Neuroprotective effects of novel cholinesterase inhibitors derived from rasagiline as potential anti-Alzheimer drugs

Annals of the New York Academy of Sciences

Volumn 939, Issue , 2001, Pages 148-161

  Weinstock, Marta ^a   Kirschbaum Slager, Natanja ^a   Lazarovici, Philip ^a   Bejar, Corina ^a   Youdim, Moussa B H ^b   Shoham, Shai ^c  

^a HEBREW UNIVERSITY OF JERUSALEM   (Israel)

^b TECHNION ISRAEL INSTITUTE OF TECHNOLOGY   (Israel)

^c HERZOG HOSPITAL   (Israel)

Author keywords

Closed head injury; Glucose oxygen deprivation; PC12 cells; Streptozotocin memory deficits

Indexed keywords

CARBAMIC ACID DERIVATIVE; CHOLINESTERASE; CHOLINESTERASE INHIBITOR; LADOSTIGIL; MONOAMINE OXIDASE B INHIBITOR; N PROPARGYL 3 AMINOINDAN 5 YL ETHYL METHYL CARBAMATE; NERVE GROWTH FACTOR; RASAGILINE; RIVASTIGMINE; STREPTOZOCIN; UNCLASSIFIED DRUG;

ALZHEIMER DISEASE; AMNESIA; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; BRAIN EDEMA; CELL STRAIN; CONFERENCE PAPER; CONTROLLED STUDY; DOSE RESPONSE; GLIOSIS; HEAD INJURY; MOTOR PERFORMANCE; NERVE DEGENERATION; NEUROPROTECTION; NONHUMAN; RAT; SPATIAL MEMORY;

EID: 0034932067     PISSN: 00778923     EISSN: None     Source Type: Book Series    
DOI: 10.1111/j.1749-6632.2001.tb03622.x     Document Type: Conference Paper

References (52)

1. Oxidative stress, glutamate, and neurodegenerative disorders
2. Oxidative stress as a mediator of apoptosis
3. Brain cytochrome oxidase activity in Alzheimer's disease
4. Cortical cytochrome oxidase is reduced in Alzheimer's disease
5. Neuroimmune mechanisms in Alzheimer's disease pathogenesis
6. Microglia, an in vivo source of reactive oxygen species in the brain
7. Alzheimer's disease: A disorder of cortical cholinergic innervation
8. Selectivity of cholinesterase inhibition: Clinical implications for the treatment of Alzheimer's disease
9. A controlled trial of selegiline, alpha-tocopherol, or both as treatment for Alzheimer's disease. The Alzheimer's Disease Cooperative Study
10. Selegiline in the treatment of Alzheimer's disease: A long-term randomized placebo-controlled trial
11. Suppression of hydroxyl radical formation and protection of nigral neurons by 1-deprenyl (selegiline)
12. L-Deprenyl reduces brain damage in rats exposed to transient hypoxia-ischemia
13. The neuroprotective and neuronal rescue effects of (-)deprenyl
14. Modulation of gene expression rather than monoamine oxidase inhibition: (-)-Deprenyl-related compounds in controlling neurodegeneration
15. Pharmacology and neuroprotective properties of rasagiline
16. Increased survival of dopaminergic neurons by rasagiline, a monoamine oxidase B inhibitor
17. Rasagiline, a monoamine oxidase-B inhibitor, protects NGF-differentiated PC12 cells against oxygen-glucose deprivation
18. Neuroprotective effect of rasagiline, a selective MAO-B inhibitor, against closed head injury in the mouse
19. Neuroprotective properties of the antiparkinson drug rasagiline and its optical S-isomer
20. Development of a novel neuroprotective drug (TV3326) for the treatment of Alzheimer's disease, with cholinesterase and monoamine oxidase inhibitory activities
21. Nerve growth factor withdrawal-induced cell death in neuronal PC12 cells resembles that in sympathetic neurons
22. 25-35 fragment, glutamate, and hydrogen peroxide
23. Tacrine and donezepil attenuate the neurotoxic effect of A beta (25-35) in rat PC12 cells
24. Huperzine A protects rat pheochromocytoma cells against hydrogen peroxide-induced injury
25. (-)-Deprenyl reduces PC12 cell apoptosis by inducing new protein synthesis
26. Rivastigmine, a brain-selective acetylcholinesterase inhibitor, ameliorates cognitive and motor deficits induced by closed-head injury in the mouse
27. Intra- cerebroventricular injection of streptozotocin induces discrete local changes in cerebral glucose utilization in rats
28. Nerve growth factor and choline acetyltransferase activity levels in the rat brain following experimental impairment of cerebral glucose and energy metabolism
29. Behavioral and biochemical effects of an icv injection of streptozotocin in Old Lewis rats
30. Intracerebroventricular injection of streptozotocin: An animal model for sporadic Alzheimer's disease?
31. Effect of streptozotocin on glutathione and lipid peroxide levels in various tissues of rats
32. Dehydroepiandrosterone protects tissues of streptozotocin-treated rats against oxidative stress
33. Neurons undergo apoptosis in animal and cell culture models of diabetes
34. A new and rapid colorimetric determination of acetylcholinesterase activity
35. An experimental model of closed head injury in mice: Pathophysiology, histopathology and cognitive deficits
36. Effect of rivastigmine on scopolamine-induced memory impairment in rats
37. An attempt to dissociate "spatial-mapping" and "working memory" theories of hippocampal function
38. Golgi-like demonstration of "dark" neurons with an argyrophilia. III method for experimental neuropathology
39. The distribution of beta amyloid precursor protein in rat cortex after kainate-induced seizures
40. Are reactive oxygen species involved in Alzheimer's disease?
41. Oxidative alterations in Alzheimer's disease
42. Is Alzheimer's a disease of oxidative stress?
43. Increased in vitro lipid peroxidation of gerbil cerebral cortex as compared with rat
44. Lipid peroxidation, oxygen radicals, cell damage, and antioxidant therapy
45. Protective effects of huperizine A on -amyloid25-d35 induced oxidative injury in rat pheochromocytoma cells
46. Anti-apoptotic function of propargylamine series of monoamine oxidase inhibitors
47. Fluid percussion injury causes loss of forebrain choline acetyltransferase and nerve growth factor receptor immunoreactive cells in the rat
48. Effects of traumatic brain injury on the cholinergic system in the rat
49. Streptozotocin at low doses induces apoptosis and at high doses causes necrosis in a murine pancreatic beta cell line INS-1
50. Streptozotocin increases free fatty acids and decreases phospholipids in rat brain
51. Cognitive performance and biochemical markers in septum, hippocampus and striatum of rats after an icv injection of streptozotocin: A correlation analysis
52. Intracerebroventricular administration of streptozotocin causes long-term diminutions in learning and memory abilities and in cerebral energy metabolism in adult rats