Glutathione depletion resulting in selective mitochondrial complex I inhibition in dopaminergic cells is via an NO-mediated pathway not involving peroxynitrite: Implications for Parkinson's disease

Journal of Neurochemistry

Volumn 92, Issue 5, 2005, Pages 1091-1103

  Hsu, Michael ^a   Srinivas, Bharath ^b   Kumar, Jyothi ^b   Subramanian, Rajagopalan ^b   Andersen, Julie K ^b,c  

^a UNIVERSITY OF SOUTHERN CALIFORNIA   (United States)

^b BUCK INSTITUTE FOR RESEARCH ON AGING   (United States)

^c NONE   (United States)

Author keywords

Complex I; Glutathione; Parkinson's disease; PC12; Reactive nitrogen species; Reactive oxygen species

Indexed keywords

DOPAMINE; GLUTATHIONE; HYDROGEN PEROXIDE; NITRIC OXIDE; OXOGLUTARATE DEHYDROGENASE; PEROXYNITRITE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE DEHYDROGENASE (UBIQUINONE);

ANIMAL CELL; ARTICLE; CELL STRAIN; CITRIC ACID CYCLE; CONTROLLED STUDY; DOPAMINERGIC NERVE CELL; ENZYME ACTIVITY; ENZYME INHIBITION; GENETIC ENGINEERING; MITOCHONDRIAL RESPIRATION; MOUSE; NERVE CELL NECROSIS; NONHUMAN; OXIDATION; PARKINSON DISEASE; PRIORITY JOURNAL; SUBSTANTIA NIGRA;

ADENOSINE DIPHOSPHATE; ADENOSINE TRIPHOSPHATE; ALDEHYDES; ANIMALS; ANTI-BACTERIAL AGENTS; BLOTTING, WESTERN; CELL DIFFERENTIATION; CITRATE (SI)-SYNTHASE; DOPAMINE; DOSE-RESPONSE RELATIONSHIP, DRUG; DOXYCYCLINE; ELECTRON TRANSPORT COMPLEX I; GLUTATHIONE; HYDROGEN PEROXIDE; KETOGLUTARATE DEHYDROGENASE COMPLEX; MITOCHONDRIA; MULTIENZYME COMPLEXES; NITRIC OXIDE; OXYGEN; PARKINSON DISEASE; PC12 CELLS; RATS; SIGNAL TRANSDUCTION;

PARKINSONIA;

EID: 14644416354     PISSN: 00223042     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1471-4159.2004.02929.x     Document Type: Article

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