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Volumn 3, Issue 3, 2004, Pages 276-283

TGFβ1, back to the future: Revisiting its role as a transforming growth factor

Author keywords

EMT; Metastasis; Mouse models; Neovascularization; TGF 1; Tumor progression

Indexed keywords

TRANSFORMING GROWTH FACTOR BETA1; TGFB1 PROTEIN, HUMAN; TRANSFORMING GROWTH FACTOR BETA;

EID: 15244340251     PISSN: 15384047     EISSN: 15558576     Source Type: Journal    
DOI: 10.4161/cbt.3.3.849     Document Type: Review
Times cited : (59)

References (92)
  • 1
    • 0034612789 scopus 로고    scopus 로고
    • Role of transforming growth factor-β signaling in cancer
    • de Caestecker MP, Piek E, Roberts AB. Role of transforming growth factor-β signaling in cancer. J Natl Cancer Inst 2000; 92:1388-402.
    • (2000) J Natl Cancer Inst , vol.92 , pp. 1388-1402
    • De Caestecker, M.P.1    Piek, E.2    Roberts, A.B.3
  • 2
    • 0031685620 scopus 로고    scopus 로고
    • TGF-β signal transduction
    • Massague J. TGF-β signal transduction. Annu Rev Biochem 1998; 67:753-91.
    • (1998) Annu Rev Biochem , vol.67 , pp. 753-791
    • Massague, J.1
  • 3
    • 0142104985 scopus 로고    scopus 로고
    • Smad-dependent and Smad-independent pathways in TGF-β family signalling
    • Derynck R, Zhang YE. Smad-dependent and Smad-independent pathways in TGF-β family signalling. Nature 2003; 425:577-84.
    • (2003) Nature , vol.425 , pp. 577-584
    • Derynck, R.1    Zhang, Y.E.2
  • 4
    • 0034604110 scopus 로고    scopus 로고
    • Role of transforming growth factor β in human disease
    • Blobe GC, Schiemann WP, Lodish HF. Role of transforming growth factor β in human disease. N Engl J Med 2000; 342:1350-8.
    • (2000) N Engl J Med , vol.342 , pp. 1350-1358
    • Blobe, G.C.1    Schiemann, W.P.2    Lodish, H.F.3
  • 5
    • 0345275872 scopus 로고    scopus 로고
    • Smad7 but not Smad6 cooperates with oncogenic ras to cause malignant conversion in a mouse model for squamous cell carcinoma
    • Liu X., LeeJ, Cooley M, Bhogte E, Hartley S, Glick A. Smad7 but not Smad6 cooperates with oncogenic ras to cause malignant conversion in a mouse model for squamous cell carcinoma. Cancer Res 2003; 63:7760-8.
    • (2003) Cancer Res , vol.63 , pp. 7760-7768
    • Liu, X.1    Lee, J.2    Cooley, M.3    Bhogte, E.4    Hartley, S.5    Glick, A.6
  • 6
    • 0027053058 scopus 로고
    • Immunohistochemical staining for transforming growth factor β1 associates with disease progression in human breast cancer
    • Gorsch SM, Memoli VA, Stukel TA, Gold LI, Arrick BA. Immunohistochemical staining for transforming growth factor β1 associates with disease progression in human breast cancer. Cancer Res 1992; 52:6949-52.
    • (1992) Cancer Res , vol.52 , pp. 6949-6952
    • Gorsch, S.M.1    Memoli, V.A.2    Stukel, T.A.3    Gold, L.I.4    Arrick, B.A.5
  • 8
    • 0031948084 scopus 로고    scopus 로고
    • A subset of metastatic human colon cancers expresses elevated levels of transforming growth factor β1
    • Picon A, Gold LI, Wang J, Cohen A, Friedman E. A subset of metastatic human colon cancers expresses elevated levels of transforming growth factor β1. Cancer Epidemiol Biomarkers Prev 1998; 7:497-504.
    • (1998) Cancer Epidemiol Biomarkers Prev , vol.7 , pp. 497-504
    • Picon, A.1    Gold, L.I.2    Wang, J.3    Cohen, A.4    Friedman, E.5
  • 9
    • 0027742864 scopus 로고
    • Immunocytochemical localization of secreted transforming growth factor-β 1 to the advancing edges of primary tumors and to lymph node metastases of human mammary carcinoma
    • Dalal BI, Keown PA, Greenberg AH. Immunocytochemical localization of secreted transforming growth factor-β 1 to the advancing edges of primary tumors and to lymph node metastases of human mammary carcinoma. Am J Pathol 1993; 143:381-9.
    • (1993) Am J Pathol , vol.143 , pp. 381-389
    • Dalal, B.I.1    Keown, P.A.2    Greenberg, A.H.3
  • 10
    • 0006335227 scopus 로고    scopus 로고
    • Elevated serum levels of transforming growth factor-β1 in patients with colorectal carcinoma: Its association with tumor progression and its significant decrease after curative surgical resection
    • Shim KS, Kim KH, Han WS, Park EB. Elevated serum levels of transforming growth factor-β1 in patients with colorectal carcinoma: Its association with tumor progression and its significant decrease after curative surgical resection. Cancer 1999; 85:554-61.
    • (1999) Cancer , vol.85 , pp. 554-561
    • Shim, K.S.1    Kim, K.H.2    Han, W.S.3    Park, E.B.4
  • 11
    • 0030024536 scopus 로고    scopus 로고
    • High levels of transforming growth factor β 1 in patients with colorectal cancer: Association with disease progression
    • Tsushima H, Kawata S, Tamura S, Ito N, Shirai Y, Kiso S, et al. High levels of transforming growth factor β 1 in patients with colorectal cancer: Association with disease progression. Gastroenterology 1996; 110:375-82.
    • (1996) Gastroenterology , vol.110 , pp. 375-382
    • Tsushima, H.1    Kawata, S.2    Tamura, S.3    Ito, N.4    Shirai, Y.5    Kiso, S.6
  • 12
    • 0030965529 scopus 로고    scopus 로고
    • Roles of the transforming growth factor β 1 and its type I and II receptors in the development of a pulmonary adenocarcinoma: Results of an immunohistochemical study
    • Takanami I, Tanaka F, Hashizume T, Kodaira S. Roles of the transforming growth factor β 1 and its type I and II receptors in the development of a pulmonary adenocarcinoma: Results of an immunohistochemical study. J Surg Oncol 1997; 64:262-7.
