메뉴 건너뛰기




Volumn 271, Issue 5, 2004, Pages 1046-1053

Carboxydipeptidase activities of recombinant cysteine peptidases Cruzain of Trypanosoma cruzi and CPB of Leishmania mexicana

Author keywords

Cathepsin B; Cathepsin L; Cruzipain; Exoproteases; Proteases

Indexed keywords

2,4 DINITROPHENOL; AMINO ACID; AMINOBENZOIC ACID; CARBOXYPEPTIDASE; CATHEPSIN B; CATHEPSIN L; CYSTEINE PROTEINASE; LYSINE; PAPAIN;

EID: 1542374556     PISSN: 00142956     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1432-1033.2004.04008.x     Document Type: Article
Times cited : (24)

References (45)
  • 1
    • 0021137779 scopus 로고
    • Purification and characterization of proteolytic enzymes of Leishmania mexicana amastigotes and promastigotes
    • Pupkis, M.F. & Coombs, G.H. (1984) Purification and characterization of proteolytic enzymes of Leishmania mexicana amastigotes and promastigotes. J. General Microbiol. 130, 2375-2383.
    • (1984) J. General Microbiol. , vol.130 , pp. 2375-2383
    • Pupkis, M.F.1    Coombs, G.H.2
  • 2
    • 0025113919 scopus 로고
    • Characterization of three groups of cysteine proteinases in the amastigotes of Leishmania Mexicana
    • Robertson, C.D. & Coombs, G.H. (1990) Characterization of three groups of cysteine proteinases in the amastigotes of Leishmania Mexicana. Mol. Biochem. Parasitol. 42, 269-276.
    • (1990) Mol. Biochem. Parasitol. , vol.42 , pp. 269-276
    • Robertson, C.D.1    Coombs, G.H.2
  • 3
    • 0026890633 scopus 로고
    • Stage-specific proteinases of Leishmania mexicana promastigotes
    • Robertson, C.D. & Coombs, G.H. (1992) Stage-specific proteinases of Leishmania mexicana promastigotes. FEMS Microbiol. Lett. 94, 127-132.
    • (1992) FEMS Microbiol. Lett. , vol.94 , pp. 127-132
    • Robertson, C.D.1    Coombs, G.H.2
  • 4
    • 0028425460 scopus 로고
    • Expression of cysteine proteinases by metacyclic promastigotes of Leishmania mexicana
    • Bates, PA., Robertson, C.D. & Coombs, G.H. (1994) Expression of cysteine proteinases by metacyclic promastigotes of Leishmania mexicana. J. Euk. Microbiol. 41, 199-203.
    • (1994) J. Euk. Microbiol. , vol.41 , pp. 199-203
    • Bates, P.A.1    Robertson, C.D.2    Coombs, G.H.3
  • 5
    • 0030970429 scopus 로고    scopus 로고
    • The multiple cpb cysteine proteinase genes of Leishmania mexicana encode isoenzymes that differ in their stage regulation and substrate preferences
    • Mottram, J.C., Frame, M.C., Brooks, D.R., Tetley, L., Hutchison, J.E., Souza, A.E. & Coombs, G.H. (1997) The multiple cpb cysteine proteinase genes of Leishmania mexicana encode isoenzymes that differ in their stage regulation and substrate preferences. J. Biol. Chem. 272, 14285-14293.
    • (1997) J. Biol. Chem. , vol.272 , pp. 14285-14293
    • Mottram, J.C.1    Frame, M.C.2    Brooks, D.R.3    Tetley, L.4    Hutchison, J.E.5    Souza, A.E.6    Coombs, G.H.7
  • 6
    • 0026783342 scopus 로고
    • Characterization of a multicopy gene for a major stage-specific cysteine proteinase of Leishmania mexicana
    • Souza, A.E., Waugh, S., Coombs, G.H. & Mottram, J.C. (1992) Characterization of a multicopy gene for a major stage-specific cysteine proteinase of Leishmania mexicana. FEBS Lett. 311, 124-127.
