메뉴 건너뛰기




Volumn 5, Issue 1, 2005, Pages 31-39

Therapeutic potential of Rho-kinase inhibitors in cardiovascular diseases

Author keywords

[No Author keywords available]

Indexed keywords

4 (1 AMINOETHYL) N (4 PYRIDYL)CYCLOHEXANECARBOXAMIDE; ACETYLSALICYLIC ACID; ANGIOTENSIN RECEPTOR ANTAGONIST; BETA ADRENERGIC RECEPTOR BLOCKING AGENT; CALCIUM CHANNEL BLOCKING AGENT; DIPEPTIDYL CARBOXYPEPTIDASE INHIBITOR; DRUG METABOLITE; FASUDIL; GLYCERYL TRINITRATE; HYDROXYFASUDIL; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE INHIBITOR; NITRIC ACID DERIVATIVE; RHO GUANINE NUCLEOTIDE BINDING PROTEIN; RHO KINASE; RHO KINASE INHIBITOR; UNCLASSIFIED DRUG;

EID: 12744255285     PISSN: 11753277     EISSN: None     Source Type: Journal    
DOI: 10.2165/00129784-200505010-00005     Document Type: Review
Times cited : (76)

References (76)
  • 1
    • 0037069690 scopus 로고    scopus 로고
    • Rho GTPases in cell biology
    • Etienne-Manneville S, Hall A. Rho GTPases in cell biology. Nature 2002; 420: 629-35
    • (2002) Nature , vol.420 , pp. 629-635
    • Etienne-Manneville, S.1    Hall, A.2
  • 2
    • 0037292463 scopus 로고    scopus 로고
    • Small G proteins as novel therapeutic targets in cardiovascular medicine
    • Brandier C, Ming X-F, Yang Z. Small G proteins as novel therapeutic targets in cardiovascular medicine. News Physiol Sci 2003; 18: 18-22
    • (2003) News Physiol. Sci. , vol.18 , pp. 18-22
    • Brandier, C.1    Ming, X.-F.2    Yang, Z.3
  • 4
    • 0036182417 scopus 로고    scopus 로고
    • Rho-kinase as a novel target in treatment of cardiovascular diseases
    • Shimokawa H. Rho-kinase as a novel target in treatment of cardiovascular diseases. J Cardiovasc Pharmacol 2002; 39: 319-27
    • (2002) J. Cardiovasc. Pharmacol. , vol.39 , pp. 319-327
    • Shimokawa, H.1
  • 5
    • 0036460051 scopus 로고    scopus 로고
    • Rho/Rho-kinase mediated signaling in physiology and pathophysiology
    • Wettschureck N, Offermanns S. Rho/Rho-kinase mediated signaling in physiology and pathophysiology. J Mol Med 2002; 80: 629-38
    • (2002) J. Mol. Med. , vol.80 , pp. 629-638
    • Wettschureck, N.1    Offermanns, S.2
  • 6
    • 0021830154 scopus 로고
    • A novel ras-related gene family
    • Madaule P, Axel R. A novel ras-related gene family. Cell 1985; 41: 31-40
    • (1985) Cell , vol.41 , pp. 31-40
    • Madaule, P.1    Axel, R.2
  • 7
    • 0030656619 scopus 로고    scopus 로고
    • Calcium sensitization of smooth muscle mediated by a Rho-associated protein kinase in hypertension
    • Uehata M, Ishizaki T, Satoh H, et al. Calcium sensitization of smooth muscle mediated by a Rho-associated protein kinase in hypertension. Nature 1997; 389: 990-4
    • (1997) Nature , vol.389 , pp. 990-994
    • Uehata, M.1    Ishizaki, T.2    Satoh, H.3
  • 8
    • 0034650714 scopus 로고    scopus 로고
    • Signal transduction by G-proteins, Rho-kinase and protein phosphatase to smooth muscle and non-muscle myosin II
    • Somlyo AP, Somlyo AV. Signal transduction by G-proteins, Rho-kinase and protein phosphatase to smooth muscle and non-muscle myosin II. J Physiol 2000; 522: 177-85
    • (2000) J. Physiol. , vol.522 , pp. 177-185
    • Somlyo, A.P.1    Somlyo, A.V.2
  • 9
    • 0141751697 scopus 로고    scopus 로고
    • 2+ sensitivity of smooth muscle and nonmuscle myosin II: Modulated by G proteins, kinases, and myosin phosphatase
    • 2+ sensitivity of smooth muscle and nonmuscle myosin II: modulated by G proteins, kinases, and myosin phosphatase. Physiol Rev 2003; 83: 1325-58
    • (2003) Physiol. Rev. , vol.83 , pp. 1325-1358
    • Somlyo, A.P.1    Somlyo, A.V.2
  • 10
    • 0034306450 scopus 로고    scopus 로고
    • Specificity and metabolism of action of some commonly used protein kinase inhibitors
    • Davies SP, Reddy H, Caivano M, et al. Specificity and metabolism of action of some commonly used protein kinase inhibitors. Biochem J 2000; 351: 95-105
    • (2000) Biochem. J. , vol.351 , pp. 95-105
    • Davies, S.P.1    Reddy, H.2    Caivano, M.3
  • 11
    • 0032877847 scopus 로고    scopus 로고
    • Rho-kinase pathway induces enhanced myosin light chain phosphorylations in a swine model of coronary artery spasm
