Down-regulation of N-type voltage-activated Ca2+ channels by gabapentin

Cellular and Molecular Neurobiology

Volumn 22, Issue 2, 2002, Pages 185-190

  Vega Hernández, Alfonso ^a   Felix, Ricardo ^a  

^a DEPARTAMENTO DE FÍSICA   (Mexico)

Author keywords

Ca2+ channels; Gabapentin; PC12 cells; conotoxin GVIA

Indexed keywords

CALCIUM CHANNEL; CALCIUM ION; GABAPENTIN; RECEPTOR SUBUNIT;

ANIMAL CELL; ANTICONVULSANT ACTIVITY; ARTICLE; CALCIUM CURRENT; CELL STRAIN; CHANNEL GATING; DOWN REGULATION; DRUG EFFECT; LIGAND BINDING; LONG TERM EXPOSURE; NONHUMAN; PRIORITY JOURNAL; RECEPTOR DOWN REGULATION;

ACETIC ACIDS; ACTION POTENTIALS; AMINES; AMINO ACID TRANSPORT SYSTEM L; ANIMALS; ANTICONVULSANTS; BRAIN; CALCIUM; CALCIUM CHANNELS, N-TYPE; CALCIUM SIGNALING; CELL MEMBRANE; CYCLOHEXANECARBOXYLIC ACIDS; DOWN-REGULATION; EPILEPSY; GAMMA-AMINOBUTYRIC ACID; NEURAL INHIBITION; NEURONS; OMEGA-CONOTOXINS; RATS; TUMOR CELLS, CULTURED;

ANIMALIA;

EID: 0036553731     PISSN: 02724340     EISSN: None     Source Type: Journal    
DOI: 10.1023/A:1019865822069     Document Type: Article

References (17)

1. Alden, K. J., and Garcia, J. (2001). Differential effect of gabapentin on neuronal and muscle calcium currents. J. Pharmacol. Exp. Ther. 297:727-735.
2. 2δ auxiliary subunit: Structure, function and regulation. Receptors Channels 6:351-362.
3. 2δ subunit of a calcium channel. J. Biol. Chem. 271:5768-5776.
4. 2δ subunit in current stimulation and subunit interaction. Neuron 16:431-440.
5. 2+ channels in PC12 cells. J. Neurosci. 16:7557-7565.
6. 2δ subunits-structure and Gabapentin binding. Mol. Pharmacol. 59:1243-1248.
7. McLean, M. J. (1995). Gabapentin. Epilepsia 36(Suppl. 2):S73-S86.
8. Rock, D. M., Kelly, K. C., and Macdonald, R. L. (1993). Gabapentin actions on ligand- and voltage-gated responses in culture rodent neurons. Epilepsy Res. 16:89-98.
9. Stefani, A., Spadoni, F., and Bernardi, G. (1998). Gabapentin inhibits calcium currents in isolated rat brain neurons. Neuropharmacology 37:83-91.
10. Stefani, A., Spadoni, F., Giacomini, P., Lavaron, F., and Bernardi, G. (2001). The effects of gabapentin on different ligand- and voltage-gated currents in isolated cortical neurons. Epilepsy Res. 43:239-248.
11. Sutton, K. G., Martin, D. J., Pinnock, R. D., Lee, K., and Scott, R. H. (2002). Gabapentin inhibits high-threshold calcium channel currents in cultured rat dorsal root ganglion neurones. Br. J. Pharmacol. 135:257-265.
12. + channels in a voltage-dependent manner but gabapentin does not. Soc. Neurosci. Abst. 19:1631.
13. Taylor, C. P., Gee, N. S., Su, T. Z., Kocsis, J. D., Welty, D. F., Brown, J. P., Dooley, D. J., Boden, P., and Singh, L. (1998). A summary of mechanistic hypotheses of gabapentin pharmacology. Epilepsy Res. 29:233-249.
14. 2+ channels in rat phaeochromocytoma cell lines. J. Physiol. 426:95-116.
15. Wamil, A. W., and McLean, M. J. (1994). Limitation by gabapentin of high-frequency action potential firing by mouse central neurons in cell culture. Epilepsy Res. 17:1-11.
16. 2δ for gabapentin binding. Biochem. J. 342:313-320.
17. + channel expressed in a stable mammalian cell line. Pflugers Arch. 441:425-433.