    • (1992) FEBS Lett. , vol.311 , pp. 124-127
    • Souza, A.E.1    Waugh, S.2    Coombs, G.H.3    Mottram, J.C.4
  • 7
    • 0028202206 scopus 로고
    • Multiple high activity cysteine proteases of Leishmania mexicana are encoded by the lmcpb gene array
    • Robertson, C.D. &Coombs, G.H. (1994) Multiple high activity cysteine proteases of Leishmania mexicana are encoded by the lmcpb gene array. Microbiology 140, 417-424.
    • (1994) Microbiology , vol.140 , pp. 417-424
    • Robertson, C.D.1    Coombs, G.H.2
  • 8
    • 0029898541 scopus 로고    scopus 로고
    • Evidence from disruption of the lmcpb gene array of Leishmania mexicana that cysteine proteinases are virulence factors
    • Mottram, J.C., Souza, A.E., Hutchison, J.E., Carter, R., Frame, M.J. & Coombs, G.H. (1996) Evidence from disruption of the lmcpb gene array of Leishmania mexicana that cysteine proteinases are virulence factors. Proc. Natl Acad. Sci. USA 93, 6008-6013.
    • (1996) Proc. Natl Acad. Sci. USA , vol.93 , pp. 6008-6013
    • Mottram, J.C.1    Souza, A.E.2    Hutchison, J.E.3    Carter, R.4    Frame, M.J.5    Coombs, G.H.6
  • 9
    • 0038104859 scopus 로고    scopus 로고
    • Expression of multiple CPB genes encoding cysteine proteases is required for Leishmania mexicana virulence in vivo
    • Denise, H., McNeil, K., Brooks, D.R., Alexander, J., Coombs, G.H. & Mottram, J.C. (1997) Expression of multiple CPB genes encoding cysteine proteases is required for Leishmania mexicana virulence in vivo. Infect. Immun. 71, 3190-3195.
    • (1997) Infect. Immun. , vol.71 , pp. 3190-3195
    • Denise, H.1    McNeil, K.2    Brooks, D.R.3    Alexander, J.4    Coombs, G.H.5    Mottram, J.C.6
  • 10
    • 0027476019 scopus 로고
    • Identification of two distinct cysteine proteinase genes of Leishmania pifanoi axenic amastigotes using the polymerase chain reaction
    • Traub-Cseko, Y.M., Duboise, M., Boukai, L.K. & McMahon-Pratt, D. (1993) Identification of two distinct cysteine proteinase genes of Leishmania pifanoi axenic amastigotes using the polymerase chain reaction. Mol. Biochem. Parasitol. 57, 101-116.
    • (1993) Mol. Biochem. Parasitol. , vol.57 , pp. 101-116
    • Traub-Cseko, Y.M.1    Duboise, M.2    Boukai, L.K.3    McMahon-Pratt, D.4
  • 11
    • 0030981096 scopus 로고    scopus 로고
    • Leishmania major: Comparison of the cathepsin L- and B-like cysteine protease genes with those of other trypano-somatids
    • Sakanari, J.A., Nadler, SA., Chan, V.J., Engel, J.C., Leptak, C. & Bouvier, J. (1997) Leishmania major: comparison of the cathepsin L-and B-like cysteine protease genes with those of other trypano-somatids. Exp. Parasitol. 85, 63-76.
    • (1997) Exp. Parasitol. , vol.85 , pp. 63-76
    • Sakanari, J.A.1    Nadler, S.A.2    Chan, V.J.3    Engel, J.C.4    Leptak, C.5    Bouvier, J.6
  • 12
    • 0026570815 scopus 로고
    • The major cysteine proteinase (cruzipain) from Trypanosoma cruzi is encoded by multiple polymorphic tandemly organized genes located on different chromosomes
    • Campetella, O., Henriksson, J., Åslund, L., Frasch, A.C.C., Pettersson, U. & Cazzulo, J.J. (1992) The major cysteine proteinase (cruzipain) from Trypanosoma cruzi is encoded by multiple polymorphic tandemly organized genes located on different chromosomes. Mol. Biochem. Parasitol. 50, 225-234.
