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Volumn 284, Issue 6 53-6, 2003, Pages

Improved erectile function after Rho-kinase inhibition in a rat castrate model of erectile dysfunction

Author keywords

Corpus cavernosum; Phenylephrine; RhoA; Smooth muscle contraction; Testosterone

Indexed keywords

4 (1 AMINOETHYL) N (4 PYRIDYL)CYCLOHEXANECARBOXAMIDE; ANDROGEN; ENZYME INHIBITOR; NITRIC OXIDE; PHENYLEPHRINE; RHO KINASE; TESTOSTERONE; VASOCONSTRICTOR AGENT;

EID: 0013198310     PISSN: 03636119     EISSN: None     Source Type: Journal    
DOI: 10.1152/ajpregu.00041.2003     Document Type: Article
Times cited : (71)

References (38)
  • 1
    • 0033072874 scopus 로고    scopus 로고
    • The effects of castration on relaxation of rat corpus caveosum smooth muscle in vitro
    • Alcorn JF, Toepfer JR, and Leipheimer RE. The effects of castration on relaxation of rat corpus caveosum smooth muscle in vitro. J Urol 161: 686-689, 1999.
    • (1999) J Urol , vol.161 , pp. 686-689
    • Alcorn, J.F.1    Toepfer, J.R.2    Leipheimer, R.E.3
  • 2
    • 0034849563 scopus 로고    scopus 로고
    • Pharmacology of penile erection
    • Andersson KE. Pharmacology of penile erection. Pharmacol Rev 53: 417-450, 2001.
    • (2001) Pharmacol Rev , vol.53 , pp. 417-450
    • Andersson, K.E.1
  • 3
    • 0029870714 scopus 로고    scopus 로고
    • Improvement of sexual function in testosteronedeficient men treated for 1 year with a permeation enhanced testosterone transdermal system
    • , Arver S, Dobs AS, Meikle AW, Allen RP, Sanders SW, and Mazer NA. Improvement of sexual function in testosteronedeficient men treated for 1 year with a permeation enhanced testosterone transdermal system. J Urol 155: 1604-1608, 1996.
    • (1996) J Urol , vol.155 , pp. 1604-1608
    • Arver, S.1    Dobs, A.S.2    Meikle, A.W.3    Allen, R.P.4    Sanders, S.W.5    Mazer, N.A.6
  • 4
    • 0034097064 scopus 로고    scopus 로고
    • Delayed testosterone replacement restores nitric oxide synthase-containing nerve fibres and the erectile response in rat penis
    • Baba K, Yajima M, Carrier S, Morgan DM, Nunes L, Lue TF, and Iwamoto T. Delayed testosterone replacement restores nitric oxide synthase-containing nerve fibres and the erectile response in rat penis. BJU Int 85: 953-958, 2000.
    • (2000) BJU Int , vol.85 , pp. 953-958
    • Baba, K.1    Yajima, M.2    Carrier, S.3    Morgan, D.M.4    Nunes, L.5    Lue, T.F.6    Iwamoto, T.7
  • 7
    • 0035674453 scopus 로고    scopus 로고
    • Decreased penile erection in DOCA-salt and stroke prone-spontaneously hypertensive rats
    • Chitaley K, Webb RC, Dorrance AM, and Mills TM. Decreased penile erection in DOCA-salt and stroke prone-spontaneously hypertensive rats. Int J Impot Res 13, Suppl 5: S16-S20, 2001.
    • (2001) Int J Impot Res , vol.13 , Issue.SUPPL. 5
    • Chitaley, K.1    Webb, R.C.2    Dorrance, A.M.3    Mills, T.M.4
  • 10
    • 0030667961 scopus 로고    scopus 로고
    • Relationship between sleep-related erections and testosterone levels in men
    • Granata AR, Rochira V, Lerchl A, Marrama P, and Carani C. Relationship between sleep-related erections and testosterone levels in men. J Androl 18: 522-527, 1997.
    • (1997) J Androl , vol.18 , pp. 522-527
    • Granata, A.R.1    Rochira, V.2    Lerchl, A.3    Marrama, P.4    Carani, C.5
  • 11
    • 0028051386 scopus 로고
    • Study on nocturnal penile tumescence (NPT) in healthy males. Study on the relationship between the serum free testosterone level and NPT
    • Horita H and Kumamoto Y. Study on nocturnal penile tumescence (NPT) in healthy males. Study on the relationship between the serum free testosterone level and NPT. Nippon Hinyokika Gakkai Zasshi 85: 1511-1520, 1994.
    • (1994) Nippon Hinyokika Gakkai Zasshi , vol.85 , pp. 1511-1520
    • Horita, H.1    Kumamoto, Y.2
  • 13
    • 0028903821 scopus 로고
    • Inhibition of the spontaneous rate of contraction of neonatal cardiac myocytes by protein kinase C isozymes. A putative role for the epsilon isozyme
    • Johnson JA and Mochly-Rosen D. Inhibition of the spontaneous rate of contraction of neonatal cardiac myocytes by protein kinase C isozymes. A putative role for the epsilon isozyme. Circ Res 76: 654-663, 1995.
