Pharmacokinetics in older persons

American Journal Geriatric Pharmacotherapy

Volumn 2, Issue 4, 2004, Pages 274-302

  Cusack, Barry J ^a,b  

^a Boise VA Medical Center   (United States)

^b UNIVERSITY OF WASHINGTON SCHOOL OF MEDICINE   (United States)

Author keywords

Aging; Elderly; Metabolism; Older persons; Pharmacokinetics

Indexed keywords

BUMETANIDE; CARBOXYLIC ACID; CEFRADINE; CIPROFLOXACIN; COLCHICINE; CREATININE; CYTOCHROME P450 3A; DILTIAZEM; FENTANYL; FEXOFENADINE; FLUCLOXACILLIN; FLUOXETINE; GLYCOPROTEIN P; INDOMETACIN; KETANSERIN; LANSOPRAZOLE; METOCLOPRAMIDE; MONOCARBOXYLATE TRANSPORTER; MONTELUKAST; MORPHINE; NALBUPHINE; ONDANSETRON; OXYGEN; PEGINTERFERON ALPHA2B; REBOXETINE; REPAGLINIDE; RIZATRIPTAN; TELITHROMYCIN; UNINDEXED DRUG; WATER;

AGED; AGING; AREA UNDER THE CURVE; CREATININE CLEARANCE; DRUG ABSORPTION; DRUG BIOAVAILABILITY; DRUG DISTRIBUTION; DRUG ELIMINATION; DRUG HALF LIFE; DRUG METABOLISM; DRUG SOLUBILITY; DRUG TRANSPORT; ELDERLY CARE; ENZYME METABOLISM; HEALTH STATUS; HUMAN; INFORMATION PROCESSING; INTESTINE ABSORPTION; KIDNEY TUBULE FUNCTION; LIVER BLOOD FLOW; LIVER METABOLISM; LIVER SINUSOID; LIVER SIZE; MEDICAL LITERATURE; MEDLINE; OXYGEN DIFFUSION; PREDICTION; PRIORITY JOURNAL; REVIEW; STRESS; URINARY EXCRETION;

ABSORPTION; AGED; AGING; BIOLOGICAL AVAILABILITY; BIOTRANSFORMATION; FRAIL ELDERLY; HUMANS; KIDNEY; LIVER; PHARMACOKINETICS; POLYMORPHISM, GENETIC; SEVERITY OF ILLNESS INDEX; SKIN ABSORPTION;

EID: 15044344552     PISSN: 15435946     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.amjopharm.2004.12.005     Document Type: Review

References (229)

1. Woodhouse KW Pharmacokinetics of drugs in the elderly J R Soc Med 87 Suppl 23 1994 2-4
2. Abernethy DR Altered pharmacodynamics of cardiovascular drugs and their relation to altered pharmacokinetics in elderly patients Clin Geriatr Med 6 2000 285-292
3. Cloyd JC Lackner TE Leppik IE Antiepileptics in the elderly. Pharmacoepidemiology and pharmacokinetics Arch Fam Med 3 1994 589-598
4. Durnas C Loi CM Cusack BJ Hepatic drug metabolism and aging Clin Pharmacokinet 19 1990 359-389
5. Greenblatt DJ Harmatz JS Shader RI Clinical pharmacokinetics of anxiolytics and hypnotics in the elderly. Therapeutic considerations (Part I) Clin Pharmacokinet 21 1991 165-177
6. Greenblatt DJ Harmatz JS Shader RI Clinical pharmacokinetics of anxiolytics and hypnotics in the elderly. Therapeutic considerations (Part II) Clin Pharmacokinet 21 1991 262-273
7. Montamat SC Cusack BJ Vestal RE Management of drug therapy in the elderly N Engl J Med. 321 1989 303-309
8. Parker BM Cusack BJ Vestal RE Pharmacokinetic optimisation of drug therapy in elderly patients Drugs Aging 7 1995 10-18
9. von Moltke LL Greenblatt DJ Shader RI Clinical pharmacokinetics of antidepressants in the elderly. Therapeutic implications Clin Pharmacokinet. 24 1993 141-160
10. Woodhouse K Drugs and the liver. Part III: Ageing of the liver and the metabolism of drugs Biopharm Drug Dispos. 13 1992 311-320
11. Yuen GJ Altered pharmacokinetics in the elderly Clin Geriatr Med 6 1990 257-267
12. Bressler R Bahl JJ Principles of drug therapy for the elderly patient Mayo Clin Proc 78 2003 1564-1577
13. Herrlinger C Klotz U Drug metabolism and drug interactions in the elderly Best Pract Res Clin Gastroenterol 15 2001 897-918
14. Kinirons MT O'Mahony MS Drug metabolism and ageing Br J Clin Pharmacol 57 2004 540-544
15. Klotz U Effect of age on pharmacokinetics and pharmacodynamics in man Int J Clin Pharmacol Ther 36 1998 581-585
16. Muhlberg W Platt D Age-dependent changes of the kidneys: Pharmacological implications Gerontology 45 1999 243-253
17. Schumucker DL Aging and the liver: An update J Gerontol A Biol Sci Med Sci 53 1998 B315-B320
18. Turnheim K When drug therapy gets old: Pharmacokinetics and pharmacodynamics in the elderly Exp Gerontol 38 2003 843-853
19. Vestal RE Aging and pharmacology Cancer 80 1997 1302-1310
20. Oberbauer R Krivanek P Turnheim K Pharmacokinetics and pharmacodynamics of the diuretic bumetanide in the elderly Clin Pharmacol Ther 57 1995 42-51
21. Schwinghammer TL Norden CW Gill E Pharmacokinetics of cephradine administered intravenously and orally to young and elderly subjects J Clin Pharmacol. 30 1990 893-899
22. Ljungberg B Nilsson-Ehle I Pharmacokinetics of ciprofloxacin in the elderly: Increased oral bioavailability and reduced renal clearance Eur J Clin Microbiol Infect Dis 8 1989 515-520
23. Rochdi M Sabouraud A Girre C et al. Pharmacokinetics and absolute bioavailability of colchicine after i.v. and oral administration in healthy human volunteers and elderly subjects Eur J Clin Pharmacol. 46 1994 351-354
24. Thompson JP Bower S Liddle AM Rowbotham DJ Perioperative pharmacokinetics of transdermal fentanyl in elderly and young adult patients Br J Anaesth 81 1998 152-154
