Neuroimaging of histamine H1-receptor occupancy in human brain by positron emission tomography (PET): A comparative study of ebastine, a second-generation antihistamine, and (+)-chlorpheniramine, a classical antihistamine

British journal of clinical pharmacology

Volumn 52, Issue 5, 2001, Pages 501-509

  Tagawa, Masaaki ^a   Kano, Michiko ^a   Okamura, Nobuyuki ^b   Higuchi, Makoto ^b   Matsuda, Michiaki ^d   Mizuki, Yasuyuki ^d   Arai, Hiroyuki ^b   Iwata, Ren ^c   Fujii, Toshihiko ^d   Komemushi, Sadao ^e   Ido, Tatsuo ^c   Itoh, Masatoshi ^c   Sasaki, Hidetada ^b   Watanabe, Takehiko ^a   Yanai, Kazuhiko ^a  

^a Department of Pharmacology ^*  (Japan)

^b TOHOKU UNIVERSITY SCHOOL OF MEDICINE   (Japan)

^c TOHOKU UNIVERSITY   (Japan)

^d DAINIPPON SUMITOMO PHARMA CO LTD   (Japan)

^e KINKI UNIVERSITY   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

BUTYROPHENONE DERIVATIVE; CARBON; CHLORPHENIRAMINE; DIAGNOSTIC AGENT; EBASTINE; HISTAMINE H1 RECEPTOR; HISTAMINE H1 RECEPTOR ANTAGONIST; PIPERIDINE DERIVATIVE;

ADULT; ARTICLE; BIOLOGICAL MODEL; BRAIN CORTEX; CLINICAL TRIAL; COMPARATIVE STUDY; COMPUTER ASSISTED EMISSION TOMOGRAPHY; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; CROSSOVER PROCEDURE; DRUG EFFECT; HUMAN; MALE; METABOLISM; RANDOMIZED CONTROLLED TRIAL; SINGLE BLIND PROCEDURE; THALAMUS; TREATMENT OUTCOME;

ADULT; BUTYROPHENONES; CARBON RADIOISOTOPES; CEREBRAL CORTEX; CHLORPHENIRAMINE; CROSS-OVER STUDIES; HISTAMINE H1 ANTAGONISTS; HUMANS; MALE; MODELS, BIOLOGICAL; PIPERIDINES; RECEPTORS, HISTAMINE H1; SINGLE-BLIND METHOD; THALAMUS; TOMOGRAPHY, EMISSION-COMPUTED; TREATMENT OUTCOME;

EID: 17944374941     PISSN: 03065251     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1365-2125.2001.01471.x     Document Type: Article

References (0)