    • Shimokawa H, Seto M, Katsumata N, et al. Rho-kinase pathway induces enhanced myosin light chain phosphorylations in a swine model of coronary artery spasm. Cardiovasc Res 1999; 43: 1029-39
    • (1999) Cardiovasc. Res. , vol.43 , pp. 1029-1039
    • Shimokawa, H.1    Seto, M.2    Katsumata, N.3
  • 12
    • 0032894607 scopus 로고    scopus 로고
    • Intra-arterial infusion of fasudil hydrochloride for treating vasospasm following subarachnoid haemorrhage
    • Tachibana E, Harada T, Shibuya M, et al. Intra-arterial infusion of fasudil hydrochloride for treating vasospasm following subarachnoid haemorrhage. Acta Neurochir 1999; 141: 13-9
    • (1999) Acta Neurochir. , vol.141 , pp. 13-19
    • Tachibana, E.1    Harada, T.2    Shibuya, M.3
  • 13
    • 0141794500 scopus 로고    scopus 로고
    • 2+-dependent activation of Rho and Rho kinase in membrane depolarization-induced and receptor stimulation-induced vascular smooth muscle contraction
    • 2+-dependent activation of Rho and Rho kinase in membrane depolarization-induced and receptor stimulation-induced vascular smooth muscle contraction. Circ Res 2003; 93: 548-56
    • (2003) Circ. Res. , vol.93 , pp. 548-556
    • Sakurada, S.1    Takuwa, N.2    Sugimoto, N.3
  • 15
    • 0037423816 scopus 로고    scopus 로고
    • Activation of RhoA and inhibition of myosin phosphatase as important components in hypertension in vascular smooth muscle
    • Seko T, Ito M, Kureishi Y, et al. Activation of RhoA and inhibition of myosin phosphatase as important components in hypertension in vascular smooth muscle. Circ Res 2003; 92: 411-8
    • (2003) Circ. Res. , vol.92 , pp. 411-418
    • Seko, T.1    Ito, M.2    Kureishi, Y.3
  • 16
    • 0035316139 scopus 로고    scopus 로고
    • Involvement of Rho-kinase in hypertensive vascular disease: A novel therapeutic target in hypertension
    • Mukai Y, Shimokawa H, Matoba T, et al. Involvement of Rho-kinase in hypertensive vascular disease: a novel therapeutic target in hypertension. FASEB J 2001; 15: 1062-4
    • (2001) FASEB J. , vol.15 , pp. 1062-1064
    • Mukai, Y.1    Shimokawa, H.2    Matoba, T.3
  • 17
    • 0035679020 scopus 로고    scopus 로고
    • Possible involvement of Rho-kinase in the pathogenesis of hypertension in humans
    • [published erratum appears in Hypertension 2002; 39: e19]
    • Masumoto A, Hirooka Y, Shimokawa H, et al. Possible involvement of Rho-kinase in the pathogenesis of hypertension in humans [published erratum appears in Hypertension 2002; 39: e19]. Hypertension 2001; 38: 1307-10
    • (2001) Hypertension , vol.38 , pp. 1307-1310
    • Masumoto, A.1    Hirooka, Y.2    Shimokawa, H.3
  • 18
    • 0034682993 scopus 로고    scopus 로고
    • Activation of RhoA by thrombin in endothelial hyperpermeability: Role of Rho-kinase and protein tyrosine kinases
    • van Nieuw Amerongen GP, van Delft S, Vermeer MA, et al. Activation of RhoA by thrombin in endothelial hyperpermeability: role of Rho-kinase and protein tyrosine kinases. Circ Res 2000; 87: 3365-40
    • (2000) Circ. Res. , vol.87 , pp. 3365-3440
    • van Nieuw Amerongen, G.P.1    van Delft, S.2    Vermeer, M.A.3
  • 20
    • 12944289797 scopus 로고    scopus 로고
    • Gene transfer of dominant negative Rho kinase suppresses neointimal formation after balloon injury in pigs
    • Eto Y, Shimokawa H, Hiroki J, et al. Gene transfer of dominant negative Rho kinase suppresses neointimal formation after balloon injury in pigs. Am J Physiol 2000; 278: H1744-50
    • (2000) Am. J. Physiol. , vol.278
    • Eto, Y.1    Shimokawa, H.2    Hiroki, J.3
  • 21
    • 0342314481 scopus 로고    scopus 로고
    • Inhibition of Rho-associated kinase results in suppression of neointimal formation of balloon-injured arteries
    • Sawada N, Itoh H, Ueyama K, et al. Inhibition of Rho-associated kinase results in suppression of neointimal formation of balloon-injured arteries. Circulation 2000; 101: 2030-3
    • (2000) Circulation , vol.101 , pp. 2030-2033
    • Sawada, N.1    Itoh, H.2    Ueyama, K.3
  • 22
    • 0035895335 scopus 로고    scopus 로고