25. Gath J Charles B Sampson J Smithurst B Pharmacokinetics and bioavailability of flucloxacillin in elderly hospitalized patients J Clin Pharmacol 35 1995 31-36
26. Oberbauer R Krivanek P Turnheim K Pharmacokinetics of indomethacin in the elderly Clin Pharmacokinet 24 1993 428-434
27. Gould SE Silas JH Hosie J Could the increased antihypertensive efficacy of ketanserin in the elderly be due to altered pharmacokinetics? Cardiovasc Drugs Ther 4 Suppl 1 1990 89-92
28. Pritchard JF Bryson JC Kernodle AE et al. Age and gender effects on ondansetron pharmacokinetics: Evaluation of healthy aged volunteers Clin Pharmacol Ther 51 1992 51-55
29. Wynne HA Yelland C Cope LH et al. The association of age and frailty with the pharmacokinetics and pharmacodynamics of metoclopramide Age Ageing 22 1993 354-359
30. Baillie SP Bateman DN Coates PE Woodhouse KW Age and the pharmacokinetics of morphine Age Ageing 18 1989 258-262
31. Zhao JJ Rogers JD Holland SD et al. Pharmacokinetics and bioavailabity of montelukast sodium (MK-0476) in healthy young and elderly volunteers Biopharm Drug Dispos. 18 1997 769-777
32. Jaillon P Gardin ME Lecocq B et al. Pharmacokinetics of nalbuphine in infants, young healthy volunteers, and elderly patients Clin Pharmacol Ther 46 1989 226-233
33. Hatorp V Huang WC Strange P Repaglinide pharmacokinetics in healthy young adult and elderly subjects Clin Ther 21 1999 702-710
34. Perret C Lenfant B Weinling E et al. Pharmacokinetics and absolute oral bioavailability of an 800-mg oral dose of telithromycin in healthy young and elderly volunteers Chemotherapy 48 2002 217-223
35. Gainsborough N Maskrey VL Nelson ML et al. The association of age with gastric emptying Age Ageing 22 1993 37-40
36. Cusack B O'Malley K Lavan J et al. Protein binding and disposition of lignocaine in the elderly Eur J Clin Pharmacol 29 1985 323-329
37. Storstein L Larsen A Midtbo K Saevareid L Pharmacokinetics of calcium blockers in patients with renal insufficiency and in geriatric patients Acta Med Scand Suppl. 681 1984 25-30
38. Kelly JG McGarry K O'Malley K O'Brien ET Bioavailability of labetalol increases with age Br J Clin Pharmacol 14 1982 304-305
39. von Richter O Burk O Fromm MF et al. Cytochrome P450 3A4 and P-glycoprotein expression in human small intestinal enterocytes and hepatocytes: A comparative analysis in paired tissue specimens Clin Pharmacol Ther 75 2004 172-183
40. Grevel J Reynolds KL Rutzky LP Kahan BD Influence of demographic factors on cyclosporine pharmacokinetics in adult uremic patients J Clin Pharmacol 29 1989 261-266
41. Lown KS Bailey DG Fontana RJ et al. Grapefruit juice increases felodipine oral availability in humans by decreasing intestinal CYP3A protein expression J Clin Invest 99 1997 2545-2553
42. Dresser GK Bailey DG Carruthers SG Grapefruit juice - felodipine interaction in the elderly Clin Pharmacol Ther 68 2000 28-34
43. Hamman MA Bruce MA Haehner-Daniels BD Hall SD The effect of rifampin administration on the disposition of fexofenadine Clin Pharmacol Ther 69 2001 114-121
44. Dresser GK Bailey DG Leake BF et al. Fruit juices inhibit organic anion transporting polypeptide-mediated drug uptake to decrease the oral availability of fexofenadine Clin Pharmacol Ther 71 2002 11-20
45. Dill WA Glazko AJ Kazenko A Wolf LM Studies on 5, 5′-diphenylhydantoin (dilantin) in animals and man J Pharmacol Exp Ther 118 1956 270-279
46. [published correction appears in Neurology. 2003;60:1727] Birnbaum A Hardie NA Leppik IE et al. Variability of total phenytoin serum concentrations within elderly nursing home residents Neurology 60 2003 555-559
47. Roskos KV Maibach HI Percutaneous absorption and age. Implications for therapy Drugs Aging 2 1992 432-449
48. Roskos KV Maibach HI Guy RH The effect of aging on percutaneous absorption in man J Pharmacokinet Biopharm 17 1989 617-630
49. Kharasch ED Hoffer C Whittington D Influence of age on the pharmacokinetics and pharmacodynamics of oral transmucosal fentanyl citrate Anesthesiology 101 2004 738-743
50. Harman SM Blackman MR Use of growth hormone for prevention or treatment of effects of aging J Gerontol A Biol Sci Med Sci 59 2004 652-658
51. Kehayias JJ Fiatarone MA Zhuang H Roubenoff R Total body potassium and body fat: Relevance to aging Am J Clin Nutr. 66 1997 904-910
52. Ruiz-Torres A Gimeno A Munoz FJ Vicent D Are antropometric changes in healthy adults caused by modifications in dietary habits or by aging? Gerontology 41 1995 243-251
53. Ishizaki T Hirayam H Tawara K et al. Pharmacokinetics and pharmacodynamics in young normal and elderly hypertensive subjects: A study using sotalol as a model drug J Pharmacol Exp Ther 212 1980 173-181