    • (1997) J Surg Oncol , vol.64 , pp. 262-267
    • Takanami, I.1    Tanaka, F.2    Hashizume, T.3    Kodaira, S.4
  • 13
    • 0034480072 scopus 로고    scopus 로고
    • An elevated serum level of transforming growth factor-β 1 (TGF-β 1) significantly correlated with lymph node metastasis and poor prognosis in patients with gastric carcinoma
    • Saito H, Tsujitani S, Oka S, Kondo A, Ikeguchi M, Maeta M, et al. An elevated serum level of transforming growth factor-β 1 (TGF-β 1) significantly correlated with lymph node metastasis and poor prognosis in patients with gastric carcinoma. Anticancer Res 2000; 20:4489-93.
    • (2000) Anticancer Res , vol.20 , pp. 4489-4493
    • Saito, H.1    Tsujitani, S.2    Oka, S.3    Kondo, A.4    Ikeguchi, M.5    Maeta, M.6
  • 14
    • 0034911060 scopus 로고    scopus 로고
    • Serum levels of transforming growth factor β1 in patients with breast cancer
    • Sheen-Chen SM, Chen HS, Sheen CW, Eng HL, Chen WJ. Serum levels of transforming growth factor β1 in patients with breast cancer. Arch Surg 2001; 136:937-40.
    • (2001) Arch Surg , vol.136 , pp. 937-940
    • Sheen-Chen, S.M.1    Chen, H.S.2    Sheen, C.W.3    Eng, H.L.4    Chen, W.J.5
  • 15
    • 11944255353 scopus 로고
    • Transforming growth factor β stimulates mammary adenocarcinoma cell invasion and metastatic potential
    • USA
    • Welch D, Fabra A, Nakajima M. Transforming growth factor β stimulates mammary adenocarcinoma cell invasion and metastatic potential. Proc Natl Acad Sci USA 1990; 87:7678-82.
    • (1990) Proc Natl Acad Sci , vol.87 , pp. 7678-7682
    • Welch, D.1    Fabra, A.2    Nakajima, M.3
  • 16
    • 0026712153 scopus 로고
    • Excessive production of transforming growth-factor β 1 can play an important role in the development of tumorigenesis by its action for angiogenesis: Validity of neutralizing antibodies to block tumor growth
    • Ueki N, Nakazato M, Ohkawa T, Ikeda T, Amuro Y, Hada T, et al. Excessive production of transforming growth-factor β 1 can play an important role in the development of tumorigenesis by its action for angiogenesis: Validity of neutralizing antibodies to block tumor growth. Biochim Biophys Acta 1992; 1137:189-96.
    • (1992) Biochim Biophys Acta , vol.1137 , pp. 189-196
    • Ueki, N.1    Nakazato, M.2    Ohkawa, T.3    Ikeda, T.4    Amuro, Y.5    Hada, T.6
  • 17
    • 0027569092 scopus 로고
    • Transforming growth factor β 1 can induce estrogen- Independent tumorigenicity of human breast cancer cells in athymic mice
    • Arteaga CL, Carty-Dugger T, Moses HL, Hurd SD, Pietenpol JA. Transforming growth factor β 1 can induce estrogen- independent tumorigenicity of human breast cancer cells in athymic mice. Cell Growth Differ 1993; 4:193-201.
    • (1993) Cell Growth Differ , vol.4 , pp. 193-201
    • Arteaga, C.L.1    Carty-Dugger, T.2    Moses, H.L.3    Hurd, S.D.4    Pietenpol, J.A.5
  • 18
    • 0026656525 scopus 로고
    • Altered metabolic and adhesive properties and increased tumorigenesis associated with increased expression of transforming growth factor β1
    • Arrick BA, Lopez AR, Elfman F, Ebner R, Damsky CH, Derynck R. Altered metabolic and adhesive properties and increased tumorigenesis associated with increased expression of transforming growth factor β1. J Cell Biol 1992; 118:715-26.
    • (1992) J Cell Biol , vol.118 , pp. 715-726
    • Arrick, B.A.1    Lopez, A.R.2    Elfman, F.3    Ebner, R.4    Damsky, C.H.5    Derynck, R.6
  • 19
    • 0028171401 scopus 로고
    • Targeted deletion of the TGF-β1 gene causes rapid progression to squamous cell carcinoma
    • Glick AB, Lee MM, Darwiche N, Kulkarni AB, Karlsson S, Yuspa SH. Targeted deletion of the TGF-β1 gene causes rapid progression to squamous cell carcinoma. Genes Dev 1994; 8:2429-40.
    • (1994) Genes Dev , vol.8 , pp. 2429-2440
    • Glick, A.B.1    Lee, M.M.2    Darwiche, N.3    Kulkarni, A.B.4    Karlsson, S.5    Yuspa, S.H.6
  • 20
    • 0032500010 scopus 로고    scopus 로고
    • Expression of a dominant negative type II TGF-β receptor in mouse skin results in an increase in carcinoma incidence and an acceleration of carcinoma development
    • Amendt C, Schirmacher P, Weber H, Blessing M. Expression of a dominant negative type II TGF-β receptor in mouse skin results in an increase in carcinoma incidence and an acceleration of carcinoma development. Oncogene 1998; 17:25-34.
    • (1998) Oncogene , vol.17 , pp. 25-34
    • Amendt, C.1    Schirmacher, P.2    Weber, H.3    Blessing, M.4
  • 21
    • 0030598681 scopus 로고    scopus 로고
    • TGFβ1 inhibits the formation of benign skin tumors, but enhances progression to invasive spindle carcinomas in transgenic mice
    • Cui W, Fowlis DJ, Bryson S, Duffie E, Ireland H, Balmain A, et al. TGFβ1 inhibits the formation of benign skin tumors, but enhances progression to invasive spindle carcinomas in transgenic mice. Cell 1996; 86:531-42.
    • (1996) Cell , vol.86 , pp. 531-542
    • Cui, W.1    Fowlis, D.J.2    Bryson, S.3    Duffie, E.4    Ireland, H.5    Balmain, A.6
  • 22
    • 0035887461 scopus 로고    scopus 로고
    • Inducible expression of transforming growth factor β1 in papillomas causes rapid metastasis
    • Weeks BH, He W, Olson KL, Wang XJ. Inducible expression of transforming growth factor β1 in papillomas causes rapid metastasis. Cancer Res 2001; 61:7435-43.
