Gene expression of divalent metal transporter 1 and transferrin receptor in duodenum of Belgrade rats

American Journal of Physiology - Gastrointestinal and Liver Physiology

Volumn 278, Issue 6 41-6, 2000, Pages

  Oates, Phillip S ^a   Thomas, Carla ^a   Freitas, Elizabeth ^a   Callow, Matthew J ^a   Morgan, Evan H ^a  

^a UNIVERSITY OF WESTERN AUSTRALIA   (Australia)

Author keywords

Absorption; HFE; Iron; Nramp2; Regulation; Transferrin

Indexed keywords

IRON; PROTEIN DERIVATIVE; TRANSFERRIN RECEPTOR;

ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; CONTROLLED STUDY; CRYPT CELL; DUODENUM; GENE EXPRESSION; GENE MUTATION; INTESTINE CELL; IRON ABSORPTION; IRON BLOOD LEVEL; IRON TRANSPORT; MALE; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; RAT; REGULATORY MECHANISM;

EID: 0033935567     PISSN: 01931857     EISSN: None     Source Type: Journal    
DOI: 10.1152/ajpgi.2000.278.6.g930     Document Type: Article

References (38)

1. Anderson GJ, Powell LW, and Halliday JW The endocytosis of transferrin by rat intestinal epithelial cells. Gastroenterology 106: 414-422, 1994.
2. Bastin JM, Jones M, O'Callaghan CA, Schimanshi L, and Mason DY. Kupffer cell staining by a HFE-specific monoclonal antibody: implications for hereditary haemochromatosis. Br J Haematol 103: 931-941, 1998.
3. Bieri JG, Stoewsand GS, Briggs GM, Phillips RW, Woodard JC, and Knapka JJ. Report of the American Institute of Nutrition Ad Hoc committee on standards for nutritional studies. J Nutr 107: 1340-1348, 1977.
4. Bowen BJ and Morgan EH. Anemia of the Belgrade rat: evidence for defective membrane transport. Blood 70: 38-44, 1987.
5. Canonne-Hergaux F, Gruenheid S, Ponka P, and Gros P. Cellular and subcellular localisation of the Nramp2 iron transporter in the intestinal brush border and regulation by dietary iron. Blood 93: 4406-4417, 1999.
6. Conrad ME, Weintraub LR, and Crosby WH. The role of the intestine in iron kinetics. J Clin Invest 43: 963-974, 1964.
7. Crosby WH. The control of iron balance by the intestinal mucosa. Blood 22: 441-449, 1963.
8. Edwards JA and Hoke JE. Defect of intestinal mucosal iron uptake in mice with hereditary microcytic anaemia. Proc Soc Exp Biol Med 141: 81-84, 1972.
9. Edwards JA, Sullivan AL, and Hoke JE. Defective delivery of iron to the developing red cell of the Belgrade laboratory rat. Blood 55: 645-648, 1980.
10. Farcich EA and Morgan EH. Uptake of transferrin-bound and nontransferrin-bound iron by reticulocytes from the Belgrade rat. Am J Hematol 39: 9-14, 1992.
11. Feder JN, Gnirke A, Thomas W, Tsuchihashi Z, Ruddy DA, Basava A, Dormishian F, Domingo R, Ellis MC, Fullan A, Hinton LM, Jones NL, Kimmel BE, Kronmal GS, Lauer P, Lee VK, Loeb DB, Mapa FA, McClelland E, Meyer NC, Mintier GA, Moeller N, Moore T, Morikang E, Prass CE, Quintana L, Starnes SM, Schatzman RC, Brunke KJ, Drayna DT, Risch NJ, Bacon BR, and Wolf RK. A novel MHC class I-like gene is mutated in patients with hereditary haematochromatosis. Nat Genet 13: 399-408, 1996.
12. Feder JN, Tsuchihashi Z, Irrinki A, Lee VK, Mapa FA, Morikang E, Prass CE, Starnes SM, Wolff RK, Parkkila S, Sly WS, and Schatzman RC. The hemochromatosis founder mutation in HLA-H disrupts β2-microglobulin interaction and cell surface expression. J Biol Chem 272: 14025-14028, 1997.
13. Feder JN, Penny DM, Irrinke A, Lee A, Lebron JA, Watson N, Tsuchihashi Z, Sigal E, Bjorkman PJ, and Schatzman RC. The hemochromatosis gene product complexes with the transferrin receptor and lowers its affinity for ligand binding. Proc Natl Acad Sci USA 95: 1472-1477, 1998.
14. Fleming MD, Trenor CC, Su MA, Foernzler D, Beier DR, Dietrich WF, and Andrews NC. Microcytic anaemia mice have a mutation in Nramp2, a candidate iron transporter gene. Nat Genet 16: 383-386, 1997.
15. Fleming MD, Romano MA, Su MA, Garrick LM, Garrick MD, and Andrews NC. Nramp2 is mutated in the anemic Belgrade (b) rat: evidence of a role for Nramp2 in endosomal iron transport. Proc Natl Acad Sci USA 95: 1148-1153, 1998.
16. Fleming RE, Migas MC, Zhou XY, Jiang J, Britton RS, Brunt EM, Tomatsu S, Waheed A, Bacon BR, and Sly WS. Mechanism of increased iron absorption in murine model of hereditary hemochromatosis: increased duodenal expression of the transporter DMT1. Proc Natl Acad Sci USA 96: 3143-3148, 1999.
17. Gardiner E and Morgan EH. Transferrin and iron uptake by the liver in the rat. Aust J Exp Biol Med Sci 52: 723-736, 1974.