54. Bach B Hansen JM Kampmann JP et al. Disposition of antipyrine and phenytoin correlated with age and liver volume in man Clin Pharmacokinet 6 1981 389-396
55. Oneta CM Pedrosa M Ruttimann S et al. Age and bioavailability of alcohol Z Gastroenterol 39 2001 783-788
56. Klotz U Avant GR Hoyumpa A et al. The effects of age and liver disease on the disposition and elimination of diazepam in adult man J Clin Invest 55 1975 347-359
57. Cusack B Kelly J O'Malley K et al. Digoxin in the elderly: Pharmacokinetic consequences of old age Clin Pharmacol Ther. 25 1979 772-776
58. Tupler LA Hege S Ellinwood EH Jr Alcohol pharmacodynamics in young-elderly adults contrasted with young and middle-aged subjects Psychopharmacology (Berl) 118 1995 460-470
59. Wallace SM Verbeeck RK Plasma protein binding of drugs in the elderly Clin Pharmacokinet 12 1987 41-72
60. Woo J Chan HS Or KH Arumanayagam M Effect of age and disease on two drug binding proteins: Albumin and alpha-1-acid glycoprotein Clin Biochem 27 1994 289-292
61. Andros E Detmar-Hanna D Suteparuk S et al. The effect of aging on the pharmacokinetics and pharmacodynamics of prazosin Eur J Clin Pharmacol 50 1996 41-46
62. Barchowsky A Shand DG Stargel WW et al. On the role of alpha 1-acid glycoprotein in lignocaine accumulation following myocardial infarction Br J Clin Pharmacol 13 1982 411-415
63. Warrington JS Greenblatt DJ von Moltke LL The effect of age on P-glycoprotein expression and function in the Fischer-344 rat J Pharmacol Exp Ther 309 2004 730-736
64. Mangoni AA Jackson SH Age-related changes in pharmacokinetics and pharmacodynamics: Basic principles and practical applications Br J Clin Pharmacol 57 2004 6-14
65. Schmucker DL Liver function and phase I drug metabolism in the elderly: A paradox Drugs Aging 18 2001 837-851
66. Kato R Takanaka A Effect of phenobarbital on electron transport system, oxidation and reduction of drugs in liver microsomes of rats of different age J Biochem (Tokyo) 63 1968 406-408
67. Kato R Takanaka A Metabolism of drugs in old rats. II. Metabolism in vivo and effect of drugs in old rats Jpn J Pharmacol 18 1968 389-396
68. Schmucker DL Woodhouse KW Wang RK et al. Effects of age and gender on in vitro properties of human liver microsomal monooxygenases Clin Pharmacol Ther 48 1990 365-374
69. Sotaniemi EA Arranto AJ Pelkonen O Pasanen M Age and cytochrome P450-linked drug metabolism in humans: An analysis of 226 subjects with equal histopathologic conditions Clin Pharmacol Ther 61 1997 331-339
70. Shimada T Yamazaki H Mimura M et al. Interindividual variations in human liver cytochrome P-450 enzymes involved in the oxidation of drugs, carcinogens and toxic chemicals: Studies with liver microsomes of 30 Japanese and 30 Caucasians J Pharmacol Exp Ther 270 1994 414-423
71. Le Couteur DG Mclean AJ The aging liver. Drug clearance and an oxygen diffusion barrier hypothesis Clin Pharmacokinet. 34 1998 359-373
72. Le Couteur DG Cogger VC Markus AM et al. Pseudocapillarization and associated energy limitation in the aged rat liver Hepatology 33 2001 537-543
73. Le Couteur DG Hickey HM Harvey PJ McLean AJ Oxidative injury reproduces age-related impairment of oxygen-dependent drug metabolism Pharmacol Toxicol 85 1999 230-232
74. Cogger VC Warren A Fraser R et al. Hepatic sinusoidal pseudocapillarization with aging in the non-human primate Exp Gerontol 38 2003 1101-1107
75. McLean AJ Cogger VC Chong GC et al. Age-related pseudocapillarization of the human liver J Pathol 200 2003 112-117
76. O'Malley K Crooks J Duke E Stevenson IH Effect of age and sex on human drug metabolism Br Med J 3 1971 607-609
77. Engel G Hofmann U Heidemann H et al. Antipyrine as a probe for human oxidative drug metabolism: Identification of the cytochrome P450 enzymes catalyzing 4-hydroxyantipyrine, 3-hydroxymethylantipyrine, and norantipyrine formation Clin Pharmacol Ther 59 1996 613-623
78. Vestal RE Norris AH Tobin JD et al. Antipyrine metabolism in man: Influence of age, alcohol, caffeine, and smoking Clin Pharmacol Ther 18 1975 425-432
79. Wood AJ Vestal RE Wilkinson GR et al. Effect of aging and cigarette smoking on antipyrine and indocyanine green elimination Clin Pharmacol Ther 26 1979 16-20
80. Flouvat B Delhotal-Landes B Cournot A Dellatolas F Single and multiple dose pharmacokientics of lansoprazole in elderly subjects Br J Clin Pharmacol 36 1993 467-469
81. Gupta SK Glue P Jacobs S et al. Single-dose pharmacokinetics and tolerability of pegylated interferon-alpha2b in young and elderly healthy subjects Br J Clin Pharmacol 56 2003 131-134
82. Argenti D Huang MY Heald D Ziemniak J The pharmacokinetics of once-daily diltiazem SR (sustained-release) in young versus elderly hypertensive patients Am J Ther 1 1994 133-139
83. Musson DG Birk KL Panebianco DL et al. Pharmacokinetics of rizatriptan in healthy elderly subjects Int J Clin Pharmacol Ther 39 2001 447-452