    • (2001) Cancer Res , vol.61 , pp. 7435-7443
    • Weeks, B.H.1    He, W.2    Olson, K.L.3    Wang, X.J.4
  • 23
    • 0242552529 scopus 로고    scopus 로고
    • Increased malignancy of Neu-induced mammary tumors overexpressing active transforming growth factor β1
    • Muraoka RS, Koh Y, Roebuck LR, Sanders ME, Brantley-Sieders D, Gorska AE, et al. Increased malignancy of Neu-induced mammary tumors overexpressing active transforming growth factor β1. Mol Cell Biol 2003; 23:8691-703.
    • (2003) Mol Cell Biol , vol.23 , pp. 8691-8703
    • Muraoka, R.S.1    Koh, Y.2    Roebuck, L.R.3    Sanders, M.E.4    Brantley-Sieders, D.5    Gorska, A.E.6
  • 24
    • 0037816160 scopus 로고    scopus 로고
    • Transforming growth factor β signaling impairs Neu-induced mammary tumorigenesis while promoting pulmonary metastasis
    • USA
    • Siegel PM, Shu W, Cardiff RD, Muller WJ, Massague J. Transforming growth factor β signaling impairs Neu-induced mammary tumorigenesis while promoting pulmonary metastasis. Proc Natl Acad Sci USA 2003; 100:8430-5.
    • (2003) Proc Natl Acad Sci , vol.100 , pp. 8430-8435
    • Siegel, P.M.1    Shu, W.2    Cardiff, R.D.3    Muller, W.J.4    Massague, J.5
  • 26
    • 0032547895 scopus 로고    scopus 로고
    • TGFβ signaling is necessary for carcinoma cell invasiveness and metastasis
    • Oft M, Heider KH, Beug H. TGFβ signaling is necessary for carcinoma cell invasiveness and metastasis. Curr Biol 1998; 8:1243-52.
    • (1998) Curr Biol , vol.8 , pp. 1243-1252
    • Oft, M.1    Heider, K.H.2    Beug, H.3
  • 27
    • 0242285692 scopus 로고    scopus 로고
    • TGF-β switches from I tumor suppressor to prometastatic factor in a model of breast cancer progression
    • Tang B, Vu M, Booker T, Santner SJ, Miller FR, Anver MR, et al. TGF-β switches from I tumor suppressor to prometastatic factor in a model of breast cancer progression. J Clin Invest 2003; 112:1116-24.
    • (2003) J Clin Invest , vol.112 , pp. 1116-1124
    • Tang, B.1    Vu, M.2    Booker, T.3    Santner, S.J.4    Miller, F.R.5    Anver, M.R.6
  • 28
    • 0347626102 scopus 로고    scopus 로고
    • Reduction in Smad2/3 signaling enhances tumorigenesis but suppresses metastasis of breast cancer cell lines
    • Tian F, DaCosta Byfield S, Parks WT, Yoo S, Felici A, Tang B, et al. Reduction in Smad2/3 signaling enhances tumorigenesis but suppresses metastasis of breast cancer cell lines. Cancer Res 2003; 63:8284-92.
    • (2003) Cancer Res , vol.63 , pp. 8284-8292
    • Tian, F.1    DaCosta Byfield, S.2    Parks, W.T.3    Yoo, S.4    Felici, A.5    Tang, B.6
  • 31
    • 0036087521 scopus 로고    scopus 로고
    • Lifetime exposure to a soluble TGF-β antagonist protects mice against metastasis without adverse side effects
    • Yang YA, Dukkanina O, Tang B, Mamura M, Letterio JJ, MacGregor J, et al. Lifetime exposure to a soluble TGF-β antagonist protects mice against metastasis without adverse side effects. J Clin Invest 2002; 109:1607-15.
    • (2002) J Clin Invest , vol.109 , pp. 1607-1615
    • Yang, Y.A.1    Dukkanina, O.2    Tang, B.3    Mamura, M.4    Letterio, J.J.5    MacGregor, J.6
  • 32
    • 0242456170 scopus 로고    scopus 로고
    • Axis of evil: Molecular mechanisms of cancer metastasis
    • Bogenrieder T, Herlyn M. Axis of evil: Molecular mechanisms of cancer metastasis. Oncogene 2003; 22:6524-36.
    • (2003) Oncogene , vol.22 , pp. 6524-6536
    • Bogenrieder, T.1    Herlyn, M.2
  • 33
    • 0343042204 scopus 로고    scopus 로고
    • Urokinase expression and binding activity associated with the transforming growth factor β1-induced migratory and invasive phenotype of mouse epidermal keratinocytes
    • Santibanez JF, Frontelo P, Iglesias M, Martinez J, Quintanilla M. Urokinase expression and binding activity associated with the transforming growth factor β1-induced migratory and invasive phenotype of mouse epidermal keratinocytes. J Cell Biochem 1999; 74:61-73.
    • (1999) J Cell Biochem , vol.74 , pp. 61-73
    • Santibanez, J.F.1    Frontelo, P.2    Iglesias, M.3    Martinez, J.4    Quintanilla, M.5
  • 34
    • 0032473479 scopus 로고    scopus 로고
    • Transforming growth factor-β1 enhances the invasiveness of human MDA-MB-231 breast cancer cells by up-regulating urokinase activity
    • Farina AR, Coppa A, Tiberio A, Tacconelli A, Turco A, Colletta G, et al. Transforming growth factor-β1 enhances the invasiveness of human MDA-MB-231 breast cancer cells by up-regulating urokinase activity. Int J Cancer 1998; 75:721-30.
    • (1998) Int J Cancer , vol.75 , pp. 721-730
    • Farina, A.R.1    Coppa, A.2    Tiberio, A.3    Tacconelli, A.4    Turco, A.5    Colletta, G.6
  • 35
    • 0031983263 scopus 로고    scopus 로고
    • Transforming growth factor β 1 and sodium butyrate differentially modulate urokinase plasminogen activator and plasminogen activator inhibitor-1 in human breast normal and cancer cells
    • Dong-Le Bourhis X, Lambrecht V, Boilly B. Transforming growth factor β 1 and sodium butyrate differentially modulate urokinase plasminogen activator and plasminogen activator inhibitor-1 in human breast normal and cancer cells. Br J Cancer 1998; 77:396-03.
