Gene expression of the small GTP-binding proteins RhoA, RhoB, Rac1, and Cdc42 in adult rat brain

Molecular Brain Research

Volumn 52, Issue 2, 1997, Pages 263-269

  Olenik, Claudia ^a   Barth, Holger ^a   Just, Ingo ^a   Aktories, Klaus ^a   Meyer, Dieter K ^a  

^a UNIVERSITY OF FREIBURG   (Germany)

Author keywords

Brain; In situ hybridization; Neuron; Northern blot hybridization; Rho GTPase; Western blot

Indexed keywords

ACTIN; CELL CYCLE PROTEIN; GUANINE NUCLEOTIDE BINDING PROTEIN; GUANOSINE TRIPHOSPHATASE; MESSENGER RNA; RHO FACTOR;

ANIMAL TISSUE; ARTICLE; BRAIN STEM; CENTRAL NERVOUS SYSTEM; CEREBELLUM; CYTOSKELETON; DENTATE GYRUS; GENE EXPRESSION; GRANULAR CELL; GRANULE CELL; HIPPOCAMPUS; IMMUNOBLOTTING; IN SITU HYBRIDIZATION; MALE; NEOCORTEX; NERVE CELL PLASTICITY; NONHUMAN; PRIORITY JOURNAL; PYRAMIDAL NERVE CELL; RAT; SYNAPSE; THALAMUS;

ANIMALS; BRAIN; CDC42 GTP-BINDING PROTEIN; CELL CYCLE PROTEINS; CEREBELLUM; GENE EXPRESSION; GTP-BINDING PROTEINS; HIPPOCAMPUS; IN SITU HYBRIDIZATION; MALE; MEMBRANE PROTEINS; NEOCORTEX; NEURONS; RATS; RATS, WISTAR; RHOA GTP-BINDING PROTEIN; RHOB GTP-BINDING PROTEIN; THALAMUS;

ANIMALIA; MAMMALIA;

EID: 0031574220     PISSN: 0169328X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0169-328X(97)00270-2     Document Type: Article

References (32)

