Functional roles of the Rho/Rho kinase pathway and protein kinase C in the regulation of cerebrovascular constriction mediated by hemoglobin: Relevance to subarachnoid hemorrhage and vasospasm

Circulation Research

Volumn 92, Issue 7, 2003, Pages 809-816

  Wickman, Grant ^a   Lan, Christopher ^c   Vollrath, Bozena ^b  

^a PFIZER GLOBAL RESEARCH AND DEVELOPMENT   (United States)

^b UNIVERSITY OF ALBERTA   (Canada)

^c NONE

Author keywords

Hemoglobin; Protein kinase C; Rho kinase; Smooth muscle; Vasospasm

Indexed keywords

3 [8 [(DIMETHYLAMINO)METHYL] 6,7,8,9 TETRAHYDROPYRIDO[1,2 A]INDOL 10 YL] 4 (1 METHYL 1H INDOL 3 YL) 1H PYRROLE 2,5 DIONE; 4 (1 AMINOETHYL) N (4 PYRIDYL)CYCLOHEXANECARBOXAMIDE; FASUDIL; GGTI 297; HEMOGLOBIN; OXYHEMOGLOBIN; PROTEIN KINASE C; PROTEIN KINASE C ALPHA; PROTEIN KINASE C EPSILON; PROTEIN KINASE C INHIBITOR; PROTEIN KINASE INHIBITOR; RHO FACTOR; RHO KINASE; TRANSFERASE INHIBITOR; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL MODEL; ANIMAL TISSUE; ARTERY CONSTRICTION; ARTICLE; BASILAR ARTERY; BRAIN BLOOD VESSEL; BRAIN VASOSPASM; CONTROLLED STUDY; DRUG EFFECT; DRUG POTENCY; DRUG SELECTIVITY; EVOKED RESPONSE; IC 50; IMMUNOBLOTTING; NONHUMAN; PRENYLATION; PRIORITY JOURNAL; PROTEIN TRANSPORT; RABBIT; REGULATORY MECHANISM; SIGNAL TRANSDUCTION; SMOOTH MUSCLE FIBER; SUBARACHNOID HEMORRHAGE; TENSION; TIME; VASCULAR ENDOTHELIUM; VASCULAR SMOOTH MUSCLE; VASOCONSTRICTION;

1-(5-ISOQUINOLINESULFONYL)-2-METHYLPIPERAZINE; AMIDES; ANIMALS; BASILAR ARTERY; BENZAMIDES; BIOLOGICAL TRANSPORT; CELL MEMBRANE; CELLS, CULTURED; DOSE-RESPONSE RELATIONSHIP, DRUG; ENZYME INHIBITORS; INDOLES; INTRACELLULAR SIGNALING PEPTIDES AND PROTEINS; ISOENZYMES; MUSCLE, SMOOTH, VASCULAR; OXYHEMOGLOBINS; PROTEIN KINASE C; PROTEIN-SERINE-THREONINE KINASES; PYRIDINES; PYRROLES; RABBITS; RHO GTP-BINDING PROTEINS; SIGNAL TRANSDUCTION; TETRADECANOYLPHORBOL ACETATE; VASOCONSTRICTION;

EID: 0037453644     PISSN: 00097330     EISSN: None     Source Type: Journal    
DOI: 10.1161/01.RES.0000066663.12256.B2     Document Type: Article

References (36)

