Regulation of the Profile of Iron-Management Proteins in Brain Microvasculature

Journal of Cerebral Blood Flow and Metabolism

Volumn 24, Issue 1, 2004, Pages 67-74

  Burdo, Joseph R ^a   Simpson, Ian A ^a   Menzies, Sharon ^a   Beard, John ^b   Connor, James R ^a  

^a PENN STATE COLLEGE OF MEDICINE   (United States)

^b PENNSYLVANIA STATE UNIVERSITY   (United States)

Author keywords

Blood brain barrier; DMT1; Ferritin; Ferroportin; Iron; Transferrin receptor

Indexed keywords

CELL PROTEIN; FERRITIN; FERROPORTIN; IRON; NATURAL RESISTANCE ASSOCIATED MACROPHAGE PROTEIN 2; TRANSFERRIN; TRANSFERRIN RECEPTOR; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BLOOD BRAIN BARRIER; BRAIN BLOOD VESSEL; BRAIN REGION; CONTROLLED STUDY; ENDOSOME; ENDOTHELIUM CELL; IRON STORAGE; IRON THERAPY; IRON TRANSPORT; MICROVASCULATURE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT;

EID: 0347363844     PISSN: 0271678X     EISSN: None     Source Type: Journal    
DOI: 10.1097/01.WCB.0000095800.98378.03     Document Type: Article

References (30)