84. Bergmann JF Laneury JP Duchene P et al. Pharmacokinetics of reboxetine in healthy, elderly volunteers Eur J Drug Metab Pharmacokinet 25 2000 195-198
85. Harvey AT Preskorn SH Fluoxetine pharmacokinetics and effect on CYP2C19 in young and elderly volunteers J Clin Psychopharmacol 21 2001 161-166
86. Molander L Hansson A Lunell E Pharmacokinetics of nicotine in healthy elderly people Clin Pharmacol Ther 69 2001 57-65
87. Gutierrez M Abramowitz W Steady-state pharmacokinetics of citalopram in young and elderly subjects Pharmacotherapy 20 2000 1441-1447
88. Stangier J Su CA Roth W Pharmacokinetics of orally and intravenously administered telmisartan in healthy young and elderly volunteers and in hypertensive patients J Int Med Res 28 2000 149-167
89. Massarella JW He GZ Dorr A et al. The pharmacokinetics and tolerability of the oral neuraminidase inhibitor oseltamivir (Ro 64-0796/GS4104) in healthy adult and elderly volunteers J Clin Pharmacol 40 2000 836-843
90. Wilner KD Tensfeldt TG Baris B et al. Single- and multiple-dose pharmacokinetics of ziprasidone in healthy young and elderly volunteers Br J Clin Pharmacol 49 Suppl 1 2000 15S-20S
91. Turnheim K Krivanek P Oberbauer R Pharmacokinetics and pharmacodynamics of allopurinol in elderly and young subjects Br J Clin Pharmacol 48 1990 501-509
92. Kovarik JM Koelle EU Cyclosporin pharmacokinetics in the elderly Drugs Aging 5 1999 197-205
93. Le Liboux A Cachia JP Kirkesseli S et al. A comparison of the pharmacokinetics and tolerability of riluzole after repeat dose administration in health elderly and young volunteers J Clin Pharmacol 39 1999 480-486
94. Hind ID Mangham JE Ghani SP et al. Sibutramine pharmacokinetics in young and elderly healthy subjects Eur J Clin Pharmacol 54 1999 847-849
95. Keung AC Eller MG Weir SJ Single-dose pharmacokinetics of rifapentine in elderly men Pharm Res 15 1998 1286-1291
96. Scavone JM Greenblatt DJ Harmatz JS et al. Pharmacokinetics and pharmacodynamics of diphenhydramine 25 mg in young and elderly volunteers J Clin Pharmacol 38 1998 603-609
97. Platten HP Schweizer E Dilger K et al. Pharmacokinetics and the pharmacodynamic action of midazolam in young and elderly patients undergoing tooth extraction Clin Pharmacol Ther 63 1998 552-560
98. Kaplan GB Greenblatt DJ Ehrenberg BL et al. Single-dose pharmacokinetics and pharmacodynamics of alprazolam in elderly and young subjects J Clin Pharmacol 38 1998 14-21
99. Suri A Forbes WP Bramer SL Pharmacokinetics of multiple-dose oral cilostazol in middle-age and elderly men and women J Clin Pharmacol 38 1998 144-150
100. Peck RW Seaber EJ Dixon RM et al. The pharmacodynamics and pharmacokinetics of the 5HT1B/1D-agonist zolmitriptan in healthy young and elderly men and women Clin Pharmacol Ther 63 1998 342-353
101. Snel S Jansen JA Mengel HB et al. The pharmacokinetics of tiagabine in healthy elderly volunteers and elderly patients with epilepsy J Clin Pharmacol 37 1997 1015-1020
102. Hubner R Hogemann AM Sunzel M Riddell JG Pharmacokinetics of candesartan after single and repeated doses of candesartan cilexitil in young and elderly healthy volunteers J Hum Hypertens 11 Suppl 2 1997 S19-S25
103. Wong SL Cao G Mack RJ Granneman GR Pharmacokinetics of sertindole in healthy young and elderly male and female subjects Clin Pharmacol Ther 62 1997 157-164
104. Richens A Banfield CR Salfi M et al. Single and multiple dose pharmacokinetics of felbamate in the elderly Br J Clin Pharmacol 44 1997 129-134
105. Nedelman J Cramer JA Robbins B et al. The effect of food on the pharmacokinetics of multiple-dose terbinafine in young and elderly healthy subjects Biopharm Drug Dispos 18 1997 127-138
106. Sorio R Robieux I Galligioni E et al. Pharmacokinetics and tolerance of vinorelbine in elderly patients with metastic breast cancer Eur J Cancer 33 1997 301-303
107. Ronfeld RA Tremaine LM Wilner KD Pharmacokinetics of sertraline and its N-demethyl metabolite in elderly and young male and female volunteers Clin Pharmacokinet 32 Suppl 1 1997 22-30
108. Dempsey E Bourque S Spenard J Landriault H Pharmacokinetics of single intravenous and oral doses of dolasetron mesylate in healthy elderly volunteers J Clin Pharmacol 36 1996 903-910
109. Jaber LA Antal EJ Welshman IR Pharmacokinetics and pharmacodynamics of glyburide in young and elderly patients with non-insulin-dependent diabetes mellitus Ann Pharmacother 30 1996 472-475
110. Sweet RA Pollock BG Kirshner M et al. Pharmacokinetics of single- and multiple-dose bupropion in elderly patients with depression J Clin Pharmacol 35 1995 876-884
111. Barbhaiya RH Shukla UA Greene DS Single-dose pharmacokinetics of nefazodone in healthy young and elderly subjects and in subjects with renal or hepatic impairment Eur J Clin Pharmacol 49 1994 221-228