    • (1992) Mol. Biochem. Parasitol. , vol.50 , pp. 225-234
    • Campetella, O.1    Henriksson, J.2    Åslund, L.3    Frasch, A.C.C.4    Pettersson, U.5    Cazzulo, J.J.6
  • 14
    • 0024329436 scopus 로고
    • A cysteine proteinase cDNA from Trypanosoma brucei predicts an enzyme with an unusual C-terminal extension
    • Mottram, J.C., North, M.J., Barry, J.D. & Coombs, G.H. (1989) A cysteine proteinase cDNA from Trypanosoma brucei predicts an enzyme with an unusual C-terminal extension. FEBS Lett. 258, 211-215.
    • (1989) FEBS Lett. , vol.258 , pp. 211-215
    • Mottram, J.C.1    North, M.J.2    Barry, J.D.3    Coombs, G.H.4
  • 15
    • 0030981772 scopus 로고    scopus 로고
    • Parasite proteinases and amino acid metabolism: Possibilities for chemotherapeutic exploitation
    • Coombs, G.H. & Mottram, J.C. (1997) Parasite proteinases and amino acid metabolism: possibilities for chemotherapeutic exploitation. Parasitology 114, S61-S80.
    • (1997) Parasitology , vol.114
    • Coombs, G.H.1    Mottram, J.C.2
  • 17
    • 0026606269 scopus 로고
    • Inhibitors of the major cysteinyl proteinase (GP57/51) impair host cell invasion and arrest the intracellular development of Trypanosoma cruzi in vitro
    • Meirelles, M.N.L., Juliano, L., Carmona, E., Silva, S.G., Costa, E.M., Murta, A.C. & Scharfstein, J. (1992) Inhibitors of the major cysteinyl proteinase (GP57/51) impair host cell invasion and arrest the intracellular development of Trypanosoma cruzi in vitro. Mol. Biochem. Parasitol. 52, 175-184.
    • (1992) Mol. Biochem. Parasitol. , vol.52 , pp. 175-184
    • Meirelles, M.N.L.1    Juliano, L.2    Carmona, E.3    Silva, S.G.4    Costa, E.M.5    Murta, A.C.6    Scharfstein, J.7
  • 18
    • 0030034874 scopus 로고    scopus 로고
    • Investigation of the substrate specificity of cruzain, the major cysteine proteinase of Trypanosoma cruzi, through the use of cystatin-derived substrates and inhibitors
    • Serveau, C., Lalmanach, G., Juliano, M.A., Scharfstein, J., Juliano, L. & Gauthie, R.F. (1996) Investigation of the substrate specificity of cruzain, the major cysteine proteinase of Trypanosoma cruzi, through the use of cystatin-derived substrates and inhibitors. Biochem. J. 313, 951-956.
    • (1996) Biochem. J. , vol.313 , pp. 951-956
    • Serveau, C.1    Lalmanach, G.2    Juliano, M.A.3    Scharfstein, J.4    Juliano, L.5    Gauthie, R.F.6
  • 19
    • 0030868997 scopus 로고    scopus 로고
    • Kininogenase activity by the major cysteinyl proteinase (cruzipain) from Trypanosoma cruzi
    • Del Nery, E., Juliano, M.A., Lima, A.P., Scharfstein, J. & Juliano, L. (1997) Kininogenase activity by the major cysteinyl proteinase (cruzipain) from Trypanosoma cruzi. J. Biol. Chem. 272, 25713-25718.
    • (1997) J. Biol. Chem. , vol.272 , pp. 25713-25718
    • Del Nery, E.1    Juliano, M.A.2    Lima, A.P.3    Scharfstein, J.4    Juliano, L.5
  • 20
    • 0030891637 scopus 로고    scopus 로고
    • Characterization of the substrate specificity of the major cysteine protease (cruzipain) from Trypanosoma cruzi using a portion-mixing combinatorial library and fluorogenic peptides
    • Del Nery, E., Juliano, M.A., Meldal, M., Svendsen, I., Scharfstein, J., Walmsley, A. & Juliano, L. (1997) Characterization of the substrate specificity of the major cysteine protease (cruzipain) from Trypanosoma cruzi using a portion-mixing combinatorial library and fluorogenic peptides. Biochem. J. 323, 427-433.
