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Volumn 61, Issue 3, 1997, Pages 331-339

Age and cytochrome P450-linked drug metabolism in humans: An analysis of 226 subjects with equal histopathologic conditions

Author keywords

[No Author keywords available]

Indexed keywords

CYTOCHROME P450; PHENAZONE; TESTOSTERONE;

EID: 0030973784     PISSN: 00099236     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0009-9236(97)90166-1     Document Type: Article
Times cited : (363)

References (42)
  • 1
    • 0009835687 scopus 로고
    • Variation in the activity of liver microsomal drugmetabolizing enzymes in rats in relation to age
    • Kato R, Vassanelli P, Frontino G, Cheara E. Variation in the activity of liver microsomal drugmetabolizing enzymes in rats in relation to age. Biochem Pharmacol 1964;13:1037-51.
    • (1964) Biochem Pharmacol , vol.13 , pp. 1037-1051
    • Kato, R.1    Vassanelli, P.2    Frontino, G.3    Cheara, E.4
  • 2
    • 0021812736 scopus 로고
    • Age-related alterations in the activities of drug-metabolizing enzymes and contents of sex-specific forms of cytochrome P450 in liver microsomes from male to female rats
    • Kamataki T, Maeda K, Shimada M, Kitani K, Nagai T, Kato R. Age-related alterations in the activities of drug-metabolizing enzymes and contents of sex-specific forms of cytochrome P450 in liver microsomes from male to female rats. J Pharmacol Exp Ther 1985;233:222-8.
    • (1985) J Pharmacol Exp Ther , vol.233 , pp. 222-228
    • Kamataki, T.1    Maeda, K.2    Shimada, M.3    Kitani, K.4    Nagai, T.5    Kato, R.6
  • 3
    • 0023801158 scopus 로고
    • Drug metabolism in the elderly
    • Loi CM, Vestal RE. Drug metabolism in the elderly. Pharmacol Ther 1988;36:131-49.
    • (1988) Pharmacol Ther , vol.36 , pp. 131-149
    • Loi, C.M.1    Vestal, R.E.2
  • 6
    • 0021032982 scopus 로고
    • Impairment of lidocaine clearance in elderly male subjects
    • Abernethy DR, Greenblatt DJ. Impairment of lidocaine clearance in elderly male subjects. J Cardiovasc Pharmacol 1983;5:1093-6.
    • (1983) J Cardiovasc Pharmacol , vol.5 , pp. 1093-1096
    • Abernethy, D.R.1    Greenblatt, D.J.2
  • 8
    • 0000952962 scopus 로고
    • Lack of ageing effects on human microsomal monooxygenase enzyme activities and on inactivation pathways for reactive metabolic intermediates
    • Kitani K, editor. Amsterdam: Elsevier Biomedical Press
    • James OFW, Rawlins MD, Woodhouse K. Lack of ageing effects on human microsomal monooxygenase enzyme activities and on inactivation pathways for reactive metabolic intermediates. In: Kitani K, editor. Liver and aging, Amsterdam: Elsevier Biomedical Press, 1982:395-406.
    • (1982) Liver and Aging , pp. 395-406
    • James, O.F.W.1    Rawlins, M.D.2    Woodhouse, K.3
  • 10
    • 0024241308 scopus 로고
    • The effect of age upon the affinity of microsomal monooxygenase enzymes for substrate in human liver
    • Wynne HA, Murch E, James OFW, Wright P, Rawlins MD, Woodhouse KW. The effect of age upon the affinity of microsomal monooxygenase enzymes for substrate in human liver. Age Ageing 1988;17: 401-5.
    • (1988) Age Ageing , vol.17 , pp. 401-405
    • Wynne, H.A.1    Murch, E.2    James, O.F.W.3    Wright, P.4    Rawlins, M.D.5    Woodhouse, K.W.6
  • 11
    • 0025245868 scopus 로고
    • The association of age with the induction of drug-metabolizing enzymes in human monocytes
    • George G, Wynne HA, Woodhouse KW. The association of age with the induction of drug-metabolizing enzymes in human monocytes. Age Ageing 1990:19: 364-7.
