-
1
-
-
0034039040
-
Dial 9-1-1 for p53: Mechanisms of p53 activation by cellular stress
-
Ljungman M. Dial 9-1-1 for p53: Mechanisms of p53 activation by cellular stress. Neoplasia 2000; 2:208-25.
-
(2000)
Neoplasia
, vol.2
, pp. 208-225
-
-
Ljungman, M.1
-
2
-
-
0034818446
-
Post-translational modifications and activation of p53 by genotoxic stresses
-
Appella E, Anderson CW. Post-translational modifications and activation of p53 by genotoxic stresses. Eur J Biochem 2001; 268:2764-72.
-
(2001)
Eur J Biochem
, vol.268
, pp. 2764-2772
-
-
Appella, E.1
Anderson, C.W.2
-
3
-
-
0037377060
-
Ubiquitination, phosphorylation and acetylation: The molecular basis for p53 regulation
-
Brooks CL, Gu W. Ubiquitination, phosphorylation and acetylation: The molecular basis for p53 regulation. Curr Opin Cell Biol 2003; 15:164-71.
-
(2003)
Curr Opin Cell Biol
, vol.15
, pp. 164-171
-
-
Brooks, C.L.1
Gu, W.2
-
4
-
-
3142534591
-
Initiating cellular stress responses
-
Bakkenist CJ, Kastan MB. Initiating cellular stress responses. Cell 2004; 118:9-17.
-
(2004)
Cell
, vol.118
, pp. 9-17
-
-
Bakkenist, C.J.1
Kastan, M.B.2
-
5
-
-
0036674617
-
Live or let die: The cell's response to p53
-
Vousden KH, Lu X. Live or let die: The cell's response to p53. Nat Rev Cancer 2002;2:594-604.
-
(2002)
Nat Rev Cancer
, vol.2
, pp. 594-604
-
-
Vousden, K.H.1
Lu, X.2
-
8
-
-
0036121363
-
p53 regulation of DNA excision repair pathways
-
Smith ML, Seo YR. p53 regulation of DNA excision repair pathways. Mutagenesis 2002;17:149-56.
-
(2002)
Mutagenesis
, vol.17
, pp. 149-156
-
-
Smith, M.L.1
Seo, Y.R.2
-
9
-
-
0042379999
-
p53 and regulation of DNA damage recognition during nucleotide excision repair
-
Amst
-
Adimoolam S, Ford JM. p53 and regulation of DNA damage recognition during nucleotide excision repair. DNA Repair (Amst) 2003; 2:947-54.
-
(2003)
DNA Repair
, vol.2
, pp. 947-954
-
-
Adimoolam, S.1
Ford, J.M.2
-
10
-
-
0036490207
-
A nucleotide excision repair master-switch: p53 regulated coordinate induction of global genomic repair genes
-
Amundson SA, Patterson A, Do KT, Fornace Jr AJ. A nucleotide excision repair master-switch: p53 regulated coordinate induction of global genomic repair genes. Cancer Biol Ther 2002; 1:145-9.
-
(2002)
Cancer Biol Ther
, vol.1
, pp. 145-149
-
-
Amundson, S.A.1
Patterson, A.2
Do, K.T.3
Fornace Jr., A.J.4
-
11
-
-
0030900605
-
Identification of redox/repair protein Ref-1 as a potent activator of p53
-
Jayaraman L, Murthy KG, Zhu C, Curran T, Xanthoudakis S, Prives C. Identification of redox/repair protein Ref-1 as a potent activator of p53. Genes Dev 1997; 11:558-70.
-
(1997)
Genes Dev
, vol.11
, pp. 558-570
-
-
Jayaraman, L.1
Murthy, K.G.2
Zhu, C.3
Curran, T.4
Xanthoudakis, S.5
Prives, C.6
-
12
-
-
0033570048
-
Ref-1 regulates the transactivation and pro-apoptotic functions of p53 in vivo
-
Gaiddon C, Moorthy NC, Prives C. Ref-1 regulates the transactivation and pro-apoptotic functions of p53 in vivo. EMBOJ 1999; 18:5609-21.
-
(1999)
EMBOJ
, vol.18
, pp. 5609-5621
-
-
Gaiddon, C.1
Moorthy, N.C.2
Prives, C.3
-
13
-
-
0035449355
-
Cell cycle checkpoint signaling through the ATM and ATR kinases
-
Abraham RT. Cell cycle checkpoint signaling through the ATM and ATR kinases. Genes Dev 2001; 15:2177-96.
