Sphingosine-1-phosphate, a platelet-derived lysophospholipid mediator, negatively regulates cellular Rac activity and cell migration in vascular smooth muscle cells

Circulation Research

Volumn 90, Issue 3, 2002, Pages 325-332

  Ryu, Yasuji ^a   Takuwa, Noriko ^a   Sugimoto, Naotoshi ^a   Sakurada, Sotaro ^a   Usui, Soichiro ^a   Okamoto, Hiroyuki ^a   Matsui, Osamu ^a   Takuwa, Yoh ^a  

^a KANAZAWA UNIVERSITY   (Japan)

Author keywords

Chemotaxis; Platelet derived growth factor; Rac; Sphingosine 1 phosphate; Vascular smooth muscle

Indexed keywords

DIHYDROSPHINGOSINE 1 PHOSPHATE; PLATELET DERIVED GROWTH FACTOR; PLATELET DERIVED GROWTH FACTOR B; PROTEIN CDC42; PROTEIN EDG1; PROTEIN EDG5; RAC PROTEIN; RECEPTOR SUBTYPE; RHOA GUANINE NUCLEOTIDE BINDING PROTEIN; SPHINGANINE; SPHINGOSINE 1 PHOSPHATE; SPHINGOSINE 1 PHOSPHATE RECEPTOR; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; CELL MIGRATION; CHEMOTAXIS; CONTROLLED STUDY; DOSE RESPONSE; GENE OVEREXPRESSION; HUMAN; HUMAN CELL; INHIBITION KINETICS; NONHUMAN; PHOSPHATE METABOLISM; PHOSPHOLIPID METABOLISM; PRIORITY JOURNAL; PROCESS MODEL; PROTEIN LIPID INTERACTION; RAT; RECEPTOR BINDING; REGULATORY MECHANISM; SMOOTH MUSCLE FIBER; UMBILICAL VEIN; VASCULAR SMOOTH MUSCLE; VIRUS EXPRESSION;

ANIMALS; BLOOD PLATELETS; CDC42 GTP-BINDING PROTEIN; CELL MOVEMENT; CELL SURFACE EXTENSIONS; CELLS, CULTURED; CHEMOTAXIS; DOSE-RESPONSE RELATIONSHIP, DRUG; ENDOTHELIUM, VASCULAR; ENZYME ACTIVATION; HUMANS; IMMEDIATE-EARLY PROTEINS; LYSOPHOSPHOLIPIDS; MUSCLE, SMOOTH, VASCULAR; NUCLEAR PROTEINS; PLATELET-DERIVED GROWTH FACTOR; RAC GTP-BINDING PROTEINS; RATS; RECEPTOR, PLATELET-DERIVED GROWTH FACTOR BETA; RECEPTORS, CELL SURFACE; RECEPTORS, G-PROTEIN-COUPLED; RECEPTORS, LYSOPHOSPHATIDIC ACID; RECEPTORS, LYSOPHOSPHOLIPID; RHOA GTP-BINDING PROTEIN; SPHINGOSINE; TRANSCRIPTION FACTORS;

EID: 0037155058     PISSN: 00097330     EISSN: None     Source Type: Journal    
DOI: 10.1161/hh0302.104455     Document Type: Article

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