    • (1990) Age Ageing , vol.19 , pp. 364-367
    • George, G.1    Wynne, H.A.2    Woodhouse, K.W.3
  • 13
    • 0028310860 scopus 로고
    • Age, environmental factors and drug metabolism
    • O'Mahony MS, Woodhouse KW. Age, environmental factors and drug metabolism. Pharmacol Ther 1994; 61:279-87.
    • (1994) Pharmacol Ther , vol.61 , pp. 279-287
    • O'Mahony, M.S.1    Woodhouse, K.W.2
  • 14
    • 9544225459 scopus 로고
    • Modification of drug metabolism in relation to age in humans tract
    • Woodhouse KW. Modification of drug metabolism in relation to age in humans [abstract]. Therapie 1995; 50(suppl):25.
    • (1995) Therapie , vol.50 , Issue.SUPPL. , pp. 25
    • Woodhouse, K.W.1
  • 15
    • 0014681324 scopus 로고
    • Cholestasis is the result of hypoactive hypertrophie smooth endoplasmic reticulum in the hepatocyte
    • Schaffner F, Popper H. Cholestasis is the result of hypoactive hypertrophie smooth endoplasmic reticulum in the hepatocyte. Lancet 1969;2:355-9.
    • (1969) Lancet , vol.2 , pp. 355-359
    • Schaffner, F.1    Popper, H.2
  • 19
    • 0029740082 scopus 로고    scopus 로고
    • Age and CYP3A4 and CYP2A6 activities marked by the metabolism of lignocaine and coumarin in man
    • Sotaniemi EA, Rautio A, Lumme P, Arvela P. Age and CYP3A4 and CYP2A6 activities marked by the metabolism of lignocaine and coumarin in man. Therapie 1996;51:363-6.
    • (1996) Therapie , vol.51 , pp. 363-366
    • Sotaniemi, E.A.1    Rautio, A.2    Lumme, P.3    Arvela, P.4
  • 20
    • 0015149537 scopus 로고
    • The apparent free testosterone concentration: An index of androgenecity
    • Vermeulen A, Stoica T, Verdonck L. The apparent free testosterone concentration: an index of androgenecity. J Clin Endocrinol 1971;33:759-67.
    • (1971) J Clin Endocrinol , vol.33 , pp. 759-767
    • Vermeulen, A.1    Stoica, T.2    Verdonck, L.3
  • 21
    • 0015320306 scopus 로고
    • Testosterone secretion and metabolism in male senescence
    • Vermeulen A, Rubens R, Verdonck L. Testosterone secretion and metabolism in male senescence. J Clin Endocrinol 1972;34:730-5.
    • (1972) J Clin Endocrinol , vol.34 , pp. 730-735
    • Vermeulen, A.1    Rubens, R.2    Verdonck, L.3
  • 22
    • 0014964290 scopus 로고
    • The influence of phenobarbital on the turnover of hepatic microsomal cytochrome b5 and cytochrome P450 in the rat
    • Greim H, Schenkman M, Klotzbucher M, Remmer H. The influence of phenobarbital on the turnover of hepatic microsomal cytochrome b5 and cytochrome P450 in the rat. Biochim Biophys Acta 1970;201:20-5.
    • (1970) Biochim Biophys Acta , vol.201 , pp. 20-25
    • Greim, H.1    Schenkman, M.2    Klotzbucher, M.3    Remmer, H.4
  • 23
    • 0019774540 scopus 로고
    • Morphologic alterations in patients with alpha-methyldopa-induced liver damage after short and long-term exposure
    • Arranto AJ, Sotaniemi EA. Morphologic alterations in patients with alpha-methyldopa-induced liver damage after short and long-term exposure. Scand J Gastroenterol 1981;16:853-63.
    • (1981) Scand J Gastroenterol , vol.16 , pp. 853-863
    • Arranto, A.J.1    Sotaniemi, E.A.2
  • 24
    • 12644280695 scopus 로고
    • Histological and morphological studies on xenobiotics induced liver injury
    • Oulu, Finland
    • Arranto AJ. Histological and morphological studies on xenobiotics induced liver injury [thesis]. Acta Universitatis Ouluensis, Oulu, Finland, 1982. 53 p.
    • (1982) Acta Universitatis Ouluensis
    • Arranto, A.J.1
  • 26
    • 0038130072 scopus 로고
    • Drug metabolism in man: In vivo and in vitro correlations