-
(2001)
Genes Dev
, vol.15
, pp. 2177-2196
-
-
Abraham, R.T.1
-
14
-
-
0037365789
-
ATM and related protein kinases: Safeguarding genome integrity
-
Shiloh Y. ATM and related protein kinases: Safeguarding genome integrity. Nat Rev Cancer 2003; 3:155-68.
-
(2003)
Nat Rev Cancer
, vol.3
, pp. 155-168
-
-
Shiloh, Y.1
-
16
-
-
0033555260
-
A role for ATR in the DNA damage-induced phosphorylation of p53
-
Tibbetts RS, Brumbaugh KM, Williams JM, Sarkaria JN, Cliby WA Shieh SY, Taya Y, Prives C, Abraham RT. A role for ATR in the DNA damage-induced phosphorylation of p53. Genes Dev 1999; 13:152-7.
-
(1999)
Genes Dev
, vol.13
, pp. 152-157
-
-
Tibbetts, R.S.1
Brumbaugh, K.M.2
Williams, J.M.3
Sarkaria, J.N.4
Cliby, W.A.5
Shieh, S.Y.6
Taya, Y.7
Prives, C.8
Abraham, R.T.9
-
17
-
-
0033485261
-
Phosphorylation of human p53 by p38 kinase coordinates N-terminal phosphorylation and apoptosis in response to UV radiation
-
Bulavin DV, Saito S, Hollander MC, Sakaguchi K, Anderson CW Appella E, Fornace AJ Jr. Phosphorylation of human p53 by p38 kinase coordinates N-terminal phosphorylation and apoptosis in response to UV radiation. EMBO J 1999; 18:6845-54.
-
(1999)
EMBO J
, vol.18
, pp. 6845-6854
-
-
Bulavin, D.V.1
Saito, S.2
Hollander, M.C.3
Sakaguchi, K.4
Anderson, C.W.5
Appella, E.6
Fornace Jr., A.J.7
-
18
-
-
0034745050
-
Jun NH2-terminal kinase phosphorylation of p53 on Thr-81 is important for p53 stabilization and transcriptional activities in response to stress
-
Buschmann T, Potapova O, Bar-Shira A, Ivanov VN, Fuchs SY, Henderson S, Fried VA, Minamoto T, Alarcon-Vargas D, Pincus MR, Gaarde WA, Holbrook NJ, Shiloh Y, Ronai Z. Jun NH2-terminal kinase phosphorylation of p53 on Thr-81 is important for p53 stabilization and transcriptional activities in response to stress. Mol Cell Biol 2001;21:2743-54.
-
(2001)
Mol Cell Biol
, vol.21
, pp. 2743-2754
-
-
Buschmann, T.1
Potapova, O.2
Bar-Shira, A.3
Ivanov, V.N.4
Fuchs, S.Y.5
Henderson, S.6
Fried, V.A.7
Minamoto, T.8
Alarcon-Vargas, D.9
Pincus, M.R.10
Gaarde, W.A.11
Holbrook, N.J.12
Shiloh, Y.13
Ronai, Z.14
-
19
-
-
3142570737
-
Mdm2-mediated NEDD8 conjugation of p53 inhibits its transcriptional activity
-
Xirodimas DP, Saville MK, Bourdon JC, Hay RT, Lane DP. Mdm2-mediated NEDD8 conjugation of p53 inhibits its transcriptional activity. Cell 2004; 118:83-97.
-
(2004)
Cell
, vol.118
, pp. 83-97
-
-
Xirodimas, D.P.1
Saville, M.K.2
Bourdon, J.C.3
Hay, R.T.4
Lane, D.P.5
-
23
-
-
0031987277
-
Regulation of p53 downstream genes
-
el-Deiry WS. Regulation of p53 downstream genes. Semin Cancer Biol 1998; 8:345-57.
-
(1998)
Semin Cancer Biol
, vol.8
, pp. 345-357
-
-
El-Deiry, W.S.1
-
24
-
-
0027459198
-
Mdm2 expression is induced by wild type p53 activity
-
Barak Y, Juven T, Haffner R, Oren M. Mdm2 expression is induced by wild type p53 activity. EMBO J 1993; 12:461-8.