    • Role of Rho-associated kinase neointima formation after vascular injury
    • Shibata R, Kai H, Seki Y, et al. Role of Rho-associated kinase neointima formation after vascular injury. Circulation 2001; 103: 284-9
    • (2001) Circulation , vol.103 , pp. 284-289
    • Shibata, R.1    Kai, H.2    Seki, Y.3
  • 23
    • 0033765588 scopus 로고    scopus 로고
    • Rho-kinase is involved in macrophage-mediated formation of coronary vascular lesions in pigs in vivo
    • Miyata K, Shimokawa H, Kandabashi T, et al. Rho-kinase is involved in macrophage-mediated formation of coronary vascular lesions in pigs in vivo. Arterioscl Thromb Vasc Biol 2000; 20: 2351-8
    • (2000) Arterioscl. Thromb. Vasc. Biol. , vol.20 , pp. 2351-2358
    • Miyata, K.1    Shimokawa, H.2    Kandabashi, T.3
  • 24
    • 0036873027 scopus 로고    scopus 로고
    • Anti-anginal effect of fasudil, a Rho-kinase inhibitor, in patients with stable effort angina: A multicenter study
    • Shimokawa H, Hiramori K, Iinuma H, et al. Anti-anginal effect of fasudil, a Rho-kinase inhibitor, in patients with stable effort angina: a multicenter study. J Cardiovasc Pharmacol 2002; 40: 751-61
    • (2002) J. Cardiovasc. Pharmacol. , vol.40 , pp. 751-761
    • Shimokawa, H.1    Hiramori, K.2    Iinuma, H.3
  • 25
    • 12744264383 scopus 로고    scopus 로고
    • A randomized, double-blind, placebo-controlled, phase 2 study: The efficacy of fasudil in patients with stable angina
    • [abstract no. 877]
    • Vicari RM, Smith W, Chairman BR, et al. A randomized, double-blind, placebo-controlled, phase 2 study: the efficacy of fasudil in patients with stable angina [abstract no. 877]. Eur Heart J 2004; 25: 138
    • (2004) Eur. Heart J. , vol.25 , pp. 138
    • Vicari, R.M.1    Smith, W.2    Chairman, B.R.3
  • 26
    • 0023234158 scopus 로고
    • Clinical characteristics associated with myocardial infarction, arrhythmias, and sudden death in patients with vasospastic angina
    • Nakamura M, Takeshita A, Nose Y. Clinical characteristics associated with myocardial infarction, arrhythmias, and sudden death in patients with vasospastic angina. Circulation 1987; 75: 1110-6
    • (1987) Circulation , vol.75 , pp. 1110-1116
    • Nakamura, M.1    Takeshita, A.2    Nose, Y.3
  • 27
    • 0031469111 scopus 로고    scopus 로고
    • Enhanced myosin light chain phosphorylations as a central mechanism for coronary artery spasm in a swine model with interleukin-1β
    • Katsumata N, Shimokawa H, Seto M, et al. Enhanced myosin light chain phosphorylations as a central mechanism for coronary artery spasm in a swine model with interleukin-1β. Circulation 1997; 96: 4357-67
    • (1997) Circulation , vol.96 , pp. 4357-4367
    • Katsumata, N.1    Shimokawa, H.2    Seto, M.3
  • 28
    • 0030020406 scopus 로고    scopus 로고
    • Chronic treatment with interleukin-1β induces coronary intimal lesions and vasospastic responses in pigs in vivo: The role of platelet-derived growth factor
    • Shimokawa H, Ito A, Fukumoto Y, et al. Chronic treatment with interleukin-1β induces coronary intimal lesions and vasospastic responses in pigs in vivo: the role of platelet-derived growth factor. J Clin Invest 1996; 97: 769-76
    • (1996) J. Clin. Invest. , vol.97 , pp. 769-776
    • Shimokawa, H.1    Ito, A.2    Fukumoto, Y.3
  • 29
    • 0034696624 scopus 로고    scopus 로고
    • Inhibition of myosin phosphatase by upregulated Rho-kinase plays a key role for coronary artery spasm in a porcine model with interleukin-1β
    • Kandabashi T, Shimokawa H, Miyata K, et al. Inhibition of myosin phosphatase by upregulated Rho-kinase plays a key role for coronary artery spasm in a porcine model with interleukin-1β. Circulation 2000; 101: 1319-23
    • (2000) Circulation , vol.101 , pp. 1319-1323
    • Kandabashi, T.1    Shimokawa, H.2    Miyata, K.3
  • 30
    • 10744227785 scopus 로고    scopus 로고
    • Evidence for protein kinase C-mediated activation of Rho-kinase in a porcine model of coronary artery spasm
    • Kandabashi T, Shimokawa H, Miyata K, et al. Evidence for protein kinase C-mediated activation of Rho-kinase in a porcine model of coronary artery spasm. Arterioscl Thromb Vasc Biol 2003; 23: 2209-14