    • (1998) Br J Cancer , vol.77 , pp. 396-403
    • Dong-Le Bourhis, X.1    Lambrecht, V.2    Boilly, B.3
  • 36
    • 0025050820 scopus 로고
    • Differentiation repertoire of fibroblastic cells: Expression of cytoskeletal proteins as marker of phenotypic modulations
    • Sappino AP, Schurch W, Gabbiani G. Differentiation repertoire of fibroblastic cells: Expression of cytoskeletal proteins as marker of phenotypic modulations. Lab Invest 1990; 63:144-61.
    • (1990) Lab Invest , vol.63 , pp. 144-161
    • Sappino, A.P.1    Schurch, W.2    Gabbiani, G.3
  • 37
    • 0028890174 scopus 로고
    • The origin of the myofibroblasts in breast cancer. Recapitulation of tumor environment in culture unravels diversity and implicates converted fibroblasts and recruited smooth muscle cells
    • Ronnov-Jessen L, Petersen OW, Koteliansky VE, Bissell MJ. The origin of the myofibroblasts in breast cancer. Recapitulation of tumor environment in culture unravels diversity and implicates converted fibroblasts and recruited smooth muscle cells. J Clin Invest 1995; 95:859-73.
    • (1995) J Clin Invest , vol.95 , pp. 859-873
    • Ronnov-Jessen, L.1    Petersen, O.W.2    Koteliansky, V.E.3    Bissell, M.J.4
  • 38
    • 0022471924 scopus 로고
    • Transforming growth factor type β: Rapid induction of fibrosis and angiogenesis in vivo and stimulation of collagen formation in vitro
    • USA
    • Roberts AB, Sporn MB, Assoian RK, Smith JM, Roche NS, Wakefield LM, et al. Transforming growth factor type β: Rapid induction of fibrosis and angiogenesis in vivo and stimulation of collagen formation in vitro. Proc Natl Acad Sci USA 1986; 83:4167-71.
    • (1986) Proc Natl Acad Sci , vol.83 , pp. 4167-4171
    • Roberts, A.B.1    Sporn, M.B.2    Assoian, R.K.3    Smith, J.M.4    Roche, N.S.5    Wakefield, L.M.6
  • 39
    • 0842288323 scopus 로고    scopus 로고
    • TGF-β signaling in fibroblasts modulates the oncogenic potential of adjacent epithelia
    • Bhowmick NA, Chytil A, Plieth D, Gorska AE, Dumont N, Skappell S, et al. TGF-β signaling in fibroblasts modulates the oncogenic potential of adjacent epithelia. Science 2004; 303:848-51.
    • (2004) Science , vol.303 , pp. 848-851
    • Bhowmick, N.A.1    Chytil, A.2    Plieth, D.3    Gorska, A.E.4    Dumont, N.5    Skappell, S.6
  • 40
    • 0032848957 scopus 로고    scopus 로고
    • Epithelial cell plasticity in development and tumor progression
    • Thiery JP, Chopin D. Epithelial cell plasticity in development and tumor progression. Cancer Metastasis Rev 1999; 18:31-42.
    • (1999) Cancer Metastasis Rev , vol.18 , pp. 31-42
    • Thiery, J.P.1    Chopin, D.2
  • 41
    • 0031007646 scopus 로고    scopus 로고
    • Spindle cell carcinoma of the larynx: Review of 26 cases including DNA content and immunohistochemistry
    • Lewis JE, Olsen KD, Sebo TJ. Spindle cell carcinoma of the larynx: Review of 26 cases including DNA content and immunohistochemistry. Hum Pathol 1997; 28:664-73.
    • (1997) Hum Pathol , vol.28 , pp. 664-673
    • Lewis, J.E.1    Olsen, K.D.2    Sebo, T.J.3
  • 42
    • 0026532804 scopus 로고
    • Poorly differentiated squamous cell carcinomas of the skin can express vimentin
    • Iyer PV, Leong AS. Poorly differentiated squamous cell carcinomas of the skin can express vimentin. J Cutan Pathol 1992; 19:34-9.
    • (1992) J Cutan Pathol , vol.19 , pp. 34-39
    • Iyer, P.V.1    Leong, A.S.2
  • 44
    • 0028603343 scopus 로고
    • TGF-β induced transdifferentiation of mammary epithelial cells to mesenchymal cells: Involvement of type I receptors
    • Miettinen PJ, Ebner R, Lopez AR, Derynck R. TGF-β induced transdifferentiation of mammary epithelial cells to mesenchymal cells: Involvement of type I receptors. J Cell Biol 1994; 127:2021-36.
    • (1994) J Cell Biol , vol.127 , pp. 2021-2036
    • Miettinen, P.J.1    Ebner, R.2    Lopez, A.R.3    Derynck, R.4
  • 45
    • 0029662049 scopus 로고    scopus 로고
    • TGF-β1 and Ha-Ras collaborate in modulating the phenotypic plasticity and invasiveness of epithelial tumor cells
    • Oft M, Peli J, Rudaz C, Schwarz H, Beug H, Reichmann E. TGF-β1 and Ha-Ras collaborate in modulating the phenotypic plasticity and invasiveness of epithelial tumor cells. Genes Dev 1996; 10:2462-77.
    • (1996) Genes Dev , vol.10 , pp. 2462-2477
    • Oft, M.1    Peli, J.2    Rudaz, C.3    Schwarz, H.4    Beug, H.5    Reichmann, E.6
  • 46
    • 0031817391 scopus 로고    scopus 로고
    • Transforming growth factor β is essential for spindle cell conversion of mouse skin carcinoma in vivo: Implications for tumor invasion
    • Portella G, Cumming SA, Liddell J, Cui W, Ireland H, Akhurst RJ, et al. Transforming growth factor β is essential for spindle cell conversion of mouse skin carcinoma in vivo: Implications for tumor invasion. Cell Growth Differ 1998; 9:393-404.
    • (1998) Cell Growth Differ , vol.9 , pp. 393-404
    • Portella, G.1    Cumming, S.A.2    Liddell, J.3    Cui, W.4    Ireland, H.5    Akhurst, R.J.6
  • 47
    • 0035872426 scopus 로고    scopus 로고
    • Transforming growth factor β1 treatment leads to an epithelial-mesenchymal transdifferentiation of pancreatic cancer cells requiring extracellular signal-regulated kinase 2 activation
    • Ellenrieder V, Hendler SF, Boeck W, Seufferlein T, Menke A, Ruhland C, et al. Transforming growth factor β1 treatment leads to an epithelial-mesenchymal transdifferentiation of pancreatic cancer cells requiring extracellular signal-regulated kinase 2 activation. Cancer Res 2001; 61:4222-8.
