Aging and pharmacology

Cancer

Volumn 80, Issue 7, 1997, Pages 1302-1310

  Vestal, Robert E ^a,b,c  

^a Boise VA Medical Center   (United States)

^b St Luke's Mountain States Tumor Institute   (United States)

^c UNIVERSITY OF WASHINGTON SCHOOL OF MEDICINE   (United States)

Author keywords

Adverse drug events; Aging; Clinical pharmacology; Drug interactions; Drug utilization; Geriatrics; Pharmacodynamics; Pharmacokinetics

Indexed keywords

ALCOHOL; AMANTADINE; CHLORPROPAMIDE; CIMETIDINE; CIPROFLOXACIN; DIAZEPAM; DIPEPTIDYL CARBOXYPEPTIDASE INHIBITOR; ENOXACIN; FOSINOPRIL; FUROSEMIDE; GENTAMICIN; IMIPRAMINE; LABETALOL; LEVODOPA; LIDOCAINE; METFORMIN; METOPROLOL; MIDAZOLAM; MORPHINE; NIFEDIPINE; NORTRIPTYLINE; PHENAZONE; PHENYTOIN; PROCAINAMIDE; PROPRANOLOL; RANITIDINE; THEOPHYLLINE DERIVATIVE; VERAPAMIL; WARFARIN;

AGED; CLINICAL PHARMACOLOGY; DRUG ABSORPTION; DRUG DISTRIBUTION; DRUG USE; GERIATRIC CARE; HUMAN; HUMAN CELL; HUMAN TISSUE; LIVER METABOLISM; MAJOR CLINICAL STUDY; PATIENT COMPLIANCE; PRIORITY JOURNAL; REVIEW; SELF MEDICATION; URINARY EXCRETION;

AGED; AGING; DRUG INTERACTIONS; DRUG UTILIZATION; GERIATRICS; HUMANS; PATIENT COMPLIANCE; PHARMACOKINETICS; PHARMACOLOGY, CLINICAL; POLYPHARMACY; RESEARCH;

EID: 0030931530     PISSN: 0008543X     EISSN: None     Source Type: Journal    
DOI: 10.1002/(SICI)1097-0142(19971001)80:7<1302::AID-CNCR16>3.0.CO;2-B     Document Type: Review

References (49)