112. Braeckman RA Granneman GR Locke CS et al. The pharmacokinetics of zileuton in healthy young and elderly volunteers Clin Pharmacokinet 29 Suppl 2 1995 42-48
113. Tornatore KM Logue G Venuto RC Davis PJ Pharmacokinetics of methylprednisolone in elderly and young healthy males J Am Geriatr Soc 42 1994 1118-1122
114. Helmers JH van Leeuwen L Zuurmond WW Sufentanil pharmacokinetics in young adult and elderly surgical patients Eur J Anaesthesiol 11 1994 181-185
115. Abernethy DR An overview of the pharmacokinetics and pharmacodynamics of amlodipine in elderly persons with systemic hypertension Am J Cardiol 73 1994 10A-17A
116. Rudy AC Figueroa NL Hall SD Brater DC The pharmacokinetics of piroxicam in elderly persons with and without renal impairment Br J Clin Pharmacol 37 1994 1-5
117. Arner P Wade A Engfeldt P et al. Pharmacokinetics and pharmacodynamics of trandolapril after repeated administration of 2 mg to young and elderly patients with mild-to-moderate hypertension J Cardiovasc Pharmacol 23 Suppl 4 1994 S44-S49
118. Macdonald NJ Elliott HL Hughes DM Reid JL A comparison in young and elderly subjects of the pharmacokinetics and pharmacodynamics of single and multiple doses of benazepril Br J Clin Pharmacol 36 1993 201-204
119. Pan HY Waclawski AP Funke PT Whigan D Pharmacokinetics of pravastatin in elderly versus young men and women Ann Pharmacother 27 1993 1029-1033
120. Geny F Costa P Bressolle F Galtier M Ceftriaxone pharmacokinetics in elderly subjects and penetration into epididymis Biopharm Drug Dispos 14 1993 161-169
121. Brocks DR Jamali F Russell AS Skeith KJ The stereo-selective pharmacokinetics of etodolac in young and elderly subjects, and after cholecystectomy J Clin Pharmacol 32 1992 982-989
122. Chu SY Wilson DS Guay DR Craft C Clarithromycin pharmacokinetics in healthy young and elderly volunteers J Clin Pharmacol 32 1992 1045-1049
123. Sitar DS Warren CP Aoki FY Pharmacokinetics and pharmacodynamics of bambuterol, a long-acting bronchodilator pro-drug of terbutaline, in young and elderly patients with asthma Clin Pharmacol Ther 52 1992 297-306
124. Elliott HL Green ST Vincent J Meredith PA An assessment of the pharmacokinetics and pharmacodynamics of single doses of amlodipine in elderly normotensives Pharmacol Res 26 1992 33-39
125. Eller MG Walker BJ Westmark PA et al. Pharmacokinetics of terfenadine in healthy elderly subjects J Clin Pharmacol 32 1992 267-271
126. Kean WF Antal EJ Grace EM et al. The pharmacokinetics of flurbiprofen in younger and elderly patients with rheumatoid arthritis J Clin Pharmacol 32 1992 41-48
127. Skinner MH Kuan HY Skerjanec A et al. Effect of age on the pharmacokinetics of duloxetine in women Br J Clin Pharmacol 57 2004 54-61
128. Isah AO Rawlins MD Bateman DN The pharmacokinetics and effects of prochlorperazine in elderly female volunteers Age Ageing 21 1992 27-31
129. Shah J Teitelbaum P Molony B et al. Single and multiple dose pharmacokinetics of ticlopidine in young and elderly subjects Br J Clin Pharmacol 32 1991 761-764
130. Wanwimolruk S Chalcroft S Coville PF Campbell AJ Pharmacokinetics of quinine in young and elderly subjects Trans R Soc Trop Med Hyg 85 1991 714-717
131. Schwinghammer TL Antal EJ Kubacka RT et al. Pharmacokinetics and pharmacodynamics of glyburide in young and elderly nondiabetic adults Clin Pharm. 10 1991 532-538
132. Sonne J Loft S Dossing M et al. Single dose pharmacokinetics and pharmacodynamics in oral oxazepam in very elderly institutionalised subjects Br J Clin Pharmacol 31 1991 719-722
133. Baksi AK Edwards JS Ahr G A comparison of the pharmacokinetics of nisoldipine in elderly and young subjects Br J Clin Pharmacol 31 1991 367-370
134. Matteo RS Schwartz AE Ornstein E et al. Pharmacokinetics of sufentanil in the elderly surgical patient Can J Anaesth 37 1990 852-856
135. Matteo RS Young WL Ornstein E et al. Pharmacokinetics and pharmacodynamics of edrophonium in elderly surgical patients Anesth Analg 71 1990 334-339
136. Simons KJ Watson WT Martin TJ et al. Diphenhydramine: Pharmacokinetics and pharmacodynamics in elderly adults, young adults, and children J Clin Pharmacol 30 1990 665-671
137. Nicholson PA Karim A Smith M Pharmacokinetics of misoprostol in the elderly, in patients with renal failure and when coadministered with NSAID or antipyrine, propranolol or diazepam J Rheumatol Suppl 20 1990 33-37
138. Rocci ML Jr Vlasses PH Cressman MD et al. Pharmacokinetics and pharmacodynamics of labetalol in elderly and young hypertensive patients following single and multiple doses Pharmacotherapy 10 1990 92-99
139. Kaiser G Ackermann R Dieterle W et al. Pharmacokinetics and pharmacodynamics of the ACE inhibitor benazepril hydrochloride in the elderly Eur J Clin Pharmacol 38 1990 379-385