-
(1993)
EMBO J
, vol.12
, pp. 461-468
-
-
Barak, Y.1
Juven, T.2
Haffner, R.3
Oren, M.4
-
26
-
-
0030925222
-
Wip1, a novel human protein phosphatase that is induced in response to ionizing radiation in a p53-dependent manner
-
Fiscella M, Zhang H, Fan S, Sakaguchi K, Shen S, Mercer WE, Vande Woude GF, O'Connor PM, Appella E. Wip1, a novel human protein phosphatase that is induced in response to ionizing radiation in a p53-dependent manner. Proc Natl Acad Sci USA 1997;94:6048-53.
-
(1997)
Proc Natl Acad Sci USA
, vol.94
, pp. 6048-6053
-
-
Fiscella, M.1
Zhang, H.2
Fan, S.3
Sakaguchi, K.4
Shen, S.5
Mercer, W.E.6
Vande Woude, G.F.7
O'Connor, P.M.8
Appella, E.9
-
27
-
-
0024397415
-
The structure and regulation of protein phosphatases
-
Cohen P. The structure and regulation of protein phosphatases. Annu Rev Biochem 1989; 58:453-508.
-
(1989)
Annu Rev Biochem
, vol.58
, pp. 453-508
-
-
Cohen, P.1
-
28
-
-
0034383398
-
p53-inducible wip1 phosphatase mediates a negative feedback regulation of p38 MAPK-p53 signaling in response to UV radiation
-
Takekawa M, Adachi M, Nakahata A, Nakayama I, Itoh F, Tsukuda H, Taya Y, Imai K. p53-inducible wip1 phosphatase mediates a negative feedback regulation of p38 MAPK-p53 signaling in response to UV radiation. EMBO J 2000; 19:6517-26.
-
(2000)
EMBO J
, vol.19
, pp. 6517-6526
-
-
Takekawa, M.1
Adachi, M.2
Nakahata, A.3
Nakayama, I.4
Itoh, F.5
Tsukuda, H.6
Taya, Y.7
Imai, K.8
-
29
-
-
0036146455
-
Mice deficient for the wild-type p53-induced phosphatase gene (Wip1) exhibit defects in reproductive organs, immune function, and cell cycle control
-
Choi J, Nannenga B, Demidov ON, Bulavin DV, Cooney A, Brayton C, Zhang Y, Mbawuike IN, Bradley A, Appella E, Donehower LA. Mice deficient for the wild-type p53-induced phosphatase gene (Wip1) exhibit defects in reproductive organs, immune function, and cell cycle control. Mol Cell Biol 2002; 22:1094-105.
-
(2002)
Mol Cell Biol
, vol.22
, pp. 1094-1105
-
-
Choi, J.1
Nannenga, B.2
Demidov, O.N.3
Bulavin, D.V.4
Cooney, A.5
Brayton, C.6
Zhang, Y.7
Mbawuike, I.N.8
Bradley, A.9
Appella, E.10
Donehower, L.A.11
-
30
-
-
0036613212
-
Amplification of PPM1D in human tumors abrogates p53 tumor-suppressor activity
-
Bulavin DV, Demidov ON, Saito S, Kauraniemi P, Phillips C, Amundson SA, Ambrosino C, Sauter G, Nebreda AR, Anderson CW, Kallioniemi A, Fornace AJ Jr, Appella E. Amplification of PPM1D in human tumors abrogates p53 tumor-suppressor activity. Nat Genet 2002; 31:210-5.
-
(2002)
Nat Genet
, vol.31
, pp. 210-215
-
-
Bulavin, D.V.1
Demidov, O.N.2
Saito, S.3
Kauraniemi, P.4
Phillips, C.5
Amundson, S.A.6
Ambrosino, C.7
Sauter, G.8
Nebreda, A.R.9
Anderson, C.W.10
Kallioniemi, A.11
Fornace Jr., A.J.12
Appella, E.13
-
31
-
-
18544385947
-
Oncogenic properties of PPM1D located within a breast cancer amplification epicenter at 17q23
-
Li J, Yang Y, Peng Y, Austin RJ, van Eyndhoven WG, Nguyen KC, Gabriele T, McCurrach ME, Marks JR, Hoey T, Lowe SW, Powers S. Oncogenic properties of PPM1D located within a breast cancer amplification epicenter at 17q23. Nat Genet 2002; 31:133-4.
