Tyrosine 425 within the activated erythropoietin receptor binds Syp, reduces the erythropoietin required for Syp tyrosine phosphorylation, and promotes mitogenesis

Blood

Volumn 87, Issue 11, 1996, Pages 4495-4501

  Tauchi, Tetsuzo ^b   Damen, Jacqueline E ^b   Toyama, Keisuke ^b   Feng, Gen Sheng ^b   Broxmeyer, Hal E ^a   Krystal, Gerald ^b  

^a INDIANA UNIVERSITY   (United States)

^b NONE

Author keywords

[No Author keywords available]

Indexed keywords

ERYTHROPOIETIN; ERYTHROPOIETIN RECEPTOR;

AMINO ACID SUBSTITUTION; ANIMAL CELL; ARTICLE; CELL DIFFERENTIATION; CELL PROLIFERATION; ERYTHROPOIESIS; HORMONE RECEPTOR INTERACTION; MITOGENESIS; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION;

EID: 0029943191     PISSN: 00064971     EISSN: None     Source Type: Journal    
DOI: 10.1182/blood.v87.11.4495.bloodjournal87114495     Document Type: Article

References (40)

1. Krantz SB: Erythropoietin. Blood 77:419, 1991
2. Koury MJ, Bondurant MC: The molecular mechanism of erythropoietin action. Eur J Biochem 210:649, 1992
3. Witthuhn BA, Quelle FW, Silvennoinen O, Yi Y, Tang B, Miura O, Ihle JN: JAK2 associates with the erythropoietin receptor and is tyrosine phosphorylated and activated following stimulation with erythropoietin. Cell 74:227, 1993
4. Miura O, Nakamura N, Quelle FW, Witthuhn BA, Ihle JN, Aoki N: Erythropoietin induces association of the JAK2 protein tyrosine kinase with the erythropoietin receptor in vivo. Blood 84:1501, 1994
5. Damen J, Mui AL, Hughes P, Humphries K, Krystal G: Erythropoietin-induced tyrosine phosphorylations in a high erythropoietin receptor-expressing lymphoid cell line. Blood 80:1923, 1992
6. Miura O, D'Andrea A, Kabat D, Ihle JN: Induction of tyrosine phosphorylation by the erythropoietin receptor correlates with mitogenesis. Mol Cell Biol 11:4895, 1991
7. Yoshimura A, Lodish HF: In vitro phosphorylation of the erythropoietin receptor and an associated protein, pp 130. Mol Cell Biol 12:706, 1992
8. Damen JE, Liu L, Cutler RL, Krystal G: Erythropoietin stimulates the tyrosine phosphorylation of Shc and its association with Grb2 and a 145-Kd tyrosine phosphorylated protein. Blood 82:2296, 1993
9. Damen JE, Wakao H, Miyajima A, Krosl J, Humphries RK, Cutler RL, Krystal G: Tyrosine 343 in the erythropoietin receptor positively regulates erythropoietin-induced cell proliferation and Stat5 activation. EMBO J 14:5557, 1995
10. Damen JE, Mui AL, Puil L, Pawson T, Krystal G: Phosphatidylinositol 3-kinase associates, via its Src homology 2 domains, with the activated erythropoietin receptor. Blood 81:3204, 1993
11. He TC, Zhuang H, Jiang N, Waterfield MD, Wojchowski DM: Association of the p85 regulatory subunit of phosphatidylinositol 3-kinase with an essential erythropoietin receptor subdomain. Blood 12:3530, 1993
12. Sadowski I, Stone JC, Pawson T: A noncatalytic domain conserved among cytoplasmic protein-tyrosine kinases modifies the kinase function and transforming activity of Fujinami sarcoma virus P130gag-fps. Mol Cell Biol 6:4396, 1986
13. Koch CA, Anderson D, Moran MF, Ellis C, Pawson T: SH2 and SH3 domains: Elements that control interactions of cytoplasmic signaling proteins. Science 252:668, 1991
14. Shen SH, Bastien L, Posner BI, Chretien P: A protein-tyrosine phosphatase with sequence similarity to the SH2 domain of the protein-tyrosine kinases. Nature 352:736, 1991
15. Freeman RM Jr, Plutzky J, Neel BG: Identification of a human src homology 2-containing protein-tyrosine-phosphatase: A putative homolog of Drosophila corkscrew. Proc Natl Acad Sci USA 89:11239, 1992
16. Matthews RJ, Bowne DB, Flores E, Thomas ML: Characterization of hematopoietic intracellular protein tyrosine phosphatases: Description of a phosphatase containing an SH2 domain and another enriched in proline-, glutamic acid-, serine-, and threomne-rich sequences. Mol Cell Biol 12:2396, 1992
17. Plutzky J, Neel BG, Rosenberg RD: Isolation of a src homology 2-containing tyrosine phosphatase. Proc Natl Acad Sci USA 89:1123, 1992
18. Yi T, Cleveland JL, Ihle JN: Protein tyrosine phosphatase containing SH2 domains: characterization, preferential expression in hematopoietic cells, and localization to human chromosome 12p12-p13. Mol Cell Biol 12:836, 1992
19. Ahmad S, Banville D, Zhao Z, Fischer EH, Shen SH: A widely expressed human protein-tyrosine phosphatase containing src homology 2 domains. Proc Natl Acad Sci USA 90:2197, 1993
20. Feng GS, Hui CC, Pawson T: SH2-containing phosphotyrosine phosphatase as a target of protein-tyrosine kinases. Science 259:1607, 1993
