Respiratory rhythm generation in neonatal and adult mammals: The hybrid pacemaker-network model

Respiration Physiology

Volumn 122, Issue 2-3, 2000, Pages 131-147

  Smith, Jeffrey C ^a   Butera Jr, Robert J ^b   Koshiya, Naohiro ^a   Del Negro, Christopher ^a   Wilson, Christopher G ^a   Johnson, Sheree M ^a  

^a Sect Clin and Exp Neuropsychol   (United States)

^b GEORGIA INSTITUTE OF TECHNOLOGY   (United States)

Author keywords

Adult mammals; Hybrid pacemaker network model; Neonatal mammals; Respiratory rhythm generation

Indexed keywords

ADULT; BREATHING RATE; CONFERENCE PAPER; ELECTROPHYSIOLOGY; HUMAN; MATHEMATICAL MODEL; NEGATIVE FEEDBACK; NEWBORN; NONHUMAN; PACEMAKER; PACEMAKER NERVE CELL; PRIORITY JOURNAL; REVIEW; SIMULATION;

ANIMALS; ANIMALS, NEWBORN; BIOLOGICAL CLOCKS; HUMANS; MODELS, BIOLOGICAL; NEURAL NETWORKS (COMPUTER); RESPIRATORY MECHANICS; RESPIRATORY SYSTEM;

EID: 0034284937     PISSN: 00345687     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0034-5687(00)00155-9     Document Type: Conference Paper

References (64)