1. Chrischilles EA, Foley DJ, Wallace RB, Lemke JH, Semla TP, Hanlon JT, et al. Use of medications by persons 65 and over: data from the established populations for epidemiologic studies of the elderly. J Gerontol 1992;47:M137-44.
2. Vestal RE, Montamat SC, Nielson CP. Drugs in special patient groups: the elderly. In: Melmon KL, Morrelli HF, Hoffman BB, Nierenberg DW, editors. Clinical pharmacology - basic principles in therapeutics. 3rd edition. New York: McGraw-Hill, 1992:851-74.
3. Cusack BJ, Nielson CP, Vestal RE. Geriatric clinical pharmacology and therapeutic. In: Speight TM, Holford NHG, editors. Avery's Drug Treatment. 4th edition. Auckland: Adis International, 1996:173-223.
4. Wilcox SM, Himmelstein DU, Woolhandler S. Inappropriate drug prescribing for the community-dwelling elderly. JAMA 1994;272:292-6.
5. Beers M, Avorn J, Soumerai SB, Everitt DE, Sherman DS, Salem S. Psychoactive medication use in intermediate-care facility residents. JAMA 1988;260:3016-20.
6. Beers MH, Ouslander JG, Fingold SF, Morgenstern H, Reuben DB, Rogers W, et al. Inappropriate medication prescribing in skilled-nursing facilities. Ann Intern Med 1992;117: 684-9.
7. Eisenberg DM, Kessler RC, Foster C, Norlock FE, Calkins DR, Delbanco TL. Unconventional medicine in the United States. Prevalence, costs, and patterns of use. N Engl J Med 1993;328:246-52.
8. Zeilmann C. The utilization of herbal remedies by ambulatory Hispanic and non-Hispanic white elderly in New Mexico. Presented at the USP Open Conference on Botanicals for Medical and Dietary Uses: Standards and Information Issues, Washington, DC, July 7-9, 1996.
9. Montamat SC, Cusack BJ, Vestal RE. Management of drug therapy in the elderly. N Engl J Med 1989;321:303-9.
10. Dawling S, Crome P. Clinical pharmacokinetic considerations in the elderly. An update. Clin Pharmacokinet 1989; 17:236-63.
11. Durnas C, Loi CM, Cusack BJ. Hepatic drug metabolism and aging. Clin Pharmacokinet 1990; 19:359-89.
12. Parker BM, Cusack BJ. Pharmacology and appropriate prescribing. In: Reuben DB, Yoshikawa TT, Besdine RW, editors. Geriatrics review syllabus: a core curriculum in geriatric medicine. 3rd edition. Dubuque: Kendall/Hunt Publishing, 1996:29-36.
13. Kinirons MT, Crome P. Clinical pharmacokinetics considerations in the elderly. An update. Clin Pharmacokinet. In press.
14. Vestal RE, Cusack BJ, Mercer GD, Dawson GW, Park BK. Aging and drug interactions: I. Effect of cimetidine and smoking on the oxidation of theophylline and cortisol in healthy men. J Pharmacol Exp Ther 1987;241:488-500.
15. Crowley JJ, Cusack BJ, Jue SG, Koup JR, Park BK, Vestal RE. Aging and drug interactions: II. Effect of phenytoin and smoking on the oxidation of theophylline and cortisol in healthy men. J Pharmacol Exp Ther 1988;245:513-23.
16. Loi CM, Parker BM, Cusack BJ, Vestal RE. Aging and drug interactions. III. Individual and combined effects of cimetidine and ciprofloxacin on theophylline metabolism in healthy male and female nonsmokers. J Pharmacol Exp Ther 1997;280:627-37.
17. Cusack B, Kelly J, O'Mally K, Noel J, Lavan J, Hogan J. Digoxin in the elderly: pharmacokinetic consequences of old age. Clin Pharmacol Ther 1979;25:772-6.
18. Greenblatt DJ, Harmatz JS, Shader RI. Clinical pharmacokinetics of anxiolytics and hypnotics in the elderly. Therapeutic considerations. Clin Pharmacokinet 1991;21:165-77, 262-73.
19. Vestal RE, McGuire EA, Tobin JD, Andres R, Norris AH, Mezey E. Aging and ethanol metabolism in man. Clin Pharmacol Ther 1977;21:343-54.
20. Verbeeck RK, Cardinal J-A, Wallace SM. Effect of age and sex on the plasma binding of acidic and basic drugs. Eur J Clin Pharmacol 1984;27:91-7.
21. Walter-Sack I, Klotz U. Influence of diet and nutritional status on drug metabolism. Clin Pharmacokinet 1996;31:47-64.
22. Woodhouse K, Wynne HA. Age-related changes in hepatic function. Implications for drug therapy. Drugs Aging 1992;2: 243-55.
23. Kolars JC, Lown KS, Schmiedlin-Ren P, Ghosh M, Fang C, Wrightons SA, et al. CYP3A4 gene expression in human gut epithelium. Pharmacogenetics 1994;4:247-59.