    • Sotaniemi EA, Pelkonen RO, editors. London: Taylor & Francis
    • Sotaniemi EA, Pelkonen RO. Drug metabolism in man: in vivo and in vitro correlations. In: Sotaniemi EA, Pelkonen RO, editors. Enzyme induction in man. London: Taylor & Francis, 1987:79-93.
    • (1987) Enzyme Induction in Man , pp. 79-93
    • Sotaniemi, E.A.1    Pelkonen, R.O.2
  • 27
    • 0008750056 scopus 로고
    • Genetic and environmental factors affecting drug disposition in man
    • Vesell ES. Genetic and environmental factors affecting drug disposition in man. Clin Pharmacol Ther 1977;17:48-56.
    • (1977) Clin Pharmacol Ther , vol.17 , pp. 48-56
    • Vesell, E.S.1
  • 28
    • 0017061837 scopus 로고
    • Influence of dietary protein and carbohydrate on antipyrine and theophylline metabolism in man
    • Kappas A, Anderson KE, Conney AH, Alvares AP. Influence of dietary protein and carbohydrate on antipyrine and theophylline metabolism in man. Clin Pharmacol Ther 1976;20:643-54.
    • (1976) Clin Pharmacol Ther , vol.20 , pp. 643-654
    • Kappas, A.1    Anderson, K.E.2    Conney, A.H.3    Alvares, A.P.4
  • 29
    • 0019165164 scopus 로고
    • Age-related changes in liver drug metabolism: Structure vs function
    • Schmucker DL, Wang RK. Age-related changes in liver drug metabolism: structure vs function. Proc Soc Exp Biol Med 1980;165:178-87.
    • (1980) Proc Soc Exp Biol Med , vol.165 , pp. 178-187
    • Schmucker, D.L.1    Wang, R.K.2
  • 30
    • 0017807770 scopus 로고
    • Stereological analysis of hepatic fine structure in the Fischer 344 rat: Influence of sublobular location and animal age
    • Schmucker DL, Mooney JS, Jones AL. Stereological analysis of hepatic fine structure in the Fischer 344 rat: influence of sublobular location and animal age. J Cell Biol 1978;73:319-37.
    • (1978) J Cell Biol , vol.73 , pp. 319-337
    • Schmucker, D.L.1    Mooney, J.S.2    Jones, A.L.3
  • 31
    • 0021637522 scopus 로고
    • Age-dependent alterations in the physicochemical properties of rat liver microsomes
    • Schmucker DL, Vessey DA, Wang RK, James J, Maloney A. Age-dependent alterations in the physicochemical properties of rat liver microsomes. Mech Ageing Dev 1984;27:207-17.
    • (1984) Mech Ageing Dev , vol.27 , pp. 207-217
    • Schmucker, D.L.1    Vessey, D.A.2    Wang, R.K.3    James, J.4    Maloney, A.5
  • 32
    • 0029683112 scopus 로고    scopus 로고
    • Antipyrine as a probe for human oxidative drug metabolism; I: Identification of the cytochrome P450 enzymes catalyzing 4-hydroxyantipyrine, 3-hydromethylantopyrine, and norantipyrine formation
    • Engel G, Hoffman U, Heideman H, Cosme J, Eichelbaum M. Antipyrine as a probe for human oxidative drug metabolism; I: identification of the cytochrome P450 enzymes catalyzing 4-hydroxyantipyrine, 3-hydromethylantopyrine, and norantipyrine formation. Clin Pharmacol Ther 1996;59:613-23.
    • (1996) Clin Pharmacol Ther , vol.59 , pp. 613-623
    • Engel, G.1    Hoffman, U.2    Heideman, H.3    Cosme, J.4    Eichelbaum, M.5
  • 33
    • 0029875703 scopus 로고    scopus 로고
    • Identification of the human hepatic cytochromes P450 involved in the vitro oxidation of antipyrine
    • Sharer JE, Wrighton SA. Identification of the human hepatic cytochromes P450 involved in the vitro oxidation of antipyrine. Drug Metab Dispos 1996;24:487-94.
    • (1996) Drug Metab Dispos , vol.24 , pp. 487-494
    • Sharer, J.E.1    Wrighton, S.A.2
  • 34
    • 0019453722 scopus 로고
    • Influence of liver disease and environmental factors on hepatic monooxygenase activity in vitro