140. Jallad NS Garg DC Martinez JJ et al. Pharmacokinetics of single-dose oral and intramuscular ketorolac tromethamine in the young and elderly J Clin Pharmacol 30 1990 76-81
141. Flanagan RJ Johnston A White AS Crome P Pharmacokinetics of dextropropoxyphene and nordextropropoxyphene in young and elderly volunteers after single and multiple dextropropoxyphene dosage Br J Clin Pharmacol 28 1989 463-469
142. Grech-Belanger O Barbeau G Kishka P et al. Pharmacokinetics of mexiletine in the elderly J Clin Pharmacol 29 1989 311-315
143. Wynne HA Kamali F Edwards C et al. Effect of ageing upon warfarin dose requirements: A longitudinal study Age Ageing 25 1996 429-431
144. Kamali F Edwards C Butler TJ Wynne HA The influence of (R)- and (S)-warfarin, vitamin K and vitamin K epoxide upon warfarin anticoagulation Thromb Haemost 84 2000 39-42
145. Shepherd AM Hewick DS Moreland TA Stevenson IH Age as a determinant of sensitivity to warfarin Br J Clin Pharmacol 4 1977 315-320
146. Hunt CM Westerkam WR Stave GM Wilson JA Hepatic cytochrome P-4503A (CYP3A) activity in the elderly Meth Ageing Dev 64 1992 189-199
147. Pollock BG Perel JM Altieri LP et al. Debrisoquine hydoxylation phenotyping in geriatric psychopharmacology Psychopharmacol Bull 28 1992 163-168
148. Pollock BG Mulsant BH Sweet RA et al. Prospective cytochrome P450 phenotyping for neuroleptic treatment in dementia Psychopharmacol Bull 31 1995 327-331
149. Kamali F Khan TI King BP et al. Contribution of age, body size, and CYP2C9 genotype to anticoagulant response to warfarin Clin Pharmacol Ther 75 2004 204-212
150. Herd B Wynne H Wright P et al. The effect of age on glucuronidation and sulphation of paracetamol by human liver fractions Br J Clin Pharmacol 32 1991 768-770
151. Greenblatt DJ Allen MD Locniskar A et al. Lorazepam kinetics in the elderly Clin Pharmacol Ther 26 1979 103-113
152. Greenblatt DJ Divoll M Harmatz JS Shader RI Oxazepam kinetics: Effects of age and sex J Pharmacol Exp Ther 215 1980 86-91
153. Divoll M Greenblatt DJ Harmatz JS Shader RI Effect of age and gender on disposition of temazepam J Pharm Sci 70 1981 1104-1107
154. Siegmund W Franke G Wulkow R et al. N-acetylation and oxidative capacity in aged volunteers determined with sulfamethazine and antipyrine Int J Clin Pharmacol Ther Toxicol 29 1991 469-473
155. Siegmund W Hanke W Zschiesche M et al. N-acetylation and debrisoquine type oxidation polymorphism in Caucasians-with reference to age and sex Int J Clin Pharmacol Ther Toxicol 28 1990 504-509
156. Paulsen O Nilsson LG Distribution of acetylator phenotype in relation to age and sex in Swedish patients. A retrospective study Eur J Clin Pharmacol 28 1985 311-315
157. Woodhouse K Wynne HA Age-related changes in hepatic function. Implications for drug therapy Drugs Aging 2 1992 243-255
158. Wynne HA Cope LH Mutch E et al. The effect of age upon liver volume and apparent liver blood flow in healthy man Hepatology 9 1989 297-301
159. Swift CG Homeida M Halliwell M Roberts CJ Antipyrine disposition and liver size in the elderly Eur J Clin Pharmacol 14 1978 149-152
160. Abernethy DR Greenblatt DJ Impairment of lidocaine clearance in elderly male subjects J Cardiovasc Pharmacol 5 1983 1093-1096
161. Castleden CM George CF The effect of ageing on the hepatic clearance of propranolol Br J Clin Pharmacol 7 1979 49-54
162. Abernethy DR Schwartz JB Plachetka JR et al. Comparison in young and elderly patients of pharmacodynamics and disposition of labetalol in systemic hypertension Am J Cardiol 60 1987 697-702
163. Abernethy DR Wainer IW Longstreth JA Andrawis NS Stereoselective verapamil disposition and dynamics in aging during racemic verapamil administration J Pharmacol Exp Ther 266 1993 904-911
164. Woodhouse KW Wynne H Baillie S et al., Who are the frail elderly? Q J Med 68 1988 505-506
165. Williams FM Wynne H Woodhouse KW Rawlins MD Plasma aspirin esterase: The influence of old age and frailty Age Ageing 18 1989 39-42
166. Summerbell J Yelland C Woodhouse K The kinetics of plasma aspirin esterase in relation to old age and frailty Age Ageing 19 1990 128-130
167. Wynne HA Cope LH Herd B et al. The association of age and frailty with paracetamol conjugation in man Age Ageing 19 1990 419-424
168. O'Mahoney MS George G Westlake H Woodhouse K Plasma aspirin esterase activity in elderly patients undergoing elective hip replacement and with fractured neck of femur Age Ageing 23 1994 338-341
169. Abou-Hatab K Ganeshalingam K O'Mahony MS et al. The effect of community-acquired pneumonia on plasma esterases in older people Eur J Clin Pharmacol 57 2001 55-60
170. Abou-Hatab K O'Mahony MS Patel S et al. Plasma esterase activities in young and old patients undergoing open inguinal hernia repair Arch Gerontol Geriatr 31 2000 193-198