-
(2002)
Nat Genet
, vol.31
, pp. 133-134
-
-
Li, J.1
Yang, Y.2
Peng, Y.3
Austin, R.J.4
Van Eyndhoven, W.G.5
Nguyen, K.C.6
Gabriele, T.7
McCurrach, M.E.8
Marks, J.R.9
Hoey, T.10
Lowe, S.W.11
Powers, S.12
-
32
-
-
0037221767
-
TP53 and breast cancer
-
Borresen-Dale AL. TP53 and breast cancer. Hum Mutat 2003; 21:292-300.
-
(2003)
Hum Mutat
, vol.21
, pp. 292-300
-
-
Borresen-Dale, A.L.1
-
33
-
-
0037446975
-
PPM1D is a potential target for 17q gain in neuroblastoma
-
Saito-Ohara F, Imoto I, Inoue J, Hosoi H, Nakagawara A, Sugimoto T, Inazawa J. PPM1D is a potential target for 17q gain in neuroblastoma. Cancer Res 2003; 63:1876-83.
-
(2003)
Cancer Res
, vol.63
, pp. 1876-1883
-
-
Saito-Ohara, F.1
Imoto, I.2
Inoue, J.3
Hosoi, H.4
Nakagawara, A.5
Sugimoto, T.6
Inazawa, J.7
-
34
-
-
0037838822
-
Association of 17q21-q24 gain in ovarian clear cell adenocarcinomas with poor prognosis and identification of PPM1D and APPBP2 as likely amplification targets
-
Hirasawa A, Saito-Ohara F, Inoue J, Aoki D, Susumu N, Yokoyama T, Nozawa S, Inazawa J, Imoto I. Association of 17q21-q24 gain in ovarian clear cell adenocarcinomas with poor prognosis and identification of PPM1D and APPBP2 as likely amplification targets. Clin Cancer Res 2003; 9:1995-2004.
-
(2003)
Clin Cancer Res
, vol.9
, pp. 1995-2004
-
-
Hirasawa, A.1
Saito-Ohara, F.2
Inoue, J.3
Aoki, D.4
Susumu, N.5
Yokoyama, T.6
Nozawa, S.7
Inazawa, J.8
Imoto, I.9
-
36
-
-
1842483852
-
Arf pathway
-
Arf pathway. Nat Genet 2004; 36:343-50.
-
(2004)
Nat Genet
, vol.36
, pp. 343-350
-
-
Bulavin, D.V.1
Phillips, C.2
Nannenga, B.3
Timofeev, O.4
Donehower, L.A.5
Anderson, C.W.6
Appella, E.7
Fornace Jr., A.J.8
-
37
-
-
4344560876
-
The p53-induced oncogenic phosphatase PPM1D interacts with uracil DNA glycosylase and suppresses base excision repair
-
Lu X, Bocangel D, Nannenga B, Yamaguchi H, Appella E, Donehower LA. The p53-induced oncogenic phosphatase PPM1D interacts with uracil DNA glycosylase and suppresses base excision repair. Mol Cell 2004; 15:621-34.
-
(2004)
Mol Cell
, vol.15
, pp. 621-634
-
-
Lu, X.1
Bocangel, D.2
Nannenga, B.3
Yamaguchi, H.4
Appella, E.5
Donehower, L.A.6
-
38
-
-
18644363009
-
hUNG2 is the major repair enzyme for removal of uracil from U: A matches, U: G mismatches, and U in single-stranded DNA, with hSMUG1 as a broad specificity backup
-
Kavli B, Sundheim O, Akbari M, Otterlei M, Nilsen H, Skorpen F, Aas PA, Hagen L, Krokan HE, Slupphaug G. hUNG2 is the major repair enzyme for removal of uracil from U: A matches, U: G mismatches, and U in single-stranded DNA, with hSMUG1 as a broad specificity backup. J Biol Chem 2002; 277:39926-36.
-
(2002)
J Biol Chem
, vol.277
, pp. 39926-39936
-
-
Kavli, B.1
Sundheim, O.2
Akbari, M.3
Otterlei, M.4
Nilsen, H.5
Skorpen, F.6
Aas, P.A.7
Hagen, L.8
Krokan, H.E.9
Slupphaug, G.10
-
39
-
-
0344393408
-
Regulation of MAP kinase signaling modules by scaffold proteins in mammals
-
Morrison DK, Davis RJ. Regulation of MAP kinase signaling modules by scaffold proteins in mammals. Annu Rev Cell Dev Biol 2003; 19:91-118.
-
(2003)
Annu Rev Cell Dev Biol
, vol.19
, pp. 91-118
-
-
Morrison, D.K.1
Davis, R.J.2
|