    • (2001) Cancer Res , vol.61 , pp. 4222-4228
    • Ellenrieder, V.1    Hendler, S.F.2    Boeck, W.3    Seufferlein, T.4    Menke, A.5    Ruhland, C.6
  • 48
    • 0037405501 scopus 로고    scopus 로고
    • Central role for Rho in TGF-β1-induced α-smooth muscle actin expression during epithelial-mesenchymal transition
    • Masszi A, Di Ciano C, Sirokmany G, Arthur WT, Rotstein OD, Wang J, et al. Central role for Rho in TGF-β1-induced α-smooth muscle actin expression during epithelial-mesenchymal transition. Am J Physiol Renal Physiol 2003; 284:F911-24.
    • (2003) Am J Physiol Renal Physiol , vol.284
    • Masszi, A.1    Di Ciano, C.2    Sirokmany, G.3    Arthur, W.T.4    Rotstein, O.D.5    Wang, J.6
  • 49
    • 0029664520 scopus 로고    scopus 로고
    • Epithelial-mesenchymal transformation of a newly established cell line from ovarian adenosarcoma by transforming growth factor-β1
    • Kitagawa K, Murata A, Matsuura N, Tohya K, Takaichi S, Monden M, et al. Epithelial-mesenchymal transformation of a newly established cell line from ovarian adenosarcoma by transforming growth factor-β1. Int J Cancer 1996; 66:91-7.
    • (1996) Int J Cancer , vol.66 , pp. 91-97
    • Kitagawa, K.1    Murata, A.2    Matsuura, N.3    Tohya, K.4    Takaichi, S.5    Monden, M.6
  • 50
    • 0346727324 scopus 로고    scopus 로고
    • Targeted disruption of TGF-β1/Smad3 signaling protects against renal tubulointerstitial fibrosis induced by unilateral ureteral obstruction
    • Sato M, Muragaki Y, Saika S, Roberts AB, Ooshima A. Targeted disruption of TGF-β1/Smad3 signaling protects against renal tubulointerstitial fibrosis induced by unilateral ureteral obstruction. J Clin Invest 2003; 112:1486-94.
    • (2003) J Clin Invest , vol.112 , pp. 1486-1494
    • Sato, M.1    Muragaki, Y.2    Saika, S.3    Roberts, A.B.4    Ooshima, A.5
  • 51
    • 0034711307 scopus 로고    scopus 로고
    • Phosphatidylinositol 3-kinase function is required for transforming growth factor β-mediated epithelial to mesenchymal transition and cell migration
    • Bakin AV, Tomlinson AK, Bhowmick NA, Moses HL, Arteaga CL. Phosphatidylinositol 3-kinase function is required for transforming growth factor β-mediated epithelial to mesenchymal transition and cell migration. J Biol Chem 2000; 275:36803-10.
    • (2000) J Biol Chem , vol.275 , pp. 36803-36810
    • Bakin, A.V.1    Tomlinson, A.K.2    Bhowmick, N.A.3    Moses, H.L.4    Arteaga, C.L.5
  • 52
    • 0035185853 scopus 로고    scopus 로고
    • Transforming growth factor-β1 mediates epithelial to mesenchymal transdifferentiation through a RhoA-dependent mechanism
    • Bhowmick NA, Ghiassi M, Bakin A, Aakre M, Lundquist CA, Engel ME, et al. Transforming growth factor-β1 mediates epithelial to mesenchymal transdifferentiation through a RhoA-dependent mechanism. Mol Biol Cell 2001; 12:27-36.
    • (2001) Mol Biol Cell , vol.12 , pp. 27-36
    • Bhowmick, N.A.1    Ghiassi, M.2    Bakin, A.3    Aakre, M.4    Lundquist, C.A.5    Engel, M.E.6
  • 53
    • 0036197606 scopus 로고    scopus 로고
    • Transforming Growth Factor-β-induced Mobilization of Actin Cytoskeleton Requires Signaling by Small GTPases Cdc42 and RhoA
    • Edlund S, Landstrom M, Heldin CH, Aspenstrom P. Transforming Growth Factor-β-induced Mobilization of Actin Cytoskeleton Requires Signaling by Small GTPases Cdc42 and RhoA. Mol Biol Cell 2002; 13:902-14.
    • (2002) Mol Biol Cell , vol.13 , pp. 902-914
    • Edlund, S.1    Landstrom, M.2    Heldin, C.H.3    Aspenstrom, P.4
  • 54
    • 85047698213 scopus 로고    scopus 로고
    • Correlation of Snail expression with histological grade and lymph node status in breast carcinomas
    • Blanco MJ, Moreno-Bueno G, Sarrio D, Locascio A, Cano A, Palacios J, et al. Correlation of Snail expression with histological grade and lymph node status in breast carcinomas. Oncogene 2002; 21:3241-6.
    • (2002) Oncogene , vol.21 , pp. 3241-3246
    • Blanco, M.J.1    Moreno-Bueno, G.2    Sarrio, D.3    Locascio, A.4    Cano, A.5    Palacios, J.6
  • 55
    • 0037086277 scopus 로고    scopus 로고
    • The SLUG zinc-finger protein represses E-cadherin in breast cancer
    • Hajra KM, Chen DY, Fearon ER. The SLUG zinc-finger protein represses E-cadherin in breast cancer. Cancer Res 2002; 62:1013-8.
    • (2002) Cancer Res , vol.62 , pp. 1013-1018
    • Hajra, K.M.1    Chen, D.Y.2    Fearon, E.R.3
  • 56
    • 0038756636 scopus 로고    scopus 로고
    • Transforming growth factor β-1 induces snail transcription factor in epithelial cell lines: Mechanisms for epithelial mesenchymal transitions
    • Peinado H, Quintanilla M, Cano A. Transforming growth factor β-1 induces snail transcription factor in epithelial cell lines: Mechanisms for epithelial mesenchymal transitions. J Biol Chem 2003; 278:21113-23.
    • (2003) J Biol Chem , vol.278 , pp. 21113-21123
    • Peinado, H.1    Quintanilla, M.2    Cano, A.3
  • 57
    • 0025189335 scopus 로고
    • Transforming growth factor β 1 modulates extracellular matrix organization and cell-cell junctional complex formation during in vitro angiogenesis
    • Merwin JR, Anderson JM, Kocher O, Van Itallie CM, Madri JA. Transforming growth factor β 1 modulates extracellular matrix organization and cell-cell junctional complex formation during in vitro angiogenesis. J Cell Physiol 1990; 142:117-28.