1. Balis U.J, Morris K.F., Lindsay B.G. Simulations of a ventrolateral medullary neural network for respiratory rhythmogenesis inferred from spike train cross-correlation. Biol. Cybern. 70:1994;311-327.
2. Bianchi A.L., Denavit-Saubié M., Champagnat J. Central control of breathing in mammals: neuronal circuitry, membrane properties, and neurotransmitters. Physiol. Rev. 75:1995;1-45.
3. Botros S.M., Bruce E.N. Neural network implementation of the three-phase model of respiratory rhythm generation. Biol. Cybern. 63:1990;143-153.
4. Brochus J., Ballanyi K. Synaptic inhibition in the isolated respiratory network of neonatal rats. Eur. J. Neurosci. 10:1988;3823-3829.
5. Büsselberg D., Bishoff A., Lalley P.M., Richter D.W. Rhythm generation after disturbance of synaptic inhibition in the respiratory network. Soc. Neurosci. Abstr. 25:1999;279.
6. Butera R.J., Rinzel J., Smith J.C. Models of respiratory rhythm generation in the pre-Bötzinger complex. I. Bursting pacemaker neurons. J. Neurophysiol. 81:1999;382-397.
7. Butera R.J., Rinzel J., Smith J.C. Models of respiratory rhythm generation in the pre-Bötzinger complex. II. Populations of coupled pacemaker neurons. J. Neurophysiol. 81:1999;398-415.
8. Butera R.J., Wilson C.G., Rinzel J., Smith J.C. Burst generating mechanisms of pre-Bötzinger complex pacemaker neurons: tests with the dynamic clamp. Soc. Neurosci. Abstr. 25:1999;696.
9. Del Negro C.A., Butera R.J., Rinzel J., Smith J.C. Role of excitatory synaptic coupling and cellular heterogeneity in respiratory rhythm generation in the pre-Bötzinger complex. Soc. Neurosci. Abstr. 25:1999;696.
10. Duffin J. A model of respiratory rhythm generation. NeuroReport. 2:1991;623-626.
11. Ezure K. Synaptic connections between medullary respiratory neurons and considerations on the genesis of respiratory rhythm. Prog. Neurobiol. 35:1990;429-450.
12. Feldman J.L., Smith J.C. Cellular mechanisms underlying modulation of breathing pattern in mammals. Ann. New York Acad. Sci. 563:1989;114-130.
13. Feldman J.L, Smith J.C. Neural control of respiratory pattern in mammals: An overview. Dempsey J.A., Pack A.I. Regulation of Breathing. 1995;39-69 Marcel Dekker, New York.
14. Funk G.D., Smith J.C., Feldman J.L. Generation and transmission of respiratory oscillations in medullary slices: role of excitatory amino acids. J. Neurophysiol. 70:1993;1497-1515.
15. Funk G.D., Feldman J.L. Generation of respiratory rhythm and pattern in mammals: Insights from developmental studies. Curr. Opin. Neurobiol. 5:1995;778-785.
16. Gray P.A., Rekling J.C., Bocchiaro C.M., Feldman J.L. Modulation of respiratory frequency by peptidergic input to rhythmogenic neurons in the preBötzinger complex. Science. 286:1999;1566-1568.
17. Greer J.J., Carter J.E., Allan D.W. Respiratory rhythm generation in a precocial rodent in vitro preparation. Respir. Physiol. 103:1996;105-112.
18. Hilaire G., Duron B. Maturation of the mammalian respiratory system. Physiol. Rev. 79:1999;325-360.
19. Hayashi F., Lipski J. The role of inhibitory amino acids in control of respiratory motor output in an arterially perfused rat. Respir. Physiol. 89:1992;47-63.
20. Johnson S.M., Smith J.C., Funk G.D., Feldman J.L. Pacemaker behavior of respiratory neurons in medullary slices from neonatal rat. J. Neurophysiol. 72:1994;2598-2608.
21. Johnson S.M., Smith J.C., Feldman J.L. Modulation of respiratory rhythm in vitro. Role of Gi/o-protein regulated conductances. J. Appl. Physiol. 80:1996;2120-2133.
22. Johnson S.M., Trouth C.O., Smith J.C. Chemosensitivity of respiratory pacemaker neurons in the pre-Bötzinger complex in vitro. Soc. Neurosci. Abstr. 24:1999;875.
23. Johnson, S.M., Del Negro, C., Koshiya, N., Smith, J.C., 2000. Characterization and modulation of the spontaneous respiratory rhythm generated in a novel in vitro preparation: the pre-Bötzinger complex 'island'. FASEB Abstr. 14, A642.
24. Klages S., Bellingham M.C., Richter D.W. Late expiratory inhibition of stage 2 expiratory neurons in the cat - a correlate of expiratory termination. J. Neurophysiol. 70:1993;1305-1307.
25. Koch C., Segev I. Methods in Neuronal Modeling. 2nd edn :1998;MIT Press, Cambridge, MA.
26. Koshiya N., Guyenet P.G. Tonic sympathetic chemoreflex after blockade of respiratory rhythmogenesis in the rat. J. Physiol. Lond. 491:1996;859-869.
27. Koshiya N., Smith J.C. Neuronal pacemaker for breathing visualized in vitro. Nature. 400:1999;360-363.
28. Koshiya N., Smith J.C. Subthreshold-activating persistent sodium conductance (gNaP) in inspiratory neurons of the pre-Botzinger complex in vitro. Soc. Neurosci. Abstr. 25:1999;696.
29. Marder E., Calabrese R. Principles of rhythmic motor pattern generation. Physiol. Rev. 76:1996;687-717.
30. Matsugu M., Duffin J., Poon C.S. Entrainment, instability, quasi-periodicitiy, and chaos in a compound neural oscillator. J. Comput. Neurosci. 5:1998;35-51.
31. Nelson M., Rinzel J. The Hodgkin-Huxley model. Bower J.M., Beeman D. The Book of Genesis. Exploring Realistic Neural Models with the GEneral NEural SImulation System. 1995;29-51 Springer, New York.
32. Ogilvie M.D., Gottschalk A., Anders K., Richter D.W., Pack A.I. A network model of respiratory rhythmogenesis. Am. J. Physiol. 263:1992;R962-R975. (Regul. Integr. Comp. Physiol. 32).
33. Onimaru H., Ballanyi K, Richter D.W. Calcium-dependent responses in neurons of the isolated respiratory network of newborn rats. J. Physiol. Lond. 491:1996;677-695.
34. Pierrefiche O., Schwarzacher S.W., Bishoff A.M., Richter D.W. Blockade of synaptic inhibition within the pre-Bötzinger complex in the cat suppresses respiratory rhythm generation in vivo. J. Physiol. Lond. 509:1998;245-254.