    • (2003) Arterioscl. Thromb. Vasc. Biol. , vol.23 , pp. 2209-2214
    • Kandabashi, T.1    Shimokawa, H.2    Miyata, K.3
  • 31
    • 0036164704 scopus 로고    scopus 로고
    • Involvement of Rho-kinase in agonists-induced contractions of arteriosclerotic human arteries
    • Kandabashi T, Shimokawa H, Mukai Y, et al. Involvement of Rho-kinase in agonists-induced contractions of arteriosclerotic human arteries. Arterioscl Thromb Vasc Biol 2002; 22: 243-8
    • (2002) Arterioscl. Thromb. Vasc. Biol. , vol.22 , pp. 243-248
    • Kandabashi, T.1    Shimokawa, H.2    Mukai, Y.3
  • 32
    • 0037007054 scopus 로고    scopus 로고
    • Suppression of coronary artery spasm by the Rho-kinase inhibitor fasudil in patients with vasospastic angina
    • Masumoto A, Mohri M, Shimokawa H, et al. Suppression of coronary artery spasm by the Rho-kinase inhibitor fasudil in patients with vasospastic angina. Circulation 2002; 105: 1545-7
    • (2002) Circulation , vol.105 , pp. 1545-1547
    • Masumoto, A.1    Mohri, M.2    Shimokawa, H.3
  • 33
    • 0032542882 scopus 로고    scopus 로고
    • Angina pectoris caused by coronary microvascular spasm
    • Mohri M, Koyanagi M, Egashira K, et al. Angina pectoris caused by coronary microvascular spasm. Lancet 1998; 351: 1165-9
    • (1998) Lancet , vol.351 , pp. 1165-1169
    • Mohri, M.1    Koyanagi, M.2    Egashira, K.3
  • 34
    • 0037223388 scopus 로고    scopus 로고
    • Rho-kinase inhibition with intracoronary fasudil prevents myocardial ischemia in patients with coronary microvascular spasm
    • Mohri M, Shimokawa H, Hirakawa Y, et al. Rho-kinase inhibition with intracoronary fasudil prevents myocardial ischemia in patients with coronary microvascular spasm. J Am Coll Cardiol 2003; 41: 15-9
    • (2003) J. Am. Coll. Cardiol. , vol.41 , pp. 15-19
    • Mohri, M.1    Shimokawa, H.2    Hirakawa, Y.3
  • 35
    • 0029921443 scopus 로고    scopus 로고
    • Remodeling rather than neointimal formation explains luminal narrowing after deep vessel wall injury: Insights from a porcine coronary (re)stenosis model
    • Andersen HR, Maeng M, Thorwest M, et al. Remodeling rather than neointimal formation explains luminal narrowing after deep vessel wall injury: insights from a porcine coronary (re)stenosis model. Circulation 1996; 93: 1716-24
    • (1996) Circulation , vol.93 , pp. 1716-1724
    • Andersen, H.R.1    Maeng, M.2    Thorwest, M.3
  • 36
    • 0141618309 scopus 로고    scopus 로고
    • Elevated whole-blood tissue factor procoagulant activity as a marker of restenosis after percutaneous transluminal coronary angioplasty and stent implantation
    • Tutar E, Ozcan M, Kilickap M, et al. Elevated whole-blood tissue factor procoagulant activity as a marker of restenosis after percutaneous transluminal coronary angioplasty and stent implantation. Circulation 2003; 108: 1581-4
    • (2003) Circulation , vol.108 , pp. 1581-1584
    • Tutar, E.1    Ozcan, M.2    Kilickap, M.3
  • 37
    • 0141885290 scopus 로고    scopus 로고
    • Pathological mechanisms of fatal late coronary stent thrombosis in humans
    • Farb A, Burke AP, Kolodgie FD, et al. Pathological mechanisms of fatal late coronary stent thrombosis in humans. Circulation 2003; 108: 1701-6
    • (2003) Circulation , vol.108 , pp. 1701-1706
    • Farb, A.1    Burke, A.P.2    Kolodgie, F.D.3
  • 38
    • 0035003738 scopus 로고    scopus 로고
    • Long-term inhibition of Rho-kinase induces a regression of arteriosclerotic coronary lesions in a swine model in vivo
    • Shimokawa H, Morishige K, Miyata K, et al. Long-term inhibition of Rho-kinase induces a regression of arteriosclerotic coronary lesions in a swine model in vivo. Cardiovasc Res 2001; 51: 169-77
    • (2001) Cardiovasc. Res. , vol.51 , pp. 169-177
    • Shimokawa, H.1    Morishige, K.2    Miyata, K.3
  • 39
    • 0035049575 scopus 로고    scopus 로고
    • Adenovirus-mediated transfer of dominant-negative Rho-kinase induces a regression of coronary arteriosclerosis in pigs in vivo
