Metaphase arrest with centromere separation in polo mutants of Drosophila

Journal of Cell Biology

Volumn 153, Issue 4, 2001, Pages 663-675

  Donaldson, Mary M ^a,b   Tavares, Álvaro A M ^a   Ohkura, Hiroyuki ^a   Deak, Peter ^a,b   Glover, David M ^a,b  

^a UNIVERSITY OF DUNDEE   (United Kingdom)

^b UNIVERSITY OF CAMBRIDGE   (United Kingdom)

Author keywords

Cell cycle; Drosophila; Mitosis; Polo kinase; Spindle checkpoint

Indexed keywords

GAMMA TUBULIN; GENE PRODUCT; PROTEIN KINASE; PROTEIN POLO; UNCLASSIFIED DRUG;

ANAPHASE; ANIMAL CELL; ARTICLE; CENTROMERE; CYTOKINESIS; DROSOPHILA; GENE MUTATION; METAPHASE; MITOSIS INHIBITION; MUTANT; NONHUMAN; PRIORITY JOURNAL; SISTER CHROMATID; SPINDLE CELL;

ANAPHASE; ANIMALS; BRAIN; CELL CYCLE PROTEINS; CENTROMERE; CYCLIN A; CYCLIN B; DROSOPHILA; DROSOPHILA PROTEINS; LARVA; METAPHASE; MITOTIC SPINDLE APPARATUS; MUTATION; NEURONS; PROTEIN KINASES; PROTEIN-SERINE-THREONINE KINASES; SISTER CHROMATID EXCHANGE; TELOMERE;

ANIMALIA;

EID: 0035858876     PISSN: 00219525     EISSN: None     Source Type: Journal    
DOI: 10.1083/jcb.153.4.663     Document Type: Article

References (58)

1. The Polo-like kinase Plx is a component of the MPF amplification loop at the G2/M-phase transition of the cell cycle in Xenopus
2. Sister chromatid separation and chromosome re-duplication are regulated by different mechanisms in response to spindle damage
3. The spindle checkpoint
4. Abnormal spindle protein Asp, and the integrity of mitotic centrosomal microtubule organizing centres
5. Mutation of a Drosophila gamma tubulin ring complex subunit encoded by discs degenerate-4 differentially disrupts centrosomal protein localization
6. Mutations in the essential spindle checkpoint gene bub1 cause chromosome missegregation and fail to block apoptosis in Drosophila
7. Mitotic phospho-epitopes are expressed in Kc cells, neuroblasts and isolated chromosomes in Drosophila melanogaster
8. Drosophila polo kinase is required for cytokinesis
9. UbcD1, a Drosophila ubiquitin-conjugating enzyme required for proper telomere behavior
10. The polo-related kinase Cdc5 activates and is destroyed by the mitotic cyclin destruction machinery in S. cerevisiae
11. Anaphase initiation in Saccharomyces cerevisiae is controlled be the APC-dependent degradation of the anaphase inhibitor Pds1p
12. P-element insertion alleles of essential genes on the third chromosome of Drosophila melanogaster: Correlation of physical and cytogenic maps in chromosomal region 86E to 87F
13. The polo-like kinase Plx1 is required for M phase exit and destruction of mitotic regulators in Xenopus egg extracts
14. Budding yeast Bub2 is localized at spindle pole bodies and activates the mitotic checkpoint via a different pathway from Mad2
15. Fission yeast Cut1 and Cut2 are essential for sister chromatid separation, concentrate along the metaphase spindle and form large complexes
16. The spindle checkpoint: Two transitions, two pathways
17. Polo-like kinases: A team that plays throughout mitosis
18. Differential expression of a phospho-epitope at the kinetochores of moving chromosomes
19. Establishing biorientation occurs with precocious separation of the sister kinetochores, but not the arms, in the early spindle of budding yeast
20. Transient sister chromatid separation and elastic deformation of chromosomes during mitosis in budding yeast
21. The POLO kinase is required at multiple stages during spermatogenesis in Drosophila melanogaster
22. Mechanisms and regulation of the degradation of cyclin B
23. The Drosophila homeotic target gene centrosomin (cnn) encodes a novel centrosomal protein with leucine zippers and maps to a genomic region required for midgut morphogenesis
24. S. cerevisiae genes required for cell cycle arrest in response to loss of microtubule function
25. The sudden recruitment of gammatubulin to the centrosome at the onset of mitosis, and its dynamic exchange throughout the cell cycle, do not require microtubules
26. PKA and MPF-activated polo-like kinase regulate anaphase-promoting complex activity and mitosis progression
27. Purification and molecular cloning of Plx1, a Cdc25-regulatory kinase from Xenopus egg extracts
28. Antibody microinjection reveals an essential role for human polo-like kinase 1 (Plk1) in the functional maturation of mitotic centrosomes
29. PIk in a functional homolog of Saccharomyces cerevisiae Cdc5, and elevated PIk activity induces multiple septation structures
30. The Bub2-dependent mitotic pathway in yeast acts every cell cycle and regulates cytokinesis
31. Feedback control of mitosis in budding yeast
32. Polo encodes a protein kinase homolog required for mitosis in Drosophila
33. Recruitment of the gamma tubulin ring complex to Drosophila salt-stripped centrosome scaffolds
34. Splitting the chromosome: Cutting the ties that bind sister chromatids
35. Polo-like kinases: Positive regulators of cell division from start to finish
36. The conserved Schizosaccharomyces pombe kinase plo1, required to form a bipolar spindle, the actin ring and septum, can drive septation formation in G1 and G2 cells
37. Activated polo-like kinase Plx1 is required at multiple points during mitosis in Xenopus laevis
38. Expression of N-terminally truncated cyclin B in the Drosophila larval brain leads to mitotic delay at late anaphase
39. Failure of pronuclear migration and repeated divisions of polar body nuclei associated with MTOC defects in polo eggs of Drosophila
40. The Drosophila gene abnormal spindle encodes a novel microtubule-associated protein that associates with the polar regions of the mitotic spindle
41. The rough deal protein is a new kinetochore component required for accurate chromosome segregation in Drosophila
42. The disassembly and reassembly of functional centrosomes in vitro
43. Yeast Hct1 is a regulator of Clb2 cyclin proteolysis
44. The polo-like kinase Cdc5p and the WD-repeat protein Cdc20p/fizzy are regulators and substrates of the anaphase promoting complex in Saccharomyces cerevisisae
45. Exit from mitosis is regulated by Drosophila fizzy and the sequential destruction of cyclins A
46. A novel function of Saccharomyces cerevisiae CDC5 in cytokinesis
47. Polo, a mitotic mutant of Drosophila displaying abnormal spindle poles
48. Cohesin ensures bipolar attachment of microtubules to sister centromeres and resists their precocious separation
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50. The conserved mitotic kinase polo is regulated by phosphorylation and has preferred microtubule associated substrates in Drosophila embryo extracts
51. CDC5 and CKII control adaptation to the yeast DNA damage checkpoint
52. The product of proliferation disrupter is concentrated at centromeres and required for mitotic chromosome condensation and cell proliferation in Drosophila
53. Proteolytic ratchets that control progression through mitosis
54. Spatial and temporal patterns of neurogenesis in the central nervous system of Drosophila melanogaster
55. CDC20 and CDH1: A family of substrate-specific activators of APC-dependent proteolysis
56. Cloning of a gene encoding an antigen associated with the centrosome in Drosophila
57. The A- and B-type cyclins of Drosophila are accumulated and destroyed in temporally distinct events that define separable phases of the G2-M transition
58. Fission yeast cut mutations revisited: Control of anaphase