The Binding of Selected Therapeutic Drugs to Human Serum α-1 Acid Glycoprotein and to Human Serum Albumin In Vitro

Therapeutic Drug Monitoring

Volumn 26, Issue 1, 2004, Pages 40-43

  Bailey, David N ^a,b   Briggs, John R ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b UCSD MEDICAL CENTER   (United States)

Author keywords

1 acid glycoprotein; Albumin; Binding; Drugs; Equilibrium dialysis

Indexed keywords

ACUTE PHASE PROTEIN; DRUG BINDING PROTEIN; LIDOCAINE; OROSOMUCOID; PARACETAMOL; PHENOBARBITAL; PHENYTOIN; SERUM ALBUMIN; THEOPHYLLINE; VALPROIC ACID;

ACUTE PHASE RESPONSE; ARTICLE; BLOOD SAMPLING; CHRONIC INFLAMMATION; CHRONIC LIVER DISEASE; DRUG PROTEIN BINDING; DRUG RECEPTOR BINDING; EQUILIBRIUM DIALYSIS; ESTROGEN SYNTHESIS; HUMAN; LIVER METABOLISM; MALNUTRITION; NEPHROTIC SYNDROME; PRIORITY JOURNAL;

HUMANS; OROSOMUCOID; PHARMACEUTICAL PREPARATIONS; PROTEIN BINDING; SERUM ALBUMIN;

EID: 0942265374     PISSN: 01634356     EISSN: None     Source Type: Journal    
DOI: 10.1097/00007691-200402000-00009     Document Type: Article

References (18)

1. Kwong TC. Free drug measurements: methodology and clinical significance. Clin Chim Acta. 1985;151:193-216.
2. Soldin SJ. Free drug measurements. When and why? An overview. Arch Pathol Lab Med. 1999;123:822-823.
3. Paxton JW. Drug binding to plasma proteins. N Z Med J. 1985;98:245-248.
4. Levy RH, Moreland TA. Rationale for monitoring free drug levels. Clin Pharmacokinet. 1984;9(Suppl):1-9.
5. Piafsky KM. Disease-induced changes in the plasma binding of basic drugs. Clin Pharmacokinet. 1980;5:246-262.
6. Urien S, Albengres E, Zini R, et al. Evidence for binding of certain acidic drugs to alpha-1 acid glycoprotein. Biochem Pharmacol. 1982;31:3687-3689.
7. Pike E, Kierulf P, Skuterud B, et al. Drug binding in sera deficient in lipoproteins, albumin or orosomucoid. Br J Clin Pharmacol. 1983;16: 233-239.
8. Maruyama T, Otagiri M, Takadate A. Characterization of drug binding sites on alpha-1 acid glycoprotein. Chem Pharm Bull (Tokyo). 1990;38: 1688-1691.
9. Fournier T. Medjoubi-N N, Porquet D. Alpha-1 acid glycoprotein. Biochim Biophys Acta. 2000;1482:157-171.
10. Tietz NW. Clinical Guide to Laboratory Tests, 3rd ed. Philadelphia: WB Saunders; 1995:8, 22, 788, 840, 866, 878, 884.
11. Routledge PA, Stargel WW, Kitchell BB, et al. Sex-related differences in the plasma protein binding of lignocaine and diazepam. Br J Clin Pharmacol. 1981;11:245-250.
12. Wang HP, Chu CY. A solid-phase enzyme-linked immunosorbent assay for the quantitation of human plasma alpha-1 acid glycoprotein. Clin Chem. 1979;25:546-549.
13. Bailey DN. Cocaine and cocaethylene binding in human serum. Am J Clin Pathol. 1995;104:180-186.
14. Baselt RC. Disposition of Toxic Drugs and Chemicals in Man, 6th ed. Foster City, California: Biomedical Publications; 2002:5.
15. Israili ZH, Dayton PG. Human alpha-1-glycoprotein and its interactions with drugs. Drug Metab Rev. 2001;33:161-235.
16. Kratochwil NA, Huber W, Mueller F, et al. Predicting plasma protein binding of drugs: a new approach. Biochem Pharmacol. 2002;64:1355-1374.
17. Morse DS, Abernethy DR, Greenblatt DJ. Methodologic factors influencing plasma binding of alpha-1 acid glycoprotein-bound and albumin-bound drugs. Int J Clin Pharmacol Ther Toxicol. 1985;23:535-539.
18. Reijenga JC, Gaykema A, Mikkers FE. Determination of theophylline binding to human serum proteins by isotachophoresis. J Chromatogr. 1984;287:365-370.