    • (1990) J Cell Physiol , vol.142 , pp. 117-128
    • Merwin, J.R.1    Anderson, J.M.2    Kocher, O.3    Van Itallie, C.M.4    Madri, J.A.5
  • 58
    • 0025316140 scopus 로고
    • Transforming growth factor β 1-induced changes in cell migration, proliferation, and angiogenesis in the chicken chorioallantoic membrane
    • Yang EY, Moses HL. Transforming growth factor β 1-induced changes in cell migration, proliferation, and angiogenesis in the chicken chorioallantoic membrane. J Cell Biol 1990; 111:731-41.
    • (1990) J Cell Biol , vol.111 , pp. 731-741
    • Yang, E.Y.1    Moses, H.L.2
  • 59
    • 0035501062 scopus 로고    scopus 로고
    • TGF-β signaling in cancer - A double-edged sword
    • Akhurst RJ, Derynck R. TGF-β signaling in cancer - a double-edged sword. Trends Cell Biol 2001; 11:S44-51.
    • (2001) Trends Cell Biol , vol.11
    • Akhurst, R.J.1    Derynck, R.2
  • 60
    • 0031928528 scopus 로고    scopus 로고
    • Transforming growth factor β1 is associated with angiogenesis, metastasis, and poor clinical outcome in prostate cancer
    • Wikstrom P, Stattin P, Franck-Lissbrant I, Damber JE, Bergh A. Transforming growth factor β1 is associated with angiogenesis, metastasis, and poor clinical outcome in prostate cancer. Prostate 1998; 37:19-29.
    • (1998) Prostate , vol.37 , pp. 19-29
    • Wikstrom, P.1    Stattin, P.2    Franck-Lissbrant, I.3    Damber, J.E.4    Bergh, A.5
  • 61
    • 0035281783 scopus 로고    scopus 로고
    • Transforming growth factor-β1 level correlates with angiogenesis, tumor progression, and prognosis in patients with nonsmall cell lung carcinoma
    • Hasegawa Y, Takanashi S, Kanehira Y, Tsushima T, Imai T, Okumura K. Transforming growth factor-β1 level correlates with angiogenesis, tumor progression, and prognosis in patients with nonsmall cell lung carcinoma. Cancer 2001; 91:964-71.
    • (2001) Cancer , vol.91 , pp. 964-971
    • Hasegawa, Y.1    Takanashi, S.2    Kanehira, Y.3    Tsushima, T.4    Imai, T.5    Okumura, K.6
  • 62
    • 0033570029 scopus 로고    scopus 로고
    • The expression of transforming growth factor-β1 is significantly correlated with the expression of vascular endothelial growth factor and poor prognosis of patients with advanced gastric carcinoma
    • Saito H, Tsujitani S, Oka S, Kondo A, Ikeguchi M, Maeta M, et al. The expression of transforming growth factor-β1 is significantly correlated with the expression of vascular endothelial growth factor and poor prognosis of patients with advanced gastric carcinoma. Cancer 1999; 86:1455-62.
    • (1999) Cancer , vol.86 , pp. 1455-1462
    • Saito, H.1    Tsujitani, S.2    Oka, S.3    Kondo, A.4    Ikeguchi, M.5    Maeta, M.6
  • 63
    • 0033032231 scopus 로고    scopus 로고
    • Role of interleukin 10 and transforming growth factor β1 in the angiogenesis and metastasis of human prostate primary tumor lines from orthotopic implants in severe combined immunodeficiency mice
    • Stearns ME, Garcia FU, Fudge K, Rhim J, Wang M. Role of interleukin 10 and transforming growth factor β1 in the angiogenesis and metastasis of human prostate primary tumor lines from orthotopic implants in severe combined immunodeficiency mice. Clin Cancer Res 1999; 5:711-20.
    • (1999) Clin Cancer Res , vol.5 , pp. 711-720
    • Stearns, M.E.1    Garcia, F.U.2    Fudge, K.3    Rhim, J.4    Wang, M.5
  • 64
    • 0036828120 scopus 로고    scopus 로고
    • Inhibition of transforming growth factor-β activity decreases angiogenesis in a human prostate cancer-reactive stroma xenograft model
    • Tuxhorn JA, McAlhany SJ, Yang F, Dang TD, Rowley DR. Inhibition of transforming growth factor-β activity decreases angiogenesis in a human prostate cancer-reactive stroma xenograft model. Cancer Res 2002; 62:6021-5.
    • (2002) Cancer Res , vol.62 , pp. 6021-6025
    • Tuxhorn, J.A.1    McAlhany, S.J.2    Yang, F.3    Dang, T.D.4    Rowley, D.R.5
  • 65
    • 0033564547 scopus 로고    scopus 로고
    • Blocking transforming growth factor β signaling in transgenic epidermis accelerates chemical carcinogenesis: A mechanism associated with increased angiogenesis
    • Go C, Li P, Wang XJ. Blocking transforming growth factor β signaling in transgenic epidermis accelerates chemical carcinogenesis: A mechanism associated with increased angiogenesis. Cancer Res 1999; 59:2801-8.
    • (1999) Cancer Res , vol.59 , pp. 2801-2808
    • Go, C.1    Li, P.2    Wang, X.J.3
  • 68
    • 0037373855 scopus 로고    scopus 로고
    • Transforming growth factor β 1 stimulates vascular endothelial growth factor gene transcription in human cholangiocellular carcinoma cells
    • Benckert C, Jonas S, Cramer T, Von Marschall Z, Schafer G, Peters M, et al. Transforming growth factor β 1 stimulates vascular endothelial growth factor gene transcription in human cholangiocellular carcinoma cells. Cancer Res 2003; 63:1083-92.
    • (2003) Cancer Res , vol.63 , pp. 1083-1092
    • Benckert, C.1    Jonas, S.2    Cramer, T.3    Von Marschall, Z.4    Schafer, G.5    Peters, M.6
  • 69
    • 0031944290 scopus 로고    scopus 로고
    • Regulation of immune responses by TGF-β
    • Letterio JJ, Roberts AB. Regulation of immune responses by TGF-β. Annu Rev Immunol 1998; 16:137-61.
