Mice deficient for the wild-type p53-induced phosphatase gene (Wipl) exhibit defects in reproductive organs, immune function, and cell cycle control

Molecular and Cellular Biology

Volumn 22, Issue 4, 2002, Pages 1094-1105

  Choi, Jene ^a   Nannenga, Bonnie ^a   Demidov, Oleg N ^a   Bulavin, Dmitry V ^a   Cooney, Austin ^a   Brayton, Cory ^a   Zhang, Yongxin ^a   Mbawuike, Innocent N ^a   Bradley, Allan ^a   Appella, Ettore ^a   Donehower, Lawrence A ^a  

^a BAYLOR COLLEGE OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

MESSENGER RNA; PHOSPHATASE; PROTEIN P53; SERINE THREONINE PHOSPHATASE; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; B LYMPHOCYTE; CELL CYCLE; CELL FUNCTION; CELL PROLIFERATION; CONTROLLED STUDY; DISEASE PREDISPOSITION; FEMALE; FIBROBLAST; GENE; GENE EXPRESSION; GENE FUNCTION; GENE INDUCTION; GENITAL SYSTEM DISEASE; IMMUNE RESPONSE; IONIZING RADIATION; LONGEVITY; LYMPHOID CELL; MALE; MALE FERTILITY; MOUSE; MOUSE STRAIN; NONHUMAN; PRIORITY JOURNAL; SEMINIFEROUS TUBULE; SPERMATOGENESIS; T LYMPHOCYTE; TESTIS; TISSUE LEVEL; WIP1 GENE;

ANIMALS; B-LYMPHOCYTES; BODY CONSTITUTION; CELL CYCLE; CYCLIN-DEPENDENT KINASE INHIBITOR P21; CYCLINS; EMBRYONIC AND FETAL DEVELOPMENT; FEMALE; GENE EXPRESSION REGULATION; GENE TARGETING; HUMANS; IMMUNE SYSTEM; IN SITU HYBRIDIZATION; KIDNEY; MALE; MICE; MICE, INBRED BALB C; MICE, INBRED C57BL; MICE, TRANSGENIC; NEOPLASM PROTEINS; PHOSPHOPROTEIN PHOSPHATASE; RADIATION, IONIZING; REPRODUCTION; RNA, MESSENGER; SPERMATOGENESIS; SPLEEN; STEM CELLS; T-LYMPHOCYTES; TESTIS;

ANIMALIA; MAMMALIA;

EID: 0036146455     PISSN: 02707306     EISSN: None     Source Type: Journal    
DOI: 10.1128/MCB.22.4.1094-1105.2002     Document Type: Article

References (27)

1. Deregulation of p53/p21Cipl/Wafl pathway contributes to polyploidy and apoptosis of E1A+cHa-ras transformed cells after gamma-irradiation
2. The structure and expression of the murine wild-type p53-induced phosphatase 1 (Wipl) gene
3. The structure and regulation of protein phosphatases
4. WAF1, a potential mediator of p53 tumor suppression
5. Wipl, a novel human protein phosphatase that is induced in response to ionizing radiation in a p53-dependent manner
6. The complexity of p53 modulation: Emerging patterns from divergent signals
7. Mutations in the p53 tumor suppressor gene: Clues to cancer etiology and molecular pathogenesis
8. In vitro growth characteristics of embryo fibroblasts isolated from p53-deficient mice
9. A role for oestrogens in the male reproductive system
10. p53: Puzzle and paradigm
11. p53, the cellular gatekeeper for growth and division
12. p53 sends nucleotides to repair DNA
13. Vaccination with inactivated influenza A virus during pregnancy protects neonatal mice against lethal challenge by influenza A viruses representing three subtypes
14. Protein serine/threonine phosphatases: Structure, regulation, and functions in cell growth
15. Genomic DNA microextraction: A method to screen numerous samples
16. Gene targeting in embryonic stem cells
17. Necropsy methods for laboratory mice: Biological characterization of a new mutation
18. Mice with reduced levels of p53 protein exhibit the testicular giant-cell degenerative syndrome
19. Tumor surveillance via the ARF-p53 pathway
20. DNA damage induces phosphorylation of the amino terminus of p53
21. The p53 tumour suppressor gene
22. p53-inducible wipl phosphatase mediates a negative feedback regulation of p38 MAPK-p53 signaling in response to UV radiation
23. Surfing the p53 network
24. Splenic marginal zone B-cell and thymic T-cell lymphomas in p53-deficient mice