    • Morishige K, Shimokawa H, Eto Y, et al. Adenovirus-mediated transfer of dominant-negative Rho-kinase induces a regression of coronary arteriosclerosis in pigs in vivo. Arterioscler Thromb Vasc Biol 2001; 21: 548-54
    • (2001) Arterioscler. Thromb. Vasc. Biol. , vol.21 , pp. 548-554
    • Morishige, K.1    Shimokawa, H.2    Eto, Y.3
  • 40
    • 9144227431 scopus 로고    scopus 로고
    • Long-term inhibition of Rho-kinase suppresses neointimal formation after stent implantation in porcine coronary arteries: Involvement of multiple mechanisms
    • Matsumoto Y, Uwatoku T, Oi K, et al. Long-term inhibition of Rho-kinase suppresses neointimal formation after stent implantation in porcine coronary arteries: involvement of multiple mechanisms. Arterioscler Thromb Vasc Biol 2004; 24: 181-6
    • (2004) Arterioscler. Thromb. Vasc. Biol. , vol.24 , pp. 181-186
    • Matsumoto, Y.1    Uwatoku, T.2    Oi, K.3
  • 41
    • 0346690256 scopus 로고    scopus 로고
    • Long-term treatment with a specific Rho-kinase inhibitor suppresses cardiac allograft vasculopathy in mice
    • Hattori T, Shimokawa H, Higashi M, et al. Long-term treatment with a specific Rho-kinase inhibitor suppresses cardiac allograft vasculopathy in mice. Circ Res 2004; 94: 46-52
    • (2004) Circ. Res. , vol.94 , pp. 46-52
    • Hattori, T.1    Shimokawa, H.2    Higashi, M.3
  • 42
    • 0028809857 scopus 로고
    • Chronic inhibition of nitric oxide synthesis causes coronary microvascular remodeling in rats
    • Numaguchi K, Egashira K, Takemoto M, et al. Chronic inhibition of nitric oxide synthesis causes coronary microvascular remodeling in rats. Hypertension 1995; 26: 957-62
    • (1995) Hypertension , vol.26 , pp. 957-962
    • Numaguchi, K.1    Egashira, K.2    Takemoto, M.3
  • 43
    • 0031029539 scopus 로고    scopus 로고
    • Important role of tissue angiotensin-converting enzyme activity in the pathogenesis of coronary vascular and myocardial structural changes induced by long-term blockade of nitric oxide synthesis in rats
    • Takemoto M, Egashira K, Usui M, et al. Important role of tissue angiotensin-converting enzyme activity in the pathogenesis of coronary vascular and myocardial structural changes induced by long-term blockade of nitric oxide synthesis in rats. J Clin Invest 1997; 99: 278-98
    • (1997) J. Clin. Invest. , vol.99 , pp. 278-298
    • Takemoto, M.1    Egashira, K.2    Usui, M.3
  • 44
    • 18244401416 scopus 로고    scopus 로고
    • Important role of Rho-kinase in the pathogenesis of cardiovascular inflammation and remodeling induced by long-term blockade of nitric oxide synthesis in rats
    • Kataoka C, Egashira K, Inoue S, et al. Important role of Rho-kinase in the pathogenesis of cardiovascular inflammation and remodeling induced by long-term blockade of nitric oxide synthesis in rats. Hypertension 2002; 39: 245-50
    • (2002) Hypertension , vol.39 , pp. 245-250
    • Kataoka, C.1    Egashira, K.2    Inoue, S.3
  • 45
    • 0035823041 scopus 로고    scopus 로고
    • Involvement of Rho-kinase in vascular remodeling caused by long-term inhibition of nitric oxide synthesis in rats
    • Ikegaki I, Hattori T, Yamaguchi T, et al. Involvement of Rho-kinase in vascular remodeling caused by long-term inhibition of nitric oxide synthesis in rats. Eur J Pharmacol 2001; 427: 69-75
    • (2001) Eur. J. Pharmacol. , vol.427 , pp. 69-75
    • Ikegaki, I.1    Hattori, T.2    Yamaguchi, T.3
  • 46
    • 0035572718 scopus 로고    scopus 로고
    • Pleiotropic effects of 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitors
    • Takemoto M, Liao JK. Pleiotropic effects of 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitors. Arterioscler Thromb Vasc Biol 2001; 21: 1712-9
    • (2001) Arterioscler. Thromb. Vasc. Biol. , vol.21 , pp. 1712-1719
    • Takemoto, M.1    Liao, J.K.2
  • 47
    • 0036199909 scopus 로고    scopus 로고
    • Impact of HMG CoA reductase inhibition on small GTPases in the heart
    • Laufs U, Kilter H, Konkol C, et al. Impact of HMG CoA reductase inhibition on small GTPases in the heart. Cardiovasc Res 2002; 53: 911-20
    • (2002) Cardiovasc. Res. , vol.53 , pp. 911-920
    • Laufs, U.1    Kilter, H.2    Konkol, C.3
