Novel transient receptor potential vanilloid 1 receptor antagonists for the treatment of pain; Structure-activity relationships for ureas with quinoline, isoquinoline, quinazoline, phthalazine, quinoxaliue, and cinnoline moieties

Journal of Medicinal Chemistry

Volumn 48, Issue 3, 2005, Pages 744-752

  Gomtsyan, Arthur ^a   Bayburt, Erol K ^a   Schmidt, Robert G ^a   Guo, Zhu Zheng ^a   Perner, Richard J ^a   Didomenico, Stanley ^a   Koenig, John R ^a   Turner, Sean ^a   Jinkerson, Tammie ^a   Drizin, Irene ^a   Hannick, Steven M ^a   Macri, Bryan S ^a   McDonald, Heath A ^a   Honore, Prisca ^a   Wismer, Carol T ^a   Marsh, Kennan C ^a   Wetter, Jill ^a   Stewart, Kent D ^a   Oie, Tetsuro ^a   Jarvis, Michael F ^a   Surowy, Carol S ^a   Faltynek, Connie R ^a   Lee, Chih Hung ^a   more..

^a ABBOTT LABORATORIES   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CINNOLINE; ISOQUINOLINE DERIVATIVE; N ISOQUINOLIN 5 YL N' (4 TRIFLUOROMETHYLBENZYL)UREA; PHTHALAZINE DERIVATIVE; QUINAZOLINE DERIVATIVE; QUINOLINE DERIVATIVE; QUINOXALINE DERIVATIVE; RECEPTOR BLOCKING AGENT; UNCLASSIFIED DRUG; UREA DERIVATIVE; VANILLOID RECEPTOR 1 ANTAGONIST;

ANIMAL EXPERIMENT; ANTIINFLAMMATORY ACTIVITY; ARTICLE; CONTROLLED STUDY; DRUG BIOAVAILABILITY; DRUG CLEARANCE; DRUG DISTRIBUTION; DRUG ELIMINATION; DRUG HALF LIFE; DRUG POTENCY; DRUG SYNTHESIS; HIGH THROUGHPUT SCREENING; HYPERALGESIA; IC 50; IN VITRO STUDY; IN VIVO STUDY; NONHUMAN; PHARMACOPHORE; RAT; STRUCTURE ACTIVITY RELATION;

ABDOMINAL PAIN; ADMINISTRATION, ORAL; ANALGESICS; ANIMALS; BIOLOGICAL AVAILABILITY; CALCIUM; CELLS, CULTURED; DISEASE MODELS, ANIMAL; ELECTROSTATICS; HETEROCYCLIC COMPOUNDS, 2-RING; HUMANS; HYPERALGESIA; ISOQUINOLINES; MODELS, MOLECULAR; PAIN; QUINAZOLINES; QUINOLINES; RATS; RECEPTORS, DRUG; STRUCTURE-ACTIVITY RELATIONSHIP; UREA;

EID: 13444274350     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm0492958     Document Type: Article

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