    • (1998) Annu Rev Immunol , vol.16 , pp. 137-161
    • Letterio, J.J.1    Roberts, A.B.2
  • 70
    • 0025055406 scopus 로고
    • A highly immunogenic tumor transfected with a murine transforming growth factor type β 1 cDNA escapes immune surveillance
    • USA
    • TorreAmione G, Beauchamp RD, Koeppen H, Park BH, Schreiber H, Moses HL, et al. A highly immunogenic tumor transfected with a murine transforming growth factor type β 1 cDNA escapes immune surveillance. Proc Natl Acad Sci USA 1990; 87:1486-90.
    • (1990) Proc Natl Acad Sci , vol.87 , pp. 1486-1490
    • TorreAmione, G.1    Beauchamp, R.D.2    Koeppen, H.3    Park, B.H.4    Schreiber, H.5    Moses, H.L.6
  • 71
    • 0031717878 scopus 로고    scopus 로고
    • Decorin gene transfer-mediated suppression of TGF-β synthesis abrogates experimental malignant glioma growth in vivo
    • Stander M, Naumann U, Dumitrescu L, Heneka M, Loschmann P, Gulbins E, et al. Decorin gene transfer-mediated suppression of TGF-β synthesis abrogates experimental malignant glioma growth in vivo. Gene Ther 1998; 5:1187-94.
    • (1998) Gene Ther , vol.5 , pp. 1187-1194
    • Stander, M.1    Naumann, U.2    Dumitrescu, L.3    Heneka, M.4    Loschmann, P.5    Gulbins, E.6
  • 72
    • 0034770605 scopus 로고    scopus 로고
    • Immune-mediated eradication of tumors through the blockade of transforming growth factor-β signaling in T cells
    • Gorelik L, Flavell RA. Immune-mediated eradication of tumors through the blockade of transforming growth factor-β signaling in T cells. Nat Med 2001; 7:1118-22.
    • (2001) Nat Med , vol.7 , pp. 1118-1122
    • Gorelik, L.1    Flavell, R.A.2
  • 73
    • 0037115396 scopus 로고    scopus 로고
    • Suppression of tumor metastasis by blockade of transforming growth factor β signaling in bone marrow cells through a retroviral-mediated gene therapy in mice
    • Shah AH, Tabayoyong WB, Kundu SD, Kim SJ, Van Parijs L, Liu VC, et al. Suppression of tumor metastasis by blockade of transforming growth factor β signaling in bone marrow cells through a retroviral-mediated gene therapy in mice. Cancer Res 2002; 62:7135-8.
    • (2002) Cancer Res , vol.62 , pp. 7135-7138
    • Shah, A.H.1    Tabayoyong, W.B.2    Kundu, S.D.3    Kim, S.J.4    Van Parijs, L.5    Liu, V.C.6
  • 74
    • 0141688283 scopus 로고    scopus 로고
    • Adoptive-cell-transfer therapy for the treatment of patients with cancer
    • Dudley ME, Rosenberg SA. Adoptive-cell-transfer therapy for the treatment of patients with cancer. Nat Rev Cancer 2003; 3:666-75.
    • (2003) Nat Rev Cancer , vol.3 , pp. 666-675
    • Dudley, M.E.1    Rosenberg, S.A.2
  • 76
    • 0037148532 scopus 로고    scopus 로고
    • Ras and TGFβ cooperatively regulate epithelial cell plasticity and metastasis: Dissection of Ras signaling pathways
    • Janda E, Lehmann K, Killisch I, Jechlinger M, Herzig M, Downward J, et al. Ras and TGFβ cooperatively regulate epithelial cell plasticity and metastasis: Dissection of Ras signaling pathways. J Cell Biol 2002; 156:299-313.
    • (2002) J Cell Biol , vol.156 , pp. 299-313
    • Janda, E.1    Lehmann, K.2    Killisch, I.3    Jechlinger, M.4    Herzig, M.5    Downward, J.6
  • 77
    • 0036304111 scopus 로고    scopus 로고
    • Metastasis is driven by sequential elevation of H-ras and Smad2 levels
    • Oft M, Akhurst RJ, Balmain A. Metastasis is driven by sequential elevation of H-ras and Smad2 levels. Nat Cell Biol 2002; 4:487-94.
    • (2002) Nat Cell Biol , vol.4 , pp. 487-494
    • Oft, M.1    Akhurst, R.J.2    Balmain, A.3
  • 78
    • 0037036387 scopus 로고    scopus 로고
    • Ets1 is an effector of the transforming growth factor β (TGF-β) signaling pathway and an antagonist of the profibrotic effects of TGF-β
    • Czuwara-Ladykowska J, Sementchenko VI, Watson DK, Trojanowska M. Ets1 is an effector of the transforming growth factor β (TGF-β) signaling pathway and an antagonist of the profibrotic effects of TGF-β. J Biol Chem 2002; 277:20399-408.
    • (2002) J Biol Chem , vol.277 , pp. 20399-20408
    • Czuwara-Ladykowska, J.1    Sementchenko, V.I.2    Watson, D.K.3    Trojanowska, M.4
  • 79
    • 0035824687 scopus 로고    scopus 로고
    • Transforming growth factor β regulates parathyroid hormone-related protein expression in MDA-MB-231 breast cancer cells through a novel Smad/Ets synergism
    • Lindemann RK, Ballschmieter P, Nordheim A, Dittmer J. Transforming growth factor β regulates parathyroid hormone-related protein expression in MDA-MB-231 breast cancer cells through a novel Smad/Ets synergism. J Biol Chem 2001; 276:46661-70.
    • (2001) J Biol Chem , vol.276 , pp. 46661-46670
    • Lindemann, R.K.1    Ballschmieter, P.2    Nordheim, A.3    Dittmer, J.4
  • 81
    • 0032507971 scopus 로고    scopus 로고
    • Transition from SCLC to NSCLC phenotype is accompanied by an increased TREbinding activity and recruitment of specific AP-1 proteins
    • Risse-Hackl G, Adamkiewicz J, Wimmel A, Schuermann M. Transition from SCLC to NSCLC phenotype is accompanied by an increased TREbinding activity and recruitment of specific AP-1 proteins. Oncogene 1998; 16:3057-68.