    • (1997) Biochem. J. , vol.323 , pp. 427-433
    • Del Nery, E.1    Juliano, M.A.2    Meldal, M.3    Svendsen, I.4    Scharfstein, J.5    Walmsley, A.6    Juliano, L.7
  • 21
    • 0033555294 scopus 로고    scopus 로고
    • Discrimination of cruzipain, the major cysteine proteinase of Trypanosoma cruzi, and mammalian cathepsins B and L, by a pH-inducible fluorogenic substrate of trypanosomal cysteine proteinases
    • Serveau, C., Lalmanach, G., Hirata, I., Scharfstein, J., Juliano, M.A. & Gauthier, F. (1999) Discrimination of cruzipain, the major cysteine proteinase of Trypanosoma cruzi, and mammalian cathepsins B and L, by a pH-inducible fluorogenic substrate of trypanosomal cysteine proteinases. Eur. J. Biochem. 259, 275-280.
    • (1999) Eur. J. Biochem. , vol.259 , pp. 275-280
    • Serveau, C.1    Lalmanach, G.2    Hirata, I.3    Scharfstein, J.4    Juliano, M.A.5    Gauthier, F.6
  • 23
  • 25
    • 0034683233 scopus 로고    scopus 로고
    • The substrate specificity of a recombinant cysteine protease from Leishmania mexicana: Application of a combinatorial peptide library approach
    • St Hilaire, P.M., Alves, L.C., Sanderson, S.J., Mottram, J.C., Juliano, M.A., Juliano, L., Coombs, G.H. & Meldal, M. (2000) The substrate specificity of a recombinant cysteine protease from Leishmania mexicana: application of a combinatorial peptide library approach. Chembiochem. 1, 115-122.
    • (2000) Chembiochem. , vol.1 , pp. 115-122
    • St Hilaire, P.M.1    Alves, L.C.2    Sanderson, S.J.3    Mottram, J.C.4    Juliano, M.A.5    Juliano, L.6    Coombs, G.H.7    Meldal, M.8
  • 28
    • 18544391789 scopus 로고    scopus 로고
    • Interdependency of sequence and positional specificities for cysteine proteases of the papain family
    • Nägler, D.K., Tam, W., Storer, A.C., Krupa, J.C., Mort, J.S. & Ménard, R. (1999) Interdependency of sequence and positional specificities for cysteine proteases of the papain family. Biochemistry 38, 4868-4874.
    • (1999) Biochemistry , vol.38 , pp. 4868-4874
    • Nägler, D.K.1    Tam, W.2    Storer, A.C.3    Krupa, J.C.4    Mort, J.S.5    Ménard, R.6
  • 29
    • 0034176273 scopus 로고    scopus 로고
    • Probing the specificity of cysteine proteinases at subsites remote from the active site: Analysis of P4, P3, P2′ and P3′ variations in extended substrates
    • Portaro, F.C.V., Santos, A.B.F., Cezari, M.H.S., Juliano, M.A., Juliano, L. & Carmona, L. (2000) Probing the specificity of cysteine proteinases at subsites remote from the active site: analysis of P4, P3, P2′ and P3′ variations in extended substrates. Biochem. J. 347, 123-129.
    • (2000) Biochem. J. , vol.347 , pp. 123-129
    • Portaro, F.C.V.1    Santos, A.B.F.2    Cezari, M.H.S.3    Juliano, M.A.4    Juliano, L.5    Carmona, L.6
  • 30
    • 0037113185 scopus 로고    scopus 로고
    • Cathepsin B carboxydipeptidase specificity analysis using internally quenched fluorescent peptides
    • Cezari, M.H., Puzer, L., Juliano, M.A., Carmona, A.K. & Juliano, L. (2002) Cathepsin B carboxydipeptidase specificity analysis using internally quenched fluorescent peptides. Biochem. J. 368, 365-369.
