The effects of N-methyl-D-aspartate antagonist 2-amino-7-phosphonoheptanoic acid microinfusions into the adult male rat substantia nigra pars reticulata are site-specific

Neuroscience Letters

Volumn 316, Issue 2, 2001, Pages 108-110

  Velíšková, Jana ^a   Liptáková, Soa ^a   Hussain, Shaun ^a  

^a ALBERT EINSTEIN COLLEGE OF MEDICINE   (United States)

Author keywords

Localized microinfusions; N methyl D aspartate receptor antagonist; Rat; Seizures; Substantia nigra pars reticulata

Indexed keywords

2 AMINO 7 PHOSPHONOHEPTANOIC ACID; ANTICONVULSIVE AGENT; FLUROTHYL; GLUTAMINE; N METHYL DEXTRO ASPARTIC ACID RECEPTOR BLOCKING AGENT;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTICONVULSANT ACTIVITY; ARTICLE; BRAIN REGION; CLONIC SEIZURE; CONTROLLED STUDY; DOSE RESPONSE; DRUG EFFECT; DRUG INFUSION; MALE; NONHUMAN; PRIORITY JOURNAL; SEIZURE THRESHOLD; SUBSTANTIA NIGRA;

2-AMINO-5-PHOSPHONOVALERATE; ANIMALS; CONVULSANTS; DOSE-RESPONSE RELATIONSHIP, DRUG; EXCITATORY AMINO ACID ANTAGONISTS; FLUROTHYL; GAMMA-AMINOBUTYRIC ACID; GLUTAMIC ACID; MALE; NEURAL INHIBITION; NEURAL PATHWAYS; NEURONS; RATS; RATS, SPRAGUE-DAWLEY; SEIZURES; SUBSTANTIA NIGRA; SYNAPTIC TRANSMISSION;

EID: 0035909891     PISSN: 03043940     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0304-3940(01)02379-5     Document Type: Article

References (21)

1. Endogenous control of epilepsy: The nigral inhibitory system
2. Anticonvulsant action of 2-amino-7-phosphonoheptanoic acid in the substantia nigra
3. Induction of preconvulsive behavior and Fos expression by dopamine-induced nigral lesion in the rat
4. Substantia nigra: Site of anticonvulsant activity mediated by γ-aminobutyric acid
5. A receptor channel function in the nervous system
6. Seizures evoked from area tempestas are subject to control by GABA and glutamate receptors in substantia nigra
7. Maturation and segregation of brain networks that modify seizures
8. Pathophysiology of the basal ganglia in Parkinson's disease
9. Regulation of substantia nigra pars reticulata neuronal activity by excitatory amino acids
10. Bilateral intranigral NMDA blockade increases status duration and neuronal injury from systemic kainic acid
11. Modulation of the N-methyl-D-aspartate channel by extracellular H+
12. Conditionally immortalized cell lines, engineered to produce and release GABA, modulate the development of behavioral seizures
13. Proton inhibition of N-methyl-D-aspartate receptors in cerebellar neurons
14. Cellular expression of ionotropic glutamate receptor subunits in subpopulations of neurons in the rat substantia nigra pars reticulata
15. Excitatory neurotransmission within substantia nigra pars reticulata regulates threshold for seizures produced by pilocarpine in rats: Effects of intranigral 2-amino-7-phosphonoheptanoate and N-methyl-D-aspartate
16. Site-specific effects of local pH changes in the substantia nigra pars reticulata on flurothyl-induced seizures
17. Sexual dimorphism and developmental regulation of substantia nigra function
18. A receptors involved in seizures
19. Physiology of the basal ganglia and pathophysiology of movement disorders of basal ganglia origin
20. Activation of group III mGluRs inhibits GABAergic and glutamatergic transmission in the substantia nigra pars reticulata
21. Age-dependent differences in the anticonvulsant effects of 2-amino-7-phosphono-heptanoic acid or ketamine infusions into the substantia nigra of rats