOSINE 1 PHOSPHATE RECEPTOR; SPHINGOSINE 5 PHOSPHATE RECEPTOR; UNCLASSIFIED DRUG; CALCIUM; CYCLIC AMP; DIHYDROSPHINGOSINE 1 PHOSPHATE; DIHYDROSPHINGOSINE 1-PHOSPHATE; DRUG DERIVATIVE; GUANOSINE 5' O (3 THIOTRIPHOSPHATE); LYSOPHOSPHOLIPID; LYSOPHOSPHOLIPID RECEPTOR; SPHINGOSINE; SPHINGOSINE 1 PHOSPHATE; SPHINGOSINE 1-PHOSPHATE; SULFUR;

ARTICLE; CALCIUM CELL LEVEL; CALCIUM MOBILIZATION; COMPARATIVE STUDY; ENZYME ACTIVATION; HUMAN; HUMAN CELL; LIGAND BINDING; MOLECULAR CLONING; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN FAMILY; PROTEIN FUNCTION; RECEPTOR AFFINITY; RECEPTOR UPREGULATION; SCREENING; ANIMAL; DRUG EFFECT; DRUG POTENTIATION; DRUG SCREENING; FLUOROMETRY; GENETICS; HAMSTER; INSTRUMENTATION; METABOLISM; METHODOLOGY; MOLECULAR BIOLOGY; PHOSPHORYLATION;

ADENYLATE CYCLASE; AEQUORIN; ANIMALS; CALCIUM; CRICETINAE; CYCLIC AMP; DRUG EVALUATION, PRECLINICAL; FLUOROMETRY; GUANOSINE 5'-O-(3-THIOTRIPHOSPHATE); HUMANS; LIGANDS; LYSOPHOSPHOLIPIDS; MITOGEN-ACTIVATED PROTEIN KINASES; MOLECULAR BIOLOGY; PHOSPHORYLATION; RECEPTORS, G-PROTEIN-COUPLED; RECEPTORS, LYSOPHOSPHOLIPID; SPHINGOSINE; SULFUR RADIOISOTOPES;

EID: 1542598049     PISSN: 10870571     EISSN: None     Source Type: Journal    
DOI: 10.1177/1087057103257555     Document Type: Article

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