Regional and age specific effects of zolpidem microinfusions in the substantia nigra on seizures

Epilepsy Research

Volumn 30, Issue 2, 1998, Pages 107-114

  Velíšková, Jana ^a   Löscher, Wolfgang ^b   Moshé, Solomon L ^a  

^a ALBERT EINSTEIN COLLEGE OF MEDICINE   (United States)

^b UNIVERSITY OF VETERINARY MEDICINE HANNOVER   (Germany)

Author keywords

Development; GABA; GABA(A) receptors; Rat; Seizures; Substantia nigra

Indexed keywords

BENZODIAZEPINE RECEPTOR; ZOLPIDEM;

4 AMINOBUTYRIC ACID BRAIN LEVEL; AGE; ANIMAL EXPERIMENT; ANTICONVULSANT THERAPY; ARTICLE; BRAIN REGION; CONTROLLED STUDY; DRUG RECEPTOR BINDING; MALE; MICROINJECTION; NONHUMAN; PRIORITY JOURNAL; RAT; SEIZURE; SUBSTANTIA NIGRA;

AGING; ANIMALS; ANTICONVULSANTS; CONVULSANTS; FLUROTHYL; HYPNOTICS AND SEDATIVES; MALE; MICROINJECTIONS; PYRIDINES; RATS; RATS, SPRAGUE-DAWLEY; RECEPTORS, GABA-A; SEIZURES; SUBSTANTIA NIGRA;

EID: 0344624855     PISSN: 09201211     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0920-1211(97)00096-X     Document Type: Article

References (44)