24. Vestal RE, Norris AH, Tobin JD, Cohen BH, Shock NW, Andres R. Antipyrine metabolism in man: influence of age, alcohol, caffeine and smoking. Clin Pharmacol Ther 1975; 18:425-32.
25. Steiner E, Bertilsson L, Säwe J, Ingegärd B, Sjöqvist F. Polymorphic debrisoquin hydroxylation in 757 Swedish subjects. Clin Pharmacol Ther 1988;44:431-5.
26. Siegmund W, Hanke W, Zschiesche M, Franke G, Biebler KE, Wilke A. N-acetylation and debrisoquin type oxidation polymorphism in Caucasians - with reference to age and sex. Int J Clin Pharmacol Ther Toxicol 1990;28:504-9.
27. Korrapati MR, Sorkin JD, Andres R, Muller DC, Loi CM, Vesell ES, et al. Acetylator phenotype in relation to age and gender in the Baltimore Longitudinal Study of Aging. J Clin Pharmacol 1997;37:83-91.
28. Chandler MHH, Scott SR, Blouin RA. Age-associated stereo-selective alterations in hexobarbital metabolism. Clin Pharmacol Ther 1988;43:436-41.
29. Wynne HA, Cope LH, James OFW, Rawlins MD, Woodhouse KW. The effect of age and frailty upon acetanilide clearance in man. Age Ageing 1989; 18:415-8.
30. Wynne H, Cope L, Kelly P, Whittingham T, Edwards C, Kamali F. The influence of age, liver size and enantiomer concentrations on warfarin requirements. Br J Clin Pharmacol 1995;40:203-7.
31. Lindeman RD. Changes in renal function with aging. Implications for treatment. Drugs Aging 1992;2:423-31.
32. Lamy P. Physiological changes due to age. Pharmacodynamic changes of drug action and implications for therapy. Drugs Aging 1991;1:385-404.
33. Scarpace PJ, Turner N, Mader SL. β-Adrenergic function in aging. Basic mechanisms and clinical implications. Drugs Aging 1991; 1:116-29.
34. Vestal RE, Wood AJJ, Shand DG. Reduced β-adrenoceptor sensitivity in the elderly. Clin Pharmacol Ther 1979;26:181-6.
35. Bellville JW, Forrest WH, Miller E, Brown BW. Influence of age on pain relief from analgesics. A study of postoperative patients. JAMA 1971;217:1835-41.
36. Kaiko RF. Age and morphine analgesia in cancer patients with postoperative pain. Clin Pharmacol Ther 1980;28:823-6.
37. Berkowitz BA, Ngai SH, Yang JC, Hempstead J, Spector S. The disposition of morphine in surgical patients. Clin Pharmacol Ther 1975;17:629-35.
38. Stanski DR, Greenblatt DJ, Lowenstein E. Kinetics of intravenous and intramuscular morphine. Clin Pharmacol Ther 1978;24:52-9.
39. Owen JA, Sitar DS, Berger L, Brownell L, Duke PC, Mitenko PA. Age-related morphine kinetics. Clin Pharmacol Ther 1983;34:364-8.
40. Scott JC, Stanski DR. Decreased fentanyl and alfentanil dose requirements with age. A simultaneous pharmacokinetic and pharmacodynamic evaluation. J Pharmacol Exp Ther 1987;240:159-66.
41. Nolan L, O'Malley K. Prescribing for the elderly: I. Sensitivity of the elderly to adverse drug reactions. J Am Geriatr Soc 1988;36:142-9.
42. Gurwitz JH, Avorn J. The ambiguous relation between aging and adverse drug reactions. Ann Intern Med 1991;114:956-66.
43. Grymonpre RE, Mitenko PA, Sitar DS, Aoki FY, Montgomery PR. Drug-associated hospital admissions in older medical patients. J Am Geriatr Soc 1988;36:1092-8.
44. Phister JE, Jue SG, Cusack BJ. Problems in the use of anticancer drugs in the elderly. Drugs 1989;37:551-65.
45. Vestal RE, Cusack BJ, Crowley JJ, Loi CM. Aging and the response to inhibition and induction of theophylline metabolism. Exp Gerontol 1993;28:421-33.
46. Kivistö KT, Kroemer HK, Eichelbaum M. The role of human cytochrome P450 enzymes in the metabolism of anticancer agents: implications for drug interactions. Br J Clin Pharmacol 1995;40:523-30.
47. Black DM, Brand RJ, Greenlick M, Hughes G, Smith J. Compliance to treatment for hypertension in elderly patients: the SHEP pilot study. J Gerontol 1987;42:552-7.
48. Stewart RB. Noncompliance in the elderly. Is there a cure? Drugs Aging 1991;1:163-7.
49. Abernethy DR, Azarnoff DL. Pharmacokinetic investigations in elderly patients. Clinical and ethical considerations. Clin Pharmacokinet 1990; 19:89-93.