Carbamazepine pharmacokinetics-pharmacodynamics in genetically epilepsy-prone rats

European Journal of Pharmacology

Volumn 369, Issue 3, 1999, Pages 305-311

  Graumlich, James F ^a   McLaughlin, Richard G ^a   Birkhahn, Donna ^a   Shah, Neha ^a   Burk, Annette ^a   Jobe, Phillip C ^a   Dailey, John W ^a  

^a UNIVERSITY OF ILLINOIS AT URBANA CHAMPAIGN   (United States)

Author keywords

Anticonvulsant; Carbamazepine; Epilepsy; Focal administration; Genetically epilepsy prone rat; Hippocampus; Microdialysis; Pharmacodynamics; Pharmacokinetics; Seizure

Indexed keywords

CARBAMAZEPINE; CARBAMAZEPINE 10,11 OXIDE; SEROTONIN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; AREA UNDER THE CURVE; ARTICLE; AUDIOGENIC SEIZURE; CONTROLLED STUDY; DRUG BLOOD LEVEL; DRUG METABOLISM; ELECTRIC SHOCK; EPILEPSY; GENETIC DISORDER; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HIPPOCAMPUS; INTRACEREBRAL DRUG ADMINISTRATION; INTRAPERITONEAL DRUG ADMINISTRATION; MICRODIALYSIS; NONHUMAN; PRIORITY JOURNAL; RAT; SEROTONIN RELEASE; STRAIN DIFFERENCE;

ACOUSTIC STIMULATION; ANIMALS; ANTICONVULSANTS; AREA UNDER CURVE; CARBAMAZEPINE; DOSE-RESPONSE RELATIONSHIP, DRUG; EPILEPSY; HALF-LIFE; HIPPOCAMPUS; INJECTIONS, INTRAPERITONEAL; MICRODIALYSIS; RATS; RATS, SPRAGUE-DAWLEY; SEROTONIN; SPECIES SPECIFICITY;

EID: 0032916535     PISSN: 00142999     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0014-2999(99)00083-7     Document Type: Article

References (33)