1. Dietrich HH, Dacey RG. Molecular keys to the problems of cerebral vasospasm. Neurosurgery. 2000;46:517-530.
2. Macdonald RL, Weir BKA. A review of hemoglobin and the pathogenesis of cerebral vasospasm. Stroke. 1991;22:971-982.
3. Toda N, Kawakami M, Yoshida K. Constrictor action of oxyhemoglobin in monkey and dog basilar arteries in vivo and in vitro. Am J Physiol. 1991;260:H420-H425.
4. Macdonald RL, Weir BKA, Runzer TD, Grace MGA, Findlay JM, Saito K, Cook DA, Mielke BW, Kanamaru K. Etiology of cerebral vasospasm in primates. J Neurosurg. 1991;75:415-424.
5. Mayberg MR, Okada T, Bark DH. The role of hemoglobin in arterial narrowing after subarachnoid hemorrhage. J Neurosurg. 1990;22:634-640.
6. Vollrath B, Weir BKA, Macdonald RL, Cook DA. Intracellular mechanisms involved in the responses of cerebrovascular smooth muscle cells to hemoglobin. J Neurosurg. 1994;80:261-268.
7. Cook DA, Vollrath B. Free radicals and intracellular events associated with cerebrovascular spasm. Cardiovasc Res. 1995;30:493-500.
8. Kamm KE, Stull JT. The function of myosin and myosin light chain phosphorylation in smooth muscle. Annu Rev Pharmacol Toxicol. 1985;25:593-620.
9. Somlyo AP, Somlyo AV. Signal transduction by G proteins, Rho kinase and protein phosphatase to smooth muscle and non-muscle myosin II. J Physiol. 2000;522:177-185.
10. Sato M, Tani E, Fujikawa H, Kaibuchi K. Involvement of Rho-kinase-mediated phosphorylation of myosin light chain in enhancement of cerebral vasospasm. Circ Res. 2000;87:195-200.
11. Somlyo AP, Somlyo AV. Signal transduction and regulation in smooth muscle. Nature. 1994;372:231-236.
12. 2+-sensitizing effect of protein kinase C on vascular smooth muscle: inhibition of myosin light chain phosphatase. J Gen Physiol. 1994;104:265-286.
13. Matsui T, Takuwa Y, Joshita H, Yamashita K, Asano T. Possible role of protein kinase C-dependent smooth muscle contraction in the pathogenesis of chronic cerebral vasospasm. J Cereb Blood Flow Metab. 1991;11:143-149.
14. Minami N, Tani E, Maeda Y, Yamaura I, Fukami M. Effects of inhibitors of protein kinase C and calpain in experimental delayed cerebral vasospasm. J Neurosurg. 1992;76:111-118.
15. Eto M, Ohmori T, Suzuki M, Furuya K, Morita F. A novel protein phosphatase-1 inhibitory protein potentiated by protein kinase C: isolation from porcine aorta media and characterization. J Biochem. 1995;118:1104-1107.
16. 2+-sensitization in Triton X-100 demembranated rabbit arterial smooth muscle. J Physiol. 1999;520:139-152.
17. Kimura K, Ito M, Chihara K, Fukata Y, Nakafuku M, Yamamori B, Feng J, Nakano T, Okawa K, Iwamatsu A, Kaibuchi K. Regulation of myosin phosphatase by Rho and Rho- associated kinase (Rho-kinase). Science. 1996;273:245-248.
18. Shimokawa H, Seto M, Katsumata N, Amano M, Kozai T, Yamawaki T, Kuwata K, Kandabashi T, Egashira K, Ikegaki I, Asano T, Kaibuchi K. Rho-kinase-mediated pathway induces enhanced myosin light chain phosphorylation in a swine model of coronary artery spasm. Cardiovasc Res. 1999;43:1029-1039.
19. Kim I, Leinweber BD, Morgalla M, Butler WE, Seto M, Sasaki Y, Peterson JW, Morgan KG. Thin and thick filament regulation of contractility in experimental cerebral vasospasm. Neurosurgery. 2000;46:440-447.
20. Shibuya M, Suzuki Y, Sugita K, Saito I, Sasaki T, Takakura K, Nagata I, Kikuchi H, Takema T, Hidaka H, Nakashima M. Effect of AT 877 on cerebral vasospasm after aneurysmal subarachnoid hemorrhage: results of a prospective placebo controlled, double blind trial. J Neurosurg. 1992;76:571-577.
21. Vollrath B, Chan P, Findlay M, Cook D. Lazaroids and deferoxamine attenuate the intracellular effects of oxyhemoglobin in vascular smooth muscle. Cardiovasc Res. 1995;30:619-626.
22. Vollrath B, Cook D, Megyesi J, Findlay JM, Ohkuma H. Novel mechanism by which hemoglobin induces constriction of cerebral arteries. Eur J Pharmacol. 1998;361:311-319.
23. Wickman G, Nessim MA, Cook DA, Vollrath B. The polycationic aminoglycosides modulate the vasoconstrictive effects of endothelin: relevance to cerebral vasospasm. Br J Pharmacol. 2001;133:5-12.
24. McGuire TF, Qian Y, Vogt A, Hamilton AD, Sebti SM. Platelet-derived growth factor receptor tyrosine phosphorylation requires protein geranylgeranylation but not farnesylation. J Biol Chem. 1996;27:27402-27407.
25. Wilkinson SE, Parker PJ, Nixon JS. Isoenzyme specificity of bisindolylmaleimides, selective inhibitors of protein kinase C. Biochem J. 1993;294:335-337.
26. 2- sensitization of smooth muscle. J Biol Chem. 1997;272:10704-10709.
27. Hall A. Rho GTPase and the actin cytoskeleton. Science. 1998;279:509-514.
28. Uehata M, Ishizaki T, Satoh H, Ono T, Kawahara T, Morishita T, Tamakawa H, Yamagami K, Inui J, Maekawa M, Narumiya S. Calcium sensitization of smooth muscle mediated by a Rho-associated protein kinase in hypertension. Nature. 1997;389:990-994.
29. 2+ sensitization in porcine coronary artery. Circ Res. 2001;88:1283-1290.
30. Arai T, Takeyama N, Tanaka T. Glutathione monoethyl ester and inhibition of the oxyhemoglobin-induced increase in cytosolic calcium in cultured smooth muscle cells. J Neurosurg. 1999;90:527-532.
31. Laher I, Zhang JH. Protein kinase C and cerebral vasospasm. J Cereb Blood Flow Metab. 2001;21:887-906.
32. Way KJ, Chou E, King GL. Identification of PKC-isoform-specific biological actions using pharmacological approaches. Trends Pharmacol Sci. 2000;21:181-186.
33. 2+ sensitization by PKC and rho proteins in ovine cerebral arteries: effects of artery size and age. Am J Physiol. 1998;275:H930-H939.
34. Webb BLJ, Lindsay MA, Barnes PJ, Giembycz MA. Protein kinase C isoenzymes in airway smooth muscle. Biochem J. 1997;324:167-175.
35. Hippenstiel S, Kratz T, Krull M, Seybold J, Eichel-Streiber C, Suttorp, N. Rho protein inhibition blocks protein kinase C translocation and activation. Biochem Biophys Res Commun. 1998;245:830-834.
36. Chrissobolis S, Sobey CG. Evidence that Rho-kinase activity contributes to cerebral vascular tone in vivo and is enhanced during chronic hypertension: comparison with protein kinase C. Circ Res. 2001;88:774-779.