Amino acid mutagenesis of the ligand binding site and the dimer interface of the metabotropic glutamate receptor 1: Identification of crucial residues for setting the activated state

Journal of Biological Chemistry

Volumn 278, Issue 6, 2003, Pages 4314-4321

  Sato, Toshihiro ^a   Shimada, Yoshimi ^a   Nagasawa, Naoko ^a   Nakanishi, Shigetada ^b   Jingami, Hisato ^a  

^a BIOMOL ENG RESEARCH INSTITUTE   (Japan)

^b KYOTO UNIVERSITY FACULTY OF MEDICINE   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

AMINO ACIDS; CALCIUM; CHEMICAL ACTIVATION; CONFORMATIONS; CRYSTAL STRUCTURE; DIMERS; INTERFACES (MATERIALS); MUTAGENESIS; PROTEINS; SUBSTITUTION REACTIONS;

LIGAND BINDING SITES;

BIOCHEMISTRY;

ALANINE; ALPHA AMINO ACID; AMINO ACID; ARGININE; ASPARTIC ACID; CALCIUM; CARBOXYL GROUP; DIMER; GLUTAMIC ACID; GLYCINE; INOSITOL PHOSPHATE; ISOLEUCINE; METABOTROPIC RECEPTOR; METABOTROPIC RECEPTOR 1; MUTANT PROTEIN; QUISQUALIC ACID; THREONINE; TYROSINE; UNCLASSIFIED DRUG; METABOTROPIC GLUTAMATE RECEPTOR TYPE 1; PRIMER DNA;

ALPHA HELIX; AMINO ACID SUBSTITUTION; ANIMAL CELL; ARTICLE; BINDING ASSAY; BINDING SITE; CONTROLLED STUDY; CRYSTAL STRUCTURE; GENE MUTATION; HUMAN; HUMAN CELL; LIGAND BINDING; MUTATIONAL ANALYSIS; NONHUMAN; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN BINDING; PROTEIN CONFORMATION; PROTEIN DOMAIN; PROTEIN FUNCTION; PROTEIN INDUCTION; PROTEIN PROTEIN INTERACTION; PROTEIN PURIFICATION; PROTEIN STRUCTURE; SIGNAL TRANSDUCTION; SITE DIRECTED MUTAGENESIS; STRUCTURE ANALYSIS; CELL LINE; CHEMICAL STRUCTURE; CHEMISTRY; DIMERIZATION; GENETICS; METABOLISM; MUTAGENESIS; NUCLEOTIDE SEQUENCE; RADIOASSAY;

ANIMALIA;

AMINO ACIDS; BASE SEQUENCE; BINDING SITES; CELL LINE; DIMERIZATION; DNA PRIMERS; HUMANS; MODELS, MOLECULAR; MUTAGENESIS; QUISQUALIC ACID; RADIOLIGAND ASSAY; RECEPTORS, METABOTROPIC GLUTAMATE;

EID: 0037423395     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.M210278200     Document Type: Article

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