Glutathione depletion switches nitric oxide neurotrophic effects to cell death in midbrain cultures: Implications for Parkinson's disease

Journal of Neurochemistry

Volumn 79, Issue 6, 2001, Pages 1183-1195

  Canals, S ^a   Casarejos, M J ^a   De Bernardo, S ^a   Rodriguez Martin E ^a   Mena, M A ^a  

^a HOSPITAL RAMÓN Y CAJAL   (Spain)

Author keywords

Ascorbic acid; cGMP dependent protein kinase; Dopamine neurones; Glutathione; Guanylate cyclase; Nitric oxide

Indexed keywords

ASCORBIC ACID; BUTHIONINE SULFOXIMINE; CASPASE; CYCLIC GMP DEPENDENT PROTEIN KINASE; CYCLIC GMP DEPENDENT PROTEIN KINASE INHIBITOR; DNA FRAGMENT; FREE RADICAL; GLUTATHIONE; GUANYLATE CYCLASE; GUANYLATE CYCLASE INHIBITOR; NITRIC OXIDE; RNA;

ANIMAL CELL; APOPTOSIS; ARTICLE; CELL DEATH; CELL PROTECTION; CHROMATIN CONDENSATION; CONTROLLED STUDY; EMBRYO; ENZYME ACTIVITY; GLUTATHIONE METABOLISM; MESENCEPHALON; NERVE CELL CULTURE; NERVE CELL NECROSIS; NEUROTOXICITY; NONHUMAN; PARKINSON DISEASE; PRIORITY JOURNAL; PROTEIN SYNTHESIS; RAT; RNA SYNTHESIS; SIGNAL TRANSDUCTION;

ALKALOIDS; AMINOQUINOLINES; ANIMALS; ANTIOXIDANTS; APOPTOSIS; ASCORBIC ACID; BUTHIONINE SULFOXIMINE; CARBAZOLES; CELL DIVISION; CELLS, CULTURED; CYCLIC GMP-DEPENDENT PROTEIN KINASES; DOPAMINE; ENZYME INHIBITORS; FREE RADICALS; GLUTATHIONE; GLUTATHIONE SYNTHASE; GUANYLATE CYCLASE; HOMEOSTASIS; HYDRAZINES; INDOLES; MESENCEPHALON; METHYLENE BLUE; NERVE TISSUE PROTEINS; NEURONS; NITRIC OXIDE; NITRIC OXIDE DONORS; NITROGEN OXIDES; NUCLEIC ACID SYNTHESIS INHIBITORS; PARKINSON DISEASE; PENICILLAMINE; PROTEIN SYNTHESIS INHIBITORS; RATS; RATS, SPRAGUE-DAWLEY; TYROSINE 3-MONOOXYGENASE;

ANIMALIA;

EID: 0035664304     PISSN: 00223042     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1471-4159.2001.00635.x     Document Type: Article

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