    • (2002) Biochem. J. , vol.368 , pp. 365-369
    • Cezari, M.H.1    Puzer, L.2    Juliano, M.A.3    Carmona, A.K.4    Juliano, L.5
  • 31
    • 0040084898 scopus 로고    scopus 로고
    • Major increase in endopeptidase activity of human cathepsin B upon removal of occluding loop contacts
    • Nägler, D.K., Storer, A.C., Portaro, F.C.V., Carmona, E., Juliano, L. & Ménard, R. (1997) Major increase in endopeptidase activity of human cathepsin B upon removal of occluding loop contacts. Biochemistry 36, 12608-12615.
    • (1997) Biochemistry , vol.36 , pp. 12608-12615
    • Nägler, D.K.1    Storer, A.C.2    Portaro, F.C.V.3    Carmona, E.4    Juliano, L.5    Ménard, R.6
  • 32
    • 0033898794 scopus 로고    scopus 로고
    • Altered expression of cruzipain and a cathepsin B-like target in a Trypanosoma cruzi cell line displaying resistance to synthetic inhibitors of cysteine-proteinases
    • Yong, V., Schmitz, V., Vannier-Santos, M.A., Lima, A.P., Lalmanach, G., Juliano, L., Gauthier, F. & Scharfstein, J. (2000) Altered expression of cruzipain and a cathepsin B-like target in a Trypanosoma cruzi cell line displaying resistance to synthetic inhibitors of cysteine-proteinases. Mol. Biochem. Parasitol. 109, 47-59.
    • (2000) Mol. Biochem. Parasitol. , vol.109 , pp. 47-59
    • Yong, V.1    Schmitz, V.2    Vannier-Santos, M.A.3    Lima, A.P.4    Lalmanach, G.5    Juliano, L.6    Gauthier, F.7    Scharfstein, J.8
  • 33
    • 0027745973 scopus 로고
    • Cathepsin B-like cysteine proteases of Leishmania mexicana
    • Robertson, C.D. & Coombs, G.H. (1993) Cathepsin B-like cysteine proteases of Leishmania mexicana. Mol. Biochem. Parasitol. 62, 271-279.
    • (1993) Mol. Biochem. Parasitol. , vol.62 , pp. 271-279
    • Robertson, C.D.1    Coombs, G.H.2
  • 35
    • 0019765848 scopus 로고
    • Cathepsin B, cathepsin H and cathepsin L.
    • Barret, A.J. & Kirshke, H. (1981) Cathepsin B, cathepsin H and cathepsin L. Methods Enzymol. 80, 535-561.
    • (1981) Methods Enzymol. , vol.80 , pp. 535-561
    • Barret, A.J.1    Kirshke, H.2
  • 36
    • 0026781519 scopus 로고
    • The sequence, organization and expression of a major cysteine protease (cruzain) from Trypanosoma cruzi
    • Eakin, A.E., Mills, A.A., Harth, G., McKerrow, J.H. & Craik, C.S. (1992) The sequence, organization and expression of a major cysteine protease (cruzain) from Trypanosoma cruzi. J. Biol. Chem. 267, 7411-7420.
    • (1992) J. Biol. Chem. , vol.267 , pp. 7411-7420
    • Eakin, A.E.1    Mills, A.A.2    Harth, G.3    McKerrow, J.H.4    Craik, C.S.5
  • 37
    • 0030038759 scopus 로고    scopus 로고
    • Potency and selectivity of the cathepsin L propeptide as an inhibitor of cysteine protease
    • Carmona, E., Dufour, E., Plouffe, C., Takebe, S., Manson, P., Mort, S.M. & Ménard, R. (1996) Potency and selectivity of the cathepsin L propeptide as an inhibitor of cysteine protease. Biochemistry 35, 8149-8157.
