Toward an HDAC6 inhibitor: Synthesis and conformational analysis of cyclic hexapeptide hydroxamic acid designed from α-tubulin sequence

Bioorganic and Medicinal Chemistry

Volumn 12, Issue 6, 2004, Pages 1351-1356

  Jose, Binoy ^a   Okamura, Shinji ^b   Kato, Tamaki ^b   Nishino, Norikazu ^a,b   Sumida, Yuko ^a   Yoshida, Minoru ^a,c  

^a JAPAN SCIENCE AND TECHNOLOGY AGENCY   (Japan)

^b KYUSHU INSTITUTE OF TECHNOLOGY   (Japan)

^c RIKEN   (Japan)

Author keywords

Cyclic peptide; Histone deacetylase; Inhibitor; Tubulin

Indexed keywords

ALPHA TUBULIN; AMINOSUBERATE HYDROXAMIC ACID; CYCLIC HEXAPEPTIDE HYDROXAMIC ACID; HISTONE DEACETYLASE; HYDROLASE INHIBITOR; HYDROXAMIC ACID DERIVATIVE; LYSINE; PROTEIN INHIBITOR; UNCLASSIFIED DRUG;

ACETYLATION; ARTICLE; BINDING AFFINITY; CONFORMATION; CRYSTAL STRUCTURE; ENZYME INHIBITION; ENZYME SUBSTRATE;

ACETYLATION; ENZYME INHIBITORS; HISTONE DEACETYLASES; HUMANS; HYDROXAMIC ACIDS; LYSINE; PEPTIDES, CYCLIC; PROTEIN CONFORMATION; STRUCTURE-ACTIVITY RELATIONSHIP; TUBULIN;

EID: 1542331640     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmc.2004.01.014     Document Type: Article

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