  • 48
    • 0034810237 scopus 로고    scopus 로고
    • cGMP-dependent protein kinase phosphorylates and inactivates RhoA
    • Sawada N, Itoh H, Yamashita J, et al. cGMP-dependent protein kinase phosphorylates and inactivates RhoA. Biochem Biophys Res Commun 2001; 280: 798-805
    • (2001) Biochem. Biophys. Res. Commun. , vol.280 , pp. 798-805
    • Sawada, N.1    Itoh, H.2    Yamashita, J.3
  • 49
    • 0036892061 scopus 로고    scopus 로고
    • Rho GTPase/Rho kinase negatively regulates endothelial nitric oxide synthase phosphorylation through the inhibition of protein kinase B/Akt in human endothelial cells
    • Ming X-F, Viswambharan H, Barandier C, et al. Rho GTPase/Rho kinase negatively regulates endothelial nitric oxide synthase phosphorylation through the inhibition of protein kinase B/Akt in human endothelial cells. Mol Cell Biol 2002; 22: 8467-77
    • (2002) Mol. Cell Biol. , vol.22 , pp. 8467-8477
    • Ming, X.-F.1    Viswambharan, H.2    Barandier, C.3
  • 50
    • 0142120102 scopus 로고    scopus 로고
    • Long-term inhibition of Rho-kinase suppresses angiotensin II-induced cardiovascular hypertrophy in rats in vivo: Effect on endothelial NAD(P)H oxidase system
    • Higashi M, Shimokawa H, Hattori T, et al. Long-term inhibition of Rho-kinase suppresses angiotensin II-induced cardiovascular hypertrophy in rats in vivo: effect on endothelial NAD(P)H oxidase system. Circ Res 2003; 93: 767-75
    • (2003) Circ. Res. , vol.93 , pp. 767-775
    • Higashi, M.1    Shimokawa, H.2    Hattori, T.3
  • 51
    • 0032489871 scopus 로고    scopus 로고
    • Angiotensin II activates RhoA in cardiac myocytes: A critical role of RhoA in angiotensin II-induced premyofibril formation
    • Aoki H, Izumo S, Sadoshima J, et al. Angiotensin II activates RhoA in cardiac myocytes: a critical role of RhoA in angiotensin II-induced premyofibril formation. Circ Res 1998; 82: 666-76
    • (1998) Circ. Res. , vol.82 , pp. 666-676
    • Aoki, H.1    Izumo, S.2    Sadoshima, J.3
  • 52
    • 0035571072 scopus 로고    scopus 로고
    • Rho-kinase mediates angiotensin II-induced monocyte chemoattractant protein-1 expression in rat vascular smooth muscle cells
    • Funakoshi Y, Ichiki T, Shimokawa H, et al. Rho-kinase mediates angiotensin II-induced monocyte chemoattractant protein-1 expression in rat vascular smooth muscle cells. Hypertension 2001; 38: 100-4
    • (2001) Hypertension , vol.38 , pp. 100-104
    • Funakoshi, Y.1    Ichiki, T.2    Shimokawa, H.3
  • 53
    • 0035041566 scopus 로고    scopus 로고
    • Critical role of Rho-kinase and MEK/ERK pathways for angiotensin II-induced plasminogen activator inhibitor type-1 gene expression
    • Takeda K, Ichiki T, Tokunou T, et al. Critical role of Rho-kinase and MEK/ERK pathways for angiotensin II-induced plasminogen activator inhibitor type-1 gene expression. Arterioscler Thromb Vasc Biol 2001; 21: 868-73
    • (2001) Arterioscler. Thromb. Vasc. Biol. , vol.21 , pp. 868-873
    • Takeda, K.1    Ichiki, T.2    Tokunou, T.3
  • 54
    • 12244285281 scopus 로고    scopus 로고
    • Rho-kinase inhibition blunts renal vasoconstriction induced by distinct signaling pathways in vivo
    • Cavapare A, Endolich N, Assaloni R, et al. Rho-kinase inhibition blunts renal vasoconstriction induced by distinct signaling pathways in vivo. J Am Soc Nephrol 2003; 13: 37-45
    • (2003) J. Am. Soc. Nephrol. , vol.13 , pp. 37-45
    • Cavapare, A.1    Endolich, N.2    Assaloni, R.3
  • 55
    • 5344233478 scopus 로고    scopus 로고
    • Pulmonary arterial hypertension
    • Farber HW, Loscalzo J. Pulmonary arterial hypertension. New Engl J Med 2004; 351 (16): 1655-65
    • (2004) New Engl. J. Med. , vol.351 , Issue.16 , pp. 1655-1665
    • Farber, H.W.1    Loscalzo, J.2
  • 56
    • 10744222390 scopus 로고    scopus 로고
    • Long-term treatment with a Rho-kinase inhibitor improves monocrotaline-induced fatal pulmonary hypertension in rats
    • Abe K, Shimokawa H, Uwatoku T, et al. Long-term treatment with a Rho-kinase inhibitor improves monocrotaline-induced fatal pulmonary hypertension in rats. Circ Res 2004; 94 (3): 385-93
