Pharmacokinetic and pharmacodynamic evaluation of central effect of the novel antiallergic agent betotastine besilate

Arzneimittel-Forschung/Drug Research

Volumn 47, Issue 10, 1997, Pages 1116-1124

  Kato, Masaya ^a   Nishida, Atsushi ^a   Aga, Yasuhiro ^b   Kita, Junichiro ^b   Kudo, Yukitsuka ^a   Narita, Hiroshi ^a   Endo, Toshio ^a  

^a MITSUBISHI TANABE PHARMA CORPORATION   (Japan)

^b UBE INDUSTRIES LTD   (Japan)

Author keywords

Antiallergic agents; Antihistamines; Betotastine; CAS 125602 71 3; TAU 284, studies for sedation and CNS penetration

Indexed keywords

ANTIALLERGIC AGENT; ASTEMIZOLE; ATROPINE; BETOTASTINE; CETIRIZINE; DIAZEPAM; DIHYDROALPRENOLOL; EPINASTINE; FLUNITRAZEPAM; HALOPERIDOL; HEXOBARBITAL; HISTAMINE RECEPTOR; KETANSERIN; KETOTIFEN; MEPYRAMINE; PENTOBARBITAL; QUINUCLIDINYL BENZILATE; TERFENADINE; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BLOOD BRAIN BARRIER; CONTROLLED STUDY; DROWSINESS; DRUG BRAIN LEVEL; DRUG DISTRIBUTION; DRUG RECEPTOR BINDING; INTRAVENOUS DRUG ADMINISTRATION; MALE; MOTOR ACTIVITY; NONHUMAN; PHARMACODYNAMICS; RAT; SEDATION; SLEEP;

ANIMALS; ANTI-ALLERGIC AGENTS; AROUSAL; CATS; CENTRAL NERVOUS SYSTEM; CHO CELLS; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; CRICETINAE; FEMALE; GUINEA PIGS; MALE; MICE; MOTOR ACTIVITY; PIPERIDINES; PYRIDINES; RATS; RATS, WISTAR; RECEPTORS, DRUG; SLEEP;

EID: 0030821786     PISSN: 00044172     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (44)