1. 3H]zolpidem binding in the rat brain: an imidazopyridine with agonist properties at central benzodiazepine receptors. Eur. J. Pharmacol. 130:1986;257-263.
2. Arbilla S., Depoortere H., George P., Langer S.Z. Pharmacological profile of the imidazopyridine zolpidem at benzodiazepine receptors and electrocorticogram in rats. Naunyn-Schmiedeberg's Arch. Pharmacol. 330:1985;248-251.
3. Benavides J., Peny B., Ruano D., Victorica J., Scatton B. Comparative autoradiographic distribution of central omega (benzodiazepine) modulatory site subtypes with high, intermediate, and low affinity for zolpidem and alpidem. Brain Res. 604:1993;240-250.
4. A receptors transiently expressed in HEK 293 cells. XII VIPHAR, Montreal, 1994.
5. Depoortere H., Zivkovic B., Lloyd K.G., Sanger D.J., Perrault G., Langer S.Z., Bartholini G. Zolpidem, a novel nonbenzodiazepine hypnotic. I. neuropharmacological and behavioral effects. J. Pharmacol. Exp. Ther. 237:1986;649-658.
6. Doble A., Martin I.L. Multiple benzodiazepine receptors: no reason for anxiety. Trends Pharmacol. Sci. 13:1992;76-81.
7. A receptors in rat brain. Neuroscience. 64:1995;1113-1128.
8. Gale K. Mechanisms of seizure control mediated by γ-aminobutyric acid: a role of the substantia nigra. Fed. Proc. Fed. Am. Soc. Exp. Biol. 44:1985;2414-2424.
9. Hajós M., Greenfield S.A. Topographic heterogeneity of substantia nigra neurons: diversity in intrinsic membrane properties and synaptic inputs. Neuroscience. 55:1993;919-934.
10. Heyer E.J., Nowak L.M., Macdonald R.L. Bicuculline: A convulsant with synaptic and nonsynaptic actions. Neurology. 31:1981;1381-1390.
11. Hunkeler W., Möhler H., Pieri L., Polc P., Bonetti E.P., Cumin R., Schaffner R., Haefely W. Selective antagonists of benzodiazepines. Nature. 290:1981;514-516.
12. Iadarola M.J., Gale K. Substantia nigra: site of anticonvulsant activity mediated by γ-aminobutyric acid. Science. 218:1982;1237-1240.
13. Krogsgaard-Larsen P. THIP, a specific and clinically active GABA agonist. Neuropharmacology. 23:1984;837-838.
14. A receptor subunits expressed in xenopus oocytes. Neuron. 1:1988;773-781.
15. A receptor heterogeneity. Nature. 335:1988;76-79.
16. Lo M.M.S., Niehoff D.L., Kuhar M.J., Snyder S.H. Differential localization of type I and type II benzodiazepine binding sites in substantia nigra. Let. Nat. 306:1983;57-60.
17. Löscher W., Schwark W.S. Evidence for impaired GABA-ergic activity in the substantia nigra in amygdaloid kindled rats. Brain Res. 339:1985;146-150.
18. McCabe R.T., Wamsley J.K. Autoradiographic localization of subcomponents of the macromolecular GABA receptor complex. Life Sci. 39:1986;1937-1945.
19. Meldrum, B.S., 1981. GABA-agonists as antiepileptic agents. In: Costa, E. (Ed.), GABA and Benzodiazepine Receptor. Raven Press, New York, pp. 207-217.
20. A receptor populations with novel subunit combinations and drug binding profiles identified in brain by α5- and δ-subunit-specific immunopurification. J. Biol. Chem. 268:1993;5965-5973.
21. Moshé S.L., Albala B.J. Nigral muscimol infusions facilitate the development of seizures in immature rats. Dev. Brain Res. 13:1984;305-308.
22. Moshé S.L., Brown L.L., Kubová H., Velíšková J., Zukin R.S., Sperber E.F. Maturation and segregation of brain networks that modify seizures. Brain Res. 665:1994;141-146.
23. A/benzodiazepine receptors in the substantia nigra of the rat. Neuroscience. 50:1992;355-370.
24. Niemi, U.J., Redgrave, P., Westby, G.W.M., 1994. Regional variation in the effects of nigral GABA on collicular neuronal activity: implications for the role of the nigrotectal pathway. Eur. J. Neurosci. (Suppl. 7), 213.
25. A receptor subtypes: autoradiographic comparison of GABA, benzodiazepine, and convulsant binding sites in the rat central nervous system. J. Chem. Neuroanat. 3:1990;59-76.
26. 3H-bicuculline methochloride. Eur. J. Pharmacol. 99:1983;247-248.
27. 3H] bicuculline methochloride. Eur. J. Pharmacol. 99:1984;247-248.
28. Palacios J.M., Wamsley J.K., Kuhar M.J. High affinity GABA receptors-autoradiographic localization. Brain Res. 222:1981;285-330.
29. Paxinos, G., Watson, C., 1986. The rat brain in stereotaxic coordinates, second ed. Academic Press, Orlando.
30. Pritchett D.B., Seeburg P.H. γ-aminobutyric acidA receptor α5-subunit creates novel type II benzodiazepine receptor pharmacology. J. Neurochem. 54:1990;1802-1804.
31. Puia G., Vicini S., Seeburg P.H., Costa E. Influence of recombinant g-aminobutyric acid-A receptor subunit composition on the action of allosteric modulators of γ-aminobutyric acid-gated Cl-currents. Mol. Pharmacol. 39:1991;691-696.
32. Sanger D.J., Benavides J., Perrault G., Morel E., Cohen C., Joly D., Zivkovic B. Recent developments in the behavioral pharmacology of benzodiazepine (omega) receptors: evidence for the functional significance of receptor subtypes. Neurosci. Biobehav. Rev. 18:1994;355-372.
33. Saxena N.C., Macdonald R.L. Properties of putative cerebellar γ-aminobutyric acid A receptor isoforms. Mol. Pharmacol. 49:1996;567-579.
34. A receptors on channel function. Neuron. 5:1990;703-711.
35. Sperber E.F., Wong B.Y., Wurpel J.N.D., Moshé S.L. Nigral infusions of muscimol or bicuculline facilitate seizures in developing rats. Dev. Brain Res. 37:1987;243-250.
36. Turski L., Klockgether T., Schwartz M., Turski W.A., Sontag K.-H. Substantia nigra: a site of actions of muscle relaxant drugs. Ann. Neurol. 28:1990;341-348.
37. Unnerstall J.R., Kuhar M.J., Niehoff D.L., Palacios J.M. Benzodiazepine receptors are coupled to a subpopulation of GABA receptors: Evidence from a quantitative autoradiographic study. J. Pharm. Exp. Ther. 218:1981;797-804.
38. Velíšek L., Velíšková J., Ptachewich Y., Ortíz J., Shinnar S., Moshe S.L. Age-dependent effects of GABA agents on flurothyl seizures. Epilepsia. 36:1995;636-643.
39. Velíšková J., Velíšek L., Moshé S.L. Subthalamic nucleus: A new anticonvulsant site in the brain. Neuroreport. 7:1996;1786-1788.
40. A receptors involved in seizures. Eur. J. Pharmacol. 309:1996;167-173.
41. A receptors depend upon subunit composition. Neuron. 4:1990;919-928.
42. Wafford K., Whiting P., Kemp J. Differences in affinity and efficacy of benzodiazepine receptor ligands at recombinant g-aminobutyric acid A receptor subtypes. Mol. Pharmacol. 43:1992;240-244.
43. Wurpel J.N.D., Tempel A., Sperber E.F., Moshé S.L. Age-related changes of muscimol binding in the substantia nigra. Dev. Brain Res. 43:1988;305-308.
44. Yakushiji T., Shirasaki T., Munakata M., Hirata A., Akaike N. Differential properties of type I and type II benzodiazepine receptors in mammalian CNS neurons. Brit. J. Pharmacol. 109:1993;819-825.