    • (2004) Circ. Res. , vol.94 , Issue.3 , pp. 385-393
    • Abe, K.1    Shimokawa, H.2    Uwatoku, T.3
  • 57
    • 0035134310 scopus 로고    scopus 로고
    • Antagonism of Rho-kinase stimulates rat penile erection via a nitric oxide-independent pathway
    • Chitaley K, Wingard CJ, Webb RC, et al. Antagonism of Rho-kinase stimulates rat penile erection via a nitric oxide-independent pathway. Nat Med 2001; 7: 119-22
    • (2001) Nat. Med. , vol.7 , pp. 119-122
    • Chitaley, K.1    Wingard, C.J.2    Webb, R.C.3
  • 60
    • 0031574220 scopus 로고    scopus 로고
    • Gene expression of the small GTP-binding proteins RhoA, RhoB, Rac1, and Cdc42 in adult rat brain
    • Olenik C, Barth H, Just I, et al. Gene expression of the small GTP-binding proteins RhoA, RhoB, Rac1, and Cdc42 in adult rat brain. Brain Res Mol Brain Res 1997; 52: 263-9
    • (1997) Brain Res. Mol. Brain Res. , vol.52 , pp. 263-269
    • Olenik, C.1    Barth, H.2    Just, I.3
  • 61
    • 14444288533 scopus 로고    scopus 로고
    • Molecular dissection of the Rho-associated protein kinase (p160ROCK)-regulated neurite remodeling in neuroblastoma N1E-115 cells
    • Hirose M, Ishizaki T, Watanabe N, et al. Molecular dissection of the Rho-associated protein kinase (p160ROCK)-regulated neurite remodeling in neuroblastoma N1E-115 cells. J Cell Biol 1998; 141: 1625-36
    • (1998) J. Cell Biol. , vol.141 , pp. 1625-1636
    • Hirose, M.1    Ishizaki, T.2    Watanabe, N.3
  • 62
    • 0033711895 scopus 로고    scopus 로고
    • A critical role for a Rho-associated kinase, p160ROCK, in determining axon outgrowth in mammalian CNS neurons
    • Bito H, Furuyashiki T, Ishihara H, et al. A critical role for a Rho-associated kinase, p160ROCK, in determining axon outgrowth in mammalian CNS neurons. Neuron 2000; 26: 431-41
    • (2000) Neuron , vol.26 , pp. 431-441
    • Bito, H.1    Furuyashiki, T.2    Ishihara, H.3
  • 63
    • 0033529620 scopus 로고    scopus 로고
    • Signaling from Rho to the actin cytoskeleton through protein kinases ROCK and LIM-kinase
    • Maekawa M, Ishizaki T, Boku S, et al. Signaling from Rho to the actin cytoskeleton through protein kinases ROCK and LIM-kinase. Science 1999; 285: 895-8
    • (1999) Science , vol.285 , pp. 895-898
    • Maekawa, M.1    Ishizaki, T.2    Boku, S.3
  • 64
    • 0032078861 scopus 로고    scopus 로고
    • Rapid acti-based plasticity in dendritic spines
    • Fischer M, Kaech S, Knutti D, et al. Rapid acti-based plasticity in dendritic spines. Neuron 1998; 20: 847-54
    • (1998) Neuron , vol.20 , pp. 847-854
    • Fischer, M.1    Kaech, S.2    Knutti, D.3
  • 65
    • 0033529082 scopus 로고    scopus 로고
    • Densritic spine changes associated with hippocampal long-term synaptic plasticity
    • Engert F, Bonhoeffer T. Densritic spine changes associated with hippocampal long-term synaptic plasticity. Nature 1999; 399: 66-70
    • (1999) Nature , vol.399 , pp. 66-70
    • Engert, F.1    Bonhoeffer, T.2
  • 66
    • 0033623792 scopus 로고    scopus 로고
    • 2+-dependent exocytosis through Rho/Rho-associated kinase-dependent pathway
    • 2+-dependent exocytosis through Rho/Rho-associated kinase-dependent pathway. J Neurochem 2000; 75: 708-17
    • (2000) J. Neurochem. , vol.75 , pp. 708-717
    • Yamaguchi, Y.1    Katoh, H.2    Yasui, H.3
  • 67
    • 0038463820 scopus 로고    scopus 로고
    • Rho/Rho-kinase pathway in brain stem contributes to blood pressure regulation via sympathetic nervous system: Possible involvement in neural mechanisms of hypertension
    • Ito K, Hirooka Y, Sakai K, et al. Rho/Rho-kinase pathway in brain stem contributes to blood pressure regulation via sympathetic nervous system: possible involvement in neural mechanisms of hypertension. Circ Res 2003; 92: 1337-43
    • (2003) Circ. Res. , vol.92 , pp. 1337-1343
    • Ito, K.1    Hirooka, Y.2    Sakai, K.3
  • 68
    • 0033870561 scopus 로고    scopus 로고
    • Angiotensin in the nucleus tractus solitarii contributes to neurogenic hypertension caused by chronic nitric oxide synthase inhibition
