7-Hydroxynaphthalen-1-yl-urea and -amide antagonists of human vanilloid receptor 1

Bioorganic and Medicinal Chemistry Letters

Volumn 14, Issue 2, 2004, Pages 531-534

  McDonnell, Mark E ^a   Zhang, Sui Po ^a   Nasser, Nadia ^b   Dubin, Adrienne E ^b   Dax, Scott L ^a  

^a Johnson Johnson P   (United States)

^b JOHNSON AND JOHNSON PHARMACEUTICAL RESEARCH AND DEVELOPMENT   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

1 (3,4 DICHLOROBENZYL) 3 (7 HYDROXYNAPHTHALEN 1 YL)UREA; 1 (7 HYDROXYNAPHTHALEN 1 YL) 3 (4 TRIFLUOROMETHYLBENZYL)UREA; 1 BENZYL 3 (7 HYDROXYNAPHTHALEN 1 YL)UREA; 2 (3,4 DICHLOROPHENYL) N (7 HYDROXYNAPHTHALEN 1 YL)ACETAMIDE; 3 (3,4 DICHLOROPHENYL) N (7 HYDROXYNAPHTHALEN 1 YL)PROPIONAMIDE; 3 (4 CHLOROPHENYL) N (7 HYDROXYNAPHTHALEN 1 YL)PROPIONAMIDE; 3,4 DICHLORO N (7 HYDROXYNAPHTHALEN 1 YL)BENZAMIDE; AMIDE; ANTINOCICEPTIVE AGENT; CAPSAICIN; UNCLASSIFIED DRUG; UREA DERIVATIVE; VANILLOID RECEPTOR 1;

ARTICLE; CONTROLLED STUDY; DRUG ACTIVITY; DRUG BINDING; DRUG RECEPTOR BINDING; EMBRYO; FIBROBLAST; HUMAN; HUMAN CELL; IC 50; KIDNEY CELL; RECEPTOR AFFINITY; STRUCTURE ACTIVITY RELATION;

EID: 0347990498     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2003.09.090     Document Type: Article

References (15)

1. Jancso J. Bull. Millard Fillmore Hosp. (Buffalo). 7:1960;53.
2. Caterina M.J., Schumacher M.A., Tominaga M., Rosen T.A., Levine J.D., Julius D. Nature (London). 389:1997;816.
3. Julius, D. J.; Caterina, M.; Brake, A. US Patent 6,335,180, Jan 1, 2002.
4. McIntyre, P.; James, I. F. US Patent 6,406,908, June 18, 2002.
5. Lee J., Lee J., Kim J., Kim S.Y., Chun M.W., Cho H., Hwang S.W., Oh U., Park Y.H., Marquez V.E., Beheshti M., Szabo T., Blumberg P.M. Bioorg. Med. Chem. 9:2001;19.
6. Dax, S.; Dubin, A.; Jetter, M.; Nasser, N.; Shah, C.; Swanson, D.; Carruthers, N. I. Vanilloid Receptor Antagonists: Structure Activity Relationships via Parallel and Targeted Synthesis. In 17th International Symposium on Medicinal Chemistry, Barcelona, Spain, Sept 1-5, 2002.
7. Thavonekham B. Synthesis. 1997;1189.
8. Szallasi A., Blumberg P.M. Naunyn-Schmiedeberg's Arch. Pharmacol. 347:1993;84.
9. d .
10. 50 values.
11. 2: 360.0433; found 360.0432.
12. 2: 325.0864; found 325.0869.
13. 2: 345.0318; found 345.0323.
14. 2: 331.0170; found 331.01668.
15. Lee J., Lee J., Kang M., Shin M., Kim J.-M., Kang S.-U., Lim J.-O., Choi H.-K., Suh Y.-G., Park H.-G., Oh U., Kim H.-D., Park Y.-H., Ha H.-J., Kim Y.-H., Toth A., Wang Y., Tran R., Pearce L.V., Lundberg D.J., Blumberg P.M. J. Med. Chem. 46:2003;3116.