35. Ramirez J.-M., Richter D.W. The neuronal mechanisms of respiratory rhythm generation. Curr. Opin. Neurobiol. 6:1996;817-825.
36. Ramirez J.-M., Quellmalz U.J.A., Richter D.W. Postnatal changes in the mammalian respiratory network as revealed by the transverse brainstem slice of mice. J. Physiol. Lond. 491:1996;799-812.
37. Ramirez J.-M., Telgkamp P., Elsen F.P., Quellmalz U.J.A., Richter D.W. Respiratory rhythm generation in mammals: synaptic and membrane properties. Respir. Physiol. 110:1997;71-85.
38. Ramirez J.-M., Schwarzacher S.W., Pierrefiche O., Olivera B.M., Richter D.W. Selective lesioning of the cat pre-Bötzinger complex in vivo eliminates breathing but not gasping. J. Physiol. Lond. 507:1998;895-907.
39. Rekling J.C., Feldman J.L. PreBötzinger complex and pacemaker neurons: hypothesized site and kernel for respiratory rhythm generation. Annu. Rev. Physiol. 60:1998;385-405.
40. Richter D.W. Neural regulation of respiration: rhythmogenesis and afferent control. Greger R., Windhorst U. Comprehensive Human Physiology. 2:1996;2079-2095 Springer, Heidelberg.
41. Richter D.W., Ballantyne D., Remmers J.E. Respiratory rhythm generation: a model. News Physiol. Sci. 1:1986;109-112.
42. Richter D.W., Ballanyi K., Schwarzacher S. Mechanisms of respiratory rhythm generation. Curr. Opin. Neurobiol. 2:1992;788-793.
43. Rigatto H., Wilson C.G., Koshiya N., House S., Smith J.C. Stationary organotypic culture of the pre-Bötzinger complex from the newborn rat. Soc. Neurosci. Abstr. 25:1999;696.
44. Rybak I.A., Paton J.F.R., Schwaber J.S. Modeling neural mechanisms for genesis of respiratory rhythm and pattern. I. Models of respiratory neurons. J. Neurophysiol. 77:1997;1994-2006.
45. Rybak I.A., Paton J.F.R., Schwaber J.S. Modeling neural mechanisms for genesis of respiratory rhythm and pattern. II. Network models of the central respiratory pattern generator. J. Neurophysiol. 77:1997;2007-2026.
46. Segers L.S., Shannon R., Saporta S., Lindsey B.G. Functional associations among simultaneously monitored lateral medullary respiratory neurons in the cat. I. Evidence for excitatory and inhibitory interactions of inspiratory neurons. J. Neurophysiol. 57:1987;1078-1100.
47. Schwarzacher S.W., Smith J.C., Richter D.W. Pre-Bötzinger complex in the cat. J. Neurophysiol. 73:1995;1452-1461.
48. Shao X.M., Feldman J.L. Respiratory rhythm generation and synaptic inhibition of expiratory neurons in pre-Botzinger complex: differential roles of glycinergic and GABAergic neural transmission. J. Neurophysiol. 77:1997;1853-1860.
49. Singer J.H., Talley E.M., Bayliss D.A., Berger A.J. Development of glycinergic synaptic transmission to rat brain stem motoneurons. J. Neurophysiol. 80:1998;2608-2620.
50. Smith J.C. New computational models of the respiratory oscillator in mammals. Semple S., Guz A., Adams L. Modeling and Control of Ventilation. 1995;7-13 Plenum, New York.
51. Smith J.C. Realistic computational models of respiratory neurons and networks. Khoo M.C.K. Bioengineering Approaches to Pulmonary Physiology and Medicine. 1996;77-92 Plenum, pp, New York.
52. Smith J.C. Integration of cellular and network mechanisms in mammalian oscillatory motor circuits: insights from the respiratory oscillator. Stein P., Grillner S., Selverston A.I., Stuart D.G. Neurons, Networks, and Motor Behavior. 1997;97-104 MIT Press, Cambridge, MA.
53. Smith J.C., Greer J.J., Liu G., Feldman J.L. Neural mechanisms generating respiratory pattern in mammalian brain stem-spinal cord in vitro. I. Spatiotemporal patterns of motor and medullary neuron activity. J. Neurophysiol. 64:1990;1149-1169.
54. Smith J.C., Ellenberger H.H., Ballanyi K., Richter D.W., Feldman J.L. Pre-Bötzinger complex: a brainstem region that may generate respiratory rhythm in mammals. Science. 254:1991;726-729.
55. Smith J.C., Funk G.D., Johnson S.M., Feldman J.L. Cellular and synaptic mechanisms generating respiratory rhythm: insights from in vitro and computational studies. Trouth C.O., Millis R.M., Kiwull-Schöne H., Schläfke M.E. Ventral Brainstem Mechanisms and Control of Respiration and Blood Pressure. 1995;463-496 Marcel Dekker, New York.
56. Smith J.C., Koshiya N., Simon E. Generation of respiratory oscillations after disruption of inhibitory neurotransmission during postnatal development: in vitro and in vivo studies with mutant and normal mice. Soc. Neurosci. Abstr. 22:1996;1596.
57. Smith J.C., Koizumi H., Koshiya N., Wilson C.G. The neuronal kernel for respiratory rhythm generation studied in thin transverse medullary slice preparations in vitro. Soc. Neurosci. Abstr. 23:1997;1253.
58. Stein P.G., Grillner S., Selverston A.I., Stuart D.G. Neurons, Networks, and Motor Behavior. 1997;MIT Press, Cambridge, MA.
59. Solomon I.C., Edelman N.H., Newbauer J.A. Patterns of phrenic motor output evoked by chemical stimulation of neurons located in the pre-Bötzinger complex in vivo. J. Neurophysiol. 81:1999;1150-1161.
60. St.-Jacques R., St.-John W.M. Transient, reversible apnoea following ablation of the pre-Bötzinger complex in rats. J. Physiol. Lond. 520:1999;303-314.
61. St.-John W.M. Neurogenesis of patterns of automatic ventilatory activity. Prog. Neurobiol. 56:1998;97-117.
62. Sun Q.J., Goodchild A.K., Chalmer J.P., Pilowsky P.M. The pre-Bötzinger complex and phase-spanning neurons in the adult rat. Brain Res. 809:1998;204-213.
63. Thoby-Brisson M., Telgkamp P., Ramirez J.-M. The role of hyperpolarization-activated current in modulating rhythmic activity in the isolated respiratory network of mice. J. Neurosci. 20:2000;2994-3005.
64. Xia Y., Haddad G. Ontogeny and distribution of GABAA receptors in rat brain stem and rostral brain regions. Neuroscience. 49:1992;973-989.