1. Nicholson, A. N., Lancet II, 211 (1983)
2. Weidmann, H., Petersen, P. V. J. Pharmacol. Exp. Ther. 108, 201 (1953)
3. Lavender, S., Hagermark, O., Stahle, M., Eur. J. Clin. Pharmacol. 28, 523 (1985)
4. Spencer, C. M., Faulds, D., Peters, D. H., Drugs 46, 1055 (1993)
5. Asoh, T., Okamoto, K., Sakai, Y., Jpn. J. Clin. Pharmacol. Ther. 23, 507 (1992)
6. Sorkin, E. M., Heel, R. C., Drugs 29, 34 (1985)
7. Quach, T. T., Duchemin, A. M., Rose, C. et al., Eur. J. Pharmacol. 60, 391 (1979)
8. Yanai, K., Ryu, J. H., Watanabe, T. et al., Br. J. Pharmacol. 116, 1649 (1995)
9. Garteiz, D. A., Hook, R. H., Walker, B. J. et al., Arzneim.-Forsch./Drug Res. 32 (II), 1185 (1982)
10. Hill, S. J., J. Neurochem. 31, 997 (1978)
11. Korte, A., Myers, J., Shih, N. Y. et al., Biochem. Biophys. Res. Commun. 168, 979 (1990)
12. West, R. E., Jr., Zweig, A., Shih, N. Y. et al., Mol. Pharmacol. 38, 610 (1990)
13. Greengrass, P., Bremner, R., Eur. J. Pharmacol. 323, (1979)
14. Boyajian, C. L., Leslie, F. M., J. Pharmacol. Exp. Ther. 241, 1092 (1987)
15. Broadhurst, A. M., Alexander, B. S., Wood, M. D., Life Sci. 43, 83 (1988)
16. U'Prichard, D. C., Bylund, D. B., Snyder, S. H., J. Biol. Chem. 253, 5090 (1978)
17. Bunzow, J. R., Van Tol, H. H., Grandy, D. K. et al., Nature 336, 783 (1988)
18. Grandy, D. K., Marchionni, M. A., Makam, H. et al., Proc. Natl. Acad. Sci. USA 86, 9762 (1989)
19. Hayes, G., Biden, T. J., Selbie, L. A. et al., Mol. Endocrinol. 6, 920 (1992)
20. Leysen, J. E., Niemegeers, C. J. E., Van Nueten, J. M. et al., Mol. Pharmacol. 21, 301 (1982)
21. Luthin, G. R., Wolfe, B. B., J. Pharmacol. Exp. Ther. 228, 648 (1984)
22. Speth, R. C. Wastek, G. J., Yammamura, H. I., Life Sci. 24, 351 (1979)
23. Damm, H. W., Res. Comm. Chem. Pathol. Pharmacol. 22, 597 (1978)
24. Irwin, S., Psychopharmacologia (Berl.) 13, 222 (1968)
25. Jasper, H. H., Ajmone-Marsan, C., A stereotaxic atlas of dienchephalon of the cat. The National Research Council of Canada, Ottawa (1954)
26. Ohashi, R., Tsukimoto, M., Nakamura, S. et al., Xenobiot. Metab. Dispos., in press (1997)
27. Adamus, W. S., Oldigs-Kerber, J. Lohmann, H. F., Eur. J. Clin. Pharmacol. 33, 381 (1987)
28. Nicholson, A. N., Pascoe, P. A., Turner, C. et al., Br. J. Pharmacol. 104, 270 (1991)
29. Monti, J. M., Jantos, H., Boussard, M. et al., Eur. J. Pharmacol. 205, 283 (1991)
30. Lin, J.-S., Sakai, K., Vanni-Mercier, G. et al., Brain Res. 523, 325 (1990)
31. Timmermans, P. B. M. W. M., Sehoop, A. M. C., Kwa, H. Y. et al., Eur. J. Pharmacol. 70, 7 (1981)
32. Peroutka, S. J., U'Prichard, D. C., Greenberg, D. A. et al., Neuropharmacology 16, 549 (1976)
33. Dugovic, C., Wauquier, A., Eur. J. Pharmacol. 137, 145 (1987)
34. Idzikowski, C., Mills, F. J., Glennard, R., Brain Res. 378, 164 (1986)
35. Zoltoski, R. K., Velazquez-Moctezuma, J., Shiromani, P. J. et al., Brain Res. 608, 186 (1993)
36. Buldessarini, R. J., in: Goodman & Oilman's The pharmacological basis of therapeutics, 9th ed., J. G. Hardman, L. E. Limbird, P. B. Molinoff et al. (eds.), pp. 399-432, McGraw-Hill, New York (1995)
37. Hunger, A., Bechtel, W. D., Kuhn, F. J. et al., Arzneim. - Forsch./Drug Res. 38 (II), 1446 (1988)
38. Melville, K. J., in: Histamine and antihistamine, M. Schacter (ed.), pp. 156-157, Pergamon Press. New York (1973)
39. Tasaka, K., Kamei, C., Nakano, S. et al., Pharmacometrics 38, 53 (1989)
40. Tasaka, K., Kamei, C., Chung, Y. H. et al., Pharmacometrics 39, 197 (1990)
41. Rukart, R. T., Johnson, D. N., Pharmacologist 25, 180 (1983)
42. Miyagishi, A., Sugimoto, S., Natume, Y. et al., Clinical Report 28, 1813 (1994)
43. Yato, N., Murata, T., Saito, N. et al., Folia Pharmacol. Jpn. 110, 19 (1997)
44. Honda, H., Murata, K., Hamazaki, A. et al., Jpn. Pharmacol. Ther. 25, 879 (1997)