    • (1996) Biochemistry , vol.35 , pp. 8149-8157
    • Carmona, E.1    Dufour, E.2    Plouffe, C.3    Takebe, S.4    Manson, P.5    Mort, S.M.6    Ménard, R.7
  • 38
    • 0025967144 scopus 로고
    • Intramolecularly quenched fluorogenc tetrapeptide substrates for tissue and plasma kallikreins
    • Chagas, J.R., Juliano, L. & Prado, E.S. (1990) Intramolecularly quenched fluorogenc tetrapeptide substrates for tissue and plasma kallikreins. Anal. Biochem. 192, 419-425.
    • (1990) Anal. Biochem. , vol.192 , pp. 419-425
    • Chagas, J.R.1    Juliano, L.2    Prado, E.S.3
  • 40
    • 0005499841 scopus 로고
    • Statistical estimations in enzyme kinetics
    • Wilkinson, G.N. (1961) Statistical estimations in enzyme kinetics. Biochem. J. 80, 324-332.
    • (1961) Biochem. J. , vol.80 , pp. 324-332
    • Wilkinson, G.N.1
  • 41
    • 0030841381 scopus 로고    scopus 로고
    • Structural determinants of specificity in the cysteine protease cruzain
    • Gillmor, S.A., Craik, C.S. & Fletterick, R.J. (1997) Structural determinants of specificity in the cysteine protease cruzain. Protein Sci. 6, 1603-1611.
    • (1997) Protein Sci. , vol.6 , pp. 1603-1611
    • Gillmor, S.A.1    Craik, C.S.2    Fletterick, R.J.3
  • 42
    • 0028968184 scopus 로고
    • Crystal structures of recombinant rat cathepsin B and a cathepsin B-inhibitor complex. Implications for structure-based inhibitor design
    • Jia, Z., Hasnain, S., Hirama, T., Lee, X., Mort, J.S., To, R. & Huber, C.P. (1995) Crystal structures of recombinant rat cathepsin B and a cathepsin B-inhibitor complex. Implications for structure-based inhibitor design. J. Biol. Chem. 270, 5527-5533.
    • (1995) J. Biol. Chem. , vol.270 , pp. 5527-5533
    • Jia, Z.1    Hasnain, S.2    Hirama, T.3    Lee, X.4    Mort, J.S.5    To, R.6    Huber, C.P.7
  • 43
    • 0025292469 scopus 로고
    • Cysteine proteinase in Trypanosoma cruzi: Immunocytochemical localization and involvement in parasite-host cell interaction
    • Souto-Padron, T., Campetella, O.E., Cazzulo, J.J. & de Souza, W. (1990) Cysteine proteinase in Trypanosoma cruzi: immunocytochemical localization and involvement in parasite-host cell interaction. J. Cell Sci. 96, 485-490.
    • (1990) J. Cell Sci. , vol.96 , pp. 485-490
    • Souto-Padron, T.1    Campetella, O.E.2    Cazzulo, J.J.3    De Souza, W.4
  • 44
    • 0030055783 scopus 로고    scopus 로고
    • High resolution localization of cruzipain and Ssp4 in Trypanosoma cruzi by replica staining label fracture
    • Nascimento, A.E. & de Souza, W. (1996) High resolution localization of cruzipain and Ssp4 in Trypanosoma cruzi by replica staining label fracture. Biol. Cell 86, 53-58.
    • (1996) Biol. Cell , vol.86 , pp. 53-58
    • Nascimento, A.E.1    De Souza, W.2
  • 45
    • 0034474592 scopus 로고    scopus 로고
    • Processing and trafficking of cysteine proteases in Leishmania mexicana
    • Brooks, D.R., Tetley, L., Coombs, G.H. & Mottram, J.C. (2000) Processing and trafficking of cysteine proteases in Leishmania mexicana. J. Cell Sci. 113, 4035-4041.
    • (2000) J. Cell Sci. , vol.113 , pp. 4035-4041
    • Brooks, D.R.1    Tetley, L.2    Coombs, G.H.3    Mottram, J.C.4


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.