    • Eshima K, Hirooka Y, Shigematsu H, et al. Angiotensin in the nucleus tractus solitarii contributes to neurogenic hypertension caused by chronic nitric oxide synthase inhibition. Hypertension 2000; 36: 259-63
    • (2000) Hypertension , vol.36 , pp. 259-263
    • Eshima, K.1    Hirooka, Y.2    Shigematsu, H.3
  • 69
    • 0842332607 scopus 로고    scopus 로고
    • Rho/Rho-kinase pathway in the brainstem contributes to hypertension caused by chronic nitric oxide synthase inhibition
    • Ito K, Hirooka Y, Kishi T, et al. Rho/Rho-kinase pathway in the brainstem contributes to hypertension caused by chronic nitric oxide synthase inhibition. Hypertension 2004; 43: 156-62
    • (2004) Hypertension , vol.43 , pp. 156-162
    • Ito, K.1    Hirooka, Y.2    Kishi, T.3
  • 70
    • 4644300539 scopus 로고    scopus 로고
    • Inhibition of Rho-kinase in the brainstem augments baroreflex control of heart rate in rats
    • Ito K, Hirooka Y, Sagara Y, et al. Inhibition of Rho-kinase in the brainstem augments baroreflex control of heart rate in rats. Hypertension 2004; 44: 478-83
    • (2004) Hypertension , vol.44 , pp. 478-483
    • Ito, K.1    Hirooka, Y.2    Sagara, Y.3
  • 71
    • 0033879562 scopus 로고    scopus 로고
    • Involvement of Rho-kinase-mediated phosphorylation of myosin light chain in enhancement of cerebral vasospasm
    • Sato M, Tani E, Fujikawa H, et al. Involvement of Rho-kinase-mediated phosphorylation of myosin light chain in enhancement of cerebral vasospasm. Circ Res 2000; 87: 195-200
    • (2000) Circ. Res. , vol.87 , pp. 195-200
    • Sato, M.1    Tani, E.2    Fujikawa, H.3
  • 72
    • 0037453644 scopus 로고    scopus 로고
    • Functional roles of the Rho/Rho-kinase pathway and protein kinase C in the regulation of cerebrovascular constriction mediated by hemoglobin: Relevance to subarachnoid hemorrhage and vasopressin
    • Wickman G, Lan C, Vollrath B. Functional roles of the Rho/Rho-kinase pathway and protein kinase C in the regulation of cerebrovascular constriction mediated by hemoglobin: relevance to subarachnoid hemorrhage and vasopressin. Circ Res 2003; 92: 809-16
    • (2003) Circ. Res. , vol.92 , pp. 809-816
    • Wickman, G.1    Lan, C.2    Vollrath, B.3
  • 73
    • 0346998129 scopus 로고    scopus 로고
    • Endothelin-1 modulates hemoglobin-mediated signaling in cerebrovascular smooth muscle via RhoA/Rho-kinase and protein kinase C
    • Lan C, Das D, Wloskowicz A, et al. Endothelin-1 modulates hemoglobin-mediated signaling in cerebrovascular smooth muscle via RhoA/Rho-kinase and protein kinase C. Am J Physiol Heart Circ Physiol 2004; 286: H165-73
    • (2004) Am. J. Physiol. Heart Circ. Physiol. , vol.286
    • Lan, C.1    Das, D.2    Wloskowicz, A.3
  • 74
    • 0033953849 scopus 로고    scopus 로고
    • Thin and thick filament regulation of contractility in experimental cerebral vasospasm
    • Kim I, Leinweber BD, Morgalla M, et al. Thin and thick filament regulation of contractility in experimental cerebral vasospasm. Neurosurgery 2000; 46: 440-7
    • (2000) Neurosurgery , vol.46 , pp. 440-447
    • Kim, I.1    Leinweber, B.D.2    Morgalla, M.3
  • 75
    • 0026534605 scopus 로고
    • Effect of AT877 on cerebral vasospasm after aneurysmal subarachnoid hemorrhage: Results of a prospective, placebo controlled, double blind trial
    • Shibuya M, Suzuki Y, Sugita K, et al. Effect of AT877 on cerebral vasospasm after aneurysmal subarachnoid hemorrhage: results of a prospective, placebo controlled, double blind trial. J Neurosurg 1992; 76: 571-7
    • (1992) J. Neurosurg. , vol.76 , pp. 571-577
    • Shibuya, M.1    Suzuki, Y.2    Sugita, K.3
  • 76
    • 0032431683 scopus 로고    scopus 로고
    • Combination therapy of fasudil hydrochloride and ozagrel sodium for cerebral vasospasm following aneurysmal subrachnoid hemorrhage
    • Nakashima S, Tabuchi K, Shimokawa S, et al. Combination therapy of fasudil hydrochloride and ozagrel sodium for cerebral vasospasm following aneurysmal subrachnoid hemorrhage. Neurol Med Chir 1998; 38: 805-11
    • (1998) Neurol. Med. Chir. , vol.38 , pp. 805-811
    • Nakashima, S.1    Tabuchi, K.2    Shimokawa, S.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.