1. Abboud S, Haile DJ (2000) A novel mammalian iron-regulated protein involved in intracellular iron metabolism. J Biol Chem 275:19906-19912
2. Allen RP, Barker PB, Wehrl F, Song HK, Earley CJ (2001) MRI measurement of brain iron in patients with restless legs syndrome. Neurology 56:263-265
3. Borowsky IW, Collins RC (1989) Metabolic anatomy of brain: a comparison of regional capillary density, glucose metabolism, and enzyme activities. J Comp Neurol 288:401-413
4. Burdo, JR, Antonetti DA, Wolpert EB, Connor JR (2003) Mechanisms and regulation of transferrin and iron transport in a model blood-brain barrier system. Neuroscience (in press)
5. Burdo JR, Menzies SL, Simpson IA, Garrick LM, Garrick MD, Dolan KG, Haile DJ, Beard JL, Connor JR (2001) Distribution of divalent metal transporter 1 and metal transport protein 1 in the normal and Belgrade rat. J Neurosci Res 66:1198-1207
6. Burdo JR, Martin J, Menzies SL, Dolan KG, Romano MA, Fletcher RJ, Garrick MD, Garrick LM, Connor JR (1999) Cellular distribution of iron in the brain of the Belgrade rat. Neuroscience 93:1189-1196
7. Chen Q, Connor JR, Beard JL (1995) Brain iron, transferrin and ferritin concentrations are altered in developing iron-deficient rats. J Nutr 125:1529-1535
8. Cremer JE, Seville MP (1983) Regional brain blood flow, blood volume, and haematocrit values in the adult rat. J Cereb Blood Flow Metab 3:254-256
9. Crowe A, Morgan EH (1992) Iron and transferrin uptake by brain and cerebrospinal fluid in the rat. Brain Res 592(1-2):8-16
10. Dallman PR, Spirito RA (1977) Brain iron in the rat: extremely slow turnover in normal rats may explain long-lasting effects of early iron deficiency. J Nutr 107:1075-1081
11. Dickson PW, Aldred AR, Marley PD, Tu GF, Howlett GJ, Schreiber G (1985) High prealbumin and transferrin mRNA levels in the choroid plexus of rat brain. Biochem Biophys Res Commun 127:890-895
12. Drayer B, Burger P, Darwin R, Riederer S, Hertkens R, Johnson GA (1986) MRI of brain iron. AJR Am J Roentgenol 147:103-110
13. Earley CJ, Connor JR, Beard JL, Malecki EA, Epstein DK, Allen RP (2000) Abnormalities in CSF concentrations of ferritin and transferrin in restless legs syndrome. Neurology 54:1698-1700
14. Erikson KM, Pinero DJ, Connor JR, Beard JL (1997) Regional brain iron, ferritin and transferrin concentrations during iron deficiency and iron repletion in developing rats. J Nutr 127:2030-2038
15. Fleming MD, Romano MA, Su MA, Garrick LM, Garrick MD, Andrews NC (1998) Nramp2 is mutated in the anemic Belgrade (b) rat: evidence of a role for Nramp2 in endosomal iron transport. Proc Natl Acad Sci U S A 95:1148-1153
16. Garrick M, Gniecko K, Liu Y, Cohan D, Garrick L (1993) Transferrin and the transferrin cycle in Belgrade rat reticulocytes. J Biol Chem 268:14867-14874
17. Hening W, Allen R, Earley C, Kushida C, Picchietti D, Silber M (1999) The treatment of restless legs syndrome and periodic limb movement disorder. An American Academy of Sleep Medicine Review. Sleep 22:970-999
18. Kalaria R, Sromek S, Grahovac I, Harik S (1992) Transferrin receptors of rat and human brain and cerebral microvessels and their status in Alzheimer's disease. Brain Res 585:87-93
19. Koeppen AH (1995) The history of iron in the brain. J Neurol Sci 134(suppl): 1-9
20. McKie AT, Marciani P, Rolfs A, Brennan K, Wehr K, Barrow D, Miret S, Bomford A, Peters TJ, Farzaneh F, Hediger MA, Hentze MW, Simpson RJ (2000) A novel duodenal iron-regulated transporter, IREGI, implicated in the basolateral transfer of iron to the circulation. Mol Cell 5:299-309
21. Moos T (1995) Developmental profile of non-heme iron distribution in the rat brain during ontogenesis. Brain Res Dev Brain Res 87:203-213
22. Moos T, Morgan EH (1998) Kinetics and distribution of [59Fe-125I] transferrin injected into the ventricular system of the rat. Brain Res 790:115-128
23. Morris CM, Keith AB, Edwardson JA, Pullen RG (1992) Uptake and distribution of iron and transferrin in the adult rat brain. J Neurochem 59:300-306
24. Pinero DJ, Li NQ, Connor JR, Beard JL (2000) Variations in dietary iron alter brain iron metabolism in developing rats. J Nutr 130:254-263
25. Siddappa AJ, Rao RB, Wobken D, Leibold EA, Connor JR, Georgieff MK (2002) Developmental changes in the expression of iron regulatory protein and iron transport proteins in the perinatal rat brain. J Neurosci Res 68:761-775
26. Sourander P, Hallgren B (1958) The effect of age on the non-haemin iron in the human brain. J Neurochem 3:41-51
27. Spatz H (1922) Uber den Eisennachweis im Gehim, besonders in Zentren des extrapyramidal-motorischen Systems [On the visualization of iron in the brain, especially centers of the extrapyramidal motor system]. Z Ges Neurol Psychiatr 77:261-390
28. Tsutsumi M, Skinner MK, Sanders-Bush E (1989) Transferrin gene expression and synthesis by cultured choroids plexus epithelial cells. Regulation by serotonin and cyclic adenosine 3′,5′-monophosphate. J Biol Chem 264:9626-9631
29. van Gelder W, Huijskes-Heins MI, van Dijk JP, Cleton-Soeteman MI, van Eijk HG (1995) Quantification of different transferrin receptor pools in primary cultures of porcine blood-brain barrier endothelial cells. J Neurochem 64:2708-2715
30. Zywicke HA, van Gelderen P, Connor JR, Burdo JR, Garrick MD, Dolan KG, Frank JA, Bulte JW (2002) Microscopic R2* mapping of reduced brain iron in the Belgrade rat. Ann Neurol 52:102-105