    • Brodie MJ, Boobis AR, Bulpitt CJ, Davies DS. Influence of liver disease and environmental factors on hepatic monooxygenase activity in vitro. Eur J Clin Pharmacol 1981;20:30-46.
    • (1981) Eur J Clin Pharmacol , vol.20 , pp. 30-46
    • Brodie, M.J.1    Boobis, A.R.2    Bulpitt, C.J.3    Davies, D.S.4
  • 36
    • 0006985319 scopus 로고
    • Splanchnic blood flow in man by the bromsulfalein method: The relation of peripheral plasma bromsulfalein level to the calculated flow
    • Sherlock S, Beam AG, Billing BH, Paterson JCS. Splanchnic blood flow in man by the bromsulfalein method: the relation of peripheral plasma bromsulfalein level to the calculated flow. J Lab Clin Med 1950;35:923-32.
    • (1950) J Lab Clin Med , vol.35 , pp. 923-932
    • Sherlock, S.1    Beam, A.G.2    Billing, B.H.3    Paterson, J.C.S.4
  • 37
    • 0020285152 scopus 로고
    • Effects of total plasma concentration and age on tolbutamide plasma protein binding
    • Adir J, Miller AK, Vestal RE. Effects of total plasma concentration and age on tolbutamide plasma protein binding. Clin Pharmacol Ther 1982;31:488-93.
    • (1982) Clin Pharmacol Ther , vol.31 , pp. 488-493
    • Adir, J.1    Miller, A.K.2    Vestal, R.E.3
  • 38
    • 0029061983 scopus 로고
    • Pharmacokinetics of the novel antiestrogenic agent toremifene in subjects with altered liver and kidney function
    • Anttila M, Laakso S, Nyländen P, Sotaniemi EA, Pharmacokinetics of the novel antiestrogenic agent toremifene in subjects with altered liver and kidney function. Clin Pharmacol Ther 1995;57:628-35.
    • (1995) Clin Pharmacol Ther , vol.57 , pp. 628-635
    • Anttila, M.1    Laakso, S.2    Nyländen, P.3    Sotaniemi, E.A.4
  • 39
    • 0014125542 scopus 로고
    • Pharmacological implications of microsomal enzyme induction
    • Conney AH. Pharmacological implications of microsomal enzyme induction. Pharmacol Rev 1967;19:317-66.
    • (1967) Pharmacol Rev , vol.19 , pp. 317-366
    • Conney, A.H.1
  • 40
    • 0025293634 scopus 로고
    • Immunochemical and molecular biological studies P450-dependent monooxygenase activities
    • Pasanen M, Haaparanta T, Sundin M, Sivonen P, Vähäkangas P, Raunio H, et al. Immunochemical and molecular biological studies P450-dependent monooxygenase activities. Toxicology 1990;62:175-87.
    • (1990) Toxicology , vol.62 , pp. 175-187
    • Pasanen, M.1    Haaparanta, T.2    Sundin, M.3    Sivonen, P.4    Vähäkangas, P.5    Raunio, H.6
  • 41
    • 0025364520 scopus 로고
    • Differential expression and regulation of members of the cytochrome P450 1A gene subfamily in human tissues
    • Sesardic D, Pasanen M, Pelkonen O, Boobis AR. Differential expression and regulation of members of the cytochrome P450 1A gene subfamily in human tissues. Carcinogenesis 1990;11:1183-8.
    • (1990) Carcinogenesis , vol.11 , pp. 1183-1188
    • Sesardic, D.1    Pasanen, M.2    Pelkonen, O.3    Boobis, A.R.4
  • 42
    • 0023038691 scopus 로고
    • The effect of cigarette smoking on 7-ethoxyresorufin O-deethylase and other monooxygenase activities in human liver: Analyses with monoclonal antibodies
    • Pelkonen O, Pasanen M, Kuha H, Gachalyi B, Kairaluoma M, Sotaniemi EA, et al. The effect of cigarette smoking on 7-ethoxyresorufin O-deethylase and other monooxygenase activities in human liver: analyses with monoclonal antibodies. Br J Clin Pharmacol 1986;22:125-34.
    • (1986) Br J Clin Pharmacol , vol.22 , pp. 125-134
    • Pelkonen, O.1    Pasanen, M.2    Kuha, H.3    Gachalyi, B.4    Kairaluoma, M.5    Sotaniemi, E.A.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.