1. Browning, R.A., 1987. The role of neurotransmitters in electroshock seizure models. In: Jobe, P.C., Laird, H.E. (Eds.), Neurotransmitters and Epilepsy. Humana Press, Clifton, NJ, p. 277.
2. Browning R.A., Wang C., Lanker M.L., Jobe P.C. Electroshock- and pentylenetetrazol-induced seizures in genetically epilepsy-prone rats (GEPRs): differences in threshold and pattern. Epilepsy Res. 6:1990;1-11.
3. Dailey J.W., Jobe P.C. Anticonvulsant drugs and the genetically epilepsy-prone rat. Fed. Proc. 44:1985;2640-2644.
4. Dailey J.W., Reigel C.E., Mishra P.K., Jobe P.C. Neurobiology of seizure predisposition in the genetically epilepsy-prone rat. Epilepsy Res. 3:1989;3-17.
5. Dailey J.W., Yan Q.S., Mishra P.K., Burger R.L., Jobe P.C. Effects of fluoxetine on convulsions and on brain serotonin as detected by microdialysis in genetically epilepsy-prone rats. J. Pharmacol. Exp. Ther. 260:1992;533-540.
6. Dailey J.W., Seo D., Yan Q.S., Ko K., Jo M., Jobe P.C. The anticonvulsant effect of the broad spectrum anticonvulsant loreclezole may be mediated in part by serotonin in rats: a microdialysis study. Neurosci. Lett. 178:1994;179-183.
7. Dailey J.W., Cheong J.H., Ko K.H., Adams-Curtis L.E., Jobe P.C. Anticonvulsant properties of D-20443 in genetically epilepsy-prone rats: prediction of clinical response. Neurosci. Lett. 195:1995;77-80.
8. Dailey J.W., Yan Q.S., Adams-Curtis L.E., Ryu J.R., Ko K.H., Mishra P.K., Jobe P.C. Neurochemical correlates of antiepileptic drugs in the genetically epilepsy-prone rat (GEPR). Life Sci. 58:1996;259-266.
9. Dailey J.W., Reith M.E., Yan Q.S., Li M.Y., Jobe P.C. Anticonvulsant doses of carbamazepine increase hippocampal extracellular serotonin in genetically epilepsy-prone rats: dose response relationships. Neurosci. Lett. 227:1997;13-16.
10. Dailey J.W., Reith M.E., Yan Q.S., Li M.Y., Jobe P.C. Carbamazepine increases extracellular serotonin concentration: lack of antagonism by tetrodotoxin or zero Ca2+. Eur. J. Pharmacol. 328:1997;153-162.
11. Dailey J.W., Reith M.E., Steidley K.R., Milbrandt J.C., Jobe P.C. Carbamazepine-induced release of serotonin from rat hippocampus in vitro. Epilepsia. 39:1998;1054-1063.
12. Garg S.K., Kumar N., Bhargava V.K., Prabhakar S.K. Effect of grapefruit juice on carbamazepine bioavailability in patients with epilepsy. Clin. Pharmacol. Ther. 64:1998;286-288.
13. Jobe P.C., Picchioni A.L., Chin L. Role of brain norepinephrine in audiogenic seizure in the rat. J. Pharmacol. Exp. Ther. 184:1973;1-10.
14. Jobe P.C., Dailey J.W., Reigel C.E. Noradrenergic and serotonergic determinants of seizure susceptibility and severity in genetically epilepsy-prone rats. Life Sci. 39:1986;775-782.
15. Kaneko S., Okada M., Hirano T., Kondo T., Otani K., Fukushima Y. Carbamazepine and zonisamide increase extracellular dopamine and serotonin levels in vivo, and carbamazepine does not antagonize adenosine effect in vitro: mechanisms of blockade of seizure spread. Jpn. J. Psychiatry Neurol. 47:1993;371-373.
16. Lindefors N., Amberg G., Ungerstedt U. Intracerebral microdialysis: I. Experimental studies of diffusion kinetics. J. Pharmacol. Methods. 22:1989;141-156.
17. Macdonald R.L., McLean M.J. Anticonvulsant drugs: mechanisms of action. Adv. Neurol. 44:1986;713-736.
18. McLean M.J., Macdonald R.L. Carbamazepine and 10,11-epoxycarbamazepine produce use- and voltage-dependent limitation of rapidly firing action potentials of mouse central neurons in cell culture. J. Pharmacol. Exp. Ther. 238:1986;727-738.
19. Okada M., Kaneko S., Hirano T., Ishida M., Kondo T., Otani K., Fukushima Y. Effects of zonisamide on extracellular levels of monoamine and its metabolite, and on Ca-2+ dependent dopamine release. Epilepsy Res. 13:1992;113-119.
20. Paxinos, G., Watson C., 1986. The Rat Brain in Stereotaxic Coordinates. Academic Press Australia, Sydney, Australia, p. vii.
21. Reigel C.E., Dailey J.W., Jobe P.C. The genetically epilepsy-prone rat: an overview of seizure-prone characteristics and responsiveness to anticonvulsant drugs. Life Sci. 39:1986;763-774.
22. Remmel R.P., Sinz M.W., Cloyd J.C. Dose-dependent pharmacokinetics of carbamazepine in rats: determination of the formation clearance of carbamazepine-10,11-epoxide. Pharm. Res. 7:1990;513-517.
23. Rogawski M.A., Porter R.J. Antiepileptic drugs: pharmacological mechanisms and clinical efficacy with consideration of promising developmental stage compounds. Pharmacol. Rev. 42:1990;223-286.
24. Sawchuk R.J., Cartier L.L. Simultaneous liquid-chromatographic determination of carbamazepine and its epoxide metabolite in plasma. Clin. Chem. 28:1982;2127-2130.
25. Scheyer R.D., During M.J., Cramer J.A., Toftness B.R., Hochholzer J.M., Mattson R.H. Simultaneous HPLC analysis of carbamazepine and carbamazepine epoxide in human brain microdialysate. Journal of Liquid Chromatography. 17:1994;1567-1576.
26. Southam E., Kirkby D., Higgins G.A., Hagan R.M. Lamotrigine inhibits monoamine uptake in vitro and modulates 5-hydroxytryptamine uptake in rats. Eur. J. Pharmacol. 359:1998;19-24.
27. van Belle K., Dzeka T., Sarre S., Ebinger G., Michotte Y. In vitro and in vivo microdialysis calibration for the measurement of carbamazepine and its metabolites in rat brain tissue using the internal reference technique. J. Neurosci. Methods. 49:1993;167-173.
28. van Belle K., Sarre S., Ebinger G., Michotte Y. Brain, liver and blood distribution kinetics of carbamazepine and its metabolic interaction with clomipramine in rats - a quantitative microdialysis study. J. Pharmacol. Exp. Ther. 272:1995;1217-1222.
29. van Belle K., Sarre S., Ebinger G., Michotte Y. Quantitative microdialysis for the in vivo measurement of carbamazepine, oxcarbazepine and their major metabolites in rat brain- and liver tissue and in blood using the internal standard technique. European Journal of Pharmaceutical Sciences. 3:1995;273-280.
30. White H.S. Clinical significance of animal seizure models and mechanism of action studies of potential antiepileptic drugs. Epilepsia. 38:1997;S9-S17. Suppl. 1.
31. Whitton P.S., Fowler L.J. The effect of valproic acid on 5-hydroxytryptamine and 5- hydroxyindoleacetic acid concentration in hippocampal dialysates in vivo. Eur. J. Pharmacol. 200:1991;167-169.
32. Wong Y.Y., Ludden T.M., Bell R.D. Effect of erythromycin on carbamazepine kinetics. Clin. Pharmacol. Ther. 33:1983;460-464.
33. Yan Q.S., Mishra P.K., Burger R.L., Bettendorf A.F., Jobe P.C., Dailey J.W. Evidence that carbamazepine and antiepilepsirine may produce a component of their anticonvulsant effects by activating serotonergic neurons in genetically epilepsy-prone rats. J. Pharmacol. Exp. Ther. 261:1992;652-659.