171. Groen K Horan MA Roberts NA et al. The relationship between phenazone (antipyrine) metabolite formation and theophylline metabolism in healthy and frail elderly women Clin Pharmacokinet 25 1993 136-144
172. Agrawal AK Shapiro BH Constitutive and inducible hepatic cytochrome P450 isoforms in senescent male and female rats and response to low-dose phenobarbital Drug Metab Dispos 31 2003 612-619
173. George G Wynne H Woodhouse K Age and the rate of induction of aryl hydrocarbon hydroxylase in isolated peripheral blood monocytes Age Ageing 20 1991 421-423
174. Salem SA Rajjayabun P Shepherd AM Stevenson IH Reduced induction of drug metabolism in the elderly Age Ageing 7 1978 68-73
175. Twum-Barima Y Finnigan T Habash AI et al. Impaired enzyme induction by rifampicin in the elderly Br J Clin Pharmacol 17 1984 595-597
176. Pearson MW Roberts CJ Drug induction of hepatic enzymes in the elderly Age Ageing 13 1984 313-316
177. Crowley JJ Cusack BJ Jue SG et al. Aging and drug interactions. II. Effect of phenytoin and smoking on the oxidation of theophylline and cortisol in healthy men J Pharmacol Exp Ther 245 1988 513-523
178. Vestal RE Cusack BJ Mercer GD et al. Aging and drug interactions. I. Effect of cimetidine and smoking on the oxidation of theophylline and cortisol in healthy men J Pharmacol Exp Ther 241 1987 488-500
179. Mucklow JC Fraser HS The effects of age and smoking upon antipyrine metabolism Br J Clin Pharmacol 9 1980 613-614
180. Bonde J Pedersen LE Bodtker S et al. The influence of age and smoking on the elimination of disopyramide Br J Clin Pharmacol 20 1985 453-458
181. Dilger K Hofmann U Klotz U Enzyme induction in the elderly: Effect of rifampin on the pharmacokinetics and pharmacodynamics of propafenone Clin Pharmacol Ther 67 2000 512-520
182. Divoll M Greenblatt DJ Abernethy DR Shader RI Cimetidine impairs clearance of antipyrine and desmethyldiazepam in the elderly J Am Geriatr Soc 30 1982 684-689
183. Feely J Pereira L Guy E Hockings N Factors affecting the response to inhibition of drug metabolism by cimetidine - dose response and sensitivity of elderly and induced subjects Br J Clin Pharmacol 17 1984 77-81
184. Adebayo GI Coker HA Cimetidine inhibition of theophylline elimination: The influence of adult age and the time course Biopharm Drug Dispos 8 1987 149-158
185. Cohen IA Johnson CE Berardi RR et al. Cimetidine-theophylline interaction: Effects of age and cimetidine dose Ther Drug Monit 7 1985 426-434
186. Loi CM Parker BM Cusack BJ Vestal RE Aging and drug interactions. III. Individual and combined effects of cimetidine and cimetidine and ciprofloxacin on theophylline metabolism in healthy male and female nonsmokers J Pharmacol Exp Ther 280 1997 627-637
187. Lindeman RD Overview: Renal physiology and pathophysiology of aging Am J Kidney Dis 16 1990 275-282
188. Hoang K Tan JC Derby G et al. Determinants of glomerular hypofiltration in aging humans Kidney Int 64 2003 1417-1424
189. Rowe JW Shock NW DeFronzo RA The influence of age on the renal response to water deprivation in man Nephron 17 1976 270-278
190. Faulstick D Yiengst MJ Oursler DA Shock NW Glomerular permeability in young and old subjects J Gerontol 17 1962 40-44
191. Rowe JW Andres R Tobin JD et al. The effect of age on creatinine clearance in men: A cross-sectional and longitudinal study J Gerontol 31 1976 155-163
192. Lindeman RD Tobin J Shock NW Longitudinal studies on the rate of decline in renal function with age J Am Geriatr Soc 33 1985 278-285
193. Somogyi A Hewson D Muirhead M Bochner F Amiloride disposition in geriatric patients: Importance of renal function Br J Clin Pharmacol 29 1990 1-8
194. Bressolle F Bologna C Kinowski JM et al. Total and free methotrexate pharmacokinetics in elderly patients with rheumatoid arthritis. A comparison with young patients J Rheumatol 24 1997 1903-1909
195. Borin MT Ferry JJ Forbes KK Hughes GS Pharmacokinetics of cefpodoxime
196. Tremblay D Dupront A Ho C et al. Pharmacokinetics of cefpodoxime in young and elderly volunteers after single doses J Antimicrob Chemother 26 Suppl E 1990 21-28
197. Guay DR Vance-Bryan K Gilliland S et al. Comparison of vancomycin pharmacokinetics in hospitalized elderly and young patients using a Bayesian forecaster J Clin Pharmacol 33 1993 918-922
198. Meyers BR Wilkinson P Mendelson MH et al. Pharmacokinetics of aztreonam in healthy elderly and young adult volunteers J Clin Pharmacol 33 1993 470-474
199. Ljungberg B Nilsson-Ehle I Pharmacokinetics of meropenem and its metabolite in young and elderly healthy men Antimicrob Agents Chemother 36 1992 1437-1440
200. Jonsson M Walder M Pharmacokinetics of ceftazidime in acutely ill hospitalised elderly patients Eur J Clin Microbiol Infect Dis 11 1992 15-21