1. [1] M.M. Bradford, A rapid and sensitive method for the quantitation of microgram quantities of protein-dye binding, Anal. Biochem. 72 (1976) 248-254.
2. [2] P. Chardin, P. Bouquet, P. Maduale, M.R. Popoff, S. Rubin, D.M. Gill, The mammalian G-protein RhoC is ADP-ribosylated by Clostridium botulinum exoenzyme C3 and affects actin microfilaments in vero cells, EMBO J. 8 (1989) 1087-1092.
3. [3] S. Cheley, R. Anderson, A reproducible microanalytical method for the detection of specific RNA sequences by dot-blot hybridization, Anal. Biochem. 137 (1984) 15-19.
4. [4] L.D. Chong, A. Traynor-Kaplan, G.M. Bokoch, M.A. Schwartz, The small GTP-binding protein Rho regulates a phosphatidylinositol 4-phosphate 5-kinase in mammalian cells, Cell 79 (1994) 507-513.
5. [5] S.W. Craig, R.P. Johnson, Assembly of focal adhesions: progress, paradigms and portents, Curr. Opin. Cell. Biol. 8 (1996) 74-85.
6. [6] P.d. Cremoux, C. Gauville, V. Closson, L. Linares, F. Calvo, A. Tavitan, B. Oloffson, EGF modulation of the Ras-related RhoB gene expression in human breast-cancer cell lines, Int. J. Cancer 59 (1994) 408-415.
7. [7] A. Hall, Small GTP-binding proteins and the regulation of the actin cytoskeleton, Ann. Rev. Cell Biol. 10 (1994) 31-54.
8. [8] H.-J. Höltke, C. Kessler, Non radioactive labeling of RNA transcripts in vitro with the hapten digoxigenin (DIG); hybridization and ELISA-based detection, Nucl. Acids Res. 18 (1990) 5843-5851.
9. [9] M. Jacobson, Developmental Neurobiology, Plenum Press, New York, 1993, pp. 223-283.
10. [10] D. Jähner, T. Hunter, The Ras-related gene RhoB is an immediate-early gene inducible by v-Fps, epidermal growth factor, and platelet-derived growth factor in rat fibroblasts, Mol. Cell. Biol. 11 (1991) 3682-3690.
11. [11] K. Jalink, E.J.v. Corven, T. Hengeveld, N. Morii, S. Narumiya, W.H. Molenaar, Inhibition of LPA-and thrombin induced neurite retraction and neuronal cell rounding by ADP ribosylation of the small GTP-binding protein Rho, J. Cell. Biol. 126 (1994) 801-810.
12. [12] R. Kozma, S. Ahmed, A. Best, L. Lim, The Ras-related protein Cdc42Hs and bradykinin promote formation of peripheral actin microspikes and filopodia in Swiss 3T3 fibroblasts, Mol. Cell Biol. 15 (1995) 1942-1952.
13. [13] R. Kozma, S. Ahmed, A. Best, L. Lim, The GTPAse-activating protein n-chimaerin cooperates with Rac1 and Cdc42Hs to induce the formation of lamellipodia and filopodia, Mol. Cell. Biol. 16 (1996) 5069-5080.
14. [14] C. Lamaze, T.H. Chuang, L.J. Terleckey, G.M. Bokoch, S.L. Schmid, Regulation of receptor-mediated endocytosis by Rho and Rac, Nature 382 (1996) 177-179.
15. [15] H. Lim, G.J. Michael, P. Smith, L. Lim, C. Hall, Developmental regulation and neuronal expression of the mRNA of rat n-chimaerin, a p21Rac Gap: cDNA sequence, Biochem. J. 287 (1992) 415-422.
16. [16] L. Luo, T.K. Hensch, L. Ackerman, S. Barbel, L.Y. Jan, Y.N. Jan, Differential effects of the Rac GTPase on Purkinje cell axons and dentritic trunks and spines, Nature 379 (1996) 837-840.
17. [17] L.M. Machesky, A. Hall, Rho: a connection between membrane receptor signalling and the cytoskeleton, Trends Cell Biol. 6 (1996) 304-310.
18. [18] D.J.G. Mackay, C.D. Nobes, A. Hall, The Rho's progress: a potential role during neuritogenesis for the Rho family of GTPases, TINS 18 (1995) 496-501.
19. [19] P.W. Marks, D.J. Kwiatowski, Genomic organization and chromosomal location of Cdc42, Genomics 38 (1996) 13-18.
20. [20] J. Moll, G. Sansig, E. Fattori, H.v.d. Putten, The murine Rac1 gene: cDNA cloning, tissue distribution and regulated expression of Rac! mRNA by dissembly of actin filaments, Oncogene 6 (1991) 863-866.
21. [21] J.A. Moscow, R. He, J.M. Gudas, K.H. Cowan, Utilization of multiple polyadenylation signals in human RhoA protoncogene, Gene 144 (1994) 229-236.
22. [22] S. Munemitsu, M.A. Innis, R. Clark, F. McCormick, A. Ullrich, P. Polakis, Molecular cloning and expression of a G25K cDNA, the human homolog of the yeast cell cycle gene Cdc42, Mol. Cell. Biol. 10 (1990) 5977-5982.
23. [23] C.D. Nobes, A. Hall, Rho, Rac, and Cdc42 GTPases regulate the assembly of multimolecular focal complexes associated with actin stress fibers, lamellipodia, and filopodia, Cell 81 (1995) 53-62.
24. [24] C. Olenik, D.K. Meyer, Development of proenkephalin gene expression in rat neocortex: a non-radioactive study, Mol. Brain Res. 44 (1997) 83-91.
25. rho induces rapid changes in cell morphology, J. Cell. Biol. 111 (1990) 1001-1007.
26. [26] F.R. Postma, K. Jalink, T. Hengeveld, W.H. Moolenaar, Sphingosine-1-phosphate rapidly induces Rho-dependent neurite retraction: action through a specific surface receptor, EMBO J. 15 (1996) 2388-2395.
27. [27] A.J. Ridley, Rho: theme and variations, Curr. Biol. 6 (1996) 1256-1264.
28. [28] A.J. Ridley, A. Hall, Signal transduction pathways regulating Rhomediated stress fibre formation: requirement for a tyrosine kinase, EMBO J. 13 (1994) 2600-2610.
29. [29] Y. Takai, T. Sasaki, K. Tanaka, H. Nakanishi, Rho as a regulator of the cytoskeleton, TIBS 20 (1995) 227-231.
30. [30] A. Theodoridu, C. Olenik, C. Boeckh, P. Ziefer, P. Gebicke-Härter, D.K. Meyer, Interaction of protein kinases A and C in their effects on the proenkephalin gene in astroglial cells, Neurochem. Int. 25 (1994) 385-393.
31. 2+ signaling and Rho, J. Neurochem. 66 (1996) 537-548.
32. [32] P. Yeramian, P. Chardin, P. Madaule, A. Tavitian, Nucleotide sequence of human Rho cDNA clone 12, Nucl. Acids Res. 15 (1987) 1869.