    • (1998) Oncogene , vol.16 , pp. 3057-3068
    • Risse-Hackl, G.1    Adamkiewicz, J.2    Wimmel, A.3    Schuermann, M.4
  • 82
    • 0034623987 scopus 로고    scopus 로고
    • Structural and functional characterization of the transforming growth factor-β-induced Smad3/c-Jun transcriptional cooperativity
    • Qing J, Zhang Y, Derynck R. Structural and functional characterization of the transforming growth factor-β-induced Smad3/c-Jun transcriptional cooperativity. J Biol Chem 2000; 275:38802-12.
    • (2000) J Biol Chem , vol.275 , pp. 38802-38812
    • Qing, J.1    Zhang, Y.2    Derynck, R.3
  • 83
    • 0035821745 scopus 로고    scopus 로고
    • Smad3/AP-1 interactions control transcriptional responses to TGF-β in a promoter-specific manner
    • Verrecchia F, Vindevoghel L, Lechleider RJ, Uitto J, Roberts AB, Mauviel A. Smad3/AP-1 interactions control transcriptional responses to TGF-β in a promoter-specific manner. Oncogene 2001; 20:3332-40.
    • (2001) Oncogene , vol.20 , pp. 3332-3340
    • Verrecchia, F.1    Vindevoghel, L.2    Lechleider, R.J.3    Uitto, J.4    Roberts, A.B.5    Mauviel, A.6
  • 84
    • 0034730629 scopus 로고    scopus 로고
    • Tumor necrosis factor-α inhibits transforming growth factor-β/Smad signaling in human dermal fibroblasts via AP-1 activation
    • Verrecchia F, Pessah M, Atfi A, Mauviel A. Tumor necrosis factor-α inhibits transforming growth factor-β/Smad signaling in human dermal fibroblasts via AP-1 activation. J Biol Chem 2000; 275:30226-31.
    • (2000) J Biol Chem , vol.275 , pp. 30226-30231
    • Verrecchia, F.1    Pessah, M.2    Atfi, A.3    Mauviel, A.4
  • 85
    • 0033551691 scopus 로고    scopus 로고
    • Evidence that Smad2 is a tumor suppressor implicated in the control of cellular invasion
    • Prunier C, Mazars A, Noe V, Bruyneel E, Mareel M, Gespach C, et al. Evidence that Smad2 is a tumor suppressor implicated in the control of cellular invasion. J Biol Chem 1999; 274:22919-22.
    • (1999) J Biol Chem , vol.274 , pp. 22919-22922
    • Prunier, C.1    Mazars, A.2    Noe, V.3    Bruyneel, E.4    Mareel, M.5    Gespach, C.6
  • 86
    • 0035810944 scopus 로고    scopus 로고
    • Genetic programs of epithelial cell plasticity directed by transforming growth factor-β
    • USA
    • Zavadil J, Bitzer M, Liang D, Yang YC, Massimi A, Kneitz S, et al. Genetic programs of epithelial cell plasticity directed by transforming growth factor-β. Proc Natl Acad Sci USA 2001; 98:6686-91.
    • (2001) Proc Natl Acad Sci , vol.98 , pp. 6686-6691
    • Zavadil, J.1    Bitzer, M.2    Liang, D.3    Yang, Y.C.4    Massimi, A.5    Kneitz, S.6
  • 87
    • 0035827581 scopus 로고    scopus 로고
    • Functional characterization of transforming growth factor β signaling in Smad2- and Smad3-deficient fibroblasts
    • Piek E, Ju WJ, Heyer J, Escalante-Alcalde D, Stewart CL, Weinstein M, et al. Functional characterization of transforming growth factor β signaling in Smad2- and Smad3-deficient fibroblasts. J Biol Chem 2001; 276:19945-53.
    • (2001) J Biol Chem , vol.276 , pp. 19945-19953
    • Piek, E.1    Ju, W.J.2    Heyer, J.3    Escalante-Alcalde, D.4    Stewart, C.L.5    Weinstein, M.6
  • 88
    • 0036085920 scopus 로고    scopus 로고
    • SB-431542 is a potent and specific inhibitor of transforming growth factor-β superfamily type I activin receptor-like kinase (ALK) receptors ALK4, ALK5, and ALK7
    • Inman GJ, Nicolas FJ, Callahan JF, Harling JD, Gaster LM, Reith AD, et al. SB-431542 is a potent and specific inhibitor of transforming growth factor-β superfamily type I activin receptor-like kinase (ALK) receptors ALK4, ALK5, and ALK7. Mol Pharmacol 2002; 62:65-74.
    • (2002) Mol Pharmacol , vol.62 , pp. 65-74
    • Inman, G.J.1    Nicolas, F.J.2    Callahan, J.F.3    Harling, J.D.4    Gaster, L.M.5    Reith, A.D.6
  • 89
    • 0037186459 scopus 로고    scopus 로고
    • Identification of novel inhibitors of the transforming growth factor β1 (TGF-β1) type 1 receptor (ALK5)
    • Callahan JF, Burgess JL, Fornwald JA, Gaster LM, Harling JD, Harrington FP, et al. Identification of novel inhibitors of the transforming growth factor β1 (TGF-β1) type 1 receptor (ALK5). J Med Chem 2002; 45:999-1001.
    • (2002) J Med Chem , vol.45 , pp. 999-1001
    • Callahan, J.F.1    Burgess, J.L.2    Fornwald, J.A.3    Gaster, L.M.4    Harling, J.D.5    Harrington, F.P.6
  • 90
    • 0037742433 scopus 로고    scopus 로고
    • Smad3 regulates senescence and malignant conversion in a mouse multistage skin carcinogenesis model
    • Vijayachandra K, Lee J, Glick AB. Smad3 regulates senescence and malignant conversion in a mouse multistage skin carcinogenesis model. Cancer Res 2003; 63:3447-52.
    • (2003) Cancer Res , vol.63 , pp. 3447-3452
    • Vijayachandra, K.1    Lee, J.2    Glick, A.B.3
  • 91
    • 0028990043 scopus 로고
    • Chemical skin carcinogenesis is prevented in mice by the induced expression of a TGF-β related transgene
    • Blessing M, Nanney LB, King LE, Hogan BL. Chemical skin carcinogenesis is prevented in mice by the induced expression of a TGF-β related transgene. Teratog Carcinog Mutagen 1995; 15:11-21.
    • (1995) Teratog Carcinog Mutagen , vol.15 , pp. 11-21
    • Blessing, M.1    Nanney, L.B.2    King, L.E.3    Hogan, B.L.4


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