18. Garrick MD, Gniecko K, Liu Y, Cohen DS, and Garrick LM. Transferrin and the transferrin cycle in Belgrade rat reticulocytes. J Biol Chem 268: 14867-14874, 1993.
19. Gross CN, Irrinki A, Feder JN, and Enns CA. Co-trafficking of HFE, a nonclassical major histocompatibility complex class I protein, with the transferrin receptor implies a role in intracellular iron regulation. J Biol Chem 273: 22068-22074, 1998.
20. Gruenheid S, Canonne-Hergaux F, Gauthier S, Hackam DJ, Grinstein S, and Gros P. The iron transport protein NRAMP2 is an integral membrane glycoprotein that colocalises with transferrin in recycling endosomes. J Exp Med 189: 831-841, 1999.
21. Gunshin H, MacKenzie B, Berger UV, Gunshin Y, Romero MF, Boron WF, Nussberger S, Golan JL, and Hediger MA. Cloning and characterisation of a mammalian proton-coupled metal-ion transporter. Nature 388: 482-488, 1997.
22. Jeffrey GP, Basclain KA, and Allen TL. Molecular regulation of transferrin receptor and ferritin expression in the rat gastrointestinal tract. Gastroenterology 110: 790-800, 1996.
23. Labarca C and Paigen K. A simple, rapid, and sensitive DNA assay procedure. Anal Biochem 102: 344-352, 1980.
24. Lebron JA, Bennett MJ, Vaughn DE, Chirino AC, Snow PM, Mintier GA, Feder JN, and Bjorkman PJ. Crystal structure of the hemochromatosis protein HFE and characterisation of its interaction with transferrin receptor. Cell 93: 111-123, 1998.
25. Oates PS and Morgan EH. Effects of dietary iron loading with carbonyl iron and of iron depletion on intestinal growth, morphology, and expression of transferrin receptor in rats. Anat Rec 246: 364-371, 1996.
26. Oates PS and Morgan EH. Defective iron uptake by the duodenum of Belgrade rats fed diets of different iron contents. Am J Physiol Gastrointest Liver Physiol 270: G826-G832, 1996.
27. Oates PS and Morgan EH. Ferritin gene expression and transferrin receptor activity in intestine of rats with varying iron stores. Am J Physiol Gastrointest Liver Physiol 273: G636-G646, 1997.
28. Oates PS, Thomas C, and Morgan EH. Characterization of isolated duodenal epithelial cells along a crypt-villus axis in rats fed diets with different iron contents. J Gastroenterol Hepatol 12: 829-838, 1997.
29. Pakkila S, Waheed A, Britton RS, Feder JN, Tsuchihashi Z, Schatzman RC, Bacon BR, and Sly WS. Immunohistochemistry of HLA-H, the protein defective in patients with hereditary hemochromatosis, reveals unique pattern of expression in the gastrointestinal tract. Proc Natl Acad Sci USA 94: 2534-2539, 1997.
30. Pietrangelo A, Casalgrandi G, Quaglino D, Gualdi R, Conte D, Milani S, Montosi G, Cesarini L, Ventura E, and Cairo G. Duodenal ferritin synthesis in genetic hemochromatosis. Gastroenterology 108: 208-217, 1995.
31. Riedel HD, Muckenthaler MU, Gehrke SG, Mohr I, Brennan K, Herrmann T, Fitscher BA, Hentze MW, and Stremmel W. HFE downregulates iron uptake from transferrin and induces iron-regulatory protein activity in stably transfected cells. Blood 94: 3915-3921, 1999.
32. Rolfs A and Hediger MA. Metal ion transporters in mammals: structure, function and pathological implications. J Physiol (Lond) 518: 1-12, 1999.
33. Roy CN, Penny DM, Feder JN, and Enns CA. The hereditary hemochromatosis protein, HFE, specifically regulates transferrin-mediated iron uptake in HeLa cells. J Biol Chem 26: 9022-9028, 1999.
34. Schümann K, Moret R, Kunzle H, and Kühn LC. Iron regulatory protein as an endogenous sensor of iron in rat intestinal mucosa. Eur J Biochem 260: 362-372, 1999.
35. Su MA, Trenor CC, Fleming JC, Fleming MD, and Andrews NC. The G185R mutation disrupts function of the iron transporter Nramp2. Blood 92: 2157-2163, 1998.
36. Trinder D, Oates PS, Thomas C, Sadleir J, and Morgan EH Localisation of DMT1 to the microvillus membrane of rat duodenal enterocytes in iron deficiency but to hepatocytes in iron overload. Gut 46: 270-276, 2000.
37. Waheed A, Parkkila S, Saarnio J, Fleming RE, Zhou XY, Tomatsu S, Britton RS, Bacon BR, and Sly WS. Association of HFE protein with transferrin receptor in crypt enterocytes of human duodenum. Proc Natl Acad Sci USA 96: 1579-1584, 1999.
38. Zhou XY, Tomatsu S, Fleming RE, Parkkila S, Waheed S, Jiang J, Fei Y, Brunt EM, Ruddy DA, Prass CE, Schatzman RC, O'Neill RO, Britton RS, Bacon BR, and Sly WS. HFE gene knockout produces mouse model of hereditary hemochromatosis. Proc Natl Acad Sci USA 95: 2492-2497, 1998.