201. [in French] Bardin C Clavier M Darchis JP et al. Pharmacokinetics of ofloxacin administered orally in elderly subjects with bronchial or urinary tract infections Therapie 47 1992 35-39
202. Molinaro M Villani P Regazzi MB et al. Pharmacokinetics of ofloxacin in elderly patients and in healthy young subjects Eur J Clin Pharmacol 43 1992 105-107
203. Meyers BR Wilkinson P Mendelson MH et al. Pharmacokinetics of ampicillin-sulbactam in healthy elderly and young volunteers Antimicrob Agents Chemother 35 1991 2098-2101
204. Coates P Daniel R Houston AC et al. An open study to compare the pharmacokinetics, safety and tolerability of a multiple-dose regimen of azithromycin in young and elderly volunteers Eur J Clin Microbiol Infect Dis 10 1991 850-852
205. Lepage JY Caillon J Malinowsky JM Pharmacokinetics of norfloxacin in the elderly Fundam Clin Pharmacol 5 1991 203-208
206. Hirata CA Guay DR Awni WM et al. Steady-state pharmacokinetics of intravenous and oral ciprofloxacin in elderly patients Antimicrob Agents Chemother 33 1989 1927-1931
207. LaCreta FP Kollia GD Duncan G et al. Age and gender effects on the pharmacokinetics of gatifloxacin Pharmacotherapy 20 2000 67S-75S
208. Chien SC Chow AT Natarajan J et al. Absence of age and gender effects on the pharmacokinetics of a single 500-milligram oral dose of levofloxacin in healthy subjects Antimicrob Agents Chemother 41 1997 1562-1565
209. Urien S Laurent N Barre J et al. Pharmacokinetic modelling of cefotaxime and desacetylcefotaxime-a population study in 25 elderly patients Eur J Clin Pharmacol 60 2004 11-16
210. Pietroski NA Graziani AL Lawson LA et al. Steady-state pharmacokinetics of intramuscular imipenemcilastatin in elderly patients with various degrees of renal function Antimicrob Agents Chemother 35 1991 972-975
211. Toon S Hopkins KJ Garstang FM et al. Pharmacokinetics of imipenem and cilastatin after their simultaneous administration to the elderly Br J Clin Pharmacol 23 1987 143-149
212. [in French] Fourtillan JB Couet W Mignot A et al. Comparative pharmacokinetics of piperacillin in young and elderly subjects Presse Med 15 1986 2321-2323
213. Meyers BR Wilkinson P Clinical pharmacokinetics of antibacterial drugs in the elderly. Implications for selection and dosage Clin Pharmacokinet 17 1989 385-395
214. Reidenberg MM Camacho M Kluger J Drayer DE Aging and renal clearance of procainamide and acetylprocainamide Clin Pharmacol Ther 28 1980 732-735
215. McQuay HJ Carroll D Faura CC et al. Oral morphine in cancer pain: Influences on morphine and metabolite concentration Clin Pharmacol Ther 48 1990 236-244
216. Odar-Cederlof I Boreus LO Bondesson U et al. Comparison of renal excretion of pethidine (meperidine) and its metabolites in old and young patients Eur J Clin Pharmacol 28 1985 171-175
217. Szeto HH Inturrisi CE Houde R et al. Accumulation of normeperidine, an active metabolite of meperidine, in patients with renal failure of cancer Ann Intern Med 86 1977 738-741
218. Marx GM Blake GM Galani E et al. Evaluation of the Cockroft-Gault, Jelliffe and Wright formulae in estimating renal function in elderly cancer patients Ann Oncol 15 2004 291-295
219. Monfardini S Evaluation of renal function in elderly cancer patients Ann Oncol 15 2004 183-184
220. Lubran MM Renal function in the elderly Ann Clin Lab Sci 25 1995 122-133
221. Lindeman RD Assessment of renal function in the old. Special considerations Clin Lab Med 13 1993 269-277
222. Friedman JR Norman DC Yoshikawa TT Correlation of estimated renal function parameters versus 24-hour creatinine clearance in ambulatory elderly J Am Geriatr Soc 37 1989 145-149
223. Cockcroft DW Gault MH Prediction of creatinine clearance from serum creatinine Nephron 16 1976 31-41
224. Malmrose LC Gray SL Pieper CF et al. Measured versus estimated creatinine clearance in a high-functioning elderly sample: MacArthur Foundation Study of Successful Aging J Am Geriatr Soc 41 1993 715-721
225. Fliser D Bischoff I Hanses A et al. Renal handling of drugs in the healthy elderly. Creatinine clearance under-estimates renal function and pharmacokinetics remain virtually unchanged Eur J Clin Pharmacol 55 1999 205-211
226. Drayer DE Romankiewicz J Lorenzo B Reidenberg MM Age and renal clearance of cimetidine Clin Pharmacol Ther 31 1982 45-50
227. Ujhelyi MR Bottorff MB Schur M et al. Aging effects on the organic base transporter and stereoselective renal clearance Clin Pharmacol Ther 62 1997 117-128
228. Andreasen F Hansen U Husted SE Jansen JA The pharmacokinetics of furosemide are influenced by age Br J Clin Pharmacol 16 1983 391-397
229. Andreasen F Hansen U Husted SE et al. The influence of age on renal and extrarenal effects of furosemide Br J Clin Pharmacol 18 1984 65-74