Regional distribution of iron, transferrin, ferritin, and oxidatively- modified proteins in young and aged Fischer 344 rat brains

Neuroscience

Volumn 79, Issue 1, 1997, Pages 255-261

  Focht, S J ^a   Snyder, B S ^a   Beard, J L ^b   Van Gelder, W ^c   Williams, L R ^d   Connor, J R ^a  

^a PENN STATE MILTON S HERSHEY MEDICAL CENTER   (United States)

^b PENNSYLVANIA STATE UNIVERSITY   (United States)

^c ERASMUS UNIVERSITY ROTTERDAM   (Netherlands)

^d PFIZER INC   (United States)

Author keywords

Ageing; Alzheimer's disease; Metal neurotoxicity; Neurodegeneration; Oxidative damage

Indexed keywords

FERRITIN; IRON; TRANSFERRIN;

AGING; ALZHEIMER DISEASE; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DEGENERATIVE DISEASE; MALE; NERVE DEGENERATION; NONHUMAN; OXIDATIVE STRESS; PRIORITY JOURNAL; RAT;

AGING; ANIMALS; BRAIN; BRAIN CHEMISTRY; CEREBELLUM; FERRITINS; IRON; MALE; NERVE TISSUE PROTEINS; ORGAN SPECIFICITY; OXIDATION-REDUCTION; OXIDATIVE STRESS; RATS; RATS, INBRED F344; TEMPORAL LOBE; TRANSFERRIN;

EID: 0030957951     PISSN: 03064522     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0306-4522(96)00607-0     Document Type: Article

References (26)

1. Beard J. L., Connor J. R. and Jones B. C. (1993) Iron in the brain. Nutrit. Rev. 51, 157-170.
2. Benkovic S. A. and Connor J. R. (1993) Ferritin, transferrin and iron in selected regions of adult and aged rat brain. J. comp. Neurol. 338, 97-113.
3. Carney J. M., Starke-Reed P. E., Oliver C. N., Landrum R. W., Cheng M. S. and Wu J. F. (1991) Reversal of age-related increase in brain protein oxidation, decrease in enzyme activity, and loss in temporal and spatial memory by chronic administration of spin-trapping compound N-tert-butyl-alpha-phenylnitrone. Proc. natn. Acad. Sci. U.S.A. 88, 3633-3636.
4. Connor J. R. (1992) Proteins of iron regulation in the brain in Alzheimer's disease. In Iron and Human Disease (ed. Lauffer R. B.), pp. 365-393. CRC Press, Inc. Boca Raton, Florida.
5. Connor J. R. (1993) Cellular and regional maintenance of iron homeostasis in the brain: normal and disease states. In Iron in Central Nervous System Disorders (eds Riederer P. and Youdim M. B. H.), pp. 1-18. Springer-Verlag/Wien, Austria.
6. Connor J. R. and Benkovic S. A. (1992) Iron regulation in the brain: histochemical, biochemical, and molecular considerations. Ann. Neurol. 32 suppl., S51-S61.
7. Connor J. R., Snyder B. S., Arosio P., Loeffler D. A. and LeWitt P. (1995) A quantitative analysis of isoferritins in select regions of aged, parkinsonian, and Alzheimer's diseased brains. J. Neurochem. 65, 717-724.
8. Cuello A. C. and Carson S. (1983) Microdissection of fresh rat brain tissue slices. In Methods of Neurosciences (ed. Cuello A. C.), Vol. 2, pp. 37-125. John Wiley and Sons, New York.
9. Dexter D. T., Carter C., Wells F. R., Javoy-Agid F., Agid Y., Lees A., Jenner P. and Marsden C. D. (1989) Basal lipid peroxidation in substantia nigra is increased in Parkinson's disease. J. Neurochem. 52, 881-889.
10. Hallgren B. and Sourander P. (1958) The effect of age on non-haem iron in the human brain. J. Neurochem. 3, 41-51.
11. Hill J. M. and Switzer R. C. (1984) The regional distribution and cellular localization of iron in the rat brain. Neuroscience 11, 595-603.
12. LeBel C. P. and Bondy S. C. (1992) Oxidative damage and cerebral aging. Prog. Neurobiol. 38, 601-609.
13. Loeffler D. A., Connor J. R., Juneau P. A., Snyder B. S., Kanaley L., DeMaggio A. J., Nguyen H., Brickman C. M. and LeWitt P. A. (1995) Transferrin and iron in normal, Alzheimer's disease and Parkinson's disease brain regions. J. Neurochem. 65, 710-716.
14. Olanow C. W. (1990) Oxidation reactions in Parkinson's disease. Neurology 40, 32-37.
15. Oliver C. N., Starke-Reed P. E., Stadtman E. R., Liu G. J., Carney J. M. and Floyd R. A. (1990) Oxidative damage to brain proteins, loss of glutamine synthetase activity, and production of free radicals during ischemia/reperfusion-induced injury to gerbil brain. Proc. natn. Acad. Sci. U.S.A. 87, 5144-5147.
16. Roskams A. J. I. and Connor J. R. (1994) Iron, transferrin, and ferritin in the rat brain during development and aging. J. Neurochem. 63, 709-716.
17. Saguaro N., Ikeda T., Saguaro C., Kohgo Y., Kato J. and Takeichi N. (1992) Regional distribution of copper, zinc and iron in the brain in Long-Evans Cinnamon rats with a new mutation causing hereditary hepatitis. Brain Res. 588, 278-290.
18. Slavin W. (1988) Atomic absorption spectrometry. In Methods of Enzymology (eds Riordan J. F. and Vallee B. L.), Vol. 158, pp. 117-145. Academic Press, Inc. New York.
19. Smith C. D., Carney J. M., Starke-Reed P. E., Oliver C. N., Stadtman E. R., Floyd R. A. and Markesbery W. R. (1991) Excess brain protein oxidation and enzyme dysfunction in normal and Alzheimer disease. Proc. natn. Acad. Sci. U.S.A. 88, 10,540-10,543.
20. Subbarao K. V. and Richardson J. S. (1990) Iron-dependent peroxidation of rat brain: a regional study. J. Neurosci. Res. 26, 224-232.
21. Wallwork J. C., Milne D. B., Sims R. L. and Sandstead H. (1983) Severe zinc deficiency: effects on the distribution of nine elements (potassium, phosphorus, sodium, magnesium, calcium, iron, zinc, copper and manganese) in regions of the rat brain. J. Nutr. 113, 1895-1905.
22. Williams L. R., Jodelis K. S. and Donald M. R. (1989) Axotomy-dependent stimulation of choline acetyltransferase by exogenous mouse nerve growth factor in the rat basal forebrain. Brain Res. 498, 243-256.
23. Zaleska M. M. and Floyd R. A. (1985) Regional lipid peroxidation in rat brain in vitro: possible role of endogenous iron. Neurochem. Res. 10, 397-410.
24. Zellis K. and Wree A. (1985) Cortex: Areal and laminar structure. In The Rat Nervous System (ed. Paxinos G.), Vol. 1, pp. 375-415. Academic Press, Inc., New York.
25. Zhang J. -R., Andrus P. K. and Hall E. D. (1994) Age-related phospholipid hydroperoxide levels in gerbil brain measured by HPLC-chemiluminescence and their relation to hydroxyl radical stress. Brain Res. 639, 275-282.
26. Zhang J. -R., Andrus P. K. and Hall E. D. (1993) Age-related regional changes in hydroxyl radical stress and antioxidants in gerbil brain. J. Neurochem. 61, 1640-1647.