21. Vogel W, Lammers R, Huang J, Ullrich A: Activation of a phosphotyrosine phosphatase by tyrosine phosphorylation. Science 259:1611, 1993
22. Shultz LD, Schweitzer PA, Rajan TV, Yi T, Ihle JN, Matthews RJ, Thomas ML, Beier DR: Mutations at the murine motheaten locus are within the hematopoietic cell protein-tyrosine phosphatase (Hcph) gene. Cell 73:1445, 1993
23. Klingmuller U, Lorenz U, Cantly LC, Neel BG, Lodish HF: Specific recruitment of SH-PTP1 to the erythropoietin receptor causes inactivation of JAK2 and termination of proliferative signals. Cell 80:729, 1995
24. Tang TL, Freeman RM Jr, O'Reilly AM, Neel BG, Sokol SY: The SH2-containing protein-tyrosine phosphatase SH-PTP2 is required upstream of MAP kinase for early Xenopus development. Cell 80:473, 1995
25. Lechleider RJ, Freeman RM Jr, Neel BG: Tyrosyl phosphorylation and growth factor receptor association of the human corkscrew homologue, SH-PTP2. J Biol Chem 268:13434, 1993
26. Kazlauskas A, Feng GS, Pawson T, Valius M: The 64-kDa protein that associates with the platelet-derived growth factor receptor beta subunit via Tyr-1009 is the SH2-containing phosphotyrosine phosphatase Syp. Proc Natl Acad Sci USA 90:6939, 1993
27. Kuhne MR, Pawson T, Lienhard GE, Feng GS: The insulin receptor substrate 1 associates with the SH2-containing phosphotyrosine phosphalase Syp. J Biol Chem 268:11479, 1993
28. Feng GS, Shen R, Heng HH, Tsui LC, Kazlauskas A, Pawson T: Receptor-binding, tyrosine phosphorylation and chromosome localization of the mouse SH2-containing phosphotyrosine phosphatase Syp. Oncogene 9:1545, 1994
29. Tauchi T, Feng GS, Shen R, Song HY, Donner D, Pawson T, Broxmeyer HE: SH2-containing phosphotyrosine phosphatase Syp is a target of p210bcr-abl tyrosine kinase. J Biol Chem 269:15381, 1994
30. Tauchi T, Feng GS, Marshall MS, Shen R, Mantel C, Pawson T, Broxmeyer HE: The ubiquitously expressed Syp phosphatase interacts with c-kit and Grb2 in hematopoietic cells. J Biol Chem 269:25206, 1994
31. Case RD, Piccione E, Wolf G, Benett AM, Lechleider RJ, Neel BG, Shoelson SE: SH-PTP2/Syp SH2 domain binding specificity is defined by direct interactions with platelet-derived growth factor beta-receptor, epidermal growth factor receptor, and insulin receptor substrate-1-derived phosphopeptides. J Biol Chem 269:10467, 1994
32. Sugimoto S, Wandless TJ, Shoelson SE, Neel BG, Walsh CT: Activation of the SH2-containing protein tyrosine phosphatase, SH-PTP2, by phosphotyrosine-containing peptides derived from insulin receptor substrate-1. J Biol Chem 269:13614, 1994
33. Kazlauskas A, Feng GS, Pawson T, Valius M: The 65-kDa protein that associates with the platelet-derived growth factor receptor β subunit via Tyr-1009 is the SH2-containing phosphotyrosine phosphatase Syp. Proc Natl Acad Sci USA 90:6939, 1993
34. Tauchi T, Feng GS, Shen R, Hoatlin M, Bagby GC Jr, Kabat D, Lu L, Broxmeyer HE: Involvement of SH2-containing phosphotyrosine phosphatase Syp in erythropoietin receptor signal transduction pathways. J Biol Chem 270:5631, 1995
35. Damen JE, Cutler RL, Jiao H, Yi T, Krystal G: Phosphorylation of tyrosine 503 in the erythropoietin receptor (EpR) is essential for binding the p85 subunit of phosphatidylinositol (PI) 3-kinase and for EpR-associated PI 3-kinase activity. J Biol Chem 270:23402, 1995
36. Tauchi T, Boswell HS, Leibowitz D, Broxmeyer HE: Coupling between p210bcr-abl and She and Grb2 adaptor proteins in hematopoietic cells permits growth factor receptor-independent link to ras activation pathway. J Exp Med 179:167, 1994
37. Krystal G, Lam V, Dragowska W, Takahashi C, Appel J, Gontier A, Jenkins A, Lam H, Quon L, Lansdorp P: Transforming growth factor β1 is an inducer of erythroid differentiation. J Exp Med 180:851, 1994
38. Damen J, Liu L, Rosten P, Humphries RK, Jefferson AB, Majerus PW, Krystal G: The 145-kDa protein induced to associate with Shc by multiple cytokines is an inositol tetraphosphate 5-phosphatase. Proc Natl Acad Sci USA 93:1689, 1996
39. Li W, Nishimura R, Kashishian A, Batzer AG, Kim WJH, Cooper JA, Schlessinger J: A new function for a phosphotyrosine phosphatase: Linking Grb2-Sos to a receptor tyrosine kinase. Mol Cell Biol 14:509, 1994
40. Etienne-Julan M, Gotoh A, Braun SE, Li ZH, Tauchi T, Feng GS, Lu L, Broxmeyer HE: Involvement of Syp, a protein tyrosine phosphatase in the proliferation of human growth factor-dependent TF1 cells and immature myeloid progenitors in human cord blood, as determined by antisense oligonucleotides and retroviral-mediated gene transfer. Blood 86:14a, 1995 (abstr, suppl 1)