    • (1995) Circ Res , vol.76 , pp. 654-663
    • Johnson, J.A.1    Mochly-Rosen, D.2
  • 14
    • 0029783133 scopus 로고    scopus 로고
    • Cavernosal nerve stimulation in the rat reverses castration-induced decrease in penile NOS activity
    • Lugg J, Ng C, Rajfer J, and Gonzalez-Cadavid N. Cavernosal nerve stimulation in the rat reverses castration-induced decrease in penile NOS activity. Am J Physiol Endocrinol Metab 271: E354-E361, 1996.
    • (1996) Am J Physiol Endocrinol Metab , vol.271
    • Lugg, J.1    Ng, C.2    Rajfer, J.3    Gonzalez-Cadavid, N.4
  • 15
    • 0028904997 scopus 로고
    • Dihydrotestosterone is the active androgen in the maintenance of nitric oxide-mediated penile erection in the rat
    • Lugg JA, Rajfer J, and Gonzalez-Cadavid NF. Dihydrotestosterone is the active androgen in the maintenance of nitric oxide-mediated penile erection in the rat. Endocrinology 136: 1495-1501, 1995.
    • (1995) Endocrinology , vol.136 , pp. 1495-1501
    • Lugg, J.A.1    Rajfer, J.2    Gonzalez-Cadavid, N.F.3
  • 16
    • 0032865326 scopus 로고    scopus 로고
    • Androgen-dependent nitric oxide release in rat penis correlates with levels of constitutive nitric oxide synthase isoenzymes
    • Marin R, Escrig A, Abreu P, and Mas M. Androgen-dependent nitric oxide release in rat penis correlates with levels of constitutive nitric oxide synthase isoenzymes. Biol Reprod 61: 1012-1016, 1999.
    • (1999) Biol Reprod , vol.61 , pp. 1012-1016
    • Marin, R.1    Escrig, A.2    Abreu, P.3    Mas, M.4
  • 17
    • 0037192607 scopus 로고    scopus 로고
    • Nitric oxide inhibits RhoA/Rho-kinase signaling to cause penile erection
    • Mills TM, Chitaley K, Lewis RW, and Webb RC. Nitric oxide inhibits RhoA/Rho-kinase signaling to cause penile erection. Eur J Pharmacol 439: 173-174, 2002.
    • (2002) Eur J Pharmacol , vol.439 , pp. 173-174
    • Mills, T.M.1    Chitaley, K.2    Lewis, R.W.3    Webb, R.C.4
  • 18
    • 0034863248 scopus 로고    scopus 로고
    • Effect of Rho-kinase inhibition on vasoconstriction in the penile circulation
    • Mills TM, Chitaley K, Wingard CJ, Lewis RW, and Webb RC. Effect of Rho-kinase inhibition on vasoconstriction in the penile circulation. J Appl Physiol 91: 1269-1273, 2001.
    • (2001) J Appl Physiol , vol.91 , pp. 1269-1273
    • Mills, T.M.1    Chitaley, K.2    Wingard, C.J.3    Lewis, R.W.4    Webb, R.C.5
  • 19
    • 0036728431 scopus 로고    scopus 로고
    • Inhibition of tonic contraction - A novel way to approach erectile dysfunction?
    • Mills TM, Lewis R, Wingard CJ, Chitaley K, and Webb RC. Inhibition of tonic contraction - a novel way to approach erectile dysfunction? J Androl 23, S5-S9, 2002.
    • (2002) J Androl , vol.23
    • Mills, T.M.1    Lewis, R.2    Wingard, C.J.3    Chitaley, K.4    Webb, R.C.5
  • 20
    • 0032802156 scopus 로고    scopus 로고
    • The role of androgens in the erectile response: A 1999 perspective
    • Mills TM and Lewis RW. The role of androgens in the erectile response: a 1999 perspective. Mol Urol 3: 75-86, 1999.
    • (1999) Mol Urol , vol.3 , pp. 75-86
    • Mills, T.M.1    Lewis, R.W.2
  • 22
    • 0030444318 scopus 로고    scopus 로고
    • Androgens and penile erection: A review
    • Mills TM, Reilly CM, and Lewis RW. Androgens and penile erection: a review. J Androl 17: 633-638, 1996.
    • (1996) J Androl , vol.17 , pp. 633-638
    • Mills, T.M.1    Reilly, C.M.2    Lewis, R.W.3
  • 23
    • 0030103299 scopus 로고    scopus 로고
    • Sites of androgenic regulation of cavernosal blood pressure during penile erection in the rat
    • Mills TM, Stopper VS, and Reilly CM. Sites of androgenic regulation of cavernosal blood pressure during penile erection in the rat. Int J Impot Res 8: 29-34, 1996.
    • (1996) Int J Impot Res , vol.8 , pp. 29-34
    • Mills, T.M.1    Stopper, V.S.2    Reilly, C.M.3
  • 24
    • 0034955766 scopus 로고    scopus 로고
    • Y-27632, an inhibitor of Rho-kinase, antagonizes noradrenergic contractions in the rabbit and human penile corpus cavernosum
