Effect of age on the pharmacokinetics of duloxetine in women

British Journal of Clinical Pharmacology

Volumn 57, Issue 1, 2004, Pages 54-61

  Skinner, Michael H ^a   Kuan, Han Yi ^b   Skerjanec, Andrej ^c   Seger, Mary E ^a   Heathman, Michael ^a   O'Brien, Lisa ^a   Reddy, Shobha ^a   Knadler, Mary P ^a  

^a ELI LILLY AND COMPANY   (United States)

^b LIGAND PHARMACEUTICALS INC   (United States)

^c NOVARTIS PHARMA AG   (Switzerland)

Author keywords

Clinical trials; Duloxetine; Elderly; Pharmacokinetics

Indexed keywords

DULOXETINE; PLACEBO;

ADULT; AGE; AGED; ARTICLE; BLOOD SAMPLING; CLINICAL ARTICLE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DATA ANALYSIS; DIARRHEA; DISEASE SEVERITY; DIZZINESS; DRUG BLOOD LEVEL; DRUG CLEARANCE; DRUG ELIMINATION; DRUG SAFETY; DYSMENORRHEA; FEMALE; FLU LIKE SYNDROME; GERIATRIC PATIENT; HEADACHE; HUMAN; HYPERTENSION; INCIDENCE; MODEL; MULTICENTER STUDY; NAUSEA; NONLINEAR SYSTEM; PHASE 1 CLINICAL TRIAL; PHASE 2 CLINICAL TRIAL; POPULATION; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL; SOMNOLENCE; URINE INCONTINENCE; XEROSTOMIA;

ADRENERGIC UPTAKE INHIBITORS; ADULT; AGED; AGING; FEMALE; HUMANS; MIDDLE AGED; SEROTONIN UPTAKE INHIBITORS; THIOPHENES; URINARY INCONTINENCE;

EID: 0347319049     PISSN: 03065251     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1365-2125.2003.01963.x     Document Type: Article

References (16)

1. Wong DT, Bymaster FP, Mayle DA, Reid LR, Krushinski JH, Robertson DW. LY248686, a new inhibitor of serotonin and norepinephrine uptake. Neuropsychopharmacology 1993; 8: 23-33.
2. Thor KB, Katofiasc MA. Effects of duloxetine, a combined serotonin and norepinephrine reuptake inhibitor, on central neural control of lower urinary tract function in the chloralose-anesthetized female cat. J Pharmacol Exp Ther 1995; 274: 1014-24.
3. Katoh A, Eigyo M, Ishibashi C et al. Behavioral and electroencephalographic properties of duloxetine (LY248686), a reuptake inhibitor of norepinephrine and serotonin, in mice and rats. J Pharmacol Exp Ther 1995; 272: 1067-75.
4. Sharma A, Goldberg MJ, Cerimele BJ. Pharmacokinetics and safety of duloxetine, a dual-serotonin and norepinephrine reuptake inhibitor. J Clin Pharmacol 2000; 40: 161-7.
5. Roberts J, Tumer N. Pharmacodynamic basis for altered drug action in the elderly. Clin Geriatr Med 1988; 4: 127-49.
6. Hammerlein A, Derendorf H, Lowenthal DT. Pharmacokinetics and pharmacodynamic changes in the elderly. Clin Pharmacokinet 1998; 35: 49-64.
7. Kinirons MT, Crome P. Clinical pharmacokinetic considerations in the elderly. An update. Clin Pharmacokinet 1997; 33: 302-12.
8. Dawling S, Crome P. Clinical pharmacokinetic considerations in the elderly. An update. Clin Pharmacokinet 1989; 17: 236-63.
9. Johnson JT, Oldham SW, Lantz RJ, DeLong AF. High performance liquid chromatographic method for the determination of duloxetine and desmethyl duloxetine in human plasma. J Liq Chrom Rel Technol 1996; 19: 1631-41.
10. Beal SL, Sheiner LB. NONMEM users guide, Part VII, Conditional estimation methods. University of California, San Francisco: NONMEM Project Group, 1992.
11. Allerheiligen S, Cerimele B, Milosevich S, Johnson R, Nelson R, Tarassoff P. A population pharmacokinetic analysis of gemcitabine following variable length infusions. Pharmaceutical Res 1994; 11 (Abstr. 8178): S-377.
12. O'Brien L, Hewitt R, Heathman M, Ni L, Allerheiligen S. Challenging the robustness of a population pharmacokinetic model obtained from a Phase III raloxifene study. AAPS Annual Meeting and Exposition 1998. AAPS Pharm Sci 1998; 1 (Abstr. 3548).
13. Lantz RJ, Gillespie TA, Rash TJ, Kuo F, Skinner M, Kuan HY, Knadler MP. Metabolism, excretion, and pharmokinetics of duloxetine in healthy human subjects. Drug Metab Disp 2003; 31: 1142-50.
14. Bender A. Effect of age on intestinal absorption: implications for drug absorption in the elderly. J Am Geriatr Soc 1968; 16: 1331-9.
15. Richey D, Bender A. Pharmacokinetic consequences of aging. Annu Rev Pharmacol Toxicol 1977; 17: 49-65.
16. Evens MA, Triggs EJ, Cheung M, Broe GA, Creasey H. Gastric emptying rate in the elderly. J Am Geriatr Soc 1981; 29: 201-5.