Interferon-γ and lipopolysaccharide regulate the expression of Nramp2 and increase the uptake of iron from low relative molecular mass complexes by macrophages

European Journal of Biochemistry

Volumn 267, Issue 22, 2000, Pages 6586-6593

  Wardrop, S L ^a   Richardson, D R ^a,b  

^a ROYAL BRISBANE AND WOMEN'S HOSPITAL   (Australia)

^b HEART RESEARCH INSTITUTE   (Australia)

Author keywords

Iron; Iron metabolism; Iron transport; Nramp2; Transferrin

Indexed keywords

GAMMA INTERFERON; GENE PRODUCT; IRON 59; IRON COMPLEX; LIPOPOLYSACCHARIDE; MESSENGER RNA; NATURAL RESISTANCE ASSOCIATED MACROPHAGE PROTEIN 2; NITRIC OXIDE SYNTHASE; NITRILOTRIACETIC ACID; REGULATOR PROTEIN; TRANSFERRIN; TRANSFERRIN RECEPTOR; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; CELL LINEAGE; CONTROLLED STUDY; GENE EXPRESSION REGULATION; IRON TRANSPORT; MACROPHAGE; MOLECULAR WEIGHT; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN RNA BINDING; REGULATORY MECHANISM; RNA TRANSCRIPTION;

ANIMALS; BIOLOGICAL TRANSPORT; CARRIER PROTEINS; CATION TRANSPORT PROTEINS; CELL LINE; FERRIC COMPOUNDS; GENE EXPRESSION REGULATION; INTERFERON TYPE II; IRON; IRON-BINDING PROTEINS; LIPOPOLYSACCHARIDES; MACROPHAGES; MEMBRANE PROTEINS; MICE; NITRIC OXIDE SYNTHASE; NITRIC OXIDE SYNTHASE TYPE II; QUATERNARY AMMONIUM COMPOUNDS; RECEPTORS, TRANSFERRIN; RNA, MESSENGER; TRANSCRIPTION, GENETIC; TRANSFERRIN;

ANIMALIA;

EID: 0033769626     PISSN: 00142956     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1432-1327.2000.01752.x     Document Type: Article

References (44)

1. Molecular control of vertebrate iron metabolism: mRNA-based regulatory circuits operated by iron, nitric oxide, and oxidative stress
2. The molecular mechanisms of the metabolism and transport of iron in normal and neoplastic cells
3. Regulating the fate of mRNA: The control of cellular iron metabolism
4. The effect of intracellular iron concentration and nitrogen monoxide on Nramp2 expression and non-transferrin-bound iron uptake
5. Cloning and characterization of a mammalian proton-coupled metal ion transporter
6. Microcytic anaemia mice have a mutation in Nramp2, a candidate iron transporter gene
7. Nramp2 is mutated in the anemic Belgrade (b) rat: Evidence of a role for Nramp2 in endosomal iron transport
8. The human Nramp2 gene: Characterization of the gene structure, alternative splicing, promoter region and polymorphisms
9. Natural resistance to infection with intracellular parasites: Isolation of a candidate for Bcg
10. Genomic expression, promoter sequence, and induction of expression of the mouse Nramp1 gene in macrophages
11. Identification and characterization of a second mouse Nramp gene
12. Ectopic expression of Nramp1 in COS-1 cells modulates iron accumulation
13. High level expression of Nramp1G169 in RAW264.7 cell transfectants: Analysis of intracellular iron transport
14. Functional expression of Nramp1 in vitro in the murine macrophage cell line RAW264.7
15. Ferrokinetics in man
16. Secretory products of macrophages
17. Interleukin 1 and interferon-gamma: Cytokines that provide reciprocal regulation of macrophage and T cell function
18. Release of iron by resident and stimulated mouse peritoneal macrophages following ingestion and degradation of transferrin-anti-transferrin immune complexes
19. The relationship between iron release, ferritin synthesis and intracellular iron distribution in mouse peritoneal macrophages. Evidence for a reduced level of metabolically available iron in elicited macrophages
20. Modulation of iron metabolism in monocyte cell line U937 by inflammatory cytokines: Changes in transferrin uptake, iron handling and ferritin mRNA
21. Converse modulation of IRP1 and IRP2 by immunological stimuli in murine RAW264.7 macrophages
22. Nitric oxide-mediated induction of ferritin synthesis in J774 macrophages by inflammatory cytokines: Role of selective iron regulatory protein-2 downregulation
23. Nitrogen monoxide (NO) activates IRP-RNA binding by two possible mechanisms - An effect on the Fe-S cluster and iron release from cells
24. The uptake of iron and transferrin by the human melanoma cell
25. Biosynthesis of nitric oxide activates iron regulatory factor in macrophages
26. 15N]nitrate in biological fluids
27. Uptake of non-transferrin-bound iron by both reductive and non-reductive processes is modulated by intracellular iron
28. Iron metabolism in K562 erythroleukemia cells
29. Ferritin iron kinetics and protein turnover in K562 cells
30. Effect of cellular iron concentration on iron uptake by hepatocytes
31. Two mechanisms of iron uptake from transferrin by melanoma cells. The effect of desferrioxamine and ferric ammonium citrate
32. A specific mRNA binding factor regulates the iron-dependent stability of the cytoplasmic transferrin receptor mRNA
33. Iron regulates nitric oxide synthase activity by controlling nuclear transcription
34. The effect of redox-related species of nitrogen monoxide on transferrin and iron uptake and cellular proliferation of erythroleukemia (K562) cells
35. The potential of analogues of the pyridoxal isonicotinoyl hydrazone class as effective antiproliferative agents III: The effect of the ligands on molecular targets involved in proliferation
36. Translational regulation via iron-responsive elements by nitric oxide/NO-synthase pathway
37. Effect of nitric oxide on expression of transferrin receptor and ferritin and on cellular iron metabolism in K562 human erythroleukemia cells
38. Reticulum cell sarcoma: An effector cell in antibody-dependent cell-mediated immunity
39. Regulation of iron metabolism in murine J774 macrophages: Role of nitric oxide-dependent and -independent pathways following activation with gamma interferon and lipopolysaccharide
40. Nitrogen monoxide decreases iron uptake from transferrin but does not mobilize iron from prelabelled neoplastic cells
41. Nitric oxide reduces nontransferrin-bound iron transport in HepG2 cells
42. Pathways for the regulation of macrophage iron metabolism by the anti-inflammatory cytokines IL-4 and IL-13
43. The Mycobacterium tuberculosis phagosome interacts with early endosomes and is accessible to exogenously administered transferrin
44. Constitutive and interleukin-1 (IL-1)-inducible factors interact with IL-1-responsive element in the IL-6 gene