    • Rees RW, Ralph DJ, Royle M, Moncada S, and Cellek S. Y-27632, an inhibitor of Rho-kinase, antagonizes noradrenergic contractions in the rabbit and human penile corpus cavernosum. Br J Pharmacol 133: 455-458, 2001.
    • (2001) Br J Pharmacol , vol.133 , pp. 455-458
    • Rees, R.W.1    Ralph, D.J.2    Royle, M.3    Moncada, S.4    Cellek, S.5
  • 26
    • 0031406114 scopus 로고    scopus 로고
    • Androgenic maintenance of the rat erectile response via a non-nitricoxide-dependent pathway
    • Reilly CM, Lewis RW, Stopper VS, and Mills TM. Androgenic maintenance of the rat erectile response via a non-nitricoxide-dependent pathway. J Androl 18: 588-594, 1997.
    • (1997) J Androl , vol.18 , pp. 588-594
    • Reilly, C.M.1    Lewis, R.W.2    Stopper, V.S.3    Mills, T.M.4
  • 27
    • 0031055155 scopus 로고    scopus 로고
    • Androgens modulate the α-adrenergic responsiveness of vascular smooth muscle in the corpus cavernosum
    • Reilly CM, Stopper VS, and Mills TM. Androgens modulate the α-adrenergic responsiveness of vascular smooth muscle in the corpus cavernosum. J Androl 18: 26-31, 1997.
    • (1997) J Androl , vol.18 , pp. 26-31
    • Reilly, C.M.1    Stopper, V.S.2    Mills, T.M.3
  • 28
    • 0030987422 scopus 로고    scopus 로고
    • Androgenic regulation of NO availability in rat penile erection
    • Reilly CM, Zamorano P, Stopper VS, and Mills TM. Androgenic regulation of NO availability in rat penile erection. J Androl 18: 110-115, 1997.
    • (1997) J Androl , vol.18 , pp. 110-115
    • Reilly, C.M.1    Zamorano, P.2    Stopper, V.S.3    Mills, T.M.4
  • 30
    • 0030738254 scopus 로고    scopus 로고
    • Androgens modulate nitric oxide synthase messenger ribonucleic acid expression in neurons of the major pelvic ganglion in the rat
    • Schirar A, Bonnefond C, Meusnier C, and Devinoy E. Androgens modulate nitric oxide synthase messenger ribonucleic acid expression in neurons of the major pelvic ganglion in the rat. Endocrinology 138: 3093-3102, 1997,
    • (1997) Endocrinology , vol.138 , pp. 3093-3102
    • Schirar, A.1    Bonnefond, C.2    Meusnier, C.3    Devinoy, E.4
  • 31
    • 0028043535 scopus 로고
    • Signal transduction and regulation in smooth muscle
    • Somlyo AP and Somlyo AV. Signal transduction and regulation in smooth muscle. Nature 372: 231-236, 1994.
    • (1994) Nature , vol.372 , pp. 231-236
    • Somlyo, A.P.1    Somlyo, A.V.2
  • 32
    • 0034650714 scopus 로고    scopus 로고
    • Signal transduction by G-proteins, rho-kinase and protein phosphatase to smooth muscle and non-muscle myosin II
    • Somlyo AP and Somlyo AV. Signal transduction by G-proteins, rho-kinase and protein phosphatase to smooth muscle and non-muscle myosin II. J Physiol 522: 177-185, 2000.
    • (2000) J Physiol , vol.522 , pp. 177-185
    • Somlyo, A.P.1    Somlyo, A.V.2
  • 34
    • 0032981996 scopus 로고    scopus 로고
    • Effects of castration and androgen replacement on erectile function in a rabbit model
    • Traish AM, Park K, Dhir V, Kim NN, Moreland RB, and Goldstein I. Effects of castration and androgen replacement on erectile function in a rabbit model. Endocrinology 140: 1861-1868, 1999.
    • (1999) Endocrinology , vol.140 , pp. 1861-1868
    • Traish, A.M.1    Park, K.2    Dhir, V.3    Kim, N.N.4    Moreland, R.B.5    Goldstein, I.6
  • 37
    • 0034884487 scopus 로고    scopus 로고
    • Erection and NO override the vasoconstrictive effect of α-adrenergic stimulation in the rat penile vasculature
    • Wingard CJ, Lewis R, and Mills TM. Erection and NO override the vasoconstrictive effect of α-adrenergic stimulation in the rat penile vasculature. Int J Impot Res 13: 1-9, 2001.
    • (2001) Int J Impot Res , vol.13 , pp. 1-9
    • Wingard, C.J.1    Lewis, R.2    Mills, T.M.3
  • 38
    • 0029557015 scopus 로고
    • Nitric oxide mediated erectile activity is a testosterone dependent event: A rat erection model
    • Zvara P, Sioufi R, Schipper HM, Begin LR, and Brock GB. Nitric oxide mediated erectile activity is a testosterone dependent event: a rat erection model. Int J Impot Res 7: 209-219, 1995.
    • (1995) Int J Impot Res , vol.7 , pp. 209-219
    • Zvara, P.1    Sioufi, R.2    Schipper, H.M.3    Begin, L.R.4    Brock, G.B.5


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