Use of photoaffinity labeling and site-directed mutagenesis for identification of the key residue responsible for extraordinarily high affinity binding of UCN-01 in human α1-acid glycoprotein

Journal of Biological Chemistry

Volumn 280, Issue 2, 2005, Pages 1384-1391

  Katsuki, Masaaki ^a   Chuang, Victor Tuan Giam ^a,b   Nishi, Koji ^a   Kawahara, Kohichi ^a   Nakayama, Hitoshi ^a   Yamaotsu, Noriyuki ^c   Hirono, Shuichi ^c   Otagiri, Masaki ^a,d  

^a KUMAMOTO UNIVERSITY   (Japan)

^b UNIVERSITI KEBANGSAAN MALAYSIA   (Malaysia)

^c KITASATO UNIVERSITY   (Japan)

^d KUMAMOTO UNIVERSITY   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

BINDING ENERGY; CHEMICAL MODIFICATION; PROTEINS; TOPOLOGY;

AFFINITY BINDING; MUTANTS; PHOTOAFFINITY LABELING; PHOTOINCORPORATION;

MUTAGENESIS;

7 HYDROXYSTAUROSPORINE; OROSOMUCOID; PARATHYROID HORMONE;

AMINO ACID SEQUENCE; ARTICLE; BINDING AFFINITY; CHEMICAL MODIFICATION; COVALENT BOND; DRUG BINDING; PHOTOAFFINITY LABELING; PRIORITY JOURNAL; SITE DIRECTED MUTAGENESIS; WILD TYPE;

AMINO ACID SEQUENCE; BINDING, COMPETITIVE; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; HUMANS; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; MUTAGENESIS, SITE-DIRECTED; MUTATION; OROSOMUCOID; PHOTOAFFINITY LABELS; PROTEIN BINDING; PROTEIN CONFORMATION; STAUROSPORINE; TIME FACTORS; TRYPSIN;

EID: 12544259594     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.M411076200     Document Type: Article

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